DNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA helicase

Gene product:

ATP-dependent DEAD/H DNA helicase recQ - putative

Species:

Leishmania infantum

UniProt:

A4I0Z1_LEIIN

TriTrypDb:

LINF_240020800

Length:

1946

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005694	chromosome	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I0Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0Z1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006310	DNA recombination	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006268	DNA unwinding involved in DNA replication	9	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0032392	DNA geometric change	7	1
GO:0032508	DNA duplex unwinding	8	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051276	chromosome organization	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071103	DNA conformation change	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004386	helicase activity	2	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016787	hydrolase activity	2	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:0140657	ATP-dependent activity	1	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003678	DNA helicase activity	3	1
GO:0008094	ATP-dependent activity, acting on DNA	2	1
GO:0009378	four-way junction helicase activity	4	1
GO:0043138	3'-5' DNA helicase activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1029	1033	PF00656	0.412
CLV_C14_Caspase3-7	1077	1081	PF00656	0.650
CLV_C14_Caspase3-7	1148	1152	PF00656	0.719
CLV_C14_Caspase3-7	1247	1251	PF00656	0.779
CLV_C14_Caspase3-7	440	444	PF00656	0.572
CLV_MEL_PAP_1	740	746	PF00089	0.532
CLV_NRD_NRD_1	1131	1133	PF00675	0.733
CLV_NRD_NRD_1	1140	1142	PF00675	0.600
CLV_NRD_NRD_1	1211	1213	PF00675	0.656
CLV_NRD_NRD_1	1243	1245	PF00675	0.677
CLV_NRD_NRD_1	1494	1496	PF00675	0.657
CLV_NRD_NRD_1	273	275	PF00675	0.489
CLV_NRD_NRD_1	461	463	PF00675	0.719
CLV_NRD_NRD_1	512	514	PF00675	0.413
CLV_NRD_NRD_1	604	606	PF00675	0.292
CLV_NRD_NRD_1	669	671	PF00675	0.301
CLV_NRD_NRD_1	756	758	PF00675	0.305
CLV_NRD_NRD_1	769	771	PF00675	0.305
CLV_NRD_NRD_1	889	891	PF00675	0.305
CLV_PCSK_FUR_1	1492	1496	PF00082	0.769
CLV_PCSK_KEX2_1	1109	1111	PF00082	0.625
CLV_PCSK_KEX2_1	1131	1133	PF00082	0.731
CLV_PCSK_KEX2_1	1140	1142	PF00082	0.598
CLV_PCSK_KEX2_1	1211	1213	PF00082	0.656
CLV_PCSK_KEX2_1	1245	1247	PF00082	0.684
CLV_PCSK_KEX2_1	1348	1350	PF00082	0.292
CLV_PCSK_KEX2_1	1494	1496	PF00082	0.657
CLV_PCSK_KEX2_1	273	275	PF00082	0.489
CLV_PCSK_KEX2_1	512	514	PF00082	0.413
CLV_PCSK_KEX2_1	604	606	PF00082	0.292
CLV_PCSK_KEX2_1	676	678	PF00082	0.396
CLV_PCSK_KEX2_1	769	771	PF00082	0.297
CLV_PCSK_KEX2_1	888	890	PF00082	0.305
CLV_PCSK_PC1ET2_1	1109	1111	PF00082	0.561
CLV_PCSK_PC1ET2_1	1131	1133	PF00082	0.795
CLV_PCSK_PC1ET2_1	1245	1247	PF00082	0.684
CLV_PCSK_PC1ET2_1	1348	1350	PF00082	0.292
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.376
CLV_PCSK_SKI1_1	1011	1015	PF00082	0.414
CLV_PCSK_SKI1_1	1016	1020	PF00082	0.377
CLV_PCSK_SKI1_1	1056	1060	PF00082	0.443
CLV_PCSK_SKI1_1	1063	1067	PF00082	0.447
CLV_PCSK_SKI1_1	1070	1074	PF00082	0.530
CLV_PCSK_SKI1_1	1144	1148	PF00082	0.750
CLV_PCSK_SKI1_1	1286	1290	PF00082	0.445
CLV_PCSK_SKI1_1	1381	1385	PF00082	0.595
CLV_PCSK_SKI1_1	1450	1454	PF00082	0.776
CLV_PCSK_SKI1_1	1495	1499	PF00082	0.720
CLV_PCSK_SKI1_1	151	155	PF00082	0.594
CLV_PCSK_SKI1_1	180	184	PF00082	0.658
CLV_PCSK_SKI1_1	1900	1904	PF00082	0.621
CLV_PCSK_SKI1_1	266	270	PF00082	0.413
CLV_PCSK_SKI1_1	274	278	PF00082	0.418
CLV_PCSK_SKI1_1	481	485	PF00082	0.584
CLV_PCSK_SKI1_1	516	520	PF00082	0.420
CLV_PCSK_SKI1_1	539	543	PF00082	0.305
CLV_PCSK_SKI1_1	605	609	PF00082	0.292
CLV_PCSK_SKI1_1	644	648	PF00082	0.292
CLV_PCSK_SKI1_1	770	774	PF00082	0.298
DEG_APCC_DBOX_1	1015	1023	PF00400	0.385
DEG_APCC_DBOX_1	238	246	PF00400	0.591
DEG_APCC_DBOX_1	285	293	PF00400	0.527
DEG_APCC_DBOX_1	792	800	PF00400	0.492
DEG_APCC_DBOX_1	867	875	PF00400	0.492
DEG_SCF_FBW7_1	1779	1785	PF00400	0.586
DEG_SCF_FBW7_1	331	336	PF00400	0.624
DEG_SCF_FBW7_1	920	927	PF00400	0.451
DEG_SPOP_SBC_1	10	14	PF00917	0.599
DEG_SPOP_SBC_1	1621	1625	PF00917	0.577
DEG_SPOP_SBC_1	223	227	PF00917	0.615
DEG_SPOP_SBC_1	46	50	PF00917	0.596
DOC_CKS1_1	1185	1190	PF01111	0.645
DOC_CKS1_1	1194	1199	PF01111	0.663
DOC_CKS1_1	1456	1461	PF01111	0.606
DOC_CKS1_1	1609	1614	PF01111	0.702
DOC_CKS1_1	1779	1784	PF01111	0.584
DOC_CKS1_1	1820	1825	PF01111	0.618
DOC_CKS1_1	622	627	PF01111	0.499
DOC_CKS1_1	680	685	PF01111	0.492
DOC_CKS1_1	921	926	PF01111	0.451
DOC_CYCLIN_RxL_1	1008	1017	PF00134	0.418
DOC_CYCLIN_RxL_1	1281	1292	PF00134	0.455
DOC_CYCLIN_RxL_1	602	610	PF00134	0.492
DOC_CYCLIN_RxL_1	698	707	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	1453	1459	PF00134	0.697
DOC_MAPK_gen_1	1356	1366	PF00069	0.608
DOC_MAPK_gen_1	728	735	PF00069	0.542
DOC_MAPK_gen_1	790	798	PF00069	0.492
DOC_MAPK_MEF2A_6	1096	1104	PF00069	0.658
DOC_MAPK_MEF2A_6	1518	1526	PF00069	0.756
DOC_MAPK_MEF2A_6	486	494	PF00069	0.568
DOC_PP2B_LxvP_1	1325	1328	PF13499	0.492
DOC_PP2B_LxvP_1	1538	1541	PF13499	0.667
DOC_PP2B_LxvP_1	1630	1633	PF13499	0.718
DOC_PP2B_LxvP_1	1684	1687	PF13499	0.685
DOC_PP2B_LxvP_1	434	437	PF13499	0.613
DOC_PP4_FxxP_1	1598	1601	PF00568	0.655
DOC_PP4_FxxP_1	1603	1606	PF00568	0.624
DOC_PP4_MxPP_1	232	235	PF00568	0.602
DOC_SPAK_OSR1_1	649	653	PF12202	0.492
DOC_USP7_MATH_1	10	14	PF00917	0.590
DOC_USP7_MATH_1	1007	1011	PF00917	0.589
DOC_USP7_MATH_1	1074	1078	PF00917	0.610
DOC_USP7_MATH_1	1085	1089	PF00917	0.679
DOC_USP7_MATH_1	1150	1154	PF00917	0.766
DOC_USP7_MATH_1	1160	1164	PF00917	0.646
DOC_USP7_MATH_1	1186	1190	PF00917	0.609
DOC_USP7_MATH_1	1202	1206	PF00917	0.557
DOC_USP7_MATH_1	1272	1276	PF00917	0.552
DOC_USP7_MATH_1	1396	1400	PF00917	0.744
DOC_USP7_MATH_1	1423	1427	PF00917	0.569
DOC_USP7_MATH_1	1462	1466	PF00917	0.762
DOC_USP7_MATH_1	155	159	PF00917	0.645
DOC_USP7_MATH_1	1616	1620	PF00917	0.758
DOC_USP7_MATH_1	1622	1626	PF00917	0.646
DOC_USP7_MATH_1	1633	1637	PF00917	0.604
DOC_USP7_MATH_1	1685	1689	PF00917	0.755
DOC_USP7_MATH_1	1714	1718	PF00917	0.709
DOC_USP7_MATH_1	175	179	PF00917	0.566
DOC_USP7_MATH_1	1782	1786	PF00917	0.630
DOC_USP7_MATH_1	1828	1832	PF00917	0.685
DOC_USP7_MATH_1	1839	1843	PF00917	0.757
DOC_USP7_MATH_1	1879	1883	PF00917	0.657
DOC_USP7_MATH_1	1891	1895	PF00917	0.609
DOC_USP7_MATH_1	197	201	PF00917	0.751
DOC_USP7_MATH_1	210	214	PF00917	0.548
DOC_USP7_MATH_1	222	226	PF00917	0.584
DOC_USP7_MATH_1	248	252	PF00917	0.726
DOC_USP7_MATH_1	33	37	PF00917	0.609
DOC_USP7_MATH_1	437	441	PF00917	0.744
DOC_USP7_MATH_1	454	458	PF00917	0.702
DOC_USP7_MATH_1	46	50	PF00917	0.601
DOC_USP7_MATH_1	603	607	PF00917	0.498
DOC_USP7_MATH_1	68	72	PF00917	0.601
DOC_USP7_MATH_1	924	928	PF00917	0.563
DOC_USP7_MATH_2	1000	1006	PF00917	0.423
DOC_USP7_UBL2_3	1004	1008	PF12436	0.579
DOC_USP7_UBL2_3	1133	1137	PF12436	0.758
DOC_USP7_UBL2_3	1344	1348	PF12436	0.492
DOC_WW_Pin1_4	1045	1050	PF00397	0.560
DOC_WW_Pin1_4	1184	1189	PF00397	0.644
DOC_WW_Pin1_4	1193	1198	PF00397	0.650
DOC_WW_Pin1_4	1455	1460	PF00397	0.633
DOC_WW_Pin1_4	1469	1474	PF00397	0.657
DOC_WW_Pin1_4	151	156	PF00397	0.597
DOC_WW_Pin1_4	1518	1523	PF00397	0.749
DOC_WW_Pin1_4	1608	1613	PF00397	0.696
DOC_WW_Pin1_4	1623	1628	PF00397	0.565
DOC_WW_Pin1_4	1643	1648	PF00397	0.658
DOC_WW_Pin1_4	1721	1726	PF00397	0.660
DOC_WW_Pin1_4	1778	1783	PF00397	0.569
DOC_WW_Pin1_4	1819	1824	PF00397	0.644
DOC_WW_Pin1_4	1904	1909	PF00397	0.632
DOC_WW_Pin1_4	258	263	PF00397	0.626
DOC_WW_Pin1_4	329	334	PF00397	0.624
DOC_WW_Pin1_4	347	352	PF00397	0.653
DOC_WW_Pin1_4	386	391	PF00397	0.711
DOC_WW_Pin1_4	569	574	PF00397	0.492
DOC_WW_Pin1_4	621	626	PF00397	0.502
DOC_WW_Pin1_4	679	684	PF00397	0.492
DOC_WW_Pin1_4	742	747	PF00397	0.546
DOC_WW_Pin1_4	920	925	PF00397	0.451
DOC_WW_Pin1_4	996	1001	PF00397	0.591
LIG_14-3-3_CanoR_1	1063	1068	PF00244	0.552
LIG_14-3-3_CanoR_1	1121	1127	PF00244	0.713
LIG_14-3-3_CanoR_1	1295	1301	PF00244	0.576
LIG_14-3-3_CanoR_1	1320	1328	PF00244	0.492
LIG_14-3-3_CanoR_1	1395	1405	PF00244	0.753
LIG_14-3-3_CanoR_1	1419	1428	PF00244	0.671
LIG_14-3-3_CanoR_1	1463	1473	PF00244	0.653
LIG_14-3-3_CanoR_1	1492	1498	PF00244	0.666
LIG_14-3-3_CanoR_1	1518	1522	PF00244	0.627
LIG_14-3-3_CanoR_1	1523	1527	PF00244	0.613
LIG_14-3-3_CanoR_1	1736	1740	PF00244	0.697
LIG_14-3-3_CanoR_1	180	186	PF00244	0.714
LIG_14-3-3_CanoR_1	1841	1845	PF00244	0.723
LIG_14-3-3_CanoR_1	462	468	PF00244	0.657
LIG_14-3-3_CanoR_1	504	514	PF00244	0.430
LIG_14-3-3_CanoR_1	604	608	PF00244	0.492
LIG_14-3-3_CanoR_1	670	675	PF00244	0.492
LIG_14-3-3_CanoR_1	868	878	PF00244	0.503
LIG_14-3-3_CanoR_1	980	990	PF00244	0.448
LIG_Actin_WH2_2	111	129	PF00022	0.513
LIG_Actin_WH2_2	265	282	PF00022	0.443
LIG_Actin_WH2_2	692	708	PF00022	0.538
LIG_Actin_WH2_2	950	968	PF00022	0.379
LIG_APCC_ABBA_1	1024	1029	PF00400	0.366
LIG_APCC_ABBA_1	1600	1605	PF00400	0.649
LIG_APCC_ABBAyCdc20_2	604	610	PF00400	0.492
LIG_BIR_III_4	156	160	PF00653	0.557
LIG_BIR_III_4	443	447	PF00653	0.589
LIG_BRCT_BRCA1_1	1648	1652	PF00533	0.576
LIG_BRCT_BRCA1_1	1893	1897	PF00533	0.718
LIG_BRCT_BRCA1_1	225	229	PF00533	0.584
LIG_BRCT_BRCA1_1	630	634	PF00533	0.492
LIG_Clathr_ClatBox_1	1336	1340	PF01394	0.576
LIG_Clathr_ClatBox_1	289	293	PF01394	0.549
LIG_CSL_BTD_1	1779	1782	PF09270	0.663
LIG_CtBP_PxDLS_1	164	168	PF00389	0.640
LIG_CtBP_PxDLS_1	337	341	PF00389	0.640
LIG_EH1_1	614	622	PF00400	0.576
LIG_eIF4E_1	555	561	PF01652	0.492
LIG_EVH1_1	1603	1607	PF00568	0.621
LIG_EVH1_1	920	924	PF00568	0.451
LIG_FHA_1	1064	1070	PF00498	0.451
LIG_FHA_1	1320	1326	PF00498	0.492
LIG_FHA_1	1569	1575	PF00498	0.692
LIG_FHA_1	1681	1687	PF00498	0.637
LIG_FHA_1	298	304	PF00498	0.457
LIG_FHA_1	485	491	PF00498	0.591
LIG_FHA_1	566	572	PF00498	0.492
LIG_FHA_1	690	696	PF00498	0.492
LIG_FHA_1	700	706	PF00498	0.394
LIG_FHA_2	1015	1021	PF00498	0.255
LIG_FHA_2	1092	1098	PF00498	0.673
LIG_FHA_2	1152	1158	PF00498	0.678
LIG_FHA_2	1226	1232	PF00498	0.776
LIG_FHA_2	1245	1251	PF00498	0.787
LIG_FHA_2	1484	1490	PF00498	0.776
LIG_FHA_2	1858	1864	PF00498	0.590
LIG_FHA_2	1938	1944	PF00498	0.654
LIG_FHA_2	262	268	PF00498	0.549
LIG_FHA_2	688	694	PF00498	0.492
LIG_FHA_2	790	796	PF00498	0.492
LIG_FHA_2	848	854	PF00498	0.547
LIG_FHA_2	945	951	PF00498	0.533
LIG_FHA_2	997	1003	PF00498	0.578
LIG_Integrin_isoDGR_2	1440	1442	PF01839	0.580
LIG_Integrin_RGD_1	1248	1250	PF01839	0.776
LIG_Integrin_RGD_1	426	428	PF01839	0.650
LIG_LIR_Apic_2	141	145	PF02991	0.579
LIG_LIR_Apic_2	552	558	PF02991	0.492
LIG_LIR_Apic_2	619	625	PF02991	0.492
LIG_LIR_Gen_1	1309	1318	PF02991	0.492
LIG_LIR_Gen_1	1553	1562	PF02991	0.716
LIG_LIR_Gen_1	314	325	PF02991	0.473
LIG_LIR_Gen_1	523	534	PF02991	0.476
LIG_LIR_Gen_1	540	546	PF02991	0.409
LIG_LIR_Gen_1	580	591	PF02991	0.492
LIG_LIR_Gen_1	959	967	PF02991	0.519
LIG_LIR_Gen_1	99	108	PF02991	0.513
LIG_LIR_Nem_3	1080	1086	PF02991	0.748
LIG_LIR_Nem_3	1553	1558	PF02991	0.712
LIG_LIR_Nem_3	314	320	PF02991	0.464
LIG_LIR_Nem_3	466	470	PF02991	0.497
LIG_LIR_Nem_3	523	529	PF02991	0.544
LIG_LIR_Nem_3	540	545	PF02991	0.409
LIG_LIR_Nem_3	580	586	PF02991	0.492
LIG_LIR_Nem_3	668	672	PF02991	0.492
LIG_LIR_Nem_3	959	964	PF02991	0.482
LIG_LIR_Nem_3	99	104	PF02991	0.519
LIG_LYPXL_S_1	110	114	PF13949	0.627
LIG_LYPXL_yS_3	111	114	PF13949	0.626
LIG_MYND_1	1536	1540	PF01753	0.767
LIG_MYND_1	1629	1633	PF01753	0.713
LIG_MYND_1	558	562	PF01753	0.492
LIG_MYND_1	918	922	PF01753	0.576
LIG_NRBOX	1284	1290	PF00104	0.448
LIG_PCNA_yPIPBox_3	1284	1297	PF02747	0.446
LIG_Pex14_1	661	665	PF04695	0.505
LIG_Pex14_2	711	715	PF04695	0.383
LIG_Rb_pABgroove_1	1099	1107	PF01858	0.598
LIG_SH2_CRK	142	146	PF00017	0.578
LIG_SH2_CRK	1555	1559	PF00017	0.715
LIG_SH2_CRK	555	559	PF00017	0.492
LIG_SH2_CRK	583	587	PF00017	0.492
LIG_SH2_CRK	669	673	PF00017	0.492
LIG_SH2_CRK	961	965	PF00017	0.495
LIG_SH2_NCK_1	142	146	PF00017	0.578
LIG_SH2_NCK_1	364	368	PF00017	0.655
LIG_SH2_NCK_1	583	587	PF00017	0.492
LIG_SH2_PTP2	1363	1366	PF00017	0.612
LIG_SH2_PTP2	622	625	PF00017	0.492
LIG_SH2_SRC	1363	1366	PF00017	0.446
LIG_SH2_SRC	142	145	PF00017	0.626
LIG_SH2_SRC	830	833	PF00017	0.563
LIG_SH2_SRC	961	964	PF00017	0.481
LIG_SH2_STAP1	470	474	PF00017	0.525
LIG_SH2_STAP1	583	587	PF00017	0.492
LIG_SH2_STAP1	961	965	PF00017	0.495
LIG_SH2_STAT3	470	473	PF00017	0.529
LIG_SH2_STAT3	722	725	PF00017	0.500
LIG_SH2_STAT5	1145	1148	PF00017	0.664
LIG_SH2_STAT5	1190	1193	PF00017	0.655
LIG_SH2_STAT5	1363	1366	PF00017	0.460
LIG_SH2_STAT5	1739	1742	PF00017	0.728
LIG_SH2_STAT5	1810	1813	PF00017	0.739
LIG_SH2_STAT5	372	375	PF00017	0.689
LIG_SH2_STAT5	622	625	PF00017	0.492
LIG_SH2_STAT5	627	630	PF00017	0.492
LIG_SH2_STAT5	753	756	PF00017	0.492
LIG_SH2_STAT5	816	819	PF00017	0.497
LIG_SH2_STAT5	880	883	PF00017	0.492
LIG_SH3_1	677	683	PF00018	0.519
LIG_SH3_2	1456	1461	PF14604	0.606
LIG_SH3_3	1191	1197	PF00018	0.728
LIG_SH3_3	1236	1242	PF00018	0.793
LIG_SH3_3	141	147	PF00018	0.623
LIG_SH3_3	1453	1459	PF00018	0.620
LIG_SH3_3	1478	1484	PF00018	0.710
LIG_SH3_3	1533	1539	PF00018	0.724
LIG_SH3_3	1582	1588	PF00018	0.772
LIG_SH3_3	1590	1596	PF00018	0.593
LIG_SH3_3	1598	1604	PF00018	0.603
LIG_SH3_3	1644	1650	PF00018	0.709
LIG_SH3_3	169	175	PF00018	0.625
LIG_SH3_3	1776	1782	PF00018	0.730
LIG_SH3_3	1790	1796	PF00018	0.681
LIG_SH3_3	198	204	PF00018	0.565
LIG_SH3_3	227	233	PF00018	0.611
LIG_SH3_3	240	246	PF00018	0.583
LIG_SH3_3	345	351	PF00018	0.635
LIG_SH3_3	384	390	PF00018	0.681
LIG_SH3_3	487	493	PF00018	0.571
LIG_SH3_3	540	546	PF00018	0.492
LIG_SH3_3	567	573	PF00018	0.498
LIG_SH3_3	677	683	PF00018	0.471
LIG_SH3_3	915	921	PF00018	0.494
LIG_SH3_3	99	105	PF00018	0.610
LIG_SH3_4	1133	1140	PF00018	0.717
LIG_SH3_CIN85_PxpxPR_1	234	239	PF14604	0.586
LIG_SUMO_SIM_anti_2	1763	1771	PF11976	0.652
LIG_SUMO_SIM_anti_2	287	296	PF11976	0.531
LIG_SUMO_SIM_anti_2	927	932	PF11976	0.451
LIG_SUMO_SIM_par_1	1100	1106	PF11976	0.651
LIG_SUMO_SIM_par_1	1335	1340	PF11976	0.576
LIG_SUMO_SIM_par_1	1450	1455	PF11976	0.636
LIG_SUMO_SIM_par_1	1682	1689	PF11976	0.601
LIG_SUMO_SIM_par_1	261	267	PF11976	0.536
LIG_SUMO_SIM_par_1	287	296	PF11976	0.531
LIG_SUMO_SIM_par_1	567	572	PF11976	0.492
LIG_SUMO_SIM_par_1	701	707	PF11976	0.498
LIG_TRAF2_1	1126	1129	PF00917	0.635
LIG_TRAF2_1	1163	1166	PF00917	0.778
LIG_TRFH_1	542	546	PF08558	0.492
LIG_UBA3_1	1336	1344	PF00899	0.576
LIG_WRC_WIRS_1	1174	1179	PF05994	0.658
LIG_WRC_WIRS_1	1497	1502	PF05994	0.715
LIG_WW_2	1536	1539	PF00397	0.766
LIG_WW_2	918	921	PF00397	0.530
LIG_WW_3	1241	1245	PF00397	0.794
MOD_CDK_SPK_2	1518	1523	PF00069	0.685
MOD_CDK_SPxK_1	1193	1199	PF00069	0.651
MOD_CDK_SPxK_1	1455	1461	PF00069	0.633
MOD_CDK_SPxK_1	1469	1475	PF00069	0.658
MOD_CK1_1	1088	1094	PF00069	0.749
MOD_CK1_1	1168	1174	PF00069	0.668
MOD_CK1_1	1184	1190	PF00069	0.585
MOD_CK1_1	1192	1198	PF00069	0.660
MOD_CK1_1	1227	1233	PF00069	0.701
MOD_CK1_1	13	19	PF00069	0.563
MOD_CK1_1	130	136	PF00069	0.590
MOD_CK1_1	138	144	PF00069	0.521
MOD_CK1_1	1465	1471	PF00069	0.663
MOD_CK1_1	1501	1507	PF00069	0.754
MOD_CK1_1	1517	1523	PF00069	0.524
MOD_CK1_1	158	164	PF00069	0.601
MOD_CK1_1	1623	1629	PF00069	0.646
MOD_CK1_1	1646	1652	PF00069	0.756
MOD_CK1_1	1705	1711	PF00069	0.715
MOD_CK1_1	178	184	PF00069	0.630
MOD_CK1_1	1840	1846	PF00069	0.749
MOD_CK1_1	1882	1888	PF00069	0.672
MOD_CK1_1	261	267	PF00069	0.562
MOD_CK1_1	339	345	PF00069	0.643
MOD_CK1_1	385	391	PF00069	0.790
MOD_CK1_1	450	456	PF00069	0.639
MOD_CK1_1	457	463	PF00069	0.603
MOD_CK1_1	6	12	PF00069	0.583
MOD_CK1_1	745	751	PF00069	0.405
MOD_CK1_1	849	855	PF00069	0.335
MOD_CK1_1	870	876	PF00069	0.492
MOD_CK1_1	929	935	PF00069	0.545
MOD_CK2_1	1014	1020	PF00069	0.257
MOD_CK2_1	1159	1165	PF00069	0.670
MOD_CK2_1	1225	1231	PF00069	0.776
MOD_CK2_1	1370	1376	PF00069	0.534
MOD_CK2_1	1396	1402	PF00069	0.749
MOD_CK2_1	1750	1756	PF00069	0.749
MOD_CK2_1	1886	1892	PF00069	0.670
MOD_CK2_1	1893	1899	PF00069	0.602
MOD_CK2_1	1903	1909	PF00069	0.595
MOD_CK2_1	780	786	PF00069	0.492
MOD_CK2_1	789	795	PF00069	0.492
MOD_CK2_1	944	950	PF00069	0.572
MOD_CK2_1	979	985	PF00069	0.409
MOD_CK2_1	996	1002	PF00069	0.540
MOD_Cter_Amidation	1138	1141	PF01082	0.775
MOD_Cter_Amidation	1209	1212	PF01082	0.758
MOD_DYRK1A_RPxSP_1	1518	1522	PF00069	0.743
MOD_GlcNHglycan	1004	1007	PF01048	0.477
MOD_GlcNHglycan	1087	1090	PF01048	0.746
MOD_GlcNHglycan	1122	1125	PF01048	0.641
MOD_GlcNHglycan	1165	1170	PF01048	0.769
MOD_GlcNHglycan	1398	1401	PF01048	0.645
MOD_GlcNHglycan	1421	1424	PF01048	0.672
MOD_GlcNHglycan	1425	1428	PF01048	0.633
MOD_GlcNHglycan	1467	1470	PF01048	0.780
MOD_GlcNHglycan	1478	1481	PF01048	0.635
MOD_GlcNHglycan	156	160	PF01048	0.646
MOD_GlcNHglycan	1618	1621	PF01048	0.594
MOD_GlcNHglycan	1653	1656	PF01048	0.713
MOD_GlcNHglycan	169	172	PF01048	0.603
MOD_GlcNHglycan	1704	1707	PF01048	0.676
MOD_GlcNHglycan	1744	1747	PF01048	0.719
MOD_GlcNHglycan	1750	1753	PF01048	0.727
MOD_GlcNHglycan	1764	1767	PF01048	0.546
MOD_GlcNHglycan	1824	1827	PF01048	0.822
MOD_GlcNHglycan	1828	1831	PF01048	0.661
MOD_GlcNHglycan	1881	1884	PF01048	0.683
MOD_GlcNHglycan	1909	1912	PF01048	0.651
MOD_GlcNHglycan	212	215	PF01048	0.657
MOD_GlcNHglycan	250	253	PF01048	0.651
MOD_GlcNHglycan	35	38	PF01048	0.651
MOD_GlcNHglycan	365	368	PF01048	0.737
MOD_GlcNHglycan	396	399	PF01048	0.806
MOD_GlcNHglycan	400	403	PF01048	0.756
MOD_GlcNHglycan	452	455	PF01048	0.650
MOD_GlcNHglycan	456	459	PF01048	0.636
MOD_GlcNHglycan	507	510	PF01048	0.468
MOD_GlcNHglycan	55	58	PF01048	0.569
MOD_GlcNHglycan	612	615	PF01048	0.286
MOD_GlcNHglycan	70	73	PF01048	0.604
MOD_GlcNHglycan	74	77	PF01048	0.598
MOD_GlcNHglycan	8	11	PF01048	0.587
MOD_GlcNHglycan	832	835	PF01048	0.302
MOD_GlcNHglycan	98	101	PF01048	0.548
MOD_GSK3_1	1180	1187	PF00069	0.821
MOD_GSK3_1	1189	1196	PF00069	0.662
MOD_GSK3_1	1214	1221	PF00069	0.632
MOD_GSK3_1	1419	1426	PF00069	0.581
MOD_GSK3_1	1465	1472	PF00069	0.675
MOD_GSK3_1	147	154	PF00069	0.689
MOD_GSK3_1	1496	1503	PF00069	0.664
MOD_GSK3_1	1514	1521	PF00069	0.494
MOD_GSK3_1	1556	1563	PF00069	0.635
MOD_GSK3_1	1616	1623	PF00069	0.622
MOD_GSK3_1	163	170	PF00069	0.635
MOD_GSK3_1	1646	1653	PF00069	0.633
MOD_GSK3_1	1676	1683	PF00069	0.698
MOD_GSK3_1	1694	1701	PF00069	0.660
MOD_GSK3_1	1721	1728	PF00069	0.656
MOD_GSK3_1	1742	1749	PF00069	0.627
MOD_GSK3_1	1750	1757	PF00069	0.698
MOD_GSK3_1	1778	1785	PF00069	0.645
MOD_GSK3_1	180	187	PF00069	0.724
MOD_GSK3_1	1822	1829	PF00069	0.672
MOD_GSK3_1	1852	1859	PF00069	0.738
MOD_GSK3_1	1881	1888	PF00069	0.643
MOD_GSK3_1	1891	1898	PF00069	0.633
MOD_GSK3_1	1903	1910	PF00069	0.608
MOD_GSK3_1	192	199	PF00069	0.552
MOD_GSK3_1	224	231	PF00069	0.606
MOD_GSK3_1	329	336	PF00069	0.654
MOD_GSK3_1	338	345	PF00069	0.682
MOD_GSK3_1	347	354	PF00069	0.640
MOD_GSK3_1	382	389	PF00069	0.697
MOD_GSK3_1	394	401	PF00069	0.618
MOD_GSK3_1	446	453	PF00069	0.658
MOD_GSK3_1	47	54	PF00069	0.586
MOD_GSK3_1	5	12	PF00069	0.593
MOD_GSK3_1	565	572	PF00069	0.494
MOD_GSK3_1	68	75	PF00069	0.619
MOD_GSK3_1	685	692	PF00069	0.526
MOD_GSK3_1	772	779	PF00069	0.499
MOD_GSK3_1	92	99	PF00069	0.543
MOD_GSK3_1	920	927	PF00069	0.487
MOD_N-GLC_1	135	140	PF02516	0.564
MOD_N-GLC_1	1396	1401	PF02516	0.745
MOD_N-GLC_1	1634	1639	PF02516	0.721
MOD_N-GLC_1	25	30	PF02516	0.606
MOD_N-GLC_2	533	535	PF02516	0.292
MOD_NEK2_1	1014	1019	PF00069	0.495
MOD_NEK2_1	114	119	PF00069	0.621
MOD_NEK2_1	1170	1175	PF00069	0.764
MOD_NEK2_1	1263	1268	PF00069	0.570
MOD_NEK2_1	1296	1301	PF00069	0.496
MOD_NEK2_1	1321	1326	PF00069	0.498
MOD_NEK2_1	1498	1503	PF00069	0.652
MOD_NEK2_1	1659	1664	PF00069	0.626
MOD_NEK2_1	167	172	PF00069	0.606
MOD_NEK2_1	1698	1703	PF00069	0.657
MOD_NEK2_1	1720	1725	PF00069	0.655
MOD_NEK2_1	1735	1740	PF00069	0.642
MOD_NEK2_1	1750	1755	PF00069	0.577
MOD_NEK2_1	1886	1891	PF00069	0.723
MOD_NEK2_1	1902	1907	PF00069	0.603
MOD_NEK2_1	209	214	PF00069	0.608
MOD_NEK2_1	323	328	PF00069	0.505
MOD_NEK2_1	343	348	PF00069	0.751
MOD_NEK2_1	382	387	PF00069	0.796
MOD_NEK2_1	484	489	PF00069	0.595
MOD_NEK2_1	593	598	PF00069	0.492
MOD_NEK2_1	634	639	PF00069	0.492
MOD_NEK2_1	687	692	PF00069	0.492
MOD_NEK2_1	711	716	PF00069	0.385
MOD_NEK2_1	720	725	PF00069	0.383
MOD_NEK2_1	847	852	PF00069	0.547
MOD_NEK2_1	878	883	PF00069	0.502
MOD_NEK2_1	904	909	PF00069	0.492
MOD_NEK2_1	96	101	PF00069	0.615
MOD_NEK2_2	224	229	PF00069	0.565
MOD_NEK2_2	447	452	PF00069	0.639
MOD_NEK2_2	603	608	PF00069	0.492
MOD_PIKK_1	1218	1224	PF00454	0.776
MOD_PIKK_1	1299	1305	PF00454	0.576
MOD_PIKK_1	1725	1731	PF00454	0.641
MOD_PIKK_1	175	181	PF00454	0.591
MOD_PIKK_1	1773	1779	PF00454	0.647
MOD_PIKK_1	656	662	PF00454	0.492
MOD_PIKK_1	904	910	PF00454	0.492
MOD_PIKK_1	929	935	PF00454	0.492
MOD_PK_1	1030	1036	PF00069	0.442
MOD_PK_1	670	676	PF00069	0.492
MOD_PKA_1	1244	1250	PF00069	0.674
MOD_PKA_1	670	676	PF00069	0.492
MOD_PKA_2	1074	1080	PF00069	0.580
MOD_PKA_2	1117	1123	PF00069	0.711
MOD_PKA_2	1213	1219	PF00069	0.755
MOD_PKA_2	1319	1325	PF00069	0.492
MOD_PKA_2	1441	1447	PF00069	0.657
MOD_PKA_2	1462	1468	PF00069	0.767
MOD_PKA_2	1493	1499	PF00069	0.660
MOD_PKA_2	1517	1523	PF00069	0.655
MOD_PKA_2	1702	1708	PF00069	0.731
MOD_PKA_2	1735	1741	PF00069	0.707
MOD_PKA_2	1826	1832	PF00069	0.767
MOD_PKA_2	1840	1846	PF00069	0.620
MOD_PKA_2	603	609	PF00069	0.492
MOD_PKA_2	77	83	PF00069	0.579
MOD_PKA_2	789	795	PF00069	0.492
MOD_PKA_2	867	873	PF00069	0.502
MOD_PKA_2	979	985	PF00069	0.428
MOD_PKB_1	1212	1220	PF00069	0.668
MOD_Plk_1	1014	1020	PF00069	0.500
MOD_Plk_1	1079	1085	PF00069	0.604
MOD_Plk_1	1165	1171	PF00069	0.669
MOD_Plk_1	1180	1186	PF00069	0.600
MOD_Plk_1	135	141	PF00069	0.554
MOD_Plk_1	1891	1897	PF00069	0.688
MOD_Plk_1	420	426	PF00069	0.724
MOD_Plk_2-3	1151	1157	PF00069	0.649
MOD_Plk_2-3	1370	1376	PF00069	0.534
MOD_Plk_2-3	1893	1899	PF00069	0.683
MOD_Plk_2-3	1937	1943	PF00069	0.657
MOD_Plk_2-3	944	950	PF00069	0.540
MOD_Plk_4	1173	1179	PF00069	0.653
MOD_Plk_4	1186	1192	PF00069	0.650
MOD_Plk_4	1296	1302	PF00069	0.493
MOD_Plk_4	1314	1320	PF00069	0.563
MOD_Plk_4	1677	1683	PF00069	0.632
MOD_Plk_4	1735	1741	PF00069	0.663
MOD_Plk_4	224	230	PF00069	0.645
MOD_Plk_4	323	329	PF00069	0.563
MOD_Plk_4	343	349	PF00069	0.656
MOD_Plk_4	352	358	PF00069	0.630
MOD_Plk_4	565	571	PF00069	0.492
MOD_Plk_4	616	622	PF00069	0.492
MOD_Plk_4	670	676	PF00069	0.492
MOD_Plk_4	772	778	PF00069	0.492
MOD_Plk_4	926	932	PF00069	0.451
MOD_ProDKin_1	1045	1051	PF00069	0.555
MOD_ProDKin_1	1184	1190	PF00069	0.647
MOD_ProDKin_1	1193	1199	PF00069	0.654
MOD_ProDKin_1	1455	1461	PF00069	0.633
MOD_ProDKin_1	1469	1475	PF00069	0.658
MOD_ProDKin_1	151	157	PF00069	0.597
MOD_ProDKin_1	1518	1524	PF00069	0.752
MOD_ProDKin_1	1608	1614	PF00069	0.699
MOD_ProDKin_1	1623	1629	PF00069	0.565
MOD_ProDKin_1	1643	1649	PF00069	0.656
MOD_ProDKin_1	1721	1727	PF00069	0.657
MOD_ProDKin_1	1778	1784	PF00069	0.569
MOD_ProDKin_1	1819	1825	PF00069	0.646
MOD_ProDKin_1	1904	1910	PF00069	0.634
MOD_ProDKin_1	258	264	PF00069	0.613
MOD_ProDKin_1	329	335	PF00069	0.628
MOD_ProDKin_1	347	353	PF00069	0.651
MOD_ProDKin_1	386	392	PF00069	0.709
MOD_ProDKin_1	569	575	PF00069	0.492
MOD_ProDKin_1	621	627	PF00069	0.502
MOD_ProDKin_1	679	685	PF00069	0.492
MOD_ProDKin_1	742	748	PF00069	0.539
MOD_ProDKin_1	920	926	PF00069	0.451
MOD_ProDKin_1	996	1002	PF00069	0.585
MOD_SUMO_for_1	268	271	PF00179	0.422
MOD_SUMO_rev_2	1373	1383	PF00179	0.562
MOD_SUMO_rev_2	261	270	PF00179	0.472
TRG_DiLeu_BaEn_1	1292	1297	PF01217	0.492
TRG_DiLeu_BaEn_1	1715	1720	PF01217	0.704
TRG_DiLeu_BaLyEn_6	1626	1631	PF01217	0.710
TRG_DiLeu_BaLyEn_6	570	575	PF01217	0.492
TRG_DiLeu_BaLyEn_6	856	861	PF01217	0.492
TRG_ENDOCYTIC_2	111	114	PF00928	0.583
TRG_ENDOCYTIC_2	1310	1313	PF00928	0.502
TRG_ENDOCYTIC_2	1358	1361	PF00928	0.416
TRG_ENDOCYTIC_2	1363	1366	PF00928	0.464
TRG_ENDOCYTIC_2	1555	1558	PF00928	0.715
TRG_ENDOCYTIC_2	583	586	PF00928	0.492
TRG_ENDOCYTIC_2	669	672	PF00928	0.492
TRG_ENDOCYTIC_2	961	964	PF00928	0.481
TRG_ER_diArg_1	1067	1070	PF00400	0.424
TRG_ER_diArg_1	1211	1214	PF00400	0.662
TRG_ER_diArg_1	1243	1246	PF00400	0.681
TRG_ER_diArg_1	1387	1390	PF00400	0.636
TRG_ER_diArg_1	1491	1494	PF00400	0.646
TRG_ER_diArg_1	272	274	PF00400	0.483
TRG_ER_diArg_1	511	513	PF00400	0.413
TRG_ER_diArg_1	768	770	PF00400	0.497
TRG_ER_diArg_1	888	890	PF00400	0.504
TRG_ER_diArg_1	992	995	PF00400	0.469
TRG_NES_CRM1_1	510	523	PF08389	0.418
TRG_NES_CRM1_1	797	813	PF08389	0.492
TRG_NLS_MonoExtC_3	1136	1141	PF00514	0.662
TRG_NLS_MonoExtC_3	1243	1248	PF00514	0.674
TRG_NLS_MonoExtN_4	1134	1141	PF00514	0.662
TRG_NLS_MonoExtN_4	1242	1249	PF00514	0.670
TRG_Pf-PMV_PEXEL_1	1016	1020	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	1900	1904	PF00026	0.697
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	605	609	PF00026	0.292
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P880	Leptomonas seymouri	50%	98%
A0A3Q8IC54	Leishmania donovani	100%	100%
A4HDI8	Leishmania braziliensis	74%	100%
E9AWZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAH8	Leishmania major	92%	100%