Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0Y3_LEIIN

TriTrypDb:

LINF_240019800

Length:

806

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0Y3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0Y3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	42	46	PF00656	0.738
CLV_C14_Caspase3-7	651	655	PF00656	0.781
CLV_C14_Caspase3-7	719	723	PF00656	0.634
CLV_MEL_PAP_1	356	362	PF00089	0.733
CLV_NRD_NRD_1	225	227	PF00675	0.645
CLV_NRD_NRD_1	272	274	PF00675	0.821
CLV_NRD_NRD_1	566	568	PF00675	0.806
CLV_NRD_NRD_1	626	628	PF00675	0.828
CLV_NRD_NRD_1	663	665	PF00675	0.603
CLV_NRD_NRD_1	796	798	PF00675	0.722
CLV_NRD_NRD_1	799	801	PF00675	0.766
CLV_PCSK_FUR_1	567	571	PF00082	0.750
CLV_PCSK_FUR_1	661	665	PF00082	0.633
CLV_PCSK_FUR_1	797	801	PF00082	0.709
CLV_PCSK_KEX2_1	565	567	PF00082	0.804
CLV_PCSK_KEX2_1	569	571	PF00082	0.690
CLV_PCSK_KEX2_1	663	665	PF00082	0.603
CLV_PCSK_KEX2_1	776	778	PF00082	0.650
CLV_PCSK_KEX2_1	796	798	PF00082	0.605
CLV_PCSK_KEX2_1	799	801	PF00082	0.766
CLV_PCSK_PC1ET2_1	565	567	PF00082	0.786
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.707
CLV_PCSK_PC1ET2_1	776	778	PF00082	0.611
CLV_PCSK_SKI1_1	316	320	PF00082	0.664
CLV_PCSK_SKI1_1	566	570	PF00082	0.684
CLV_PCSK_SKI1_1	573	577	PF00082	0.640
CLV_PCSK_SKI1_1	613	617	PF00082	0.761
CLV_PCSK_SKI1_1	692	696	PF00082	0.755
DEG_SCF_FBW7_1	285	291	PF00400	0.640
DEG_SCF_FBW7_1	97	104	PF00400	0.603
DEG_SPOP_SBC_1	251	255	PF00917	0.597
DEG_SPOP_SBC_1	288	292	PF00917	0.748
DEG_SPOP_SBC_1	435	439	PF00917	0.745
DOC_ANK_TNKS_1	78	85	PF00023	0.759
DOC_CKS1_1	285	290	PF01111	0.638
DOC_CYCLIN_yCln2_LP_2	584	590	PF00134	0.606
DOC_MAPK_gen_1	273	279	PF00069	0.822
DOC_MAPK_gen_1	548	556	PF00069	0.712
DOC_MAPK_gen_1	776	782	PF00069	0.605
DOC_PP2B_LxvP_1	275	278	PF13499	0.818
DOC_PP2B_LxvP_1	373	376	PF13499	0.763
DOC_PP4_FxxP_1	710	713	PF00568	0.712
DOC_USP7_MATH_1	103	107	PF00917	0.645
DOC_USP7_MATH_1	160	164	PF00917	0.695
DOC_USP7_MATH_1	168	172	PF00917	0.539
DOC_USP7_MATH_1	229	233	PF00917	0.703
DOC_USP7_MATH_1	289	293	PF00917	0.850
DOC_USP7_MATH_1	297	301	PF00917	0.750
DOC_USP7_MATH_1	308	312	PF00917	0.553
DOC_USP7_MATH_1	341	345	PF00917	0.666
DOC_USP7_MATH_1	398	402	PF00917	0.779
DOC_USP7_MATH_1	414	418	PF00917	0.811
DOC_USP7_MATH_1	431	435	PF00917	0.593
DOC_USP7_MATH_1	476	480	PF00917	0.778
DOC_USP7_MATH_1	481	485	PF00917	0.728
DOC_USP7_MATH_1	525	529	PF00917	0.829
DOC_USP7_MATH_1	653	657	PF00917	0.633
DOC_USP7_MATH_1	684	688	PF00917	0.669
DOC_USP7_MATH_1	747	751	PF00917	0.800
DOC_USP7_MATH_1	772	776	PF00917	0.722
DOC_USP7_UBL2_3	565	569	PF12436	0.772
DOC_WW_Pin1_4	129	134	PF00397	0.718
DOC_WW_Pin1_4	172	177	PF00397	0.739
DOC_WW_Pin1_4	218	223	PF00397	0.752
DOC_WW_Pin1_4	264	269	PF00397	0.654
DOC_WW_Pin1_4	284	289	PF00397	0.668
DOC_WW_Pin1_4	316	321	PF00397	0.762
DOC_WW_Pin1_4	343	348	PF00397	0.727
DOC_WW_Pin1_4	388	393	PF00397	0.769
DOC_WW_Pin1_4	424	429	PF00397	0.774
DOC_WW_Pin1_4	477	482	PF00397	0.785
DOC_WW_Pin1_4	513	518	PF00397	0.768
DOC_WW_Pin1_4	530	535	PF00397	0.776
DOC_WW_Pin1_4	57	62	PF00397	0.840
DOC_WW_Pin1_4	97	102	PF00397	0.781
LIG_14-3-3_CanoR_1	159	169	PF00244	0.723
LIG_14-3-3_CanoR_1	213	217	PF00244	0.712
LIG_14-3-3_CanoR_1	233	243	PF00244	0.648
LIG_14-3-3_CanoR_1	432	436	PF00244	0.625
LIG_14-3-3_CanoR_1	477	481	PF00244	0.773
LIG_14-3-3_CanoR_1	708	713	PF00244	0.695
LIG_14-3-3_CanoR_1	763	769	PF00244	0.628
LIG_14-3-3_CanoR_1	777	783	PF00244	0.762
LIG_14-3-3_CanoR_1	79	83	PF00244	0.837
LIG_APCC_ABBA_1	554	559	PF00400	0.784
LIG_BIR_III_2	187	191	PF00653	0.821
LIG_BRCT_BRCA1_1	327	331	PF00533	0.760
LIG_BRCT_BRCA1_1	438	442	PF00533	0.703
LIG_DLG_GKlike_1	720	728	PF00625	0.690
LIG_eIF4E_1	704	710	PF01652	0.744
LIG_FHA_1	111	117	PF00498	0.807
LIG_FHA_1	142	148	PF00498	0.590
LIG_FHA_1	184	190	PF00498	0.676
LIG_FHA_1	265	271	PF00498	0.796
LIG_FHA_1	460	466	PF00498	0.845
LIG_FHA_1	499	505	PF00498	0.778
LIG_FHA_1	531	537	PF00498	0.783
LIG_FHA_2	133	139	PF00498	0.698
LIG_FHA_2	279	285	PF00498	0.665
LIG_FHA_2	317	323	PF00498	0.700
LIG_FHA_2	676	682	PF00498	0.760
LIG_FHA_2	686	692	PF00498	0.628
LIG_FHA_2	746	752	PF00498	0.816
LIG_FHA_2	753	759	PF00498	0.746
LIG_Integrin_isoDGR_2	25	27	PF01839	0.762
LIG_Integrin_RGD_1	43	45	PF01839	0.741
LIG_LIR_Gen_1	328	335	PF02991	0.756
LIG_LIR_Gen_1	354	362	PF02991	0.731
LIG_LIR_Gen_1	439	449	PF02991	0.710
LIG_LIR_Nem_3	328	334	PF02991	0.758
LIG_LIR_Nem_3	354	360	PF02991	0.734
LIG_LIR_Nem_3	439	445	PF02991	0.706
LIG_MYND_1	243	247	PF01753	0.614
LIG_REV1ctd_RIR_1	123	132	PF16727	0.786
LIG_SH2_CRK	357	361	PF00017	0.814
LIG_SH2_NCK_1	357	361	PF00017	0.814
LIG_SH2_STAP1	557	561	PF00017	0.780
LIG_SH2_STAT3	704	707	PF00017	0.735
LIG_SH2_STAT5	200	203	PF00017	0.822
LIG_SH2_STAT5	704	707	PF00017	0.735
LIG_SH2_STAT5	724	727	PF00017	0.769
LIG_SH3_1	451	457	PF00018	0.848
LIG_SH3_2	518	523	PF14604	0.735
LIG_SH3_3	216	222	PF00018	0.809
LIG_SH3_3	241	247	PF00018	0.648
LIG_SH3_3	282	288	PF00018	0.729
LIG_SH3_3	373	379	PF00018	0.802
LIG_SH3_3	389	395	PF00018	0.779
LIG_SH3_3	451	457	PF00018	0.806
LIG_SH3_3	514	520	PF00018	0.746
LIG_SH3_3	765	771	PF00018	0.796
LIG_SUMO_SIM_anti_2	778	787	PF11976	0.719
LIG_SUMO_SIM_anti_2	90	96	PF11976	0.614
LIG_SUMO_SIM_par_1	462	474	PF11976	0.818
LIG_SUMO_SIM_par_1	93	100	PF11976	0.746
LIG_TRAF2_1	74	77	PF00917	0.712
LIG_TYR_ITIM	355	360	PF00017	0.812
MOD_CDK_SPxxK_3	516	523	PF00069	0.778
MOD_CK1_1	120	126	PF00069	0.745
MOD_CK1_1	132	138	PF00069	0.698
MOD_CK1_1	150	156	PF00069	0.568
MOD_CK1_1	172	178	PF00069	0.709
MOD_CK1_1	19	25	PF00069	0.791
MOD_CK1_1	211	217	PF00069	0.642
MOD_CK1_1	218	224	PF00069	0.696
MOD_CK1_1	232	238	PF00069	0.587
MOD_CK1_1	252	258	PF00069	0.641
MOD_CK1_1	290	296	PF00069	0.851
MOD_CK1_1	329	335	PF00069	0.718
MOD_CK1_1	367	373	PF00069	0.656
MOD_CK1_1	434	440	PF00069	0.695
MOD_CK1_1	479	485	PF00069	0.825
MOD_CK1_1	516	522	PF00069	0.748
MOD_CK1_1	57	63	PF00069	0.649
MOD_CK1_1	702	708	PF00069	0.774
MOD_CK1_1	723	729	PF00069	0.667
MOD_CK1_1	775	781	PF00069	0.730
MOD_CK1_1	99	105	PF00069	0.699
MOD_CK2_1	132	138	PF00069	0.698
MOD_CK2_1	218	224	PF00069	0.634
MOD_CK2_1	278	284	PF00069	0.660
MOD_CK2_1	316	322	PF00069	0.704
MOD_CK2_1	368	374	PF00069	0.763
MOD_CK2_1	464	470	PF00069	0.727
MOD_CK2_1	524	530	PF00069	0.745
MOD_CK2_1	684	690	PF00069	0.670
MOD_CK2_1	70	76	PF00069	0.849
MOD_Cter_Amidation	661	664	PF01082	0.638
MOD_GlcNHglycan	105	108	PF01048	0.705
MOD_GlcNHglycan	119	122	PF01048	0.688
MOD_GlcNHglycan	149	152	PF01048	0.718
MOD_GlcNHglycan	162	165	PF01048	0.749
MOD_GlcNHglycan	18	21	PF01048	0.793
MOD_GlcNHglycan	259	262	PF01048	0.783
MOD_GlcNHglycan	310	313	PF01048	0.697
MOD_GlcNHglycan	328	331	PF01048	0.647
MOD_GlcNHglycan	339	342	PF01048	0.764
MOD_GlcNHglycan	343	346	PF01048	0.673
MOD_GlcNHglycan	349	352	PF01048	0.584
MOD_GlcNHglycan	360	363	PF01048	0.656
MOD_GlcNHglycan	400	403	PF01048	0.775
MOD_GlcNHglycan	404	407	PF01048	0.647
MOD_GlcNHglycan	462	465	PF01048	0.748
MOD_GlcNHglycan	484	487	PF01048	0.810
MOD_GlcNHglycan	527	530	PF01048	0.826
MOD_GlcNHglycan	539	542	PF01048	0.650
MOD_GlcNHglycan	56	59	PF01048	0.749
MOD_GlcNHglycan	588	591	PF01048	0.589
MOD_GlcNHglycan	620	623	PF01048	0.598
MOD_GlcNHglycan	673	676	PF01048	0.746
MOD_GlcNHglycan	690	695	PF01048	0.818
MOD_GlcNHglycan	699	702	PF01048	0.636
MOD_GlcNHglycan	72	75	PF01048	0.743
MOD_GlcNHglycan	725	728	PF01048	0.675
MOD_GlcNHglycan	760	763	PF01048	0.829
MOD_GSK3_1	16	23	PF00069	0.734
MOD_GSK3_1	160	167	PF00069	0.630
MOD_GSK3_1	168	175	PF00069	0.619
MOD_GSK3_1	198	205	PF00069	0.734
MOD_GSK3_1	208	215	PF00069	0.580
MOD_GSK3_1	229	236	PF00069	0.679
MOD_GSK3_1	249	256	PF00069	0.766
MOD_GSK3_1	264	271	PF00069	0.621
MOD_GSK3_1	284	291	PF00069	0.560
MOD_GSK3_1	299	306	PF00069	0.609
MOD_GSK3_1	322	329	PF00069	0.787
MOD_GSK3_1	337	344	PF00069	0.740
MOD_GSK3_1	347	354	PF00069	0.617
MOD_GSK3_1	364	371	PF00069	0.740
MOD_GSK3_1	386	393	PF00069	0.689
MOD_GSK3_1	398	405	PF00069	0.711
MOD_GSK3_1	431	438	PF00069	0.710
MOD_GSK3_1	460	467	PF00069	0.748
MOD_GSK3_1	477	484	PF00069	0.630
MOD_GSK3_1	509	516	PF00069	0.854
MOD_GSK3_1	537	544	PF00069	0.729
MOD_GSK3_1	582	589	PF00069	0.678
MOD_GSK3_1	653	660	PF00069	0.835
MOD_GSK3_1	66	73	PF00069	0.740
MOD_GSK3_1	671	678	PF00069	0.525
MOD_GSK3_1	690	697	PF00069	0.832
MOD_GSK3_1	758	765	PF00069	0.670
MOD_GSK3_1	95	102	PF00069	0.778
MOD_N-GLC_1	657	662	PF02516	0.824
MOD_N-GLC_1	702	707	PF02516	0.711
MOD_NEK2_1	1	6	PF00069	0.674
MOD_NEK2_1	18	23	PF00069	0.827
MOD_NEK2_1	28	33	PF00069	0.630
MOD_NEK2_1	436	441	PF00069	0.674
MOD_NEK2_1	537	542	PF00069	0.724
MOD_NEK2_1	65	70	PF00069	0.806
MOD_NEK2_1	764	769	PF00069	0.621
MOD_NEK2_2	268	273	PF00069	0.688
MOD_NEK2_2	431	436	PF00069	0.626
MOD_NEK2_2	694	699	PF00069	0.748
MOD_PIKK_1	415	421	PF00454	0.767
MOD_PIKK_1	436	442	PF00454	0.744
MOD_PK_1	500	506	PF00069	0.692
MOD_PKA_2	16	22	PF00069	0.720
MOD_PKA_2	212	218	PF00069	0.677
MOD_PKA_2	232	238	PF00069	0.604
MOD_PKA_2	257	263	PF00069	0.669
MOD_PKA_2	26	32	PF00069	0.727
MOD_PKA_2	337	343	PF00069	0.764
MOD_PKA_2	358	364	PF00069	0.810
MOD_PKA_2	431	437	PF00069	0.760
MOD_PKA_2	476	482	PF00069	0.786
MOD_PKA_2	685	691	PF00069	0.712
MOD_PKA_2	762	768	PF00069	0.601
MOD_PKA_2	78	84	PF00069	0.807
MOD_PKA_2	795	801	PF00069	0.614
MOD_Plk_1	784	790	PF00069	0.683
MOD_Plk_4	351	357	PF00069	0.726
MOD_Plk_4	368	374	PF00069	0.534
MOD_Plk_4	431	437	PF00069	0.647
MOD_Plk_4	464	470	PF00069	0.844
MOD_Plk_4	720	726	PF00069	0.780
MOD_Plk_4	764	770	PF00069	0.640
MOD_Plk_4	778	784	PF00069	0.609
MOD_ProDKin_1	129	135	PF00069	0.718
MOD_ProDKin_1	172	178	PF00069	0.741
MOD_ProDKin_1	218	224	PF00069	0.754
MOD_ProDKin_1	264	270	PF00069	0.651
MOD_ProDKin_1	284	290	PF00069	0.670
MOD_ProDKin_1	316	322	PF00069	0.764
MOD_ProDKin_1	343	349	PF00069	0.722
MOD_ProDKin_1	388	394	PF00069	0.768
MOD_ProDKin_1	424	430	PF00069	0.774
MOD_ProDKin_1	477	483	PF00069	0.785
MOD_ProDKin_1	513	519	PF00069	0.767
MOD_ProDKin_1	530	536	PF00069	0.773
MOD_ProDKin_1	57	63	PF00069	0.840
MOD_ProDKin_1	97	103	PF00069	0.780
MOD_SUMO_rev_2	750	755	PF00179	0.629
TRG_DiLeu_BaLyEn_6	532	537	PF01217	0.744
TRG_ENDOCYTIC_2	357	360	PF00928	0.820
TRG_ER_diArg_1	661	664	PF00400	0.682
TRG_ER_diArg_1	739	742	PF00400	0.625
TRG_ER_diArg_1	795	797	PF00400	0.704
TRG_NLS_MonoExtC_3	564	569	PF00514	0.768
TRG_NLS_MonoExtN_4	562	569	PF00514	0.759

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID28	Leishmania donovani	99%	88%
A4HDJ8	Leishmania braziliensis	56%	100%
E9ACS9	Leishmania major	84%	100%
E9AWY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%