Uncharacterized protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I101_LEIIN

TriTrypDb:

LINF_240025500

Length:

711

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 108

Expansion

Sequence features

A4I101

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I101

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0019637	organophosphate metabolic process	3	7
GO:0019751	polyol metabolic process	4	7
GO:0032957	inositol trisphosphate metabolic process	5	7
GO:0043647	inositol phosphate metabolic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044281	small molecule metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901615	organic hydroxy compound metabolic process	3	7
GO:0005975	carbohydrate metabolic process	3	1
GO:0006020	inositol metabolic process	4	1
GO:0016310	phosphorylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0046835	carbohydrate phosphorylation	4	1
GO:0052746	obsolete inositol phosphorylation	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0000287	magnesium ion binding	5	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0047325	inositol tetrakisphosphate 1-kinase activity	6	7
GO:0051765	inositol tetrakisphosphate kinase activity	5	7
GO:0051766	inositol trisphosphate kinase activity	5	7
GO:0052725	inositol-1,3,4-trisphosphate 6-kinase activity	6	7
GO:0052726	inositol-1,3,4-trisphosphate 5-kinase activity	6	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.674
CLV_NRD_NRD_1	237	239	PF00675	0.456
CLV_NRD_NRD_1	242	244	PF00675	0.469
CLV_NRD_NRD_1	299	301	PF00675	0.629
CLV_NRD_NRD_1	564	566	PF00675	0.454
CLV_NRD_NRD_1	611	613	PF00675	0.646
CLV_NRD_NRD_1	706	708	PF00675	0.673
CLV_PCSK_FUR_1	238	242	PF00082	0.447
CLV_PCSK_FUR_1	99	103	PF00082	0.713
CLV_PCSK_KEX2_1	101	103	PF00082	0.669
CLV_PCSK_KEX2_1	236	238	PF00082	0.454
CLV_PCSK_KEX2_1	240	242	PF00082	0.475
CLV_PCSK_KEX2_1	299	301	PF00082	0.629
CLV_PCSK_KEX2_1	705	707	PF00082	0.823
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.500
CLV_PCSK_PC1ET2_1	705	707	PF00082	0.688
CLV_PCSK_PC7_1	237	243	PF00082	0.484
CLV_PCSK_SKI1_1	148	152	PF00082	0.435
CLV_PCSK_SKI1_1	214	218	PF00082	0.399
CLV_PCSK_SKI1_1	261	265	PF00082	0.373
CLV_PCSK_SKI1_1	368	372	PF00082	0.458
CLV_PCSK_SKI1_1	377	381	PF00082	0.316
CLV_PCSK_SKI1_1	436	440	PF00082	0.487
DEG_APCC_DBOX_1	242	250	PF00400	0.609
DEG_APCC_DBOX_1	260	268	PF00400	0.300
DEG_APCC_DBOX_1	376	384	PF00400	0.347
DEG_Nend_UBRbox_3	1	3	PF02207	0.680
DEG_SCF_FBW7_1	522	528	PF00400	0.399
DOC_CKS1_1	218	223	PF01111	0.483
DOC_CKS1_1	522	527	PF01111	0.408
DOC_CYCLIN_RxL_1	133	143	PF00134	0.415
DOC_MAPK_gen_1	146	153	PF00069	0.451
DOC_MAPK_gen_1	236	248	PF00069	0.455
DOC_MAPK_MEF2A_6	146	153	PF00069	0.451
DOC_MAPK_MEF2A_6	240	249	PF00069	0.440
DOC_MAPK_MEF2A_6	404	411	PF00069	0.443
DOC_MAPK_NFAT4_5	146	154	PF00069	0.461
DOC_PP2B_PxIxI_1	244	250	PF00149	0.417
DOC_PP4_FxxP_1	218	221	PF00568	0.435
DOC_PP4_FxxP_1	519	522	PF00568	0.419
DOC_USP7_MATH_1	114	118	PF00917	0.654
DOC_USP7_MATH_1	17	21	PF00917	0.641
DOC_USP7_MATH_1	199	203	PF00917	0.533
DOC_USP7_MATH_1	339	343	PF00917	0.471
DOC_USP7_MATH_1	359	363	PF00917	0.464
DOC_USP7_MATH_1	407	411	PF00917	0.451
DOC_USP7_MATH_1	430	434	PF00917	0.514
DOC_USP7_MATH_1	443	447	PF00917	0.521
DOC_USP7_MATH_1	456	460	PF00917	0.658
DOC_USP7_MATH_1	499	503	PF00917	0.693
DOC_USP7_MATH_1	505	509	PF00917	0.417
DOC_USP7_MATH_1	584	588	PF00917	0.592
DOC_USP7_MATH_1	592	596	PF00917	0.620
DOC_USP7_MATH_1	607	611	PF00917	0.624
DOC_USP7_MATH_1	617	621	PF00917	0.591
DOC_USP7_UBL2_3	232	236	PF12436	0.398
DOC_WW_Pin1_4	10	15	PF00397	0.656
DOC_WW_Pin1_4	177	182	PF00397	0.658
DOC_WW_Pin1_4	217	222	PF00397	0.427
DOC_WW_Pin1_4	278	283	PF00397	0.392
DOC_WW_Pin1_4	3	8	PF00397	0.804
DOC_WW_Pin1_4	305	310	PF00397	0.458
DOC_WW_Pin1_4	467	472	PF00397	0.615
DOC_WW_Pin1_4	481	486	PF00397	0.585
DOC_WW_Pin1_4	521	526	PF00397	0.412
DOC_WW_Pin1_4	621	626	PF00397	0.591
LIG_14-3-3_CanoR_1	105	114	PF00244	0.670
LIG_14-3-3_CanoR_1	116	125	PF00244	0.550
LIG_14-3-3_CanoR_1	136	141	PF00244	0.253
LIG_14-3-3_CanoR_1	420	425	PF00244	0.489
LIG_14-3-3_CanoR_1	604	614	PF00244	0.636
LIG_14-3-3_CanoR_1	631	638	PF00244	0.451
LIG_14-3-3_CanoR_1	706	711	PF00244	0.772
LIG_BIR_III_2	480	484	PF00653	0.562
LIG_BRCT_BRCA1_1	626	630	PF00533	0.536
LIG_BRCT_BRCA1_1	632	636	PF00533	0.436
LIG_Clathr_ClatBox_1	246	250	PF01394	0.398
LIG_deltaCOP1_diTrp_1	514	519	PF00928	0.424
LIG_FHA_1	105	111	PF00498	0.828
LIG_FHA_1	19	25	PF00498	0.523
LIG_FHA_1	346	352	PF00498	0.404
LIG_FHA_1	406	412	PF00498	0.399
LIG_FHA_1	642	648	PF00498	0.400
LIG_FHA_2	314	320	PF00498	0.634
LIG_FHA_2	327	333	PF00498	0.405
LIG_FHA_2	421	427	PF00498	0.471
LIG_FHA_2	490	496	PF00498	0.703
LIG_LIR_Apic_2	217	221	PF02991	0.431
LIG_LIR_Apic_2	284	290	PF02991	0.416
LIG_LIR_Gen_1	314	320	PF02991	0.501
LIG_LIR_Gen_1	39	46	PF02991	0.451
LIG_LIR_Gen_1	514	522	PF02991	0.416
LIG_LIR_Gen_1	524	534	PF02991	0.409
LIG_LIR_Nem_3	314	318	PF02991	0.428
LIG_LIR_Nem_3	39	43	PF02991	0.450
LIG_LIR_Nem_3	514	519	PF02991	0.424
LIG_LIR_Nem_3	524	530	PF02991	0.401
LIG_NRBOX	263	269	PF00104	0.392
LIG_PTB_Apo_2	129	136	PF02174	0.398
LIG_SH2_CRK	386	390	PF00017	0.416
LIG_SH2_CRK	527	531	PF00017	0.451
LIG_SH2_CRK	663	667	PF00017	0.453
LIG_SH2_NCK_1	527	531	PF00017	0.436
LIG_SH2_SRC	384	387	PF00017	0.363
LIG_SH2_STAT3	142	145	PF00017	0.413
LIG_SH2_STAT5	384	387	PF00017	0.363
LIG_SH2_STAT5	395	398	PF00017	0.366
LIG_SH2_STAT5	414	417	PF00017	0.431
LIG_SH2_STAT5	527	530	PF00017	0.436
LIG_SH2_STAT5	558	561	PF00017	0.427
LIG_SH2_STAT5	659	662	PF00017	0.453
LIG_SH3_3	245	251	PF00018	0.410
LIG_SH3_3	358	364	PF00018	0.450
LIG_SH3_3	479	485	PF00018	0.616
LIG_SH3_3	519	525	PF00018	0.427
LIG_SH3_3	550	556	PF00018	0.353
LIG_SH3_3	6	12	PF00018	0.795
LIG_SH3_3	619	625	PF00018	0.575
LIG_SUMO_SIM_anti_2	206	212	PF11976	0.458
LIG_SUMO_SIM_anti_2	408	413	PF11976	0.417
LIG_SUMO_SIM_anti_2	551	556	PF11976	0.353
LIG_SUMO_SIM_par_1	244	250	PF11976	0.418
LIG_SUMO_SIM_par_1	276	281	PF11976	0.407
LIG_SUMO_SIM_par_1	649	656	PF11976	0.391
LIG_TRAF2_1	317	320	PF00917	0.542
LIG_TRAF2_1	82	85	PF00917	0.644
LIG_UBA3_1	673	680	PF00899	0.501
LIG_WRC_WIRS_1	215	220	PF05994	0.413
LIG_WRC_WIRS_1	312	317	PF05994	0.485
MOD_CAAXbox	708	711	PF01239	0.681
MOD_CDK_SPK_2	177	182	PF00069	0.581
MOD_CDK_SPK_2	278	283	PF00069	0.392
MOD_CDK_SPxxK_3	621	628	PF00069	0.490
MOD_CK1_1	100	106	PF00069	0.739
MOD_CK1_1	117	123	PF00069	0.534
MOD_CK1_1	13	19	PF00069	0.691
MOD_CK1_1	173	179	PF00069	0.574
MOD_CK1_1	305	311	PF00069	0.515
MOD_CK1_1	314	320	PF00069	0.475
MOD_CK1_1	399	405	PF00069	0.464
MOD_CK1_1	444	450	PF00069	0.580
MOD_CK1_1	493	499	PF00069	0.668
MOD_CK1_1	595	601	PF00069	0.650
MOD_CK1_1	624	630	PF00069	0.496
MOD_CK1_1	689	695	PF00069	0.578
MOD_CK2_1	116	122	PF00069	0.650
MOD_CK2_1	313	319	PF00069	0.615
MOD_CK2_1	326	332	PF00069	0.465
MOD_CK2_1	481	487	PF00069	0.693
MOD_CK2_1	489	495	PF00069	0.639
MOD_DYRK1A_RPxSP_1	3	7	PF00069	0.705
MOD_GlcNHglycan	127	130	PF01048	0.407
MOD_GlcNHglycan	163	166	PF01048	0.737
MOD_GlcNHglycan	175	178	PF01048	0.589
MOD_GlcNHglycan	201	204	PF01048	0.583
MOD_GlcNHglycan	3	6	PF01048	0.786
MOD_GlcNHglycan	304	307	PF01048	0.563
MOD_GlcNHglycan	443	446	PF01048	0.553
MOD_GlcNHglycan	454	457	PF01048	0.710
MOD_GlcNHglycan	495	498	PF01048	0.689
MOD_GlcNHglycan	536	540	PF01048	0.431
MOD_GlcNHglycan	594	597	PF01048	0.624
MOD_GlcNHglycan	60	63	PF01048	0.523
MOD_GlcNHglycan	619	622	PF01048	0.601
MOD_GlcNHglycan	639	642	PF01048	0.380
MOD_GlcNHglycan	70	74	PF01048	0.633
MOD_GlcNHglycan	88	91	PF01048	0.655
MOD_GSK3_1	101	108	PF00069	0.653
MOD_GSK3_1	114	121	PF00069	0.601
MOD_GSK3_1	13	20	PF00069	0.612
MOD_GSK3_1	157	164	PF00069	0.683
MOD_GSK3_1	173	180	PF00069	0.613
MOD_GSK3_1	298	305	PF00069	0.629
MOD_GSK3_1	416	423	PF00069	0.464
MOD_GSK3_1	437	444	PF00069	0.515
MOD_GSK3_1	452	459	PF00069	0.631
MOD_GSK3_1	469	476	PF00069	0.526
MOD_GSK3_1	489	496	PF00069	0.590
MOD_GSK3_1	521	528	PF00069	0.431
MOD_GSK3_1	571	578	PF00069	0.510
MOD_GSK3_1	617	624	PF00069	0.589
MOD_GSK3_1	637	644	PF00069	0.307
MOD_GSK3_1	685	692	PF00069	0.567
MOD_GSK3_1	93	100	PF00069	0.648
MOD_LATS_1	418	424	PF00433	0.535
MOD_N-GLC_1	1	6	PF02516	0.663
MOD_N-GLC_1	301	306	PF02516	0.594
MOD_N-GLC_1	326	331	PF02516	0.579
MOD_N-GLC_1	473	478	PF02516	0.628
MOD_N-GLC_2	131	133	PF02516	0.351
MOD_NEK2_1	1	6	PF00069	0.825
MOD_NEK2_1	125	130	PF00069	0.426
MOD_NEK2_1	157	162	PF00069	0.594
MOD_NEK2_1	257	262	PF00069	0.397
MOD_NEK2_1	29	34	PF00069	0.433
MOD_NEK2_1	438	443	PF00069	0.513
MOD_NEK2_1	473	478	PF00069	0.630
MOD_NEK2_1	559	564	PF00069	0.445
MOD_NEK2_1	647	652	PF00069	0.373
MOD_NEK2_2	607	612	PF00069	0.668
MOD_PIKK_1	197	203	PF00454	0.579
MOD_PIKK_1	430	436	PF00454	0.447
MOD_PIKK_1	447	453	PF00454	0.596
MOD_PKA_1	101	107	PF00069	0.669
MOD_PKA_1	236	242	PF00069	0.531
MOD_PKA_2	100	106	PF00069	0.671
MOD_PKA_2	117	123	PF00069	0.547
MOD_PKA_2	236	242	PF00069	0.531
MOD_PKA_2	298	304	PF00069	0.677
MOD_PKA_2	419	425	PF00069	0.474
MOD_PKA_2	630	636	PF00069	0.470
MOD_PKB_1	116	124	PF00069	0.516
MOD_PKB_1	99	107	PF00069	0.714
MOD_Plk_1	359	365	PF00069	0.545
MOD_Plk_1	499	505	PF00069	0.550
MOD_Plk_4	407	413	PF00069	0.463
MOD_Plk_4	499	505	PF00069	0.572
MOD_Plk_4	543	549	PF00069	0.434
MOD_Plk_4	642	648	PF00069	0.443
MOD_ProDKin_1	10	16	PF00069	0.658
MOD_ProDKin_1	177	183	PF00069	0.658
MOD_ProDKin_1	217	223	PF00069	0.418
MOD_ProDKin_1	278	284	PF00069	0.391
MOD_ProDKin_1	3	9	PF00069	0.805
MOD_ProDKin_1	305	311	PF00069	0.457
MOD_ProDKin_1	467	473	PF00069	0.615
MOD_ProDKin_1	481	487	PF00069	0.589
MOD_ProDKin_1	521	527	PF00069	0.410
MOD_ProDKin_1	621	627	PF00069	0.590
MOD_SUMO_rev_2	154	160	PF00179	0.591
MOD_SUMO_rev_2	314	324	PF00179	0.449
TRG_DiLeu_BaEn_1	253	258	PF01217	0.413
TRG_DiLeu_BaEn_2	373	379	PF01217	0.398
TRG_DiLeu_BaLyEn_6	242	247	PF01217	0.424
TRG_ENDOCYTIC_2	527	530	PF00928	0.451
TRG_ENDOCYTIC_2	663	666	PF00928	0.469
TRG_ER_diArg_1	146	149	PF00400	0.472
TRG_ER_diArg_1	237	240	PF00400	0.454
TRG_ER_diArg_1	241	243	PF00400	0.485
TRG_ER_diArg_1	99	102	PF00400	0.675
TRG_NES_CRM1_1	675	686	PF08389	0.497
TRG_NLS_MonoCore_2	703	708	PF00514	0.641
TRG_NLS_MonoExtC_3	235	240	PF00514	0.493
TRG_NLS_MonoExtN_4	704	709	PF00514	0.675
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCV4	Leptomonas seymouri	49%	100%
A0A3S5H7D6	Leishmania donovani	100%	99%
A4HDQ5	Leishmania braziliensis	69%	98%
E9AX39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QAD7	Leishmania major	93%	100%