Amastin-like surface protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein-like protein

Species:

Leishmania infantum

UniProt:

A4I0W6_LEIIN

TriTrypDb:

LINF_240018000

Length:

296

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Annotations by Jardim et al.

Plasma membrane, Amastin-like surface -like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 41
NetGPI	no	yes: 0, no: 41

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	35
GO:0110165	cellular anatomical entity	1	35
GO:0020016	ciliary pocket	2	1

Expansion

Sequence features

A4I0W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0W6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.481
CLV_PCSK_KEX2_1	178	180	PF00082	0.479
CLV_PCSK_SKI1_1	67	71	PF00082	0.341
DOC_CKS1_1	137	142	PF01111	0.415
DOC_CKS1_1	144	149	PF01111	0.298
DOC_CKS1_1	34	39	PF01111	0.567
DOC_CKS1_1	90	95	PF01111	0.542
DOC_PP1_RVXF_1	13	20	PF00149	0.561
DOC_PP2B_LxvP_1	69	72	PF13499	0.528
DOC_PP4_FxxP_1	144	147	PF00568	0.228
DOC_USP7_MATH_1	5	9	PF00917	0.569
DOC_USP7_MATH_1	52	56	PF00917	0.560
DOC_WW_Pin1_4	1	6	PF00397	0.575
DOC_WW_Pin1_4	136	141	PF00397	0.474
DOC_WW_Pin1_4	143	148	PF00397	0.326
DOC_WW_Pin1_4	26	31	PF00397	0.593
DOC_WW_Pin1_4	33	38	PF00397	0.579
DOC_WW_Pin1_4	40	45	PF00397	0.565
DOC_WW_Pin1_4	89	94	PF00397	0.577
LIG_14-3-3_CanoR_1	178	184	PF00244	0.237
LIG_FHA_1	12	18	PF00498	0.554
LIG_FHA_1	66	72	PF00498	0.544
LIG_FHA_1	90	96	PF00498	0.545
LIG_LIR_Apic_2	141	147	PF02991	0.227
LIG_LIR_Apic_2	279	284	PF02991	0.486
LIG_LIR_Gen_1	232	240	PF02991	0.299
LIG_LIR_Gen_1	256	264	PF02991	0.285
LIG_LIR_Gen_1	29	39	PF02991	0.559
LIG_LIR_Nem_3	232	236	PF02991	0.296
LIG_LIR_Nem_3	29	34	PF02991	0.555
LIG_LIR_Nem_3	62	66	PF02991	0.540
LIG_LYPXL_yS_3	74	77	PF13949	0.536
LIG_Pex14_1	132	136	PF04695	0.206
LIG_SH2_CRK	31	35	PF00017	0.565
LIG_SH2_CRK	66	70	PF00017	0.534
LIG_SH2_CRK	80	84	PF00017	0.530
LIG_SH2_STAT5	118	121	PF00017	0.355
LIG_SH2_STAT5	152	155	PF00017	0.253
LIG_SH2_STAT5	255	258	PF00017	0.226
LIG_SH3_3	134	140	PF00018	0.420
LIG_SH3_3	212	218	PF00018	0.414
LIG_SH3_3	221	227	PF00018	0.229
LIG_SH3_3	69	75	PF00018	0.536
LIG_SH3_3	90	96	PF00018	0.553
LIG_SUMO_SIM_anti_2	269	275	PF11976	0.213
LIG_TRAF2_1	285	288	PF00917	0.572
LIG_TYR_ITSM	27	34	PF00017	0.554
LIG_WRC_WIRS_1	60	65	PF05994	0.543
MOD_CK1_1	4	10	PF00069	0.569
MOD_GlcNHglycan	202	205	PF01048	0.230
MOD_GlcNHglycan	85	88	PF01048	0.354
MOD_GSK3_1	1	8	PF00069	0.573
MOD_GSK3_1	22	29	PF00069	0.568
MOD_GSK3_1	38	45	PF00069	0.580
MOD_N-GLC_1	240	245	PF02516	0.431
MOD_NEK2_1	122	127	PF00069	0.290
MOD_NEK2_1	262	267	PF00069	0.256
MOD_NEK2_1	276	281	PF00069	0.389
MOD_NEK2_1	65	70	PF00069	0.538
MOD_NEK2_2	235	240	PF00069	0.213
MOD_NEK2_2	5	10	PF00069	0.569
MOD_PIKK_1	206	212	PF00454	0.206
MOD_PKA_1	178	184	PF00069	0.206
MOD_PKA_2	177	183	PF00069	0.242
MOD_Plk_1	240	246	PF00069	0.248
MOD_Plk_4	150	156	PF00069	0.294
MOD_Plk_4	226	232	PF00069	0.285
MOD_Plk_4	235	241	PF00069	0.254
MOD_Plk_4	42	48	PF00069	0.566
MOD_ProDKin_1	1	7	PF00069	0.574
MOD_ProDKin_1	136	142	PF00069	0.474
MOD_ProDKin_1	143	149	PF00069	0.326
MOD_ProDKin_1	26	32	PF00069	0.594
MOD_ProDKin_1	33	39	PF00069	0.578
MOD_ProDKin_1	40	46	PF00069	0.567
MOD_ProDKin_1	89	95	PF00069	0.576
MOD_SUMO_for_1	285	288	PF00179	0.544
TRG_ENDOCYTIC_2	157	160	PF00928	0.219
TRG_ENDOCYTIC_2	31	34	PF00928	0.564
TRG_ENDOCYTIC_2	60	63	PF00928	0.559
TRG_ENDOCYTIC_2	66	69	PF00928	0.538
TRG_ENDOCYTIC_2	74	77	PF00928	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NYN9	Trypanosomatidae	25%	90%
A0A381MTC7	Leishmania infantum	25%	100%
A0A3Q8IFH7	Leishmania donovani	25%	100%
A0A3S5H7L2	Leishmania donovani	25%	100%
A0A3S5H7W6	Leishmania donovani	23%	100%
A0A3S7X1H6	Leishmania donovani	23%	87%
A0A3S7X357	Leishmania donovani	25%	100%
A0A3S7X7E5	Leishmania donovani	27%	100%
A0A3S7X7M4	Leishmania donovani	23%	100%
A0A3S7X7U1	Leishmania donovani	25%	100%
A0A3S7X7W2	Leishmania donovani	24%	100%
A4H6C8	Leishmania braziliensis	28%	100%
A4HBJ2	Leishmania braziliensis	22%	100%
A4HDI3	Leishmania braziliensis	39%	100%
A4HDL5	Leishmania braziliensis	60%	96%
A4HGJ1	Leishmania braziliensis	22%	87%
A4HI43	Leishmania braziliensis	25%	100%
A4I3L8	Leishmania infantum	23%	87%
A4I4J2	Leishmania infantum	26%	100%
A4I5B9	Leishmania infantum	25%	100%
A4I9R7	Leishmania infantum	27%	100%
A4I9X0	Leishmania infantum	24%	100%
E8NHD3	Leishmania infantum	26%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AG83	Leishmania infantum	23%	100%
E9AHT2	Leishmania infantum	26%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AZV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	88%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4Q309	Leishmania major	22%	100%
Q4Q325	Leishmania major	22%	100%
Q4Q397	Leishmania major	24%	100%
Q4Q3A9	Leishmania major	23%	98%
Q4Q7L6	Leishmania major	25%	100%
Q4Q8C7	Leishmania major	24%	87%