Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphorylated CTD interacting factor 1 WW domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I108_LEIIN

TriTrypDb:

LINF_240026200

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I108

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I108

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000993	RNA polymerase II complex binding	5	11
GO:0001098	basal transcription machinery binding	3	11
GO:0001099	basal RNA polymerase II transcription machinery binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008168	methyltransferase activity	4	11
GO:0008173	RNA methyltransferase activity	4	11
GO:0008174	mRNA methyltransferase activity	5	11
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	11
GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	6	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0019899	enzyme binding	3	11
GO:0043175	RNA polymerase core enzyme binding	5	11
GO:0070063	RNA polymerase binding	4	11
GO:0099122	RNA polymerase II C-terminal domain binding	6	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.445
CLV_C14_Caspase3-7	5	9	PF00656	0.728
CLV_NRD_NRD_1	206	208	PF00675	0.514
CLV_NRD_NRD_1	238	240	PF00675	0.498
CLV_NRD_NRD_1	33	35	PF00675	0.384
CLV_NRD_NRD_1	490	492	PF00675	0.469
CLV_NRD_NRD_1	54	56	PF00675	0.521
CLV_PCSK_FUR_1	204	208	PF00082	0.555
CLV_PCSK_KEX2_1	179	181	PF00082	0.434
CLV_PCSK_KEX2_1	2	4	PF00082	0.637
CLV_PCSK_KEX2_1	206	208	PF00082	0.514
CLV_PCSK_KEX2_1	238	240	PF00082	0.498
CLV_PCSK_KEX2_1	33	35	PF00082	0.384
CLV_PCSK_KEX2_1	460	462	PF00082	0.383
CLV_PCSK_KEX2_1	490	492	PF00082	0.541
CLV_PCSK_KEX2_1	572	574	PF00082	0.498
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.434
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.637
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.438
CLV_PCSK_PC1ET2_1	572	574	PF00082	0.477
CLV_PCSK_SKI1_1	21	25	PF00082	0.341
CLV_PCSK_SKI1_1	276	280	PF00082	0.550
CLV_PCSK_SKI1_1	291	295	PF00082	0.239
CLV_PCSK_SKI1_1	34	38	PF00082	0.370
CLV_PCSK_SKI1_1	402	406	PF00082	0.357
CLV_PCSK_SKI1_1	460	464	PF00082	0.385
CLV_PCSK_SKI1_1	517	521	PF00082	0.620
CLV_PCSK_SKI1_1	572	576	PF00082	0.536
CLV_PCSK_SKI1_1	67	71	PF00082	0.355
DEG_APCC_DBOX_1	33	41	PF00400	0.431
DEG_Nend_UBRbox_1	1	4	PF02207	0.635
DEG_SPOP_SBC_1	470	474	PF00917	0.629
DOC_CKS1_1	214	219	PF01111	0.590
DOC_CKS1_1	339	344	PF01111	0.324
DOC_MAPK_gen_1	97	105	PF00069	0.400
DOC_MAPK_JIP1_4	402	408	PF00069	0.352
DOC_MAPK_MEF2A_6	243	250	PF00069	0.390
DOC_MAPK_MEF2A_6	402	410	PF00069	0.358
DOC_PP1_RVXF_1	282	289	PF00149	0.308
DOC_PP1_RVXF_1	45	52	PF00149	0.548
DOC_PP2B_LxvP_1	408	411	PF13499	0.360
DOC_PP2B_LxvP_1	446	449	PF13499	0.347
DOC_USP7_MATH_1	122	126	PF00917	0.679
DOC_USP7_MATH_1	129	133	PF00917	0.684
DOC_USP7_MATH_1	227	231	PF00917	0.477
DOC_USP7_MATH_1	304	308	PF00917	0.304
DOC_USP7_MATH_1	351	355	PF00917	0.453
DOC_USP7_MATH_1	431	435	PF00917	0.512
DOC_USP7_MATH_1	470	474	PF00917	0.603
DOC_USP7_MATH_1	522	526	PF00917	0.525
DOC_USP7_MATH_1	574	578	PF00917	0.499
DOC_WW_Pin1_4	193	198	PF00397	0.474
DOC_WW_Pin1_4	213	218	PF00397	0.312
DOC_WW_Pin1_4	330	335	PF00397	0.302
DOC_WW_Pin1_4	338	343	PF00397	0.302
DOC_WW_Pin1_4	473	478	PF00397	0.701
DOC_WW_Pin1_4	565	570	PF00397	0.544
DOC_WW_Pin1_4	582	587	PF00397	0.669
DOC_WW_Pin1_4	89	94	PF00397	0.646
LIG_14-3-3_CanoR_1	291	296	PF00244	0.345
LIG_14-3-3_CanoR_1	390	399	PF00244	0.420
LIG_14-3-3_CanoR_1	500	506	PF00244	0.521
LIG_Clathr_ClatBox_1	405	409	PF01394	0.346
LIG_deltaCOP1_diTrp_1	526	535	PF00928	0.361
LIG_FHA_1	196	202	PF00498	0.421
LIG_FHA_1	292	298	PF00498	0.281
LIG_FHA_1	303	309	PF00498	0.302
LIG_FHA_1	405	411	PF00498	0.376
LIG_FHA_1	464	470	PF00498	0.652
LIG_FHA_1	555	561	PF00498	0.363
LIG_FHA_2	141	147	PF00498	0.407
LIG_FHA_2	553	559	PF00498	0.386
LIG_LIR_Apic_2	497	502	PF02991	0.422
LIG_LIR_Apic_2	576	582	PF02991	0.565
LIG_LIR_Gen_1	249	260	PF02991	0.480
LIG_LIR_Gen_1	418	428	PF02991	0.348
LIG_LIR_Gen_1	443	450	PF02991	0.323
LIG_LIR_Gen_1	525	536	PF02991	0.366
LIG_LIR_Nem_3	374	380	PF02991	0.321
LIG_LIR_Nem_3	418	424	PF02991	0.345
LIG_LIR_Nem_3	443	447	PF02991	0.316
LIG_LIR_Nem_3	525	531	PF02991	0.368
LIG_LIR_Nem_3	537	543	PF02991	0.370
LIG_LIR_Nem_3	576	581	PF02991	0.560
LIG_NRBOX	415	421	PF00104	0.455
LIG_PCNA_yPIPBox_3	55	69	PF02747	0.381
LIG_Pex14_2	366	370	PF04695	0.302
LIG_Pex14_2	531	535	PF04695	0.324
LIG_SH2_CRK	499	503	PF00017	0.443
LIG_SH2_NCK_1	160	164	PF00017	0.395
LIG_SH2_PTP2	444	447	PF00017	0.317
LIG_SH2_PTP2	579	582	PF00017	0.442
LIG_SH2_STAP1	144	148	PF00017	0.383
LIG_SH2_STAP1	392	396	PF00017	0.501
LIG_SH2_STAP1	412	416	PF00017	0.227
LIG_SH2_STAT3	144	147	PF00017	0.387
LIG_SH2_STAT5	376	379	PF00017	0.306
LIG_SH2_STAT5	444	447	PF00017	0.321
LIG_SH2_STAT5	542	545	PF00017	0.358
LIG_SH2_STAT5	579	582	PF00017	0.506
LIG_SH3_3	228	234	PF00018	0.412
LIG_SH3_3	245	251	PF00018	0.288
LIG_SH3_3	393	399	PF00018	0.533
LIG_SH3_3	73	79	PF00018	0.517
LIG_SUMO_SIM_anti_2	22	27	PF11976	0.454
LIG_SUMO_SIM_anti_2	443	449	PF11976	0.321
LIG_SUMO_SIM_par_1	402	407	PF11976	0.354
LIG_TYR_ITIM	442	447	PF00017	0.395
LIG_WRC_WIRS_1	575	580	PF05994	0.443
MOD_CDK_SPxxK_3	565	572	PF00069	0.530
MOD_CK1_1	153	159	PF00069	0.473
MOD_CK1_1	266	272	PF00069	0.502
MOD_CK1_1	379	385	PF00069	0.304
MOD_CK1_1	472	478	PF00069	0.689
MOD_CK1_1	89	95	PF00069	0.647
MOD_CK2_1	140	146	PF00069	0.520
MOD_CK2_1	501	507	PF00069	0.509
MOD_CK2_1	552	558	PF00069	0.395
MOD_GlcNHglycan	107	110	PF01048	0.448
MOD_GlcNHglycan	125	128	PF01048	0.487
MOD_GlcNHglycan	161	164	PF01048	0.521
MOD_GlcNHglycan	279	282	PF01048	0.570
MOD_GlcNHglycan	367	370	PF01048	0.302
MOD_GlcNHglycan	381	384	PF01048	0.302
MOD_GlcNHglycan	429	432	PF01048	0.548
MOD_GlcNHglycan	477	480	PF01048	0.610
MOD_GlcNHglycan	93	96	PF01048	0.719
MOD_GSK3_1	123	130	PF00069	0.648
MOD_GSK3_1	427	434	PF00069	0.423
MOD_GSK3_1	469	476	PF00069	0.673
MOD_GSK3_1	581	588	PF00069	0.667
MOD_N-GLC_1	156	161	PF02516	0.520
MOD_N-GLC_1	173	178	PF02516	0.267
MOD_NEK2_1	1	6	PF00069	0.738
MOD_NEK2_1	432	437	PF00069	0.588
MOD_NEK2_1	463	468	PF00069	0.532
MOD_NEK2_1	543	548	PF00069	0.475
MOD_NEK2_2	574	579	PF00069	0.498
MOD_PIKK_1	195	201	PF00454	0.457
MOD_PIKK_1	68	74	PF00454	0.401
MOD_PK_1	150	156	PF00069	0.487
MOD_PKA_1	2	8	PF00069	0.745
MOD_PKA_2	2	8	PF00069	0.745
MOD_Plk_1	150	156	PF00069	0.375
MOD_Plk_1	173	179	PF00069	0.537
MOD_Plk_1	227	233	PF00069	0.463
MOD_Plk_2-3	140	146	PF00069	0.539
MOD_Plk_4	130	136	PF00069	0.496
MOD_Plk_4	291	297	PF00069	0.361
MOD_Plk_4	574	580	PF00069	0.421
MOD_ProDKin_1	193	199	PF00069	0.476
MOD_ProDKin_1	213	219	PF00069	0.302
MOD_ProDKin_1	330	336	PF00069	0.302
MOD_ProDKin_1	338	344	PF00069	0.302
MOD_ProDKin_1	473	479	PF00069	0.693
MOD_ProDKin_1	565	571	PF00069	0.531
MOD_ProDKin_1	582	588	PF00069	0.670
MOD_ProDKin_1	89	95	PF00069	0.643
MOD_SUMO_for_1	456	459	PF00179	0.412
MOD_SUMO_rev_2	394	404	PF00179	0.411
TRG_DiLeu_BaLyEn_6	400	405	PF01217	0.483
TRG_ENDOCYTIC_2	262	265	PF00928	0.396
TRG_ENDOCYTIC_2	325	328	PF00928	0.302
TRG_ENDOCYTIC_2	444	447	PF00928	0.317
TRG_ENDOCYTIC_2	540	543	PF00928	0.351
TRG_ER_diArg_1	203	206	PF00400	0.536
TRG_ER_diArg_1	237	239	PF00400	0.469
TRG_ER_diArg_1	32	34	PF00400	0.370
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	284	289	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II31	Leptomonas seymouri	65%	98%
A0A1X0NXA7	Trypanosomatidae	46%	100%
A0A3Q8IBG9	Leishmania donovani	100%	100%
A0A422NWV1	Trypanosoma rangeli	47%	100%
A4HDR2	Leishmania braziliensis	84%	100%
C9ZWA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AX46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QAD0	Leishmania major	94%	100%
V5BAG8	Trypanosoma cruzi	46%	100%