Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger - C3HC4 type (RING finger)/Ring finger domain/zinc-RING finger domain/EF-hand domain pair/EF-hand domain/EF hand/Secreted protein acidic and rich in cysteine Ca binding region containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I0X7_LEIIN

TriTrypDb:

LINF_240019200

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 25
NetGPI	no	yes: 0, no: 25

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4I0X7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0X7

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	25
GO:0005509	calcium ion binding	5	19
GO:0043167	ion binding	2	25
GO:0043169	cation binding	3	25
GO:0046872	metal ion binding	4	25
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0061630	ubiquitin protein ligase activity	5	2
GO:0061659	ubiquitin-like protein ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	340	344	PF00656	0.440
CLV_C14_Caspase3-7	360	364	PF00656	0.278
CLV_NRD_NRD_1	76	78	PF00675	0.569
CLV_PCSK_KEX2_1	287	289	PF00082	0.281
CLV_PCSK_KEX2_1	76	78	PF00082	0.562
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.281
CLV_PCSK_PC7_1	72	78	PF00082	0.301
CLV_PCSK_SKI1_1	287	291	PF00082	0.442
DOC_CYCLIN_RxL_1	272	282	PF00134	0.336
DOC_MAPK_gen_1	287	295	PF00069	0.460
DOC_MAPK_MEF2A_6	62	71	PF00069	0.436
DOC_PP1_RVXF_1	273	280	PF00149	0.316
DOC_PP4_FxxP_1	123	126	PF00568	0.556
DOC_USP7_MATH_1	216	220	PF00917	0.542
DOC_USP7_MATH_1	53	57	PF00917	0.440
DOC_USP7_MATH_1	95	99	PF00917	0.639
DOC_WW_Pin1_4	122	127	PF00397	0.554
DOC_WW_Pin1_4	136	141	PF00397	0.778
DOC_WW_Pin1_4	279	284	PF00397	0.426
DOC_WW_Pin1_4	96	101	PF00397	0.638
LIG_14-3-3_CanoR_1	235	240	PF00244	0.554
LIG_APCC_ABBA_1	253	258	PF00400	0.316
LIG_BIR_II_1	1	5	PF00653	0.553
LIG_FHA_1	13	19	PF00498	0.457
LIG_FHA_1	158	164	PF00498	0.472
LIG_FHA_2	280	286	PF00498	0.343
LIG_FHA_2	338	344	PF00498	0.300
LIG_LIR_Apic_2	21	26	PF02991	0.312
LIG_LIR_Gen_1	245	255	PF02991	0.310
LIG_LIR_Gen_1	326	335	PF02991	0.348
LIG_LIR_Gen_1	350	358	PF02991	0.314
LIG_LIR_Gen_1	386	392	PF02991	0.392
LIG_LIR_Nem_3	147	153	PF02991	0.766
LIG_LIR_Nem_3	224	229	PF02991	0.535
LIG_LIR_Nem_3	245	250	PF02991	0.427
LIG_LIR_Nem_3	252	257	PF02991	0.354
LIG_LIR_Nem_3	308	312	PF02991	0.432
LIG_LIR_Nem_3	326	331	PF02991	0.436
LIG_LIR_Nem_3	350	354	PF02991	0.323
LIG_LIR_Nem_3	386	390	PF02991	0.349
LIG_LYPXL_yS_3	150	153	PF13949	0.457
LIG_SH2_CRK	247	251	PF00017	0.322
LIG_SH2_CRK	312	316	PF00017	0.385
LIG_SH2_CRK	328	332	PF00017	0.283
LIG_SH2_GRB2like	201	204	PF00017	0.523
LIG_SH2_NCK_1	312	316	PF00017	0.385
LIG_SH2_STAP1	247	251	PF00017	0.322
LIG_SH2_STAT3	127	130	PF00017	0.701
LIG_SH2_STAT3	201	204	PF00017	0.760
LIG_SH2_STAT3	212	215	PF00017	0.635
LIG_SH2_STAT5	127	130	PF00017	0.679
LIG_SH2_STAT5	201	204	PF00017	0.771
LIG_SH3_3	225	231	PF00018	0.549
LIG_SH3_3	97	103	PF00018	0.518
LIG_SH3_4	314	321	PF00018	0.547
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.371
LIG_SUMO_SIM_par_1	379	386	PF11976	0.371
MOD_CK1_1	125	131	PF00069	0.712
MOD_CK1_1	191	197	PF00069	0.696
MOD_CK1_1	221	227	PF00069	0.677
MOD_CK1_1	96	102	PF00069	0.533
MOD_CK2_1	299	305	PF00069	0.336
MOD_CK2_1	380	386	PF00069	0.396
MOD_GlcNHglycan	133	136	PF01048	0.626
MOD_GlcNHglycan	155	158	PF01048	0.657
MOD_GlcNHglycan	165	168	PF01048	0.680
MOD_GlcNHglycan	177	180	PF01048	0.595
MOD_GlcNHglycan	184	187	PF01048	0.559
MOD_GlcNHglycan	204	207	PF01048	0.556
MOD_GlcNHglycan	209	212	PF01048	0.782
MOD_GlcNHglycan	261	264	PF01048	0.361
MOD_GlcNHglycan	296	300	PF01048	0.307
MOD_GSK3_1	125	132	PF00069	0.677
MOD_GSK3_1	136	143	PF00069	0.756
MOD_GSK3_1	153	160	PF00069	0.568
MOD_GSK3_1	163	170	PF00069	0.715
MOD_GSK3_1	187	194	PF00069	0.741
MOD_GSK3_1	295	302	PF00069	0.321
MOD_GSK3_1	323	330	PF00069	0.446
MOD_GSK3_1	8	15	PF00069	0.364
MOD_N-GLC_1	187	192	PF02516	0.666
MOD_N-GLC_1	202	207	PF02516	0.786
MOD_N-GLC_1	259	264	PF02516	0.272
MOD_N-GLC_1	60	65	PF02516	0.460
MOD_N-GLC_2	3	5	PF02516	0.345
MOD_NEK2_1	153	158	PF00069	0.651
MOD_NEK2_1	163	168	PF00069	0.687
MOD_NEK2_1	202	207	PF00069	0.491
MOD_NEK2_1	323	328	PF00069	0.546
MOD_NEK2_2	380	385	PF00069	0.362
MOD_OFUCOSY	92	97	PF10250	0.405
MOD_PIKK_1	109	115	PF00454	0.782
MOD_PIKK_1	125	131	PF00454	0.559
MOD_PIKK_1	140	146	PF00454	0.791
MOD_PIKK_1	157	163	PF00454	0.593
MOD_PIKK_1	188	194	PF00454	0.550
MOD_PIKK_1	321	327	PF00454	0.421
MOD_PKA_2	54	60	PF00069	0.461
MOD_Plk_1	268	274	PF00069	0.281
MOD_Plk_1	349	355	PF00069	0.376
MOD_Plk_1	60	66	PF00069	0.473
MOD_Plk_2-3	8	14	PF00069	0.357
MOD_Plk_4	249	255	PF00069	0.354
MOD_Plk_4	305	311	PF00069	0.345
MOD_Plk_4	327	333	PF00069	0.312
MOD_ProDKin_1	122	128	PF00069	0.553
MOD_ProDKin_1	136	142	PF00069	0.780
MOD_ProDKin_1	279	285	PF00069	0.426
MOD_ProDKin_1	96	102	PF00069	0.642
TRG_DiLeu_BaEn_1	350	355	PF01217	0.440
TRG_ENDOCYTIC_2	150	153	PF00928	0.457
TRG_ENDOCYTIC_2	226	229	PF00928	0.477
TRG_ENDOCYTIC_2	247	250	PF00928	0.417
TRG_ENDOCYTIC_2	328	331	PF00928	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P229	Leptomonas seymouri	59%	100%
A0A0N1ILD7	Leptomonas seymouri	22%	87%
A0A0S4JBP2	Bodo saltans	26%	88%
A0A1X0NCU6	Trypanosomatidae	34%	100%
A0A1X0NKY5	Trypanosomatidae	25%	90%
A0A1X0NTS2	Trypanosomatidae	26%	88%
A0A3Q8IMS6	Leishmania donovani	98%	100%
A0A3R7KFH5	Trypanosoma rangeli	30%	86%
A0A3S7WWY0	Leishmania donovani	25%	88%
A0A3S7WYG1	Leishmania donovani	68%	100%
A4HDK3	Leishmania braziliensis	75%	100%
A4HDK4	Leishmania braziliensis	75%	100%
A4HZP7	Leishmania infantum	25%	100%
A4I0X8	Leishmania infantum	68%	100%
C9ZWH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AK36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AVK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AWY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AWY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	85%
O97201	Leishmania major	30%	100%
Q4QAJ2	Leishmania major	70%	85%
Q4QAJ3	Leishmania major	94%	100%
Q4QBX6	Leishmania major	25%	100%
V5BK04	Trypanosoma cruzi	33%	100%