Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4I0Y7_LEIIN

TriTrypDb:

LINF_240020400

Length:

434

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	6
GO:0005840	ribosome	5	5
GO:0032991	protein-containing complex	1	5
GO:0043228	non-membrane-bounded organelle	3	5
GO:0043232	intracellular non-membrane-bounded organelle	4	5
GO:1990904	ribonucleoprotein complex	2	5

Expansion

Sequence features

A4I0Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0Y7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.394
CLV_C14_Caspase3-7	377	381	PF00656	0.498
CLV_NRD_NRD_1	185	187	PF00675	0.461
CLV_PCSK_KEX2_1	185	187	PF00082	0.513
CLV_PCSK_KEX2_1	192	194	PF00082	0.469
CLV_PCSK_KEX2_1	196	198	PF00082	0.430
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.583
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.571
CLV_PCSK_SKI1_1	192	196	PF00082	0.458
CLV_PCSK_SKI1_1	197	201	PF00082	0.416
CLV_PCSK_SKI1_1	228	232	PF00082	0.297
DEG_APCC_DBOX_1	286	294	PF00400	0.474
DEG_MDM2_SWIB_1	162	170	PF02201	0.354
DEG_Nend_UBRbox_1	1	4	PF02207	0.698
DEG_SCF_FBW7_1	1	8	PF00400	0.681
DOC_MAPK_gen_1	391	401	PF00069	0.419
DOC_MAPK_JIP1_4	98	104	PF00069	0.533
DOC_MAPK_MEF2A_6	394	403	PF00069	0.414
DOC_PP2B_PxIxI_1	160	166	PF00149	0.407
DOC_USP7_MATH_1	140	144	PF00917	0.480
DOC_USP7_MATH_1	222	226	PF00917	0.443
DOC_USP7_MATH_1	306	310	PF00917	0.552
DOC_USP7_MATH_1	315	319	PF00917	0.362
DOC_USP7_MATH_1	338	342	PF00917	0.381
DOC_USP7_UBL2_3	192	196	PF12436	0.570
DOC_WW_Pin1_4	1	6	PF00397	0.688
DOC_WW_Pin1_4	334	339	PF00397	0.636
DOC_WW_Pin1_4	404	409	PF00397	0.387
LIG_APCC_ABBA_1	118	123	PF00400	0.385
LIG_APCC_ABBA_1	128	133	PF00400	0.400
LIG_APCC_ABBA_1	159	164	PF00400	0.333
LIG_BRCT_BRCA1_1	265	269	PF00533	0.334
LIG_BRCT_BRCA1_1	399	403	PF00533	0.387
LIG_FHA_1	2	8	PF00498	0.634
LIG_FHA_1	203	209	PF00498	0.520
LIG_FHA_1	227	233	PF00498	0.533
LIG_FHA_1	393	399	PF00498	0.394
LIG_FHA_1	424	430	PF00498	0.363
LIG_FHA_1	66	72	PF00498	0.610
LIG_FHA_1	98	104	PF00498	0.428
LIG_FHA_2	242	248	PF00498	0.383
LIG_FHA_2	40	46	PF00498	0.612
LIG_LIR_Gen_1	210	221	PF02991	0.533
LIG_LIR_Gen_1	244	251	PF02991	0.347
LIG_LIR_Nem_3	210	216	PF02991	0.533
LIG_LIR_Nem_3	244	248	PF02991	0.353
LIG_LIR_Nem_3	427	433	PF02991	0.301
LIG_Pex14_2	162	166	PF04695	0.320
LIG_SH2_CRK	288	292	PF00017	0.442
LIG_SH2_NCK_1	121	125	PF00017	0.412
LIG_SH2_SRC	121	124	PF00017	0.404
LIG_SH2_SRC	129	132	PF00017	0.395
LIG_SH2_STAP1	190	194	PF00017	0.593
LIG_SH2_STAT5	119	122	PF00017	0.375
LIG_SH2_STAT5	129	132	PF00017	0.395
LIG_SH2_STAT5	26	29	PF00017	0.559
LIG_SH2_STAT5	423	426	PF00017	0.353
LIG_SH3_3	402	408	PF00018	0.387
LIG_SUMO_SIM_par_1	152	158	PF11976	0.476
LIG_SUMO_SIM_par_1	397	402	PF11976	0.527
LIG_TRAF2_1	42	45	PF00917	0.726
MOD_CK1_1	144	150	PF00069	0.513
MOD_CK1_1	337	343	PF00069	0.607
MOD_CK1_1	36	42	PF00069	0.600
MOD_CK1_1	392	398	PF00069	0.376
MOD_CK1_1	8	14	PF00069	0.572
MOD_CK2_1	200	206	PF00069	0.408
MOD_CK2_1	241	247	PF00069	0.374
MOD_CK2_1	39	45	PF00069	0.656
MOD_CK2_1	83	89	PF00069	0.600
MOD_GlcNHglycan	222	225	PF01048	0.297
MOD_GlcNHglycan	265	268	PF01048	0.311
MOD_GlcNHglycan	301	304	PF01048	0.567
MOD_GlcNHglycan	308	311	PF01048	0.540
MOD_GlcNHglycan	317	320	PF01048	0.449
MOD_GlcNHglycan	380	384	PF01048	0.491
MOD_GlcNHglycan	416	419	PF01048	0.522
MOD_GSK3_1	1	8	PF00069	0.676
MOD_GSK3_1	140	147	PF00069	0.380
MOD_GSK3_1	184	191	PF00069	0.560
MOD_GSK3_1	222	229	PF00069	0.293
MOD_GSK3_1	324	331	PF00069	0.541
MOD_GSK3_1	334	341	PF00069	0.480
MOD_GSK3_1	350	357	PF00069	0.357
MOD_GSK3_1	36	43	PF00069	0.646
MOD_GSK3_1	93	100	PF00069	0.518
MOD_N-GLC_1	188	193	PF02516	0.579
MOD_NEK2_1	102	107	PF00069	0.506
MOD_NEK2_1	141	146	PF00069	0.433
MOD_NEK2_1	263	268	PF00069	0.329
MOD_NEK2_1	269	274	PF00069	0.357
MOD_NEK2_1	314	319	PF00069	0.367
MOD_NEK2_1	329	334	PF00069	0.537
MOD_NEK2_1	352	357	PF00069	0.428
MOD_NEK2_1	363	368	PF00069	0.364
MOD_NEK2_1	387	392	PF00069	0.515
MOD_NEK2_1	399	404	PF00069	0.409
MOD_NEK2_1	421	426	PF00069	0.361
MOD_NEK2_1	92	97	PF00069	0.595
MOD_NEK2_2	207	212	PF00069	0.379
MOD_NEK2_2	226	231	PF00069	0.299
MOD_PK_1	394	400	PF00069	0.456
MOD_PKA_2	184	190	PF00069	0.521
MOD_PKA_2	33	39	PF00069	0.563
MOD_PKA_2	378	384	PF00069	0.477
MOD_Plk_1	226	232	PF00069	0.299
MOD_Plk_1	269	275	PF00069	0.388
MOD_Plk_1	350	356	PF00069	0.357
MOD_Plk_1	65	71	PF00069	0.588
MOD_Plk_1	92	98	PF00069	0.532
MOD_Plk_2-3	83	89	PF00069	0.642
MOD_Plk_4	141	147	PF00069	0.472
MOD_Plk_4	149	155	PF00069	0.418
MOD_Plk_4	269	275	PF00069	0.414
MOD_Plk_4	338	344	PF00069	0.366
MOD_Plk_4	394	400	PF00069	0.468
MOD_ProDKin_1	1	7	PF00069	0.685
MOD_ProDKin_1	334	340	PF00069	0.630
MOD_ProDKin_1	404	410	PF00069	0.382
MOD_SUMO_rev_2	29	39	PF00179	0.684
TRG_DiLeu_BaEn_1	260	265	PF01217	0.356
TRG_DiLeu_BaEn_2	294	300	PF01217	0.434
TRG_ENDOCYTIC_2	245	248	PF00928	0.352
TRG_ENDOCYTIC_2	430	433	PF00928	0.307
TRG_NLS_MonoExtN_4	34	41	PF00514	0.611
TRG_Pf-PMV_PEXEL_1	197	202	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0A8	Leptomonas seymouri	81%	100%
A0A0S4IX69	Bodo saltans	54%	98%
A0A1X0NW69	Trypanosomatidae	56%	100%
A0A3Q8IBY9	Leishmania donovani	100%	100%
A0A3R7K1J8	Trypanosoma rangeli	56%	100%
A1Z8D0	Drosophila melanogaster	29%	95%
A4HDJ1	Leishmania braziliensis	91%	100%
C9ZWG2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AWZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P21304	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	75%
Q13610	Homo sapiens	32%	87%
Q2HJ56	Bos taurus	32%	87%
Q4QAI2	Leishmania major	96%	100%
Q99LL5	Mus musculus	32%	87%
Q9P775	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	84%
V5BFJ2	Trypanosoma cruzi	54%	100%