Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger - C3HC4 type (RING finger)/zinc-RING finger domain/EF-hand domain pair/EF-hand domain/EF hand/Secreted protein acidic and rich in cysteine Ca binding region containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I0X8_LEIIN

TriTrypDb:

LINF_240019300

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4I0X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0X8

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	24
GO:0005509	calcium ion binding	5	18
GO:0043167	ion binding	2	24
GO:0043169	cation binding	3	24
GO:0046872	metal ion binding	4	24
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0061630	ubiquitin protein ligase activity	5	2
GO:0061659	ubiquitin-like protein ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.334
CLV_NRD_NRD_1	76	78	PF00675	0.594
CLV_PCSK_KEX2_1	226	228	PF00082	0.340
CLV_PCSK_KEX2_1	76	78	PF00082	0.589
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.340
CLV_PCSK_PC7_1	72	78	PF00082	0.327
CLV_PCSK_SKI1_1	226	230	PF00082	0.446
DEG_SPOP_SBC_1	116	120	PF00917	0.731
DOC_CYCLIN_RxL_1	211	221	PF00134	0.336
DOC_MAPK_gen_1	226	234	PF00069	0.483
DOC_MAPK_MEF2A_6	62	71	PF00069	0.479
DOC_PP1_RVXF_1	212	219	PF00149	0.349
DOC_PP4_MxPP_1	110	113	PF00568	0.567
DOC_USP7_MATH_1	116	120	PF00917	0.720
DOC_USP7_MATH_1	129	133	PF00917	0.668
DOC_USP7_MATH_1	53	57	PF00917	0.420
DOC_USP7_MATH_1	94	98	PF00917	0.671
DOC_WW_Pin1_4	103	108	PF00397	0.772
DOC_WW_Pin1_4	218	223	PF00397	0.450
LIG_14-3-3_CanoR_1	174	179	PF00244	0.567
LIG_APCC_ABBA_1	192	197	PF00400	0.358
LIG_BIR_II_1	1	5	PF00653	0.577
LIG_BRCT_MDC1_1	330	334	PF00533	0.309
LIG_FHA_1	13	19	PF00498	0.475
LIG_FHA_2	219	225	PF00498	0.380
LIG_LIR_Apic_2	125	129	PF02991	0.520
LIG_LIR_Apic_2	139	143	PF02991	0.488
LIG_LIR_Apic_2	21	26	PF02991	0.325
LIG_LIR_Gen_1	184	194	PF02991	0.319
LIG_LIR_Gen_1	265	274	PF02991	0.387
LIG_LIR_Gen_1	289	297	PF02991	0.345
LIG_LIR_Gen_1	325	334	PF02991	0.462
LIG_LIR_Nem_3	184	189	PF02991	0.435
LIG_LIR_Nem_3	191	196	PF02991	0.386
LIG_LIR_Nem_3	247	251	PF02991	0.444
LIG_LIR_Nem_3	265	270	PF02991	0.387
LIG_LIR_Nem_3	289	293	PF02991	0.345
LIG_LIR_Nem_3	325	329	PF02991	0.359
LIG_SH2_CRK	126	130	PF00017	0.514
LIG_SH2_CRK	140	144	PF00017	0.501
LIG_SH2_CRK	186	190	PF00017	0.328
LIG_SH2_CRK	251	255	PF00017	0.513
LIG_SH2_CRK	267	271	PF00017	0.241
LIG_SH2_NCK_1	140	144	PF00017	0.506
LIG_SH2_NCK_1	251	255	PF00017	0.424
LIG_SH2_STAP1	124	128	PF00017	0.706
LIG_SH2_STAP1	186	190	PF00017	0.328
LIG_SH2_STAT5	140	143	PF00017	0.653
LIG_SH3_3	110	116	PF00018	0.698
LIG_SH3_3	152	158	PF00018	0.715
LIG_SH3_3	159	165	PF00018	0.715
LIG_SH3_3	167	173	PF00018	0.560
LIG_SH3_4	253	260	PF00018	0.552
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.380
LIG_SUMO_SIM_par_1	318	325	PF11976	0.409
MOD_CK1_1	118	124	PF00069	0.738
MOD_CK2_1	238	244	PF00069	0.377
MOD_CK2_1	319	325	PF00069	0.425
MOD_GlcNHglycan	120	123	PF01048	0.737
MOD_GlcNHglycan	131	134	PF01048	0.743
MOD_GlcNHglycan	151	154	PF01048	0.712
MOD_GlcNHglycan	200	203	PF01048	0.381
MOD_GlcNHglycan	235	239	PF01048	0.343
MOD_GlcNHglycan	330	333	PF01048	0.556
MOD_GlcNHglycan	94	97	PF01048	0.561
MOD_GSK3_1	101	108	PF00069	0.640
MOD_GSK3_1	234	241	PF00069	0.358
MOD_GSK3_1	262	269	PF00069	0.477
MOD_GSK3_1	8	15	PF00069	0.422
MOD_GSK3_1	92	99	PF00069	0.594
MOD_N-GLC_1	198	203	PF02516	0.325
MOD_N-GLC_1	60	65	PF02516	0.495
MOD_N-GLC_2	3	5	PF02516	0.392
MOD_NEK2_1	102	107	PF00069	0.656
MOD_NEK2_1	149	154	PF00069	0.686
MOD_NEK2_1	262	267	PF00069	0.544
MOD_NEK2_2	319	324	PF00069	0.384
MOD_PIKK_1	260	266	PF00454	0.447
MOD_PKA_2	54	60	PF00069	0.493
MOD_Plk_1	207	213	PF00069	0.340
MOD_Plk_1	288	294	PF00069	0.411
MOD_Plk_1	60	66	PF00069	0.516
MOD_Plk_2-3	8	14	PF00069	0.426
MOD_Plk_4	188	194	PF00069	0.349
MOD_Plk_4	244	250	PF00069	0.358
MOD_Plk_4	266	272	PF00069	0.355
MOD_ProDKin_1	103	109	PF00069	0.773
MOD_ProDKin_1	218	224	PF00069	0.450
TRG_DiLeu_BaEn_1	289	294	PF01217	0.461
TRG_ENDOCYTIC_2	186	189	PF00928	0.414
TRG_ENDOCYTIC_2	267	270	PF00928	0.406
TRG_ER_diArg_1	164	167	PF00400	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P229	Leptomonas seymouri	53%	100%
A0A0N1ILD7	Leptomonas seymouri	24%	74%
A0A0S4JBP2	Bodo saltans	26%	74%
A0A1X0NCU6	Trypanosomatidae	49%	100%
A0A1X0NKY5	Trypanosomatidae	33%	76%
A0A1X0NTS2	Trypanosomatidae	26%	75%
A0A3Q8IMS6	Leishmania donovani	69%	85%
A0A3R7KFH5	Trypanosoma rangeli	46%	73%
A0A3S7WWY0	Leishmania donovani	25%	75%
A0A3S7WYG1	Leishmania donovani	99%	100%
A4HDK3	Leishmania braziliensis	60%	100%
A4HDK4	Leishmania braziliensis	60%	100%
A4HZP7	Leishmania infantum	24%	100%
A4I0X7	Leishmania infantum	68%	100%
C9ZWH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AVK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	75%
E9AWY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
E9AWY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QAJ2	Leishmania major	94%	100%
Q4QAJ3	Leishmania major	67%	100%
Q4QBX6	Leishmania major	27%	100%
V5B9E6	Trypanosoma cruzi	32%	87%
V5BK04	Trypanosoma cruzi	49%	100%