Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I104_LEIIN

TriTrypDb:

LINF_240025800

Length:

962

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I104

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I104

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	441	445	PF00656	0.638
CLV_C14_Caspase3-7	745	749	PF00656	0.652
CLV_MEL_PAP_1	948	954	PF00089	0.601
CLV_NRD_NRD_1	187	189	PF00675	0.622
CLV_NRD_NRD_1	379	381	PF00675	0.675
CLV_NRD_NRD_1	421	423	PF00675	0.747
CLV_NRD_NRD_1	539	541	PF00675	0.588
CLV_NRD_NRD_1	558	560	PF00675	0.346
CLV_NRD_NRD_1	91	93	PF00675	0.592
CLV_NRD_NRD_1	914	916	PF00675	0.692
CLV_NRD_NRD_1	950	952	PF00675	0.610
CLV_PCSK_KEX2_1	187	189	PF00082	0.622
CLV_PCSK_KEX2_1	378	380	PF00082	0.682
CLV_PCSK_KEX2_1	421	423	PF00082	0.747
CLV_PCSK_KEX2_1	539	541	PF00082	0.588
CLV_PCSK_KEX2_1	557	559	PF00082	0.361
CLV_PCSK_KEX2_1	91	93	PF00082	0.575
CLV_PCSK_KEX2_1	914	916	PF00082	0.692
CLV_PCSK_KEX2_1	950	952	PF00082	0.610
CLV_PCSK_PC7_1	375	381	PF00082	0.682
CLV_PCSK_SKI1_1	246	250	PF00082	0.495
CLV_PCSK_SKI1_1	430	434	PF00082	0.782
CLV_PCSK_SKI1_1	468	472	PF00082	0.635
CLV_PCSK_SKI1_1	632	636	PF00082	0.600
CLV_PCSK_SKI1_1	868	872	PF00082	0.603
DEG_APCC_DBOX_1	467	475	PF00400	0.634
DOC_CKS1_1	798	803	PF01111	0.630
DOC_CKS1_1	835	840	PF01111	0.676
DOC_CKS1_1	907	912	PF01111	0.594
DOC_CYCLIN_RxL_1	865	873	PF00134	0.600
DOC_CYCLIN_yCln2_LP_2	679	685	PF00134	0.635
DOC_MAPK_DCC_7	468	476	PF00069	0.629
DOC_MAPK_MEF2A_6	162	169	PF00069	0.540
DOC_MAPK_NFAT4_5	162	170	PF00069	0.540
DOC_PP2B_LxvP_1	679	682	PF13499	0.632
DOC_PP4_FxxP_1	56	59	PF00568	0.534
DOC_PP4_FxxP_1	798	801	PF00568	0.634
DOC_PP4_FxxP_1	835	838	PF00568	0.680
DOC_USP7_MATH_1	141	145	PF00917	0.608
DOC_USP7_MATH_1	242	246	PF00917	0.577
DOC_USP7_MATH_1	311	315	PF00917	0.721
DOC_USP7_MATH_1	357	361	PF00917	0.755
DOC_USP7_MATH_1	424	428	PF00917	0.695
DOC_USP7_MATH_1	439	443	PF00917	0.573
DOC_USP7_MATH_1	527	531	PF00917	0.573
DOC_USP7_MATH_1	67	71	PF00917	0.548
DOC_USP7_MATH_1	706	710	PF00917	0.777
DOC_USP7_MATH_1	724	728	PF00917	0.664
DOC_USP7_MATH_1	740	744	PF00917	0.571
DOC_USP7_MATH_1	764	768	PF00917	0.696
DOC_USP7_MATH_2	760	766	PF00917	0.728
DOC_WW_Pin1_4	106	111	PF00397	0.588
DOC_WW_Pin1_4	25	30	PF00397	0.602
DOC_WW_Pin1_4	39	44	PF00397	0.508
DOC_WW_Pin1_4	422	427	PF00397	0.709
DOC_WW_Pin1_4	469	474	PF00397	0.631
DOC_WW_Pin1_4	58	63	PF00397	0.501
DOC_WW_Pin1_4	660	665	PF00397	0.755
DOC_WW_Pin1_4	672	677	PF00397	0.656
DOC_WW_Pin1_4	797	802	PF00397	0.657
DOC_WW_Pin1_4	834	839	PF00397	0.775
DOC_WW_Pin1_4	890	895	PF00397	0.736
DOC_WW_Pin1_4	906	911	PF00397	0.533
LIG_14-3-3_CanoR_1	411	415	PF00244	0.611
LIG_14-3-3_CanoR_1	585	593	PF00244	0.501
LIG_14-3-3_CanoR_1	600	608	PF00244	0.507
LIG_14-3-3_CanoR_1	686	691	PF00244	0.552
LIG_14-3-3_CanoR_1	710	716	PF00244	0.668
LIG_14-3-3_CanoR_1	834	838	PF00244	0.750
LIG_14-3-3_CanoR_1	901	911	PF00244	0.760
LIG_14-3-3_CanoR_1	914	918	PF00244	0.626
LIG_Actin_WH2_2	454	470	PF00022	0.644
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_BIR_III_4	444	448	PF00653	0.694
LIG_BRCT_BRCA1_1	322	326	PF00533	0.712
LIG_BRCT_BRCA1_1	52	56	PF00533	0.534
LIG_BRCT_BRCA1_1	645	649	PF00533	0.542
LIG_BRCT_BRCA1_1	933	937	PF00533	0.647
LIG_CtBP_PxDLS_1	910	914	PF00389	0.597
LIG_deltaCOP1_diTrp_1	636	642	PF00928	0.534
LIG_FHA_1	103	109	PF00498	0.576
LIG_FHA_1	112	118	PF00498	0.498
LIG_FHA_1	16	22	PF00498	0.628
LIG_FHA_1	372	378	PF00498	0.756
LIG_FHA_1	450	456	PF00498	0.666
LIG_FHA_1	470	476	PF00498	0.426
LIG_FHA_1	834	840	PF00498	0.647
LIG_FHA_1	937	943	PF00498	0.596
LIG_FHA_2	101	107	PF00498	0.556
LIG_FHA_2	141	147	PF00498	0.585
LIG_FHA_2	319	325	PF00498	0.635
LIG_FHA_2	439	445	PF00498	0.759
LIG_FHA_2	458	464	PF00498	0.412
LIG_FHA_2	743	749	PF00498	0.712
LIG_FHA_2	798	804	PF00498	0.778
LIG_FHA_2	907	913	PF00498	0.662
LIG_LIR_Apic_2	53	59	PF02991	0.534
LIG_LIR_Apic_2	796	801	PF02991	0.635
LIG_LIR_Apic_2	841	846	PF02991	0.738
LIG_LIR_Gen_1	213	221	PF02991	0.593
LIG_LIR_Gen_1	323	331	PF02991	0.714
LIG_LIR_Gen_1	48	59	PF02991	0.598
LIG_LIR_Gen_1	570	579	PF02991	0.572
LIG_LIR_Gen_1	621	631	PF02991	0.593
LIG_LIR_Gen_1	881	890	PF02991	0.659
LIG_LIR_Gen_1	930	941	PF02991	0.625
LIG_LIR_Nem_3	213	218	PF02991	0.590
LIG_LIR_Nem_3	323	329	PF02991	0.717
LIG_LIR_Nem_3	48	54	PF02991	0.596
LIG_LIR_Nem_3	570	575	PF02991	0.578
LIG_LIR_Nem_3	621	627	PF02991	0.595
LIG_LIR_Nem_3	881	885	PF02991	0.692
LIG_NRBOX	294	300	PF00104	0.619
LIG_PDZ_Class_2	957	962	PF00595	0.618
LIG_Pex14_2	794	798	PF04695	0.637
LIG_PTB_Apo_2	298	305	PF02174	0.609
LIG_PTB_Phospho_1	298	304	PF10480	0.608
LIG_Rb_LxCxE_1	561	580	PF01857	0.569
LIG_SH2_CRK	51	55	PF00017	0.597
LIG_SH2_CRK	624	628	PF00017	0.622
LIG_SH2_CRK	631	635	PF00017	0.568
LIG_SH2_CRK	889	893	PF00017	0.591
LIG_SH2_NCK_1	889	893	PF00017	0.591
LIG_SH2_STAP1	933	937	PF00017	0.647
LIG_SH2_STAT3	304	307	PF00017	0.631
LIG_SH2_STAT5	917	920	PF00017	0.757
LIG_SH3_1	23	29	PF00018	0.594
LIG_SH3_1	889	895	PF00018	0.672
LIG_SH3_2	416	421	PF14604	0.620
LIG_SH3_3	23	29	PF00018	0.651
LIG_SH3_3	351	357	PF00018	0.765
LIG_SH3_3	413	419	PF00018	0.632
LIG_SH3_3	420	426	PF00018	0.833
LIG_SH3_3	56	62	PF00018	0.587
LIG_SH3_3	661	667	PF00018	0.774
LIG_SH3_3	675	681	PF00018	0.588
LIG_SH3_3	826	832	PF00018	0.699
LIG_SH3_3	889	895	PF00018	0.727
LIG_SH3_3	904	910	PF00018	0.556
LIG_SH3_CIN85_PxpxPR_1	815	820	PF14604	0.708
LIG_SUMO_SIM_anti_2	452	460	PF11976	0.539
LIG_SUMO_SIM_anti_2	578	583	PF11976	0.565
LIG_SUMO_SIM_par_1	196	201	PF11976	0.654
LIG_TRAF2_1	12	15	PF00917	0.610
LIG_TRAF2_1	143	146	PF00917	0.427
LIG_TRAF2_1	521	524	PF00917	0.552
LIG_TYR_ITIM	622	627	PF00017	0.635
LIG_UBA3_1	474	479	PF00899	0.616
LIG_WW_3	831	835	PF00397	0.687
MOD_CDK_SPK_2	58	63	PF00069	0.596
MOD_CK1_1	144	150	PF00069	0.610
MOD_CK1_1	2	8	PF00069	0.617
MOD_CK1_1	360	366	PF00069	0.674
MOD_CK1_1	425	431	PF00069	0.767
MOD_CK1_1	453	459	PF00069	0.683
MOD_CK1_1	522	528	PF00069	0.494
MOD_CK1_1	587	593	PF00069	0.551
MOD_CK1_1	61	67	PF00069	0.584
MOD_CK1_1	643	649	PF00069	0.657
MOD_CK1_1	674	680	PF00069	0.708
MOD_CK1_1	709	715	PF00069	0.698
MOD_CK1_1	765	771	PF00069	0.724
MOD_CK1_1	787	793	PF00069	0.702
MOD_CK1_1	797	803	PF00069	0.693
MOD_CK1_1	83	89	PF00069	0.613
MOD_CK1_1	848	854	PF00069	0.755
MOD_CK1_1	881	887	PF00069	0.722
MOD_CK1_1	916	922	PF00069	0.727
MOD_CK2_1	100	106	PF00069	0.560
MOD_CK2_1	140	146	PF00069	0.587
MOD_CK2_1	251	257	PF00069	0.654
MOD_CK2_1	318	324	PF00069	0.633
MOD_CK2_1	379	385	PF00069	0.621
MOD_CK2_1	522	528	PF00069	0.494
MOD_CK2_1	797	803	PF00069	0.804
MOD_CK2_1	8	14	PF00069	0.625
MOD_DYRK1A_RPxSP_1	422	426	PF00069	0.735
MOD_GlcNHglycan	1	4	PF01048	0.678
MOD_GlcNHglycan	10	13	PF01048	0.612
MOD_GlcNHglycan	205	210	PF01048	0.546
MOD_GlcNHglycan	276	279	PF01048	0.688
MOD_GlcNHglycan	284	287	PF01048	0.597
MOD_GlcNHglycan	385	388	PF01048	0.642
MOD_GlcNHglycan	396	399	PF01048	0.475
MOD_GlcNHglycan	519	522	PF01048	0.551
MOD_GlcNHglycan	603	606	PF01048	0.636
MOD_GlcNHglycan	63	66	PF01048	0.565
MOD_GlcNHglycan	654	657	PF01048	0.604
MOD_GlcNHglycan	688	691	PF01048	0.758
MOD_GlcNHglycan	764	767	PF01048	0.797
MOD_GlcNHglycan	789	792	PF01048	0.715
MOD_GlcNHglycan	82	85	PF01048	0.568
MOD_GlcNHglycan	847	850	PF01048	0.711
MOD_GlcNHglycan	861	864	PF01048	0.553
MOD_GlcNHglycan	897	900	PF01048	0.584
MOD_GlcNHglycan	952	955	PF01048	0.600
MOD_GSK3_1	102	109	PF00069	0.608
MOD_GSK3_1	140	147	PF00069	0.496
MOD_GSK3_1	2	9	PF00069	0.631
MOD_GSK3_1	242	249	PF00069	0.486
MOD_GSK3_1	357	364	PF00069	0.761
MOD_GSK3_1	379	386	PF00069	0.664
MOD_GSK3_1	422	429	PF00069	0.764
MOD_GSK3_1	433	440	PF00069	0.667
MOD_GSK3_1	446	453	PF00069	0.531
MOD_GSK3_1	46	53	PF00069	0.646
MOD_GSK3_1	54	61	PF00069	0.580
MOD_GSK3_1	558	565	PF00069	0.532
MOD_GSK3_1	67	74	PF00069	0.536
MOD_GSK3_1	706	713	PF00069	0.724
MOD_GSK3_1	722	729	PF00069	0.795
MOD_GSK3_1	760	767	PF00069	0.705
MOD_GSK3_1	783	790	PF00069	0.763
MOD_GSK3_1	793	800	PF00069	0.740
MOD_GSK3_1	80	87	PF00069	0.550
MOD_GSK3_1	834	841	PF00069	0.787
MOD_GSK3_1	845	852	PF00069	0.588
MOD_GSK3_1	890	897	PF00069	0.711
MOD_GSK3_1	902	909	PF00069	0.606
MOD_GSK3_1	927	934	PF00069	0.660
MOD_LATS_1	244	250	PF00433	0.495
MOD_N-GLC_1	383	388	PF02516	0.572
MOD_N-GLC_1	927	932	PF02516	0.526
MOD_NEK2_1	371	376	PF00069	0.758
MOD_NEK2_1	383	388	PF00069	0.512
MOD_NEK2_1	433	438	PF00069	0.780
MOD_NEK2_1	562	567	PF00069	0.630
MOD_NEK2_1	652	657	PF00069	0.562
MOD_NEK2_1	716	721	PF00069	0.763
MOD_NEK2_1	859	864	PF00069	0.661
MOD_NEK2_1	870	875	PF00069	0.655
MOD_NEK2_1	880	885	PF00069	0.576
MOD_NEK2_1	913	918	PF00069	0.693
MOD_NEK2_1	956	961	PF00069	0.602
MOD_PIKK_1	340	346	PF00454	0.709
MOD_PIKK_1	410	416	PF00454	0.759
MOD_PIKK_1	439	445	PF00454	0.695
MOD_PIKK_1	450	456	PF00454	0.607
MOD_PIKK_1	519	525	PF00454	0.617
MOD_PIKK_1	67	73	PF00454	0.567
MOD_PIKK_1	77	83	PF00454	0.531
MOD_PIKK_1	785	791	PF00454	0.676
MOD_PK_1	75	81	PF00069	0.566
MOD_PKA_1	379	385	PF00069	0.644
MOD_PKA_1	558	564	PF00069	0.533
MOD_PKA_1	950	956	PF00069	0.609
MOD_PKA_2	141	147	PF00069	0.608
MOD_PKA_2	282	288	PF00069	0.649
MOD_PKA_2	379	385	PF00069	0.644
MOD_PKA_2	410	416	PF00069	0.606
MOD_PKA_2	5	11	PF00069	0.671
MOD_PKA_2	558	564	PF00069	0.533
MOD_PKA_2	584	590	PF00069	0.542
MOD_PKA_2	709	715	PF00069	0.670
MOD_PKA_2	760	766	PF00069	0.652
MOD_PKA_2	833	839	PF00069	0.755
MOD_PKA_2	913	919	PF00069	0.691
MOD_PKA_2	950	956	PF00069	0.609
MOD_PKB_1	4	12	PF00069	0.617
MOD_PKB_1	73	81	PF00069	0.599
MOD_Plk_1	16	22	PF00069	0.629
MOD_Plk_1	638	644	PF00069	0.560
MOD_Plk_1	931	937	PF00069	0.659
MOD_Plk_1	956	962	PF00069	0.610
MOD_Plk_4	16	22	PF00069	0.629
MOD_Plk_4	193	199	PF00069	0.541
MOD_Plk_4	453	459	PF00069	0.500
MOD_Plk_4	480	486	PF00069	0.531
MOD_Plk_4	711	717	PF00069	0.763
MOD_Plk_4	932	938	PF00069	0.647
MOD_ProDKin_1	106	112	PF00069	0.581
MOD_ProDKin_1	25	31	PF00069	0.602
MOD_ProDKin_1	39	45	PF00069	0.507
MOD_ProDKin_1	422	428	PF00069	0.709
MOD_ProDKin_1	469	475	PF00069	0.629
MOD_ProDKin_1	58	64	PF00069	0.502
MOD_ProDKin_1	660	666	PF00069	0.755
MOD_ProDKin_1	672	678	PF00069	0.653
MOD_ProDKin_1	797	803	PF00069	0.658
MOD_ProDKin_1	834	840	PF00069	0.776
MOD_ProDKin_1	890	896	PF00069	0.738
MOD_ProDKin_1	906	912	PF00069	0.533
MOD_SUMO_for_1	123	126	PF00179	0.601
MOD_SUMO_rev_2	116	125	PF00179	0.471
MOD_SUMO_rev_2	189	196	PF00179	0.544
TRG_DiLeu_BaEn_1	570	575	PF01217	0.578
TRG_DiLeu_BaLyEn_6	470	475	PF01217	0.628
TRG_ENDOCYTIC_2	506	509	PF00928	0.655
TRG_ENDOCYTIC_2	51	54	PF00928	0.597
TRG_ENDOCYTIC_2	624	627	PF00928	0.628
TRG_ENDOCYTIC_2	631	634	PF00928	0.561
TRG_ENDOCYTIC_2	933	936	PF00928	0.654
TRG_ER_diArg_1	151	154	PF00400	0.618
TRG_ER_diArg_1	281	284	PF00400	0.685
TRG_ER_diArg_1	377	380	PF00400	0.607
TRG_ER_diArg_1	421	423	PF00400	0.747
TRG_ER_diArg_1	492	495	PF00400	0.608
TRG_ER_diArg_1	539	541	PF00400	0.588
TRG_ER_diArg_1	556	559	PF00400	0.373
TRG_ER_diArg_1	91	93	PF00400	0.575
TRG_ER_diArg_1	913	915	PF00400	0.693
TRG_ER_diArg_1	950	952	PF00400	0.610
TRG_NES_CRM1_1	258	273	PF08389	0.578
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	308	313	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	632	636	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	856	861	PF00026	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYM1	Leishmania donovani	99%	100%
A4HDQ8	Leishmania braziliensis	68%	99%
E9AX42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QAD4	Leishmania major	84%	100%