Amastin-like surface protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein-like protein

Species:

Leishmania infantum

UniProt:

A4I0W3_LEIIN

TriTrypDb:

LINF_240017700

Length:

186

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 102
NetGPI	no	yes: 0, no: 108

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	94
GO:0110165	cellular anatomical entity	1	94

Expansion

Sequence features

A4I0W3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0W3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	68	70	PF00675	0.481
CLV_PCSK_KEX2_1	68	70	PF00082	0.480
DOC_CKS1_1	27	32	PF01111	0.362
DOC_CKS1_1	34	39	PF01111	0.313
DOC_PP4_FxxP_1	34	37	PF00568	0.333
DOC_WW_Pin1_4	26	31	PF00397	0.372
DOC_WW_Pin1_4	33	38	PF00397	0.319
LIG_14-3-3_CanoR_1	68	74	PF00244	0.280
LIG_LIR_Apic_2	169	174	PF02991	0.580
LIG_LIR_Apic_2	31	37	PF02991	0.360
LIG_LIR_Gen_1	122	130	PF02991	0.303
LIG_LIR_Gen_1	146	154	PF02991	0.407
LIG_LIR_Nem_3	122	126	PF02991	0.280
LIG_Pex14_1	22	26	PF04695	0.304
LIG_Pex14_2	20	24	PF04695	0.384
LIG_SH2_STAT5	145	148	PF00017	0.266
LIG_SH2_STAT5	42	45	PF00017	0.357
LIG_SH2_STAT5	8	11	PF00017	0.409
LIG_SH3_3	102	108	PF00018	0.539
LIG_SH3_3	111	117	PF00018	0.417
LIG_SH3_3	24	30	PF00018	0.391
LIG_SUMO_SIM_anti_2	159	165	PF11976	0.340
LIG_TRAF2_1	175	178	PF00917	0.706
MOD_GlcNHglycan	92	95	PF01048	0.365
MOD_N-GLC_1	130	135	PF02516	0.429
MOD_NEK2_1	12	17	PF00069	0.337
MOD_NEK2_1	152	157	PF00069	0.325
MOD_NEK2_1	166	171	PF00069	0.426
MOD_NEK2_2	125	130	PF00069	0.353
MOD_PIKK_1	96	102	PF00454	0.346
MOD_PKA_1	68	74	PF00069	0.245
MOD_PKA_2	67	73	PF00069	0.275
MOD_Plk_1	130	136	PF00069	0.225
MOD_Plk_4	116	122	PF00069	0.331
MOD_Plk_4	125	131	PF00069	0.342
MOD_Plk_4	40	46	PF00069	0.334
MOD_ProDKin_1	26	32	PF00069	0.372
MOD_ProDKin_1	33	39	PF00069	0.319
MOD_SUMO_for_1	175	178	PF00179	0.640
TRG_ENDOCYTIC_2	47	50	PF00928	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	34%	100%
A0A0N1I295	Leptomonas seymouri	29%	100%
A0A1X0NQ58	Trypanosomatidae	31%	100%
A0A1X0NUH1	Trypanosomatidae	28%	82%
A0A1X0NVN5	Trypanosomatidae	31%	100%
A0A1X0NVT7	Trypanosomatidae	29%	100%
A0A1X0NX02	Trypanosomatidae	28%	100%
A0A1X0NX81	Trypanosomatidae	33%	100%
A0A1X0P988	Trypanosomatidae	29%	100%
A0A381MTA7	Leishmania infantum	26%	100%
A0A381MTC7	Leishmania infantum	25%	100%
A0A381MVY0	Leishmania infantum	26%	97%
A0A3Q8ID16	Leishmania donovani	34%	100%
A0A3Q8IEI1	Leishmania donovani	21%	97%
A0A3Q8IFH7	Leishmania donovani	25%	91%
A0A3Q8IHN2	Leishmania donovani	22%	97%
A0A3Q8IMR4	Leishmania donovani	99%	100%
A0A3Q8IUK8	Leishmania donovani	25%	97%
A0A3S5H7D2	Leishmania donovani	36%	100%
A0A3S7WQA8	Leishmania donovani	26%	100%
A0A3S7WQC1	Leishmania donovani	25%	96%
A0A3S7X2E6	Leishmania donovani	25%	96%
A0A3S7X357	Leishmania donovani	25%	84%
A0A3S7X7E5	Leishmania donovani	28%	74%
A0A3S7X7U1	Leishmania donovani	24%	100%
A0A3S7X7W2	Leishmania donovani	24%	89%
A0A3S7X7Y0	Leishmania donovani	25%	96%
A4H5D1	Leishmania braziliensis	26%	100%
A4H5G0	Leishmania braziliensis	29%	97%
A4H5H2	Leishmania braziliensis	25%	100%
A4H7D7	Leishmania braziliensis	27%	100%
A4HAM2	Leishmania braziliensis	27%	100%
A4HAM4	Leishmania braziliensis	28%	100%
A4HAR1	Leishmania braziliensis	21%	97%
A4HAZ8	Leishmania braziliensis	26%	98%
A4HB00	Leishmania braziliensis	21%	97%
A4HB02	Leishmania braziliensis	26%	96%
A4HBJ1	Leishmania braziliensis	27%	100%
A4HBJ2	Leishmania braziliensis	22%	89%
A4HDI2	Leishmania braziliensis	85%	100%
A4HDI3	Leishmania braziliensis	39%	77%
A4HDI4	Leishmania braziliensis	34%	100%
A4HDL3	Leishmania braziliensis	35%	100%
A4HDL4	Leishmania braziliensis	35%	100%
A4HI43	Leishmania braziliensis	29%	100%
A4HTM3	Leishmania infantum	24%	96%
A4HTM4	Leishmania infantum	26%	98%
A4HTM5	Leishmania infantum	23%	96%
A4I0W4	Leishmania infantum	36%	100%
A4I0W5	Leishmania infantum	34%	100%
A4I4J2	Leishmania infantum	28%	91%
A4I5B9	Leishmania infantum	25%	84%
A4I9Q4	Leishmania infantum	29%	100%
A4I9R7	Leishmania infantum	27%	94%
A4I9X0	Leishmania infantum	24%	89%
A4IAM1	Leishmania infantum	21%	97%
A4IAM2	Leishmania infantum	22%	97%
C6K3X9	Leptomonas seymouri	73%	97%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	96%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	99%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	90%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AG83	Leishmania infantum	25%	93%
E9AHI9	Leishmania infantum	25%	96%
E9AHT2	Leishmania infantum	25%	88%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	96%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	99%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AWW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AWX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	94%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	90%
Q4Q1U9	Leishmania major	28%	100%
Q4Q305	Leishmania major	24%	100%
Q4Q313	Leishmania major	25%	97%
Q4Q325	Leishmania major	22%	100%
Q4Q327	Leishmania major	27%	99%
Q4Q329	Leishmania major	23%	100%
Q4Q335	Leishmania major	25%	97%
Q4Q337	Leishmania major	28%	100%
Q4Q339	Leishmania major	25%	97%
Q4Q341	Leishmania major	27%	100%
Q4Q397	Leishmania major	23%	71%
Q4Q3A9	Leishmania major	23%	94%
Q4Q7L6	Leishmania major	27%	100%
Q4QAK4	Leishmania major	95%	100%
Q4QAK5	Leishmania major	34%	100%
Q4QAK6	Leishmania major	41%	100%
Q4QAK7	Leishmania major	95%	100%
Q4QI85	Leishmania major	26%	96%
Q4QI86	Leishmania major	26%	100%
Q4QI87	Leishmania major	28%	100%
Q4QI88	Leishmania major	23%	99%