Cyclin 10

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Cyclin 10

Gene product:

cyclin 10

Species:

Leishmania infantum

UniProt:

A4I0Z6_LEIIN

TriTrypDb:

LINF_240025000

Length:

658

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0Z6

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	7
GO:0001932	regulation of protein phosphorylation	7	7
GO:0019220	regulation of phosphate metabolic process	6	7
GO:0019222	regulation of metabolic process	3	7
GO:0031323	regulation of cellular metabolic process	4	7
GO:0031399	regulation of protein modification process	6	7
GO:0042325	regulation of phosphorylation	7	7
GO:0043549	regulation of kinase activity	5	7
GO:0045859	regulation of protein kinase activity	6	7
GO:0050789	regulation of biological process	2	7
GO:0050790	regulation of catalytic activity	3	7
GO:0050794	regulation of cellular process	3	7
GO:0051171	regulation of nitrogen compound metabolic process	4	7
GO:0051174	regulation of phosphorus metabolic process	5	7
GO:0051246	regulation of protein metabolic process	5	7
GO:0051338	regulation of transferase activity	4	7
GO:0051726	regulation of cell cycle	4	7
GO:0060255	regulation of macromolecule metabolic process	4	7
GO:0065007	biological regulation	1	7
GO:0065009	regulation of molecular function	2	7
GO:0071900	regulation of protein serine/threonine kinase activity	7	7
GO:0080090	regulation of primary metabolic process	4	7
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	7

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0019899	enzyme binding	3	7
GO:0019900	kinase binding	4	7
GO:0019901	protein kinase binding	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	366	368	PF00675	0.580
CLV_NRD_NRD_1	432	434	PF00675	0.588
CLV_NRD_NRD_1	611	613	PF00675	0.602
CLV_PCSK_FUR_1	364	368	PF00082	0.578
CLV_PCSK_KEX2_1	214	216	PF00082	0.304
CLV_PCSK_KEX2_1	366	368	PF00082	0.580
CLV_PCSK_KEX2_1	432	434	PF00082	0.587
CLV_PCSK_KEX2_1	611	613	PF00082	0.602
CLV_PCSK_KEX2_1	91	93	PF00082	0.538
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.304
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.525
CLV_PCSK_PC7_1	607	613	PF00082	0.599
CLV_PCSK_SKI1_1	215	219	PF00082	0.304
CLV_PCSK_SKI1_1	253	257	PF00082	0.440
CLV_PCSK_SKI1_1	352	356	PF00082	0.600
CLV_PCSK_SKI1_1	394	398	PF00082	0.581
CLV_PCSK_SKI1_1	478	482	PF00082	0.603
CLV_PCSK_SKI1_1	586	590	PF00082	0.664
CLV_PCSK_SKI1_1	611	615	PF00082	0.606
CLV_Separin_Metazoa	130	134	PF03568	0.584
DEG_Nend_UBRbox_3	1	3	PF02207	0.554
DEG_SCF_FBW7_1	336	342	PF00400	0.612
DEG_SCF_FBW7_1	78	84	PF00400	0.610
DEG_SPOP_SBC_1	580	584	PF00917	0.524
DOC_CKS1_1	336	341	PF01111	0.611
DOC_CKS1_1	78	83	PF01111	0.597
DOC_CYCLIN_yClb1_LxF_4	287	293	PF00134	0.304
DOC_CYCLIN_yClb1_LxF_4	299	304	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.369
DOC_MAPK_gen_1	632	642	PF00069	0.620
DOC_MAPK_MEF2A_6	202	209	PF00069	0.304
DOC_PP1_RVXF_1	299	305	PF00149	0.446
DOC_PP2B_LxvP_1	522	525	PF13499	0.548
DOC_PP2B_LxvP_1	649	652	PF13499	0.661
DOC_PP2B_PxIxI_1	204	210	PF00149	0.304
DOC_PP4_FxxP_1	113	116	PF00568	0.354
DOC_SPAK_OSR1_1	112	116	PF12202	0.371
DOC_USP7_MATH_1	140	144	PF00917	0.605
DOC_USP7_MATH_1	146	150	PF00917	0.616
DOC_USP7_MATH_1	163	167	PF00917	0.617
DOC_USP7_MATH_1	21	25	PF00917	0.551
DOC_USP7_MATH_1	34	38	PF00917	0.529
DOC_USP7_MATH_1	381	385	PF00917	0.615
DOC_USP7_MATH_1	388	392	PF00917	0.576
DOC_USP7_MATH_1	399	403	PF00917	0.519
DOC_USP7_MATH_1	427	431	PF00917	0.660
DOC_USP7_MATH_1	529	533	PF00917	0.638
DOC_USP7_MATH_1	580	584	PF00917	0.568
DOC_USP7_MATH_1	65	69	PF00917	0.579
DOC_USP7_MATH_1	81	85	PF00917	0.574
DOC_USP7_MATH_2	339	345	PF00917	0.666
DOC_USP7_UBL2_3	214	218	PF12436	0.304
DOC_WW_Pin1_4	12	17	PF00397	0.615
DOC_WW_Pin1_4	141	146	PF00397	0.565
DOC_WW_Pin1_4	159	164	PF00397	0.671
DOC_WW_Pin1_4	188	193	PF00397	0.369
DOC_WW_Pin1_4	220	225	PF00397	0.304
DOC_WW_Pin1_4	335	340	PF00397	0.606
DOC_WW_Pin1_4	384	389	PF00397	0.629
DOC_WW_Pin1_4	438	443	PF00397	0.600
DOC_WW_Pin1_4	454	459	PF00397	0.597
DOC_WW_Pin1_4	495	500	PF00397	0.662
DOC_WW_Pin1_4	53	58	PF00397	0.707
DOC_WW_Pin1_4	565	570	PF00397	0.599
DOC_WW_Pin1_4	605	610	PF00397	0.594
DOC_WW_Pin1_4	77	82	PF00397	0.570
LIG_14-3-3_CanoR_1	405	410	PF00244	0.641
LIG_14-3-3_CanoR_1	478	487	PF00244	0.679
LIG_14-3-3_CanoR_1	518	523	PF00244	0.517
LIG_14-3-3_CanoR_1	586	595	PF00244	0.788
LIG_14-3-3_CanoR_1	629	639	PF00244	0.644
LIG_BIR_III_4	534	538	PF00653	0.626
LIG_Clathr_ClatBox_1	506	510	PF01394	0.641
LIG_EH1_1	291	299	PF00400	0.419
LIG_eIF4E_1	249	255	PF01652	0.437
LIG_EVH1_1	63	67	PF00568	0.499
LIG_EVH1_1	649	653	PF00568	0.664
LIG_FAT_LD_1	290	298	PF03623	0.412
LIG_FHA_1	199	205	PF00498	0.304
LIG_FHA_1	266	272	PF00498	0.304
LIG_FHA_1	409	415	PF00498	0.652
LIG_FHA_1	481	487	PF00498	0.658
LIG_FHA_1	502	508	PF00498	0.641
LIG_FHA_1	553	559	PF00498	0.602
LIG_FHA_1	58	64	PF00498	0.605
LIG_FHA_1	78	84	PF00498	0.610
LIG_FHA_2	100	106	PF00498	0.454
LIG_FHA_2	155	161	PF00498	0.583
LIG_FHA_2	281	287	PF00498	0.304
LIG_FHA_2	306	312	PF00498	0.449
LIG_FHA_2	332	338	PF00498	0.652
LIG_FHA_2	496	502	PF00498	0.648
LIG_FHA_2	67	73	PF00498	0.535
LIG_Integrin_RGD_1	512	514	PF01839	0.586
LIG_LIR_Apic_2	110	116	PF02991	0.374
LIG_LIR_Apic_2	220	224	PF02991	0.304
LIG_LIR_Apic_2	310	315	PF02991	0.481
LIG_LIR_Gen_1	275	282	PF02991	0.315
LIG_LIR_Gen_1	291	298	PF02991	0.480
LIG_LIR_Nem_3	110	114	PF02991	0.419
LIG_LIR_Nem_3	275	279	PF02991	0.315
LIG_LIR_Nem_3	291	295	PF02991	0.481
LIG_LIR_Nem_3	307	312	PF02991	0.423
LIG_MYND_1	61	65	PF01753	0.588
LIG_NRBOX	233	239	PF00104	0.304
LIG_Pex14_2	113	117	PF04695	0.416
LIG_PTB_Apo_2	270	277	PF02174	0.352
LIG_PTB_Apo_2	297	304	PF02174	0.401
LIG_PTB_Phospho_1	297	303	PF10480	0.373
LIG_SH2_CRK	111	115	PF00017	0.373
LIG_SH2_CRK	219	223	PF00017	0.403
LIG_SH2_CRK	312	316	PF00017	0.394
LIG_SH2_PTP2	221	224	PF00017	0.326
LIG_SH2_STAP1	376	380	PF00017	0.580
LIG_SH2_STAT5	212	215	PF00017	0.346
LIG_SH2_STAT5	219	222	PF00017	0.343
LIG_SH2_STAT5	233	236	PF00017	0.352
LIG_SH2_STAT5	303	306	PF00017	0.386
LIG_SH2_STAT5	312	315	PF00017	0.381
LIG_SH3_3	139	145	PF00018	0.610
LIG_SH3_3	347	353	PF00018	0.606
LIG_SH3_3	392	398	PF00018	0.609
LIG_SH3_3	439	445	PF00018	0.595
LIG_SH3_3	58	64	PF00018	0.553
LIG_SH3_3	647	653	PF00018	0.610
LIG_SH3_3	75	81	PF00018	0.538
LIG_SUMO_SIM_par_1	504	511	PF11976	0.619
LIG_TRAF2_1	102	105	PF00917	0.449
LIG_TRAF2_1	508	511	PF00917	0.608
LIG_TRFH_1	77	81	PF08558	0.521
LIG_TYR_ITIM	217	222	PF00017	0.304
LIG_WW_2	64	67	PF00397	0.515
MOD_CDC14_SPxK_1	387	390	PF00782	0.601
MOD_CDK_SPK_2	159	164	PF00069	0.636
MOD_CDK_SPxK_1	384	390	PF00069	0.595
MOD_CDK_SPxK_1	605	611	PF00069	0.594
MOD_CDK_SPxxK_3	605	612	PF00069	0.597
MOD_CK1_1	11	17	PF00069	0.708
MOD_CK1_1	144	150	PF00069	0.627
MOD_CK1_1	179	185	PF00069	0.254
MOD_CK1_1	305	311	PF00069	0.386
MOD_CK1_1	365	371	PF00069	0.639
MOD_CK1_1	379	385	PF00069	0.768
MOD_CK1_1	400	406	PF00069	0.716
MOD_CK1_1	408	414	PF00069	0.607
MOD_CK1_1	426	432	PF00069	0.753
MOD_CK1_1	546	552	PF00069	0.626
MOD_CK1_1	605	611	PF00069	0.588
MOD_CK1_1	615	621	PF00069	0.594
MOD_CK1_1	630	636	PF00069	0.552
MOD_CK1_1	90	96	PF00069	0.507
MOD_CK2_1	154	160	PF00069	0.620
MOD_CK2_1	197	203	PF00069	0.304
MOD_CK2_1	305	311	PF00069	0.571
MOD_CK2_1	331	337	PF00069	0.651
MOD_CK2_1	369	375	PF00069	0.582
MOD_CK2_1	66	72	PF00069	0.514
MOD_CK2_1	99	105	PF00069	0.492
MOD_GlcNHglycan	148	151	PF01048	0.627
MOD_GlcNHglycan	17	20	PF01048	0.641
MOD_GlcNHglycan	181	184	PF01048	0.292
MOD_GlcNHglycan	23	26	PF01048	0.653
MOD_GlcNHglycan	343	346	PF01048	0.726
MOD_GlcNHglycan	36	39	PF01048	0.641
MOD_GlcNHglycan	383	386	PF01048	0.581
MOD_GlcNHglycan	390	393	PF01048	0.598
MOD_GlcNHglycan	399	402	PF01048	0.601
MOD_GlcNHglycan	41	45	PF01048	0.563
MOD_GlcNHglycan	425	428	PF01048	0.710
MOD_GlcNHglycan	429	432	PF01048	0.726
MOD_GlcNHglycan	466	469	PF01048	0.623
MOD_GlcNHglycan	471	474	PF01048	0.600
MOD_GlcNHglycan	501	504	PF01048	0.809
MOD_GlcNHglycan	522	525	PF01048	0.595
MOD_GlcNHglycan	57	60	PF01048	0.573
MOD_GlcNHglycan	590	593	PF01048	0.716
MOD_GlcNHglycan	629	632	PF01048	0.700
MOD_GlcNHglycan	634	638	PF01048	0.788
MOD_GlcNHglycan	92	95	PF01048	0.588
MOD_GSK3_1	140	147	PF00069	0.562
MOD_GSK3_1	159	166	PF00069	0.674
MOD_GSK3_1	169	176	PF00069	0.528
MOD_GSK3_1	17	24	PF00069	0.544
MOD_GSK3_1	177	184	PF00069	0.477
MOD_GSK3_1	256	263	PF00069	0.304
MOD_GSK3_1	321	328	PF00069	0.601
MOD_GSK3_1	331	338	PF00069	0.598
MOD_GSK3_1	358	365	PF00069	0.612
MOD_GSK3_1	36	43	PF00069	0.633
MOD_GSK3_1	384	391	PF00069	0.799
MOD_GSK3_1	399	406	PF00069	0.597
MOD_GSK3_1	419	426	PF00069	0.618
MOD_GSK3_1	478	485	PF00069	0.623
MOD_GSK3_1	495	502	PF00069	0.547
MOD_GSK3_1	516	523	PF00069	0.563
MOD_GSK3_1	529	536	PF00069	0.572
MOD_GSK3_1	53	60	PF00069	0.643
MOD_GSK3_1	582	589	PF00069	0.709
MOD_GSK3_1	596	603	PF00069	0.653
MOD_GSK3_1	7	14	PF00069	0.678
MOD_GSK3_1	77	84	PF00069	0.596
MOD_N-GLC_1	174	179	PF02516	0.596
MOD_N-GLC_1	358	363	PF02516	0.596
MOD_N-GLC_1	8	13	PF02516	0.608
MOD_N-GLC_1	97	102	PF02516	0.477
MOD_N-GLC_2	570	572	PF02516	0.598
MOD_NEK2_1	254	259	PF00069	0.331
MOD_NEK2_1	436	441	PF00069	0.618
MOD_NEK2_1	543	548	PF00069	0.572
MOD_NEK2_1	600	605	PF00069	0.692
MOD_NEK2_2	205	210	PF00069	0.304
MOD_NEK2_2	8	13	PF00069	0.619
MOD_PIKK_1	369	375	PF00454	0.582
MOD_PIKK_1	379	385	PF00454	0.580
MOD_PK_1	366	372	PF00069	0.580
MOD_PK_1	405	411	PF00069	0.635
MOD_PK_1	516	522	PF00069	0.499
MOD_PKA_1	366	372	PF00069	0.581
MOD_PKA_2	163	169	PF00069	0.620
MOD_PKA_2	305	311	PF00069	0.451
MOD_PKA_2	365	371	PF00069	0.588
MOD_PKA_2	537	543	PF00069	0.785
MOD_PKA_2	87	93	PF00069	0.552
MOD_PKB_1	364	372	PF00069	0.579
MOD_PKB_1	516	524	PF00069	0.562
MOD_Plk_1	122	128	PF00069	0.360
MOD_Plk_1	274	280	PF00069	0.304
MOD_Plk_1	374	380	PF00069	0.581
MOD_Plk_1	8	14	PF00069	0.605
MOD_Plk_2-3	99	105	PF00069	0.464
MOD_Plk_4	217	223	PF00069	0.326
MOD_Plk_4	366	372	PF00069	0.561
MOD_Plk_4	482	488	PF00069	0.614
MOD_Plk_4	50	56	PF00069	0.551
MOD_Plk_4	501	507	PF00069	0.503
MOD_Plk_4	596	602	PF00069	0.653
MOD_Plk_4	635	641	PF00069	0.621
MOD_ProDKin_1	12	18	PF00069	0.613
MOD_ProDKin_1	141	147	PF00069	0.570
MOD_ProDKin_1	159	165	PF00069	0.669
MOD_ProDKin_1	188	194	PF00069	0.369
MOD_ProDKin_1	220	226	PF00069	0.304
MOD_ProDKin_1	335	341	PF00069	0.609
MOD_ProDKin_1	384	390	PF00069	0.633
MOD_ProDKin_1	438	444	PF00069	0.600
MOD_ProDKin_1	454	460	PF00069	0.600
MOD_ProDKin_1	495	501	PF00069	0.663
MOD_ProDKin_1	53	59	PF00069	0.705
MOD_ProDKin_1	565	571	PF00069	0.598
MOD_ProDKin_1	605	611	PF00069	0.594
MOD_ProDKin_1	77	83	PF00069	0.575
TRG_DiLeu_BaEn_1	110	115	PF01217	0.503
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.338
TRG_DiLeu_BaLyEn_6	538	543	PF01217	0.625
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.569
TRG_ENDOCYTIC_2	111	114	PF00928	0.380
TRG_ENDOCYTIC_2	219	222	PF00928	0.383
TRG_ENDOCYTIC_2	249	252	PF00928	0.343
TRG_ER_diArg_1	364	367	PF00400	0.581
TRG_NES_CRM1_1	285	296	PF08389	0.335
TRG_Pf-PMV_PEXEL_1	314	319	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0K2	Leptomonas seymouri	51%	94%
A0A3Q8IG93	Leishmania donovani	99%	100%
A4HDQ0	Leishmania braziliensis	79%	100%
E9AX34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QAE2	Leishmania major	94%	100%