Putative IgE-dependent histamine-releasing factor

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translationally controlled tumor protein (TCTP) - putative

Species:

Leishmania infantum

UniProt:

A4I0Y8_LEIIN

TriTrypDb:

LINF_240020500

Length:

170

Annotations

Annotations by Jardim et al.

Membrane associated proteins, IgE-dependent histamine-releasing factor

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4I0Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0Y8

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.486
CLV_NRD_NRD_1	107	109	PF00675	0.291
CLV_PCSK_SKI1_1	108	112	PF00082	0.278
CLV_PCSK_SKI1_1	120	124	PF00082	0.190
CLV_PCSK_SKI1_1	2	6	PF00082	0.291
CLV_PCSK_SKI1_1	96	100	PF00082	0.293
DEG_Nend_UBRbox_1	1	4	PF02207	0.498
DOC_CYCLIN_RxL_1	90	103	PF00134	0.494
DOC_PP4_FxxP_1	131	134	PF00568	0.486
DOC_USP7_UBL2_3	120	124	PF12436	0.486

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U9	Leptomonas seymouri	89%	100%
A0A0S4IX73	Bodo saltans	68%	99%
A0A1X0NX45	Trypanosomatidae	79%	100%
A0A1X0NXD1	Trypanosomatidae	81%	100%
A0A3S7WYJ2	Leishmania donovani	100%	100%
A0A422N031	Trypanosoma rangeli	76%	100%
A1KXP4	Davidiella tassiana	37%	100%
A4HDJ0	Leishmania braziliensis	91%	100%
A5A6K2	Pan troglodytes	34%	99%
C9ZWG0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%

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