DHC_N2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0W2_LEIIN

TriTrypDb:

LINF_240017600

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0W2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0W2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.356
CLV_NRD_NRD_1	107	109	PF00675	0.314
CLV_NRD_NRD_1	152	154	PF00675	0.356
CLV_NRD_NRD_1	194	196	PF00675	0.409
CLV_NRD_NRD_1	318	320	PF00675	0.496
CLV_PCSK_KEX2_1	109	111	PF00082	0.330
CLV_PCSK_KEX2_1	152	154	PF00082	0.460
CLV_PCSK_KEX2_1	167	169	PF00082	0.372
CLV_PCSK_KEX2_1	229	231	PF00082	0.334
CLV_PCSK_KEX2_1	317	319	PF00082	0.381
CLV_PCSK_KEX2_1	348	350	PF00082	0.322
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.330
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.294
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.334
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.381
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.322
CLV_PCSK_SKI1_1	110	114	PF00082	0.327
CLV_PCSK_SKI1_1	143	147	PF00082	0.294
CLV_PCSK_SKI1_1	222	226	PF00082	0.512
CLV_PCSK_SKI1_1	279	283	PF00082	0.440
CLV_PCSK_SKI1_1	348	352	PF00082	0.308
DEG_SPOP_SBC_1	300	304	PF00917	0.463
DOC_ANK_TNKS_1	200	207	PF00023	0.288
DOC_CYCLIN_RxL_1	346	353	PF00134	0.317
DOC_MAPK_gen_1	166	173	PF00069	0.278
DOC_MAPK_gen_1	263	272	PF00069	0.311
DOC_MAPK_gen_1	317	323	PF00069	0.311
DOC_MAPK_gen_1	40	50	PF00069	0.280
DOC_MAPK_JIP1_4	7	13	PF00069	0.358
DOC_MAPK_MEF2A_6	265	274	PF00069	0.307
DOC_MAPK_MEF2A_6	40	48	PF00069	0.284
DOC_PP1_RVXF_1	194	201	PF00149	0.395
DOC_PP1_RVXF_1	205	211	PF00149	0.243
DOC_PP2B_LxvP_1	80	83	PF13499	0.395
DOC_PP4_FxxP_1	58	61	PF00568	0.294
DOC_SPAK_OSR1_1	22	26	PF12202	0.299
DOC_USP7_MATH_1	61	65	PF00917	0.278
DOC_USP7_UBL2_3	157	161	PF12436	0.319
DOC_USP7_UBL2_3	225	229	PF12436	0.331
DOC_WW_Pin1_4	125	130	PF00397	0.346
LIG_14-3-3_CanoR_1	123	127	PF00244	0.302
LIG_14-3-3_CanoR_1	207	211	PF00244	0.414
LIG_14-3-3_CanoR_1	301	310	PF00244	0.489
LIG_APCC_ABBA_1	270	275	PF00400	0.297
LIG_BRCT_BRCA1_1	324	328	PF00533	0.278
LIG_GBD_Chelix_1	173	181	PF00786	0.316
LIG_HCF-1_HBM_1	175	178	PF13415	0.318
LIG_LIR_Apic_2	56	61	PF02991	0.289
LIG_LIR_Gen_1	175	186	PF02991	0.373
LIG_LIR_Gen_1	325	336	PF02991	0.292
LIG_LIR_Gen_1	341	352	PF02991	0.290
LIG_LIR_Gen_1	74	83	PF02991	0.287
LIG_LIR_Nem_3	175	181	PF02991	0.329
LIG_LIR_Nem_3	325	331	PF02991	0.453
LIG_LIR_Nem_3	341	347	PF02991	0.228
LIG_LIR_Nem_3	74	78	PF02991	0.283
LIG_MAD2	307	315	PF02301	0.472
LIG_Pex14_2	23	27	PF04695	0.279
LIG_Pex14_2	340	344	PF04695	0.287
LIG_SH2_CRK	178	182	PF00017	0.357
LIG_SH3_3	305	311	PF00018	0.500
LIG_SH3_3	333	339	PF00018	0.269
LIG_SUMO_SIM_par_1	48	54	PF11976	0.294
LIG_TRAF2_1	74	77	PF00917	0.273
LIG_UBA3_1	220	229	PF00899	0.300
LIG_WRC_WIRS_1	231	236	PF05994	0.297
MOD_CK1_1	159	165	PF00069	0.305
MOD_CK1_1	16	22	PF00069	0.316
MOD_CK1_1	257	263	PF00069	0.306
MOD_CK1_1	51	57	PF00069	0.290
MOD_CK2_1	15	21	PF00069	0.315
MOD_CK2_1	71	77	PF00069	0.395
MOD_Cter_Amidation	193	196	PF01082	0.428
MOD_GlcNHglycan	178	181	PF01048	0.329
MOD_GlcNHglycan	239	242	PF01048	0.424
MOD_GlcNHglycan	303	306	PF01048	0.497
MOD_GlcNHglycan	332	335	PF01048	0.341
MOD_GSK3_1	181	188	PF00069	0.494
MOD_GSK3_1	206	213	PF00069	0.372
MOD_GSK3_1	61	68	PF00069	0.269
MOD_N-GLC_1	210	215	PF02516	0.290
MOD_NEK2_1	13	18	PF00069	0.324
MOD_NEK2_1	210	215	PF00069	0.360
MOD_NEK2_1	277	282	PF00069	0.389
MOD_NEK2_1	291	296	PF00069	0.417
MOD_NEK2_1	350	355	PF00069	0.365
MOD_NEK2_1	78	83	PF00069	0.273
MOD_NEK2_2	156	161	PF00069	0.333
MOD_PIKK_1	131	137	PF00454	0.317
MOD_PKA_2	122	128	PF00069	0.312
MOD_PKA_2	206	212	PF00069	0.290
MOD_PKA_2	300	306	PF00069	0.475
MOD_PKA_2	42	48	PF00069	0.285
MOD_PKB_1	108	116	PF00069	0.310
MOD_Plk_1	146	152	PF00069	0.312
MOD_Plk_1	182	188	PF00069	0.453
MOD_Plk_1	210	216	PF00069	0.295
MOD_Plk_1	254	260	PF00069	0.304
MOD_Plk_4	210	216	PF00069	0.396
MOD_Plk_4	61	67	PF00069	0.271
MOD_ProDKin_1	125	131	PF00069	0.344
MOD_SUMO_for_1	145	148	PF00179	0.297
TRG_DiLeu_BaLyEn_6	346	351	PF01217	0.301
TRG_ENDOCYTIC_2	178	181	PF00928	0.342
TRG_ER_diArg_1	151	153	PF00400	0.310
TRG_ER_diArg_1	318	320	PF00400	0.354
TRG_NES_CRM1_1	117	127	PF08389	0.286
TRG_NLS_MonoExtN_4	315	321	PF00514	0.360
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	279	283	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.298

Homologs


Protein	Taxonomy	Sequence identity	Coverage
V5C0H3	Trypanosoma cruzi	64%	85%