Putative mismatch repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mismatch repair protein - putative

Species:

Leishmania infantum

UniProt:

A4I0Y1_LEIIN

TriTrypDb:

LINF_240019600

Length:

1007

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0032300	mismatch repair complex	2	7
GO:0032991	protein-containing complex	1	7
GO:0005737	cytoplasm	2	1
GO:0032389	MutLalpha complex	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	1
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4I0Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0Y1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006298	mismatch repair	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003690	double-stranded DNA binding	5	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0008094	ATP-dependent activity, acting on DNA	2	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0016887	ATP hydrolysis activity	7	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0030983	mismatched DNA binding	6	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140299	small molecule sensor activity	1	7
GO:0140612	DNA damage sensor activity	2	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:0140657	ATP-dependent activity	1	7
GO:0140664	ATP-dependent DNA damage sensor activity	3	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	418	422	PF00656	0.709
CLV_C14_Caspase3-7	541	545	PF00656	0.734
CLV_NRD_NRD_1	285	287	PF00675	0.851
CLV_NRD_NRD_1	33	35	PF00675	0.411
CLV_NRD_NRD_1	350	352	PF00675	0.694
CLV_NRD_NRD_1	440	442	PF00675	0.612
CLV_NRD_NRD_1	52	54	PF00675	0.415
CLV_NRD_NRD_1	6	8	PF00675	0.652
CLV_NRD_NRD_1	687	689	PF00675	0.458
CLV_NRD_NRD_1	771	773	PF00675	0.411
CLV_NRD_NRD_1	775	777	PF00675	0.411
CLV_PCSK_FUR_1	4	8	PF00082	0.699
CLV_PCSK_FUR_1	438	442	PF00082	0.606
CLV_PCSK_KEX2_1	285	287	PF00082	0.851
CLV_PCSK_KEX2_1	437	439	PF00082	0.632
CLV_PCSK_KEX2_1	440	442	PF00082	0.616
CLV_PCSK_KEX2_1	6	8	PF00082	0.652
CLV_PCSK_KEX2_1	686	688	PF00082	0.542
CLV_PCSK_KEX2_1	771	773	PF00082	0.411
CLV_PCSK_KEX2_1	775	777	PF00082	0.411
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.732
CLV_PCSK_PC1ET2_1	686	688	PF00082	0.542
CLV_PCSK_PC7_1	771	777	PF00082	0.428
CLV_PCSK_SKI1_1	222	226	PF00082	0.775
CLV_PCSK_SKI1_1	411	415	PF00082	0.723
CLV_PCSK_SKI1_1	434	438	PF00082	0.732
CLV_PCSK_SKI1_1	604	608	PF00082	0.512
CLV_PCSK_SKI1_1	630	634	PF00082	0.362
CLV_PCSK_SKI1_1	69	73	PF00082	0.428
CLV_PCSK_SKI1_1	724	728	PF00082	0.533
CLV_PCSK_SKI1_1	781	785	PF00082	0.515
DEG_Nend_UBRbox_2	1	3	PF02207	0.496
DEG_SCF_FBW7_1	929	936	PF00400	0.409
DEG_SPOP_SBC_1	182	186	PF00917	0.712
DEG_SPOP_SBC_1	245	249	PF00917	0.733
DEG_SPOP_SBC_1	250	254	PF00917	0.652
DEG_SPOP_SBC_1	328	332	PF00917	0.786
DEG_SPOP_SBC_1	834	838	PF00917	0.824
DOC_CKS1_1	648	653	PF01111	0.512
DOC_CKS1_1	869	874	PF01111	0.598
DOC_CKS1_1	930	935	PF01111	0.409
DOC_CYCLIN_RxL_1	775	786	PF00134	0.411
DOC_MAPK_gen_1	127	136	PF00069	0.548
DOC_MAPK_gen_1	34	42	PF00069	0.411
DOC_MAPK_gen_1	812	820	PF00069	0.512
DOC_MAPK_MEF2A_6	34	42	PF00069	0.411
DOC_MAPK_MEF2A_6	653	662	PF00069	0.512
DOC_MAPK_MEF2A_6	69	78	PF00069	0.411
DOC_MAPK_MEF2A_6	812	820	PF00069	0.419
DOC_PP1_RVXF_1	722	729	PF00149	0.538
DOC_PP2B_LxvP_1	640	643	PF13499	0.411
DOC_PP2B_LxvP_1	669	672	PF13499	0.588
DOC_PP2B_LxvP_1	76	79	PF13499	0.411
DOC_PP2B_LxvP_1	925	928	PF13499	0.411
DOC_PP4_FxxP_1	346	349	PF00568	0.754
DOC_PP4_FxxP_1	648	651	PF00568	0.411
DOC_USP7_MATH_1	149	153	PF00917	0.727
DOC_USP7_MATH_1	182	186	PF00917	0.663
DOC_USP7_MATH_1	187	191	PF00917	0.700
DOC_USP7_MATH_1	251	255	PF00917	0.718
DOC_USP7_MATH_1	328	332	PF00917	0.814
DOC_USP7_MATH_1	347	351	PF00917	0.705
DOC_USP7_MATH_1	519	523	PF00917	0.693
DOC_USP7_MATH_1	543	547	PF00917	0.820
DOC_USP7_MATH_1	703	707	PF00917	0.746
DOC_USP7_MATH_1	754	758	PF00917	0.614
DOC_USP7_MATH_1	828	832	PF00917	0.458
DOC_USP7_MATH_1	833	837	PF00917	0.783
DOC_USP7_MATH_1	853	857	PF00917	0.517
DOC_USP7_MATH_1	875	879	PF00917	0.742
DOC_USP7_MATH_1	933	937	PF00917	0.352
DOC_WW_Pin1_4	178	183	PF00397	0.669
DOC_WW_Pin1_4	246	251	PF00397	0.714
DOC_WW_Pin1_4	345	350	PF00397	0.742
DOC_WW_Pin1_4	476	481	PF00397	0.706
DOC_WW_Pin1_4	582	587	PF00397	0.407
DOC_WW_Pin1_4	647	652	PF00397	0.443
DOC_WW_Pin1_4	735	740	PF00397	0.743
DOC_WW_Pin1_4	868	873	PF00397	0.804
DOC_WW_Pin1_4	884	889	PF00397	0.671
DOC_WW_Pin1_4	929	934	PF00397	0.422
LIG_14-3-3_CanoR_1	129	136	PF00244	0.586
LIG_14-3-3_CanoR_1	69	74	PF00244	0.411
LIG_Actin_WH2_2	974	989	PF00022	0.394
LIG_BIR_III_2	583	587	PF00653	0.409
LIG_BRCT_BRCA1_1	340	344	PF00533	0.780
LIG_BRCT_BRCA1_1	602	606	PF00533	0.512
LIG_Clathr_ClatBox_1	994	998	PF01394	0.512
LIG_EVH1_1	640	644	PF00568	0.411
LIG_EVH1_1	925	929	PF00568	0.512
LIG_FHA_1	129	135	PF00498	0.585
LIG_FHA_1	152	158	PF00498	0.740
LIG_FHA_1	189	195	PF00498	0.749
LIG_FHA_1	362	368	PF00498	0.710
LIG_FHA_1	553	559	PF00498	0.662
LIG_FHA_1	610	616	PF00498	0.512
LIG_FHA_1	617	623	PF00498	0.411
LIG_FHA_1	70	76	PF00498	0.448
LIG_FHA_1	702	708	PF00498	0.660
LIG_FHA_1	78	84	PF00498	0.368
LIG_FHA_1	942	948	PF00498	0.512
LIG_FHA_1	952	958	PF00498	0.314
LIG_FHA_2	256	262	PF00498	0.772
LIG_FHA_2	333	339	PF00498	0.694
LIG_FHA_2	367	373	PF00498	0.721
LIG_FHA_2	88	94	PF00498	0.411
LIG_FHA_2	880	886	PF00498	0.808
LIG_FHA_2	933	939	PF00498	0.450
LIG_GBD_Chelix_1	654	662	PF00786	0.512
LIG_GBD_Chelix_1	914	922	PF00786	0.411
LIG_KLC1_Yacidic_2	786	791	PF13176	0.512
LIG_LIR_Apic_2	307	313	PF02991	0.740
LIG_LIR_Apic_2	920	926	PF02991	0.450
LIG_LIR_Gen_1	17	25	PF02991	0.404
LIG_LIR_Gen_1	314	322	PF02991	0.542
LIG_LIR_Gen_1	471	480	PF02991	0.598
LIG_LIR_Gen_1	786	797	PF02991	0.411
LIG_LIR_Nem_3	17	23	PF02991	0.404
LIG_LIR_Nem_3	314	318	PF02991	0.545
LIG_LIR_Nem_3	471	477	PF02991	0.595
LIG_LIR_Nem_3	57	63	PF02991	0.352
LIG_LIR_Nem_3	786	792	PF02991	0.411
LIG_LIR_Nem_3	998	1004	PF02991	0.411
LIG_MYND_1	667	671	PF01753	0.697
LIG_NRBOX	653	659	PF00104	0.512
LIG_PCNA_TLS_4	222	229	PF02747	0.664
LIG_PDZ_Class_3	1002	1007	PF00595	0.411
LIG_Pex14_2	628	632	PF04695	0.383
LIG_RPA_C_Fungi	435	447	PF08784	0.606
LIG_RPA_C_Fungi	619	631	PF08784	0.347
LIG_SH2_CRK	526	530	PF00017	0.684
LIG_SH2_CRK	60	64	PF00017	0.411
LIG_SH2_CRK	664	668	PF00017	0.684
LIG_SH2_CRK	923	927	PF00017	0.512
LIG_SH2_NCK_1	310	314	PF00017	0.604
LIG_SH2_NCK_1	526	530	PF00017	0.684
LIG_SH2_PTP2	789	792	PF00017	0.512
LIG_SH2_SRC	789	792	PF00017	0.512
LIG_SH2_STAT3	228	231	PF00017	0.637
LIG_SH2_STAT5	228	231	PF00017	0.637
LIG_SH2_STAT5	25	28	PF00017	0.411
LIG_SH2_STAT5	37	40	PF00017	0.341
LIG_SH2_STAT5	526	529	PF00017	0.681
LIG_SH2_STAT5	769	772	PF00017	0.411
LIG_SH2_STAT5	787	790	PF00017	0.411
LIG_SH3_1	923	929	PF00018	0.512
LIG_SH3_3	206	212	PF00018	0.650
LIG_SH3_3	240	246	PF00018	0.714
LIG_SH3_3	381	387	PF00018	0.616
LIG_SH3_3	481	487	PF00018	0.709
LIG_SH3_3	561	567	PF00018	0.628
LIG_SH3_3	635	641	PF00018	0.411
LIG_SH3_3	796	802	PF00018	0.411
LIG_SH3_3	824	830	PF00018	0.411
LIG_SH3_3	866	872	PF00018	0.604
LIG_SH3_3	923	929	PF00018	0.419
LIG_SUMO_SIM_anti_2	656	661	PF11976	0.438
LIG_SUMO_SIM_anti_2	675	682	PF11976	0.324
LIG_SUMO_SIM_anti_2	72	77	PF11976	0.512
LIG_SUMO_SIM_par_1	557	563	PF11976	0.700
LIG_SUMO_SIM_par_1	675	682	PF11976	0.536
LIG_SUMO_SIM_par_1	71	77	PF11976	0.512
LIG_SUMO_SIM_par_1	993	999	PF11976	0.411
LIG_TRAF2_1	258	261	PF00917	0.750
LIG_TRFH_1	923	927	PF08558	0.512
LIG_UBA3_1	676	685	PF00899	0.423
LIG_UBA3_1	969	974	PF00899	0.411
LIG_WW_3	809	813	PF00397	0.512
MOD_CDC14_SPxK_1	348	351	PF00782	0.733
MOD_CDK_SPxK_1	345	351	PF00069	0.733
MOD_CDK_SPxK_1	647	653	PF00069	0.512
MOD_CDK_SPxxK_3	345	352	PF00069	0.733
MOD_CK1_1	158	164	PF00069	0.666
MOD_CK1_1	181	187	PF00069	0.688
MOD_CK1_1	249	255	PF00069	0.712
MOD_CK1_1	264	270	PF00069	0.571
MOD_CK1_1	27	33	PF00069	0.453
MOD_CK1_1	304	310	PF00069	0.756
MOD_CK1_1	331	337	PF00069	0.784
MOD_CK1_1	571	577	PF00069	0.364
MOD_CK1_1	705	711	PF00069	0.623
MOD_CK1_1	77	83	PF00069	0.512
MOD_CK1_1	836	842	PF00069	0.830
MOD_CK1_1	874	880	PF00069	0.812
MOD_CK1_1	931	937	PF00069	0.442
MOD_CK1_1	993	999	PF00069	0.411
MOD_CK2_1	157	163	PF00069	0.567
MOD_CK2_1	255	261	PF00069	0.771
MOD_CK2_1	347	353	PF00069	0.670
MOD_CK2_1	366	372	PF00069	0.666
MOD_CK2_1	485	491	PF00069	0.794
MOD_CK2_1	87	93	PF00069	0.411
MOD_CK2_1	879	885	PF00069	0.807
MOD_CK2_1	932	938	PF00069	0.450
MOD_GlcNHglycan	11	14	PF01048	0.618
MOD_GlcNHglycan	141	144	PF01048	0.678
MOD_GlcNHglycan	150	154	PF01048	0.683
MOD_GlcNHglycan	156	160	PF01048	0.650
MOD_GlcNHglycan	288	291	PF01048	0.754
MOD_GlcNHglycan	298	301	PF01048	0.672
MOD_GlcNHglycan	355	358	PF01048	0.841
MOD_GlcNHglycan	406	409	PF01048	0.727
MOD_GlcNHglycan	48	51	PF01048	0.411
MOD_GlcNHglycan	487	490	PF01048	0.658
MOD_GlcNHglycan	60	63	PF01048	0.411
MOD_GlcNHglycan	672	675	PF01048	0.515
MOD_GlcNHglycan	745	748	PF01048	0.756
MOD_GlcNHglycan	763	766	PF01048	0.261
MOD_GlcNHglycan	830	833	PF01048	0.621
MOD_GlcNHglycan	840	843	PF01048	0.770
MOD_GlcNHglycan	935	938	PF01048	0.512
MOD_GSK3_1	151	158	PF00069	0.720
MOD_GSK3_1	178	185	PF00069	0.665
MOD_GSK3_1	23	30	PF00069	0.411
MOD_GSK3_1	245	252	PF00069	0.770
MOD_GSK3_1	255	262	PF00069	0.629
MOD_GSK3_1	327	334	PF00069	0.775
MOD_GSK3_1	390	397	PF00069	0.717
MOD_GSK3_1	527	534	PF00069	0.646
MOD_GSK3_1	58	65	PF00069	0.394
MOD_GSK3_1	593	600	PF00069	0.412
MOD_GSK3_1	701	708	PF00069	0.660
MOD_GSK3_1	731	738	PF00069	0.635
MOD_GSK3_1	834	841	PF00069	0.816
MOD_GSK3_1	870	877	PF00069	0.796
MOD_GSK3_1	928	935	PF00069	0.419
MOD_GSK3_1	949	956	PF00069	0.522
MOD_LATS_1	483	489	PF00433	0.747
MOD_NEK2_1	101	106	PF00069	0.450
MOD_NEK2_1	128	133	PF00069	0.591
MOD_NEK2_1	157	162	PF00069	0.776
MOD_NEK2_1	188	193	PF00069	0.692
MOD_NEK2_1	46	51	PF00069	0.400
MOD_NEK2_1	524	529	PF00069	0.688
MOD_NEK2_1	569	574	PF00069	0.465
MOD_NEK2_1	702	707	PF00069	0.599
MOD_NEK2_1	74	79	PF00069	0.355
MOD_PIKK_1	227	233	PF00454	0.646
MOD_PIKK_1	267	273	PF00454	0.657
MOD_PIKK_1	288	294	PF00454	0.686
MOD_PIKK_1	301	307	PF00454	0.695
MOD_PIKK_1	538	544	PF00454	0.776
MOD_PIKK_1	879	885	PF00454	0.795
MOD_PKA_2	128	134	PF00069	0.588
MOD_PKA_2	264	270	PF00069	0.755
MOD_PKA_2	8	14	PF00069	0.711
MOD_PKB_1	7	15	PF00069	0.607
MOD_Plk_1	394	400	PF00069	0.659
MOD_Plk_1	470	476	PF00069	0.665
MOD_Plk_1	519	525	PF00069	0.727
MOD_Plk_2-3	311	317	PF00069	0.584
MOD_Plk_4	239	245	PF00069	0.647
MOD_Plk_4	524	530	PF00069	0.690
MOD_Plk_4	554	560	PF00069	0.727
MOD_Plk_4	571	577	PF00069	0.260
MOD_Plk_4	593	599	PF00069	0.411
MOD_Plk_4	610	616	PF00069	0.411
MOD_Plk_4	672	678	PF00069	0.571
MOD_Plk_4	754	760	PF00069	0.698
MOD_Plk_4	918	924	PF00069	0.394
MOD_Plk_4	990	996	PF00069	0.411
MOD_ProDKin_1	178	184	PF00069	0.667
MOD_ProDKin_1	246	252	PF00069	0.716
MOD_ProDKin_1	345	351	PF00069	0.743
MOD_ProDKin_1	476	482	PF00069	0.707
MOD_ProDKin_1	582	588	PF00069	0.407
MOD_ProDKin_1	647	653	PF00069	0.443
MOD_ProDKin_1	735	741	PF00069	0.743
MOD_ProDKin_1	868	874	PF00069	0.804
MOD_ProDKin_1	884	890	PF00069	0.671
MOD_ProDKin_1	929	935	PF00069	0.422
MOD_SUMO_rev_2	532	541	PF00179	0.687
MOD_SUMO_rev_2	731	737	PF00179	0.686
TRG_DiLeu_BaEn_1	445	450	PF01217	0.732
TRG_DiLeu_BaLyEn_6	576	581	PF01217	0.450
TRG_ENDOCYTIC_2	1001	1004	PF00928	0.411
TRG_ENDOCYTIC_2	37	40	PF00928	0.411
TRG_ENDOCYTIC_2	526	529	PF00928	0.681
TRG_ENDOCYTIC_2	60	63	PF00928	0.411
TRG_ENDOCYTIC_2	787	790	PF00928	0.411
TRG_ER_diArg_1	4	7	PF00400	0.706
TRG_ER_diArg_1	438	441	PF00400	0.617
TRG_ER_diArg_1	770	772	PF00400	0.411
TRG_ER_diArg_1	774	776	PF00400	0.411
TRG_ER_diArg_1	811	814	PF00400	0.512
TRG_NLS_MonoCore_2	684	689	PF00514	0.441
TRG_NLS_MonoExtC_3	436	441	PF00514	0.721
TRG_NLS_MonoExtN_4	434	441	PF00514	0.726
TRG_NLS_MonoExtN_4	685	690	PF00514	0.455
TRG_Pf-PMV_PEXEL_1	579	583	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	781	786	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	916	920	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I302	Leptomonas seymouri	48%	78%
A0A3S7WYI2	Leishmania donovani	99%	74%
A4HDK0	Leishmania braziliensis	75%	100%
E9AWY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QAI9	Leishmania major	92%	100%