Hypothetical predicted transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0Y0_LEIIN

TriTrypDb:

LINF_240019500

Length:

955

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 2
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4I0Y0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0Y0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.479
CLV_C14_Caspase3-7	525	529	PF00656	0.421
CLV_C14_Caspase3-7	891	895	PF00656	0.526
CLV_NRD_NRD_1	175	177	PF00675	0.749
CLV_NRD_NRD_1	213	215	PF00675	0.565
CLV_NRD_NRD_1	3	5	PF00675	0.656
CLV_NRD_NRD_1	626	628	PF00675	0.678
CLV_NRD_NRD_1	639	641	PF00675	0.695
CLV_NRD_NRD_1	788	790	PF00675	0.703
CLV_PCSK_FUR_1	786	790	PF00082	0.606
CLV_PCSK_KEX2_1	175	177	PF00082	0.750
CLV_PCSK_KEX2_1	213	215	PF00082	0.564
CLV_PCSK_KEX2_1	3	5	PF00082	0.656
CLV_PCSK_KEX2_1	639	641	PF00082	0.726
CLV_PCSK_KEX2_1	788	790	PF00082	0.645
CLV_PCSK_SKI1_1	216	220	PF00082	0.534
CLV_PCSK_SKI1_1	316	320	PF00082	0.614
CLV_PCSK_SKI1_1	49	53	PF00082	0.651
CLV_PCSK_SKI1_1	656	660	PF00082	0.603
CLV_PCSK_SKI1_1	694	698	PF00082	0.547
CLV_PCSK_SKI1_1	951	955	PF00082	0.467
CLV_Separin_Metazoa	372	376	PF03568	0.295
DEG_APCC_DBOX_1	770	778	PF00400	0.264
DEG_ODPH_VHL_1	400	413	PF01847	0.282
DEG_SCF_FBW7_1	50	57	PF00400	0.347
DEG_SPOP_SBC_1	146	150	PF00917	0.384
DEG_SPOP_SBC_1	798	802	PF00917	0.373
DEG_SPOP_SBC_1	82	86	PF00917	0.471
DOC_ANK_TNKS_1	518	525	PF00023	0.416
DOC_CKS1_1	620	625	PF01111	0.447
DOC_CYCLIN_RxL_1	313	323	PF00134	0.355
DOC_CYCLIN_yCln2_LP_2	62	68	PF00134	0.316
DOC_MAPK_gen_1	856	865	PF00069	0.382
DOC_MAPK_MEF2A_6	809	816	PF00069	0.302
DOC_MAPK_MEF2A_6	858	867	PF00069	0.337
DOC_PP1_RVXF_1	314	321	PF00149	0.390
DOC_PP2B_LxvP_1	399	402	PF13499	0.348
DOC_PP2B_LxvP_1	447	450	PF13499	0.424
DOC_PP2B_LxvP_1	62	65	PF13499	0.321
DOC_PP4_FxxP_1	766	769	PF00568	0.369
DOC_USP7_MATH_1	146	150	PF00917	0.407
DOC_USP7_MATH_1	307	311	PF00917	0.301
DOC_USP7_MATH_1	31	35	PF00917	0.629
DOC_USP7_MATH_1	621	625	PF00917	0.385
DOC_USP7_MATH_1	692	696	PF00917	0.409
DOC_USP7_MATH_1	718	722	PF00917	0.478
DOC_USP7_MATH_1	746	750	PF00917	0.397
DOC_USP7_MATH_1	798	802	PF00917	0.449
DOC_USP7_MATH_1	82	86	PF00917	0.471
DOC_USP7_MATH_1	843	847	PF00917	0.431
DOC_WW_Pin1_4	177	182	PF00397	0.478
DOC_WW_Pin1_4	471	476	PF00397	0.498
DOC_WW_Pin1_4	50	55	PF00397	0.383
DOC_WW_Pin1_4	555	560	PF00397	0.459
DOC_WW_Pin1_4	619	624	PF00397	0.414
DOC_WW_Pin1_4	705	710	PF00397	0.366
DOC_WW_Pin1_4	78	83	PF00397	0.375
DOC_WW_Pin1_4	834	839	PF00397	0.411
DOC_WW_Pin1_4	874	879	PF00397	0.406
LIG_14-3-3_CanoR_1	175	181	PF00244	0.518
LIG_14-3-3_CanoR_1	246	256	PF00244	0.367
LIG_14-3-3_CanoR_1	296	306	PF00244	0.413
LIG_14-3-3_CanoR_1	3	8	PF00244	0.567
LIG_14-3-3_CanoR_1	479	484	PF00244	0.541
LIG_14-3-3_CanoR_1	49	54	PF00244	0.366
LIG_14-3-3_CanoR_1	627	635	PF00244	0.437
LIG_14-3-3_CanoR_1	656	661	PF00244	0.345
LIG_14-3-3_CanoR_1	691	697	PF00244	0.441
LIG_14-3-3_CanoR_1	771	775	PF00244	0.354
LIG_14-3-3_CanoR_1	858	864	PF00244	0.343
LIG_Actin_WH2_2	322	340	PF00022	0.302
LIG_Actin_WH2_2	373	389	PF00022	0.308
LIG_APCC_ABBA_1	883	888	PF00400	0.364
LIG_BIR_III_2	947	951	PF00653	0.616
LIG_BIR_III_4	160	164	PF00653	0.485
LIG_BRCT_BRCA1_1	870	874	PF00533	0.317
LIG_BRCT_BRCA1_1	88	92	PF00533	0.365
LIG_FHA_1	248	254	PF00498	0.370
LIG_FHA_1	337	343	PF00498	0.389
LIG_FHA_1	381	387	PF00498	0.379
LIG_FHA_1	452	458	PF00498	0.426
LIG_FHA_1	556	562	PF00498	0.464
LIG_FHA_1	589	595	PF00498	0.446
LIG_FHA_1	615	621	PF00498	0.348
LIG_FHA_1	676	682	PF00498	0.346
LIG_FHA_1	777	783	PF00498	0.469
LIG_FHA_1	798	804	PF00498	0.380
LIG_FHA_2	107	113	PF00498	0.330
LIG_FHA_2	148	154	PF00498	0.448
LIG_FHA_2	51	57	PF00498	0.346
LIG_FHA_2	657	663	PF00498	0.380
LIG_FHA_2	720	726	PF00498	0.463
LIG_FHA_2	808	814	PF00498	0.417
LIG_GBD_Chelix_1	859	867	PF00786	0.453
LIG_LIR_Apic_2	273	277	PF02991	0.338
LIG_LIR_Apic_2	77	82	PF02991	0.501
LIG_LIR_Gen_1	109	118	PF02991	0.341
LIG_LIR_Gen_1	219	229	PF02991	0.329
LIG_LIR_Gen_1	258	269	PF02991	0.341
LIG_LIR_Gen_1	312	319	PF02991	0.383
LIG_LIR_Gen_1	395	404	PF02991	0.345
LIG_LIR_Gen_1	415	426	PF02991	0.310
LIG_LIR_Gen_1	539	550	PF02991	0.516
LIG_LIR_Gen_1	598	606	PF02991	0.440
LIG_LIR_Gen_1	700	709	PF02991	0.395
LIG_LIR_Gen_1	846	857	PF02991	0.402
LIG_LIR_Gen_1	938	948	PF02991	0.270
LIG_LIR_Nem_3	109	114	PF02991	0.362
LIG_LIR_Nem_3	219	225	PF02991	0.327
LIG_LIR_Nem_3	258	264	PF02991	0.345
LIG_LIR_Nem_3	266	271	PF02991	0.254
LIG_LIR_Nem_3	312	317	PF02991	0.320
LIG_LIR_Nem_3	395	400	PF02991	0.307
LIG_LIR_Nem_3	415	421	PF02991	0.269
LIG_LIR_Nem_3	460	466	PF02991	0.316
LIG_LIR_Nem_3	502	507	PF02991	0.431
LIG_LIR_Nem_3	539	545	PF02991	0.467
LIG_LIR_Nem_3	598	603	PF02991	0.439
LIG_LIR_Nem_3	654	660	PF02991	0.429
LIG_LIR_Nem_3	700	704	PF02991	0.392
LIG_LIR_Nem_3	846	852	PF02991	0.395
LIG_LIR_Nem_3	873	879	PF02991	0.344
LIG_LIR_Nem_3	938	944	PF02991	0.420
LIG_NRBOX	928	934	PF00104	0.376
LIG_NRBOX	938	944	PF00104	0.317
LIG_PCNA_yPIPBox_3	316	329	PF02747	0.356
LIG_PDZ_Class_2	950	955	PF00595	0.632
LIG_Pex14_1	37	41	PF04695	0.405
LIG_Pex14_1	414	418	PF04695	0.326
LIG_Pex14_2	111	115	PF04695	0.291
LIG_SH2_CRK	261	265	PF00017	0.387
LIG_SH2_CRK	418	422	PF00017	0.230
LIG_SH2_CRK	542	546	PF00017	0.487
LIG_SH2_CRK	849	853	PF00017	0.406
LIG_SH2_GRB2like	849	852	PF00017	0.340
LIG_SH2_NCK_1	715	719	PF00017	0.466
LIG_SH2_NCK_1	849	853	PF00017	0.344
LIG_SH2_PTP2	314	317	PF00017	0.265
LIG_SH2_PTP2	79	82	PF00017	0.410
LIG_SH2_SRC	849	852	PF00017	0.325
LIG_SH2_SRC	887	890	PF00017	0.442
LIG_SH2_STAP1	261	265	PF00017	0.305
LIG_SH2_STAP1	55	59	PF00017	0.366
LIG_SH2_STAP1	660	664	PF00017	0.403
LIG_SH2_STAT5	197	200	PF00017	0.423
LIG_SH2_STAT5	269	272	PF00017	0.364
LIG_SH2_STAT5	314	317	PF00017	0.296
LIG_SH2_STAT5	600	603	PF00017	0.332
LIG_SH2_STAT5	79	82	PF00017	0.379
LIG_SH2_STAT5	918	921	PF00017	0.331
LIG_SH2_STAT5	941	944	PF00017	0.411
LIG_SH3_3	14	20	PF00018	0.489
LIG_SH3_3	178	184	PF00018	0.501
LIG_SH3_3	344	350	PF00018	0.387
LIG_SH3_3	420	426	PF00018	0.348
LIG_SH3_3	583	589	PF00018	0.299
LIG_SH3_3	617	623	PF00018	0.418
LIG_Sin3_3	823	830	PF02671	0.312
LIG_SUMO_SIM_anti_2	362	368	PF11976	0.310
LIG_SUMO_SIM_par_1	104	110	PF11976	0.339
LIG_SUMO_SIM_par_1	680	688	PF11976	0.427
LIG_SUMO_SIM_par_1	932	938	PF11976	0.311
LIG_SUMO_SIM_par_1	941	947	PF11976	0.501
LIG_TRAF2_1	238	241	PF00917	0.450
LIG_TRAF2_1	878	881	PF00917	0.472
LIG_TYR_ITIM	416	421	PF00017	0.226
LIG_TYR_ITIM	939	944	PF00017	0.414
LIG_UBA3_1	329	338	PF00899	0.331
LIG_WRC_WIRS_1	108	113	PF05994	0.277
MOD_CDK_SPxxK_3	555	562	PF00069	0.406
MOD_CK1_1	177	183	PF00069	0.507
MOD_CK1_1	231	237	PF00069	0.367
MOD_CK1_1	287	293	PF00069	0.493
MOD_CK1_1	310	316	PF00069	0.258
MOD_CK1_1	390	396	PF00069	0.347
MOD_CK1_1	471	477	PF00069	0.452
MOD_CK1_1	482	488	PF00069	0.478
MOD_CK1_1	630	636	PF00069	0.466
MOD_CK1_1	716	722	PF00069	0.456
MOD_CK1_1	81	87	PF00069	0.525
MOD_CK1_1	834	840	PF00069	0.351
MOD_CK1_1	893	899	PF00069	0.544
MOD_CK2_1	234	240	PF00069	0.399
MOD_CK2_1	390	396	PF00069	0.415
MOD_CK2_1	466	472	PF00069	0.393
MOD_CK2_1	630	636	PF00069	0.464
MOD_CK2_1	656	662	PF00069	0.382
MOD_CK2_1	719	725	PF00069	0.574
MOD_CK2_1	807	813	PF00069	0.420
MOD_CK2_1	874	880	PF00069	0.450
MOD_CMANNOS	26	29	PF00535	0.626
MOD_GlcNHglycan	120	124	PF01048	0.641
MOD_GlcNHglycan	189	192	PF01048	0.566
MOD_GlcNHglycan	230	233	PF01048	0.623
MOD_GlcNHglycan	257	260	PF01048	0.545
MOD_GlcNHglycan	291	294	PF01048	0.782
MOD_GlcNHglycan	299	302	PF01048	0.669
MOD_GlcNHglycan	325	328	PF01048	0.619
MOD_GlcNHglycan	33	36	PF01048	0.638
MOD_GlcNHglycan	42	45	PF01048	0.648
MOD_GlcNHglycan	475	478	PF01048	0.719
MOD_GlcNHglycan	487	491	PF01048	0.623
MOD_GlcNHglycan	574	577	PF01048	0.633
MOD_GlcNHglycan	596	600	PF01048	0.593
MOD_GlcNHglycan	609	612	PF01048	0.670
MOD_GlcNHglycan	623	626	PF01048	0.568
MOD_GlcNHglycan	651	654	PF01048	0.645
MOD_GlcNHglycan	718	721	PF01048	0.729
MOD_GlcNHglycan	727	730	PF01048	0.623
MOD_GlcNHglycan	742	745	PF01048	0.490
MOD_GlcNHglycan	748	751	PF01048	0.536
MOD_GlcNHglycan	758	761	PF01048	0.508
MOD_GlcNHglycan	789	792	PF01048	0.744
MOD_GlcNHglycan	817	821	PF01048	0.624
MOD_GlcNHglycan	828	831	PF01048	0.496
MOD_GlcNHglycan	845	848	PF01048	0.512
MOD_GlcNHglycan	88	91	PF01048	0.661
MOD_GlcNHglycan	897	901	PF01048	0.697
MOD_GlcNHglycan	905	908	PF01048	0.663
MOD_GSK3_1	208	215	PF00069	0.342
MOD_GSK3_1	231	238	PF00069	0.504
MOD_GSK3_1	283	290	PF00069	0.492
MOD_GSK3_1	3	10	PF00069	0.523
MOD_GSK3_1	332	339	PF00069	0.374
MOD_GSK3_1	382	389	PF00069	0.436
MOD_GSK3_1	449	456	PF00069	0.416
MOD_GSK3_1	482	489	PF00069	0.518
MOD_GSK3_1	50	57	PF00069	0.347
MOD_GSK3_1	537	544	PF00069	0.504
MOD_GSK3_1	664	671	PF00069	0.300
MOD_GSK3_1	675	682	PF00069	0.274
MOD_GSK3_1	690	697	PF00069	0.330
MOD_GSK3_1	716	723	PF00069	0.441
MOD_GSK3_1	74	81	PF00069	0.481
MOD_GSK3_1	798	805	PF00069	0.459
MOD_GSK3_1	82	89	PF00069	0.468
MOD_GSK3_1	870	877	PF00069	0.335
MOD_GSK3_1	892	899	PF00069	0.608
MOD_N-GLC_1	321	326	PF02516	0.560
MOD_N-GLC_1	387	392	PF02516	0.517
MOD_N-GLC_1	466	471	PF02516	0.561
MOD_N-GLC_1	607	612	PF02516	0.644
MOD_N-GLC_1	850	855	PF02516	0.589
MOD_N-GLC_1	86	91	PF02516	0.613
MOD_NEK2_1	114	119	PF00069	0.384
MOD_NEK2_1	147	152	PF00069	0.511
MOD_NEK2_1	208	213	PF00069	0.381
MOD_NEK2_1	228	233	PF00069	0.247
MOD_NEK2_1	332	337	PF00069	0.322
MOD_NEK2_1	380	385	PF00069	0.449
MOD_NEK2_1	386	391	PF00069	0.414
MOD_NEK2_1	465	470	PF00069	0.369
MOD_NEK2_1	541	546	PF00069	0.465
MOD_NEK2_1	664	669	PF00069	0.303
MOD_NEK2_1	7	12	PF00069	0.711
MOD_NEK2_1	710	715	PF00069	0.393
MOD_NEK2_1	74	79	PF00069	0.448
MOD_NEK2_1	745	750	PF00069	0.453
MOD_NEK2_1	775	780	PF00069	0.345
MOD_NEK2_1	799	804	PF00069	0.380
MOD_NEK2_1	816	821	PF00069	0.384
MOD_NEK2_1	859	864	PF00069	0.301
MOD_NEK2_1	935	940	PF00069	0.309
MOD_NEK2_2	382	387	PF00069	0.395
MOD_NEK2_2	770	775	PF00069	0.446
MOD_PIKK_1	133	139	PF00454	0.451
MOD_PIKK_1	651	657	PF00454	0.386
MOD_PIKK_1	776	782	PF00454	0.405
MOD_PK_1	387	393	PF00069	0.310
MOD_PKA_1	175	181	PF00069	0.458
MOD_PKA_1	3	9	PF00069	0.525
MOD_PKA_1	627	633	PF00069	0.437
MOD_PKA_2	174	180	PF00069	0.566
MOD_PKA_2	212	218	PF00069	0.344
MOD_PKA_2	247	253	PF00069	0.363
MOD_PKA_2	3	9	PF00069	0.525
MOD_PKA_2	485	491	PF00069	0.536
MOD_PKA_2	690	696	PF00069	0.389
MOD_PKA_2	756	762	PF00069	0.325
MOD_PKA_2	770	776	PF00069	0.321
MOD_PKA_2	787	793	PF00069	0.442
MOD_PKB_1	214	222	PF00069	0.329
MOD_Plk_1	208	214	PF00069	0.453
MOD_Plk_1	307	313	PF00069	0.424
MOD_Plk_1	321	327	PF00069	0.425
MOD_Plk_1	387	393	PF00069	0.374
MOD_Plk_1	466	472	PF00069	0.404
MOD_Plk_1	536	542	PF00069	0.447
MOD_Plk_1	685	691	PF00069	0.436
MOD_Plk_1	850	856	PF00069	0.349
MOD_Plk_1	86	92	PF00069	0.442
MOD_Plk_4	270	276	PF00069	0.301
MOD_Plk_4	310	316	PF00069	0.401
MOD_Plk_4	387	393	PF00069	0.394
MOD_Plk_4	457	463	PF00069	0.313
MOD_Plk_4	499	505	PF00069	0.516
MOD_Plk_4	537	543	PF00069	0.479
MOD_Plk_4	630	636	PF00069	0.451
MOD_Plk_4	74	80	PF00069	0.501
MOD_Plk_4	770	776	PF00069	0.346
MOD_Plk_4	935	941	PF00069	0.319
MOD_Plk_4	98	104	PF00069	0.390
MOD_ProDKin_1	177	183	PF00069	0.477
MOD_ProDKin_1	471	477	PF00069	0.498
MOD_ProDKin_1	50	56	PF00069	0.383
MOD_ProDKin_1	555	561	PF00069	0.456
MOD_ProDKin_1	619	625	PF00069	0.418
MOD_ProDKin_1	705	711	PF00069	0.374
MOD_ProDKin_1	78	84	PF00069	0.381
MOD_ProDKin_1	834	840	PF00069	0.414
MOD_ProDKin_1	874	880	PF00069	0.408
MOD_SUMO_for_1	206	209	PF00179	0.428
MOD_SUMO_rev_2	624	630	PF00179	0.385
TRG_DiLeu_BaEn_1	240	245	PF01217	0.401
TRG_DiLeu_BaEn_1	58	63	PF01217	0.409
TRG_DiLeu_BaEn_4	240	246	PF01217	0.397
TRG_DiLeu_BaEn_4	880	886	PF01217	0.305
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.389
TRG_DiLeu_LyEn_5	240	245	PF01217	0.401
TRG_ENDOCYTIC_2	261	264	PF00928	0.313
TRG_ENDOCYTIC_2	268	271	PF00928	0.290
TRG_ENDOCYTIC_2	314	317	PF00928	0.392
TRG_ENDOCYTIC_2	418	421	PF00928	0.305
TRG_ENDOCYTIC_2	462	465	PF00928	0.335
TRG_ENDOCYTIC_2	542	545	PF00928	0.475
TRG_ENDOCYTIC_2	600	603	PF00928	0.332
TRG_ENDOCYTIC_2	772	775	PF00928	0.292
TRG_ENDOCYTIC_2	849	852	PF00928	0.400
TRG_ENDOCYTIC_2	941	944	PF00928	0.414
TRG_ER_diArg_1	2	4	PF00400	0.571
TRG_ER_diArg_1	212	214	PF00400	0.357
TRG_ER_diArg_1	245	248	PF00400	0.433
TRG_ER_diArg_1	478	481	PF00400	0.549
TRG_ER_diArg_1	786	789	PF00400	0.407
TRG_ER_diArg_1	863	866	PF00400	0.373
TRG_NES_CRM1_1	359	372	PF08389	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L3	Leptomonas seymouri	49%	100%
A0A1X0PBB4	Trypanosomatidae	25%	99%
A0A3R7KLJ4	Trypanosoma rangeli	25%	99%
A0A3S5H7D3	Leishmania donovani	99%	100%
A4HDK1	Leishmania braziliensis	76%	100%
C9ZLZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AWY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAJ0	Leishmania major	94%	100%
V5BQI0	Trypanosoma cruzi	25%	100%