Putative mismatch repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mismatch repair protein - putative

Species:

Leishmania infantum

UniProt:

A4I0Y1_LEIIN

TriTrypDb:

LINF_240019600

Length:

1007

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032300	mismatch repair complex	2	7
GO:0032389	MutLalpha complex	3	1
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A4I0Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0Y1

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006298	mismatch repair	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003690	double-stranded DNA binding	5	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0008094	ATP-dependent activity, acting on DNA	2	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	418	422	PF00656	0.709
CLV_C14_Caspase3-7	541	545	PF00656	0.734
CLV_NRD_NRD_1	285	287	PF00675	0.851
CLV_NRD_NRD_1	33	35	PF00675	0.411
CLV_NRD_NRD_1	350	352	PF00675	0.694
CLV_NRD_NRD_1	440	442	PF00675	0.612
CLV_NRD_NRD_1	52	54	PF00675	0.415
CLV_NRD_NRD_1	6	8	PF00675	0.652
CLV_NRD_NRD_1	687	689	PF00675	0.458
CLV_NRD_NRD_1	771	773	PF00675	0.411

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I302	Leptomonas seymouri	48%	78%
A0A3S7WYI2	Leishmania donovani	99%	74%
A4HDK0	Leishmania braziliensis	75%	100%
E9AWY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QAI9	Leishmania major	92%	100%

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