Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I102_LEIIN

TriTrypDb:

LINF_240025600

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I102

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I102

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.755
CLV_C14_Caspase3-7	87	91	PF00656	0.736
CLV_PCSK_KEX2_1	362	364	PF00082	0.712
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.712
CLV_PCSK_SKI1_1	121	125	PF00082	0.493
CLV_PCSK_SKI1_1	183	187	PF00082	0.351
CLV_PCSK_SKI1_1	195	199	PF00082	0.373
DEG_APCC_DBOX_1	291	299	PF00400	0.480
DEG_SPOP_SBC_1	123	127	PF00917	0.791
DEG_SPOP_SBC_1	53	57	PF00917	0.777
DOC_CKS1_1	30	35	PF01111	0.677
DOC_MAPK_HePTP_8	216	228	PF00069	0.552
DOC_MAPK_HePTP_8	258	270	PF00069	0.441
DOC_MAPK_MEF2A_6	219	228	PF00069	0.550
DOC_MAPK_MEF2A_6	261	270	PF00069	0.576
DOC_PP2B_LxvP_1	268	271	PF13499	0.559
DOC_USP7_MATH_1	123	127	PF00917	0.774
DOC_USP7_MATH_1	253	257	PF00917	0.323
DOC_USP7_MATH_1	291	295	PF00917	0.510
DOC_USP7_MATH_1	307	311	PF00917	0.384
DOC_USP7_MATH_1	352	356	PF00917	0.336
DOC_USP7_MATH_1	39	43	PF00917	0.750
DOC_USP7_MATH_1	53	57	PF00917	0.662
DOC_USP7_MATH_1	67	71	PF00917	0.663
DOC_WW_Pin1_4	106	111	PF00397	0.695
DOC_WW_Pin1_4	129	134	PF00397	0.697
DOC_WW_Pin1_4	29	34	PF00397	0.623
DOC_WW_Pin1_4	91	96	PF00397	0.795
LIG_14-3-3_CanoR_1	106	110	PF00244	0.709
LIG_14-3-3_CanoR_1	183	190	PF00244	0.550
LIG_14-3-3_CanoR_1	292	298	PF00244	0.323
LIG_14-3-3_CanoR_1	40	46	PF00244	0.730
LIG_14-3-3_CanoR_1	51	60	PF00244	0.824
LIG_14-3-3_CanoR_1	68	74	PF00244	0.714
LIG_14-3-3_CterR_2	363	366	PF00244	0.517
LIG_Actin_RPEL_3	239	258	PF02755	0.541
LIG_BRCT_BRCA1_1	255	259	PF00533	0.323
LIG_BRCT_BRCA1_1	293	297	PF00533	0.353
LIG_FHA_1	21	27	PF00498	0.745
LIG_FHA_1	242	248	PF00498	0.352
LIG_FHA_1	258	264	PF00498	0.342
LIG_FHA_2	147	153	PF00498	0.721
LIG_FHA_2	156	162	PF00498	0.581
LIG_FHA_2	184	190	PF00498	0.605
LIG_FHA_2	196	202	PF00498	0.590
LIG_FHA_2	20	26	PF00498	0.692
LIG_LIR_Gen_1	155	164	PF02991	0.593
LIG_LIR_Gen_1	256	266	PF02991	0.323
LIG_LIR_Nem_3	155	159	PF02991	0.561
LIG_LIR_Nem_3	256	262	PF02991	0.323
LIG_LIR_Nem_3	339	345	PF02991	0.365
LIG_LIR_Nem_3	96	102	PF02991	0.739
LIG_NRP_CendR_1	363	366	PF00754	0.740
LIG_Pex14_1	344	348	PF04695	0.330
LIG_Pex14_2	304	308	PF04695	0.378
LIG_SH2_GRB2like	248	251	PF00017	0.437
LIG_SH2_NCK_1	353	357	PF00017	0.417
LIG_SH2_STAT5	238	241	PF00017	0.391
LIG_SH2_STAT5	345	348	PF00017	0.357
LIG_SH3_3	157	163	PF00018	0.609
LIG_SH3_3	306	312	PF00018	0.475
LIG_WW_3	180	184	PF00397	0.568
MOD_CDC14_SPxK_1	132	135	PF00782	0.766
MOD_CDC14_SPxK_1	94	97	PF00782	0.590
MOD_CDK_SPxK_1	129	135	PF00069	0.770
MOD_CDK_SPxK_1	91	97	PF00069	0.604
MOD_CDK_SPxxK_3	106	113	PF00069	0.705
MOD_CDK_SPxxK_3	29	36	PF00069	0.682
MOD_CK1_1	122	128	PF00069	0.716
MOD_CK1_1	155	161	PF00069	0.661
MOD_CK1_1	29	35	PF00069	0.675
MOD_CK1_1	296	302	PF00069	0.383
MOD_CK1_1	354	360	PF00069	0.505
MOD_CK1_1	5	11	PF00069	0.683
MOD_CK1_1	52	58	PF00069	0.753
MOD_CK2_1	183	189	PF00069	0.590
MOD_CK2_1	195	201	PF00069	0.542
MOD_CK2_1	81	87	PF00069	0.674
MOD_DYRK1A_RPxSP_1	106	110	PF00069	0.641
MOD_GlcNHglycan	116	120	PF01048	0.541
MOD_GlcNHglycan	121	124	PF01048	0.540
MOD_GlcNHglycan	298	301	PF01048	0.441
MOD_GlcNHglycan	354	357	PF01048	0.645
MOD_GlcNHglycan	41	44	PF01048	0.526
MOD_GlcNHglycan	51	54	PF01048	0.562
MOD_GlcNHglycan	63	66	PF01048	0.549
MOD_GlcNHglycan	69	72	PF01048	0.475
MOD_GSK3_1	111	118	PF00069	0.706
MOD_GSK3_1	119	126	PF00069	0.702
MOD_GSK3_1	181	188	PF00069	0.668
MOD_GSK3_1	211	218	PF00069	0.593
MOD_GSK3_1	253	260	PF00069	0.332
MOD_GSK3_1	41	48	PF00069	0.749
MOD_GSK3_1	49	56	PF00069	0.714
MOD_GSK3_1	89	96	PF00069	0.707
MOD_NEK2_1	124	129	PF00069	0.776
MOD_NEK2_1	2	7	PF00069	0.673
MOD_NEK2_1	227	232	PF00069	0.330
MOD_NEK2_1	286	291	PF00069	0.550
MOD_NEK2_1	336	341	PF00069	0.402
MOD_NEK2_2	233	238	PF00069	0.377
MOD_PIKK_1	20	26	PF00454	0.715
MOD_PIKK_1	307	313	PF00454	0.464
MOD_PK_1	12	18	PF00069	0.657
MOD_PKA_2	105	111	PF00069	0.785
MOD_PKA_2	134	140	PF00069	0.757
MOD_PKA_2	176	182	PF00069	0.609
MOD_PKA_2	286	292	PF00069	0.562
MOD_PKA_2	39	45	PF00069	0.669
MOD_PKA_2	5	11	PF00069	0.708
MOD_PKA_2	67	73	PF00069	0.807
MOD_Plk_1	195	201	PF00069	0.549
MOD_Plk_1	336	342	PF00069	0.350
MOD_Plk_4	233	239	PF00069	0.441
MOD_Plk_4	253	259	PF00069	0.323
MOD_Plk_4	26	32	PF00069	0.645
MOD_Plk_4	293	299	PF00069	0.323
MOD_Plk_4	55	61	PF00069	0.757
MOD_ProDKin_1	106	112	PF00069	0.696
MOD_ProDKin_1	129	135	PF00069	0.696
MOD_ProDKin_1	29	35	PF00069	0.625
MOD_ProDKin_1	91	97	PF00069	0.793
TRG_DiLeu_BaEn_1	189	194	PF01217	0.584
TRG_DiLeu_BaEn_1	273	278	PF01217	0.665
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.377
TRG_ER_diArg_1	266	269	PF00400	0.635
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	275	280	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV70	Leptomonas seymouri	46%	100%
A0A3Q8ID58	Leishmania donovani	99%	100%
A4HDQ6	Leishmania braziliensis	77%	100%
E9AX40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QAD6	Leishmania major	87%	100%
V5DB44	Trypanosoma cruzi	44%	100%