LeishMANIAdb
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Bola-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Bola-like protein
Gene product:
BolA-like protein - putative
Species:
Leishmania infantum
UniProt:
A4I112_LEIIN
TriTrypDb:
LINF_240026600
Length:
88

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005759 mitochondrial matrix 5 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I112
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I112

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0019538 protein metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044238 primary metabolic process 2 1
GO:0051604 protein maturation 4 1
GO:0071704 organic substance metabolic process 2 1
GO:0097428 protein maturation by iron-sulfur cluster transfer 5 1
GO:0106035 protein maturation by [4Fe-4S] cluster transfer 6 1
GO:1901564 organonitrogen compound metabolic process 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
DEG_Nend_Nbox_1 1 3 PF02207 0.460
DOC_CDC14_PxL_1 2 10 PF14671 0.542
DOC_USP7_MATH_1 29 33 PF00917 0.418
DOC_WW_Pin1_4 49 54 PF00397 0.481
LIG_14-3-3_CanoR_1 65 71 PF00244 0.455
LIG_Actin_WH2_2 14 30 PF00022 0.414
LIG_BRCT_BRCA1_1 51 55 PF00533 0.414
LIG_FHA_2 11 17 PF00498 0.358
LIG_LIR_Nem_3 44 48 PF02991 0.414
LIG_SH2_NCK_1 12 16 PF00017 0.419
LIG_SH2_STAT5 12 15 PF00017 0.417
LIG_SUMO_SIM_par_1 34 39 PF11976 0.383
MOD_GlcNHglycan 22 26 PF01048 0.480
MOD_GlcNHglycan 37 41 PF01048 0.338
MOD_GlcNHglycan 73 78 PF01048 0.260
MOD_NEK2_1 21 26 PF00069 0.367
MOD_NEK2_1 66 71 PF00069 0.485
MOD_NEK2_2 29 34 PF00069 0.399
MOD_NEK2_2 41 46 PF00069 0.414
MOD_Plk_1 73 79 PF00069 0.481
MOD_Plk_4 41 47 PF00069 0.434
MOD_Plk_4 56 62 PF00069 0.461
MOD_Plk_4 66 72 PF00069 0.455
MOD_ProDKin_1 49 55 PF00069 0.481
MOD_SUMO_for_1 19 22 PF00179 0.380
MOD_SUMO_for_1 71 74 PF00179 0.418
TRG_DiLeu_BaLyEn_6 4 9 PF01217 0.542

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBX7 Leptomonas seymouri 85% 100%
A0A0S4IUF9 Bodo saltans 52% 97%
A0A3Q8IC84 Leishmania donovani 100% 100%
A4HDR6 Leishmania braziliensis 90% 100%
C9ZW98 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 63% 100%
E9AX50 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
O14280 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 48% 100%
P53082 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 43% 73%
Q3SZ84 Bos taurus 35% 80%
Q4QAC6 Leishmania major 95% 100%
Q53S33 Homo sapiens 35% 82%
Q8CEI1 Mus musculus 34% 80%
Q9FIC3 Arabidopsis thaliana 40% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS