Putative DNAJ-domain protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ-domain protein - putative

Species:

Leishmania infantum

UniProt:

A4I0W8_LEIIN

TriTrypDb:

LINF_240018200

Length:

808

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0W8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	492	496	PF00656	0.594
CLV_C14_Caspase3-7	653	657	PF00656	0.528
CLV_C14_Caspase3-7	747	751	PF00656	0.526
CLV_C14_Caspase3-7	775	779	PF00656	0.377
CLV_NRD_NRD_1	163	165	PF00675	0.422
CLV_NRD_NRD_1	215	217	PF00675	0.412
CLV_NRD_NRD_1	222	224	PF00675	0.431
CLV_NRD_NRD_1	273	275	PF00675	0.746
CLV_NRD_NRD_1	3	5	PF00675	0.708
CLV_NRD_NRD_1	747	749	PF00675	0.625
CLV_NRD_NRD_1	85	87	PF00675	0.800
CLV_PCSK_KEX2_1	163	165	PF00082	0.422
CLV_PCSK_KEX2_1	215	217	PF00082	0.488
CLV_PCSK_KEX2_1	221	223	PF00082	0.499
CLV_PCSK_KEX2_1	273	275	PF00082	0.746
CLV_PCSK_KEX2_1	3	5	PF00082	0.708
CLV_PCSK_KEX2_1	548	550	PF00082	0.499
CLV_PCSK_KEX2_1	558	560	PF00082	0.470
CLV_PCSK_KEX2_1	85	87	PF00082	0.800
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.353
CLV_PCSK_PC1ET2_1	558	560	PF00082	0.334
CLV_PCSK_PC7_1	544	550	PF00082	0.441
CLV_PCSK_SKI1_1	14	18	PF00082	0.403
CLV_PCSK_SKI1_1	216	220	PF00082	0.524
CLV_PCSK_SKI1_1	514	518	PF00082	0.520
CLV_PCSK_SKI1_1	544	548	PF00082	0.368
CLV_PCSK_SKI1_1	559	563	PF00082	0.506
CLV_PCSK_SKI1_1	67	71	PF00082	0.401
CLV_PCSK_SKI1_1	743	747	PF00082	0.432
CLV_PCSK_SKI1_1	9	13	PF00082	0.472
DEG_APCC_DBOX_1	13	21	PF00400	0.428
DEG_APCC_DBOX_1	543	551	PF00400	0.433
DEG_APCC_DBOX_1	66	74	PF00400	0.422
DEG_Nend_Nbox_1	1	3	PF02207	0.585
DEG_SCF_FBW7_1	122	128	PF00400	0.551
DEG_SCF_TRCP1_1	402	407	PF00400	0.460
DEG_SPOP_SBC_1	125	129	PF00917	0.647
DOC_CKS1_1	10	15	PF01111	0.566
DOC_CKS1_1	122	127	PF01111	0.546
DOC_CKS1_1	143	148	PF01111	0.491
DOC_CKS1_1	435	440	PF01111	0.427
DOC_CYCLIN_RxL_1	14	25	PF00134	0.335
DOC_CYCLIN_yClb1_LxF_4	727	733	PF00134	0.377
DOC_CYCLIN_yCln2_LP_2	435	441	PF00134	0.356
DOC_CYCLIN_yCln2_LP_2	683	689	PF00134	0.429
DOC_CYCLIN_yCln2_LP_2	782	788	PF00134	0.342
DOC_MAPK_gen_1	333	340	PF00069	0.392
DOC_MAPK_MEF2A_6	205	214	PF00069	0.385
DOC_MAPK_MEF2A_6	333	340	PF00069	0.346
DOC_MAPK_NFAT4_5	333	341	PF00069	0.350
DOC_PP2B_LxvP_1	782	785	PF13499	0.337
DOC_PP4_FxxP_1	143	146	PF00568	0.470
DOC_PP4_FxxP_1	263	266	PF00568	0.446
DOC_USP7_MATH_1	101	105	PF00917	0.559
DOC_USP7_MATH_1	125	129	PF00917	0.706
DOC_USP7_MATH_1	281	285	PF00917	0.570
DOC_USP7_MATH_1	312	316	PF00917	0.395
DOC_USP7_MATH_1	400	404	PF00917	0.546
DOC_USP7_MATH_1	431	435	PF00917	0.513
DOC_USP7_MATH_1	800	804	PF00917	0.498
DOC_USP7_UBL2_3	501	505	PF12436	0.658
DOC_WW_Pin1_4	121	126	PF00397	0.673
DOC_WW_Pin1_4	142	147	PF00397	0.510
DOC_WW_Pin1_4	20	25	PF00397	0.285
DOC_WW_Pin1_4	26	31	PF00397	0.242
DOC_WW_Pin1_4	434	439	PF00397	0.443
DOC_WW_Pin1_4	504	509	PF00397	0.595
DOC_WW_Pin1_4	585	590	PF00397	0.546
DOC_WW_Pin1_4	756	761	PF00397	0.474
DOC_WW_Pin1_4	767	772	PF00397	0.433
DOC_WW_Pin1_4	9	14	PF00397	0.480
LIG_14-3-3_CanoR_1	114	122	PF00244	0.600
LIG_14-3-3_CanoR_1	163	169	PF00244	0.446
LIG_14-3-3_CanoR_1	18	23	PF00244	0.386
LIG_14-3-3_CanoR_1	3	7	PF00244	0.620
LIG_14-3-3_CanoR_1	301	309	PF00244	0.544
LIG_14-3-3_CanoR_1	345	353	PF00244	0.374
LIG_14-3-3_CanoR_1	39	43	PF00244	0.292
LIG_14-3-3_CanoR_1	60	68	PF00244	0.313
LIG_14-3-3_CanoR_1	651	656	PF00244	0.604
LIG_14-3-3_CanoR_1	85	95	PF00244	0.719
LIG_Actin_WH2_2	529	546	PF00022	0.369
LIG_APCC_ABBA_1	617	622	PF00400	0.535
LIG_APCC_ABBA_1	634	639	PF00400	0.306
LIG_BIR_III_4	656	660	PF00653	0.487
LIG_BRCT_BRCA1_1	62	66	PF00533	0.378
LIG_FHA_1	143	149	PF00498	0.547
LIG_FHA_1	191	197	PF00498	0.455
LIG_FHA_1	23	29	PF00498	0.363
LIG_FHA_1	318	324	PF00498	0.409
LIG_FHA_1	435	441	PF00498	0.564
LIG_FHA_1	466	472	PF00498	0.470
LIG_FHA_1	531	537	PF00498	0.432
LIG_FHA_1	688	694	PF00498	0.475
LIG_FHA_1	704	710	PF00498	0.571
LIG_FHA_2	145	151	PF00498	0.533
LIG_FHA_2	605	611	PF00498	0.377
LIG_FHA_2	679	685	PF00498	0.350
LIG_FHA_2	757	763	PF00498	0.406
LIG_HP1_1	254	258	PF01393	0.435
LIG_LIR_Apic_2	129	135	PF02991	0.638
LIG_LIR_Gen_1	226	236	PF02991	0.480
LIG_LIR_Gen_1	330	339	PF02991	0.368
LIG_LIR_Gen_1	560	567	PF02991	0.472
LIG_LIR_Gen_1	574	580	PF02991	0.537
LIG_LIR_Nem_3	226	232	PF02991	0.482
LIG_LIR_Nem_3	330	334	PF02991	0.370
LIG_LIR_Nem_3	462	466	PF02991	0.409
LIG_LIR_Nem_3	522	528	PF02991	0.469
LIG_LIR_Nem_3	560	565	PF02991	0.564
LIG_LIR_Nem_3	57	62	PF02991	0.273
LIG_LIR_Nem_3	574	579	PF02991	0.589
LIG_LYPXL_L_2	310	319	PF13949	0.403
LIG_MYND_1	46	50	PF01753	0.271
LIG_NRBOX	792	798	PF00104	0.424
LIG_PDZ_Class_2	803	808	PF00595	0.609
LIG_Pex14_1	614	618	PF04695	0.418
LIG_Pex14_2	637	641	PF04695	0.418
LIG_Pex14_2	732	736	PF04695	0.314
LIG_REV1ctd_RIR_1	188	198	PF16727	0.404
LIG_SH2_CRK	592	596	PF00017	0.477
LIG_SH2_PTP2	787	790	PF00017	0.364
LIG_SH2_SRC	195	198	PF00017	0.387
LIG_SH2_SRC	787	790	PF00017	0.364
LIG_SH2_STAT3	37	40	PF00017	0.289
LIG_SH2_STAT3	96	99	PF00017	0.467
LIG_SH2_STAT5	195	198	PF00017	0.398
LIG_SH2_STAT5	224	227	PF00017	0.443
LIG_SH2_STAT5	229	232	PF00017	0.443
LIG_SH2_STAT5	37	40	PF00017	0.271
LIG_SH2_STAT5	618	621	PF00017	0.426
LIG_SH2_STAT5	623	626	PF00017	0.377
LIG_SH2_STAT5	717	720	PF00017	0.369
LIG_SH2_STAT5	729	732	PF00017	0.349
LIG_SH2_STAT5	787	790	PF00017	0.364
LIG_SH3_3	119	125	PF00018	0.552
LIG_SH3_3	47	53	PF00018	0.289
LIG_SH3_3	503	509	PF00018	0.654
LIG_SH3_3	639	645	PF00018	0.447
LIG_SH3_3	7	13	PF00018	0.613
LIG_SH3_3	719	725	PF00018	0.379
LIG_SUMO_SIM_anti_2	337	342	PF11976	0.415
LIG_SUMO_SIM_par_1	18	23	PF11976	0.470
LIG_SUMO_SIM_par_1	792	799	PF11976	0.436
LIG_TRFH_1	562	566	PF08558	0.443
LIG_UBA3_1	540	548	PF00899	0.369
LIG_WRC_WIRS_1	165	170	PF05994	0.513
LIG_WRC_WIRS_1	729	734	PF05994	0.313
MOD_CDC14_SPxK_1	588	591	PF00782	0.484
MOD_CDC14_SPxK_1	770	773	PF00782	0.448
MOD_CDK_SPK_2	9	14	PF00069	0.462
MOD_CDK_SPxK_1	585	591	PF00069	0.503
MOD_CDK_SPxK_1	767	773	PF00069	0.427
MOD_CK1_1	123	129	PF00069	0.767
MOD_CK1_1	288	294	PF00069	0.700
MOD_CK1_1	359	365	PF00069	0.621
MOD_CK1_1	373	379	PF00069	0.302
MOD_CK1_1	419	425	PF00069	0.429
MOD_CK1_1	434	440	PF00069	0.434
MOD_CK1_1	557	563	PF00069	0.342
MOD_CK1_1	87	93	PF00069	0.769
MOD_CK2_1	516	522	PF00069	0.503
MOD_CK2_1	604	610	PF00069	0.383
MOD_Cter_Amidation	83	86	PF01082	0.665
MOD_DYRK1A_RPxSP_1	9	13	PF00069	0.507
MOD_GlcNHglycan	180	183	PF01048	0.507
MOD_GlcNHglycan	199	202	PF01048	0.251
MOD_GlcNHglycan	283	286	PF01048	0.750
MOD_GlcNHglycan	347	350	PF01048	0.396
MOD_GlcNHglycan	355	361	PF01048	0.552
MOD_GlcNHglycan	374	378	PF01048	0.473
MOD_GlcNHglycan	402	405	PF01048	0.528
MOD_GlcNHglycan	421	425	PF01048	0.469
MOD_GlcNHglycan	495	498	PF01048	0.612
MOD_GlcNHglycan	666	669	PF01048	0.446
MOD_GlcNHglycan	80	83	PF01048	0.743
MOD_GlcNHglycan	89	92	PF01048	0.777
MOD_GSK3_1	116	123	PF00069	0.712
MOD_GSK3_1	18	25	PF00069	0.311
MOD_GSK3_1	281	288	PF00069	0.654
MOD_GSK3_1	355	362	PF00069	0.605
MOD_GSK3_1	400	407	PF00069	0.563
MOD_GSK3_1	416	423	PF00069	0.649
MOD_GSK3_1	489	496	PF00069	0.714
MOD_GSK3_1	516	523	PF00069	0.498
MOD_GSK3_1	524	531	PF00069	0.379
MOD_GSK3_1	550	557	PF00069	0.471
MOD_GSK3_1	574	581	PF00069	0.647
MOD_N-GLC_1	554	559	PF02516	0.430
MOD_N-GLC_1	60	65	PF02516	0.421
MOD_N-GLC_1	800	805	PF02516	0.466
MOD_NEK2_1	176	181	PF00069	0.570
MOD_NEK2_1	190	195	PF00069	0.468
MOD_NEK2_1	2	7	PF00069	0.664
MOD_NEK2_1	372	377	PF00069	0.511
MOD_NEK2_1	516	521	PF00069	0.481
MOD_NEK2_1	524	529	PF00069	0.331
MOD_NEK2_1	567	572	PF00069	0.377
MOD_NEK2_1	736	741	PF00069	0.412
MOD_NEK2_2	101	106	PF00069	0.526
MOD_PIKK_1	489	495	PF00454	0.635
MOD_PIKK_1	678	684	PF00454	0.379
MOD_PIKK_1	800	806	PF00454	0.461
MOD_PKA_1	85	91	PF00069	0.605
MOD_PKA_2	2	8	PF00069	0.608
MOD_PKA_2	300	306	PF00069	0.510
MOD_PKA_2	38	44	PF00069	0.292
MOD_PKA_2	567	573	PF00069	0.531
MOD_PKA_2	650	656	PF00069	0.619
MOD_PKA_2	703	709	PF00069	0.508
MOD_PKA_2	84	90	PF00069	0.652
MOD_Plk_1	149	155	PF00069	0.486
MOD_Plk_1	574	580	PF00069	0.524
MOD_Plk_1	697	703	PF00069	0.338
MOD_Plk_2-3	327	333	PF00069	0.391
MOD_Plk_4	520	526	PF00069	0.564
MOD_Plk_4	567	573	PF00069	0.439
MOD_Plk_4	728	734	PF00069	0.312
MOD_ProDKin_1	121	127	PF00069	0.677
MOD_ProDKin_1	142	148	PF00069	0.499
MOD_ProDKin_1	20	26	PF00069	0.285
MOD_ProDKin_1	434	440	PF00069	0.434
MOD_ProDKin_1	504	510	PF00069	0.579
MOD_ProDKin_1	585	591	PF00069	0.547
MOD_ProDKin_1	756	762	PF00069	0.474
MOD_ProDKin_1	767	773	PF00069	0.441
MOD_ProDKin_1	9	15	PF00069	0.474
MOD_SUMO_for_1	334	337	PF00179	0.395
MOD_SUMO_for_1	572	575	PF00179	0.478
MOD_SUMO_rev_2	299	309	PF00179	0.391
TRG_DiLeu_BaEn_1	436	441	PF01217	0.419
TRG_ENDOCYTIC_2	229	232	PF00928	0.482
TRG_ENDOCYTIC_2	638	641	PF00928	0.442
TRG_ENDOCYTIC_2	729	732	PF00928	0.353
TRG_ER_diArg_1	162	164	PF00400	0.442
TRG_ER_diArg_1	2	4	PF00400	0.705
TRG_ER_diArg_1	214	216	PF00400	0.495
TRG_ER_diArg_1	221	223	PF00400	0.493
TRG_ER_diArg_1	541	544	PF00400	0.367
TRG_Pf-PMV_PEXEL_1	445	449	PF00026	0.340
TRG_Pf-PMV_PEXEL_1	559	563	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.289

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JIX4	Bodo saltans	28%	75%
A0A1X0NVN0	Trypanosomatidae	41%	97%
A0A3Q8ICX0	Leishmania donovani	100%	100%
A0A422NQ56	Trypanosoma rangeli	42%	96%
A4HDL7	Leishmania braziliensis	88%	100%
D0A799	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	96%
E9AWX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QAK2	Leishmania major	96%	100%
V5BAJ1	Trypanosoma cruzi	40%	96%