Protein prenyltransferase alpha subunit repeat-containing protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0Z8_LEIIN

TriTrypDb:

LINF_240025200

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I0Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0Z8

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0018342	protein prenylation	4	3
GO:0019538	protein metabolic process	3	3
GO:0036211	protein modification process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:0097354	prenylation	3	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004659	prenyltransferase activity	4	3
GO:0008318	protein prenyltransferase activity	3	3
GO:0016740	transferase activity	2	4
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.665
CLV_C14_Caspase3-7	112	116	PF00656	0.475
CLV_C14_Caspase3-7	310	314	PF00656	0.509
CLV_C14_Caspase3-7	437	441	PF00656	0.565
CLV_NRD_NRD_1	151	153	PF00675	0.416
CLV_NRD_NRD_1	253	255	PF00675	0.383
CLV_NRD_NRD_1	384	386	PF00675	0.505
CLV_NRD_NRD_1	79	81	PF00675	0.524
CLV_PCSK_KEX2_1	150	152	PF00082	0.405
CLV_PCSK_KEX2_1	253	255	PF00082	0.384
CLV_PCSK_KEX2_1	384	386	PF00082	0.524
CLV_PCSK_KEX2_1	79	81	PF00082	0.530
CLV_PCSK_SKI1_1	122	126	PF00082	0.571
CLV_PCSK_SKI1_1	364	368	PF00082	0.507
CLV_PCSK_SKI1_1	39	43	PF00082	0.490
CLV_PCSK_SKI1_1	86	90	PF00082	0.432
DEG_APCC_DBOX_1	121	129	PF00400	0.583
DEG_Nend_UBRbox_2	1	3	PF02207	0.575
DEG_ODPH_VHL_1	367	378	PF01847	0.544
DEG_SPOP_SBC_1	64	68	PF00917	0.592
DOC_CYCLIN_RxL_1	250	259	PF00134	0.433
DOC_CYCLIN_yCln2_LP_2	442	448	PF00134	0.641
DOC_MAPK_MEF2A_6	176	185	PF00069	0.457
DOC_PP1_RVXF_1	251	258	PF00149	0.411
DOC_USP7_MATH_1	262	266	PF00917	0.604
DOC_USP7_MATH_1	461	465	PF00917	0.514
DOC_USP7_MATH_1	48	52	PF00917	0.558
DOC_USP7_MATH_1	99	103	PF00917	0.604
DOC_WW_Pin1_4	107	112	PF00397	0.721
DOC_WW_Pin1_4	114	119	PF00397	0.575
DOC_WW_Pin1_4	406	411	PF00397	0.564
DOC_WW_Pin1_4	441	446	PF00397	0.610
LIG_14-3-3_CanoR_1	122	132	PF00244	0.486
LIG_14-3-3_CanoR_1	256	261	PF00244	0.479
LIG_14-3-3_CanoR_1	425	431	PF00244	0.439
LIG_Actin_WH2_2	142	157	PF00022	0.467
LIG_Actin_WH2_2	410	427	PF00022	0.563
LIG_CaM_IQ_9	376	391	PF13499	0.542
LIG_eIF4E_1	430	436	PF01652	0.524
LIG_FHA_1	297	303	PF00498	0.445
LIG_FHA_2	377	383	PF00498	0.481
LIG_FXI_DFP_1	70	74	PF00024	0.495
LIG_GBD_Chelix_1	435	443	PF00786	0.518
LIG_LIR_Gen_1	144	154	PF02991	0.535
LIG_LIR_Gen_1	177	185	PF02991	0.387
LIG_LIR_Gen_1	2	12	PF02991	0.559
LIG_LIR_Gen_1	299	306	PF02991	0.404
LIG_LIR_Gen_1	459	470	PF02991	0.459
LIG_LIR_Gen_1	67	77	PF02991	0.511
LIG_LIR_Nem_3	144	149	PF02991	0.536
LIG_LIR_Nem_3	177	181	PF02991	0.386
LIG_LIR_Nem_3	182	187	PF02991	0.437
LIG_LIR_Nem_3	2	8	PF02991	0.573
LIG_LIR_Nem_3	299	304	PF02991	0.408
LIG_LIR_Nem_3	428	433	PF02991	0.444
LIG_LIR_Nem_3	459	465	PF02991	0.479
LIG_LIR_Nem_3	67	73	PF02991	0.533
LIG_NRBOX	301	307	PF00104	0.428
LIG_NRBOX	473	479	PF00104	0.488
LIG_PCNA_PIPBox_1	411	420	PF02747	0.595
LIG_PCNA_yPIPBox_3	408	418	PF02747	0.597
LIG_Pex14_1	426	430	PF04695	0.519
LIG_Pex14_2	89	93	PF04695	0.545
LIG_RPA_C_Fungi	75	87	PF08784	0.455
LIG_SH2_CRK	252	256	PF00017	0.537
LIG_SH2_CRK	5	9	PF00017	0.555
LIG_SH2_NCK_1	5	9	PF00017	0.555
LIG_SH2_PTP2	430	433	PF00017	0.524
LIG_SH2_STAP1	5	9	PF00017	0.555
LIG_SH2_STAT3	470	473	PF00017	0.439
LIG_SH2_STAT5	26	29	PF00017	0.536
LIG_SH2_STAT5	301	304	PF00017	0.398
LIG_SH2_STAT5	430	433	PF00017	0.468
LIG_SH2_STAT5	5	8	PF00017	0.551
LIG_SH3_3	30	36	PF00018	0.554
LIG_SUMO_SIM_par_1	413	419	PF11976	0.570
LIG_SUMO_SIM_par_1	71	78	PF11976	0.493
LIG_UBA3_1	183	192	PF00899	0.490
LIG_WRC_WIRS_1	90	95	PF05994	0.544
MOD_CK1_1	110	116	PF00069	0.604
MOD_CK1_1	296	302	PF00069	0.432
MOD_CK1_1	3	9	PF00069	0.524
MOD_CK1_1	318	324	PF00069	0.643
MOD_CK1_1	416	422	PF00069	0.553
MOD_CK1_1	444	450	PF00069	0.579
MOD_CK1_1	454	460	PF00069	0.504
MOD_CK2_1	160	166	PF00069	0.586
MOD_CK2_1	190	196	PF00069	0.461
MOD_CK2_1	316	322	PF00069	0.579
MOD_CK2_1	376	382	PF00069	0.425
MOD_CK2_1	449	455	PF00069	0.589
MOD_CK2_1	88	94	PF00069	0.510
MOD_GlcNHglycan	166	169	PF01048	0.537
MOD_GlcNHglycan	2	5	PF01048	0.522
MOD_GlcNHglycan	295	299	PF01048	0.391
MOD_GlcNHglycan	339	342	PF01048	0.734
MOD_GlcNHglycan	418	421	PF01048	0.580
MOD_GlcNHglycan	446	449	PF01048	0.551
MOD_GlcNHglycan	455	459	PF01048	0.414
MOD_GSK3_1	110	117	PF00069	0.644
MOD_GSK3_1	154	161	PF00069	0.395
MOD_GSK3_1	293	300	PF00069	0.419
MOD_GSK3_1	318	325	PF00069	0.643
MOD_GSK3_1	406	413	PF00069	0.529
MOD_GSK3_1	449	456	PF00069	0.504
MOD_GSK3_1	457	464	PF00069	0.402
MOD_GSK3_1	64	71	PF00069	0.533
MOD_N-GLC_1	353	358	PF02516	0.630
MOD_N-GLC_1	465	470	PF02516	0.530
MOD_N-GLC_1	479	484	PF02516	0.570
MOD_N-GLC_2	204	206	PF02516	0.442
MOD_NEK2_1	154	159	PF00069	0.436
MOD_NEK2_1	183	188	PF00069	0.385
MOD_NEK2_1	337	342	PF00069	0.701
MOD_NEK2_1	376	381	PF00069	0.449
MOD_NEK2_1	42	47	PF00069	0.568
MOD_NEK2_1	465	470	PF00069	0.482
MOD_NEK2_1	478	483	PF00069	0.562
MOD_NEK2_1	88	93	PF00069	0.417
MOD_PIKK_1	376	382	PF00454	0.480
MOD_PIKK_1	42	48	PF00454	0.508
MOD_PKA_1	384	390	PF00069	0.558
MOD_PKA_2	154	160	PF00069	0.478
MOD_PKA_2	384	390	PF00069	0.558
MOD_PKA_2	478	484	PF00069	0.510
MOD_PKB_1	254	262	PF00069	0.491
MOD_Plk_1	218	224	PF00069	0.397
MOD_Plk_1	316	322	PF00069	0.668
MOD_Plk_1	465	471	PF00069	0.521
MOD_Plk_2-3	322	328	PF00069	0.649
MOD_Plk_4	128	134	PF00069	0.456
MOD_Plk_4	190	196	PF00069	0.495
MOD_Plk_4	297	303	PF00069	0.404
MOD_Plk_4	3	9	PF00069	0.571
MOD_Plk_4	322	328	PF00069	0.751
MOD_Plk_4	410	416	PF00069	0.662
MOD_Plk_4	426	432	PF00069	0.341
MOD_Plk_4	473	479	PF00069	0.505
MOD_ProDKin_1	107	113	PF00069	0.715
MOD_ProDKin_1	114	120	PF00069	0.561
MOD_ProDKin_1	406	412	PF00069	0.570
MOD_ProDKin_1	441	447	PF00069	0.605
MOD_SUMO_for_1	226	229	PF00179	0.356
MOD_SUMO_rev_2	156	165	PF00179	0.619
TRG_ENDOCYTIC_2	252	255	PF00928	0.504
TRG_ENDOCYTIC_2	301	304	PF00928	0.398
TRG_ENDOCYTIC_2	430	433	PF00928	0.477
TRG_ENDOCYTIC_2	5	8	PF00928	0.551
TRG_ER_diArg_1	149	152	PF00400	0.424
TRG_ER_diArg_1	252	254	PF00400	0.369
TRG_ER_diArg_1	383	385	PF00400	0.495
TRG_ER_diArg_1	79	81	PF00400	0.520
TRG_NES_CRM1_1	169	182	PF08389	0.511
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTJ1	Leptomonas seymouri	42%	100%
A0A0S4JLJ0	Bodo saltans	26%	100%
A0A1X0NWB3	Trypanosomatidae	26%	100%
A0A3Q8IF02	Leishmania donovani	100%	100%
A0A422NWV9	Trypanosoma rangeli	30%	100%
A4HDQ2	Leishmania braziliensis	73%	100%
C9ZWB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AX36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QAE0	Leishmania major	87%	100%