Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0W1_LEIIN

TriTrypDb:

LINF_240017500

Length:

762

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0W1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0W1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.635
CLV_C14_Caspase3-7	742	746	PF00656	0.611
CLV_C14_Caspase3-7	756	760	PF00656	0.515
CLV_NRD_NRD_1	169	171	PF00675	0.605
CLV_NRD_NRD_1	433	435	PF00675	0.443
CLV_NRD_NRD_1	494	496	PF00675	0.440
CLV_NRD_NRD_1	577	579	PF00675	0.460
CLV_NRD_NRD_1	646	648	PF00675	0.447
CLV_NRD_NRD_1	729	731	PF00675	0.618
CLV_PCSK_FUR_1	166	170	PF00082	0.686
CLV_PCSK_KEX2_1	166	168	PF00082	0.612
CLV_PCSK_KEX2_1	169	171	PF00082	0.591
CLV_PCSK_KEX2_1	433	435	PF00082	0.443
CLV_PCSK_KEX2_1	494	496	PF00082	0.440
CLV_PCSK_KEX2_1	609	611	PF00082	0.482
CLV_PCSK_KEX2_1	627	629	PF00082	0.456
CLV_PCSK_KEX2_1	731	733	PF00082	0.597
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.471
CLV_PCSK_PC1ET2_1	627	629	PF00082	0.344
CLV_PCSK_PC1ET2_1	731	733	PF00082	0.597
CLV_PCSK_SKI1_1	133	137	PF00082	0.589
CLV_PCSK_SKI1_1	285	289	PF00082	0.543
CLV_PCSK_SKI1_1	540	544	PF00082	0.456
CLV_PCSK_SKI1_1	600	604	PF00082	0.434
DEG_APCC_DBOX_1	577	585	PF00400	0.404
DEG_SPOP_SBC_1	387	391	PF00917	0.661
DOC_CYCLIN_RxL_1	133	143	PF00134	0.543
DOC_CYCLIN_RxL_1	404	418	PF00134	0.565
DOC_CYCLIN_RxL_1	535	546	PF00134	0.504
DOC_MAPK_gen_1	598	607	PF00069	0.368
DOC_MAPK_gen_1	75	85	PF00069	0.633
DOC_PP1_RVXF_1	615	621	PF00149	0.439
DOC_PP2B_LxvP_1	159	162	PF13499	0.694
DOC_PP2B_LxvP_1	185	188	PF13499	0.526
DOC_PP2B_LxvP_1	325	328	PF13499	0.639
DOC_PP2B_LxvP_1	451	454	PF13499	0.399
DOC_PP4_FxxP_1	287	290	PF00568	0.534
DOC_PP4_FxxP_1	320	323	PF00568	0.643
DOC_PP4_FxxP_1	620	623	PF00568	0.383
DOC_USP7_MATH_1	107	111	PF00917	0.656
DOC_USP7_MATH_1	176	180	PF00917	0.622
DOC_USP7_MATH_1	197	201	PF00917	0.703
DOC_USP7_MATH_1	221	225	PF00917	0.726
DOC_USP7_MATH_1	309	313	PF00917	0.610
DOC_USP7_MATH_1	378	382	PF00917	0.741
DOC_USP7_MATH_1	400	404	PF00917	0.624
DOC_USP7_MATH_1	503	507	PF00917	0.342
DOC_USP7_MATH_1	623	627	PF00917	0.417
DOC_USP7_MATH_1	94	98	PF00917	0.585
DOC_WW_Pin1_4	112	117	PF00397	0.587
DOC_WW_Pin1_4	154	159	PF00397	0.611
DOC_WW_Pin1_4	179	184	PF00397	0.602
DOC_WW_Pin1_4	226	231	PF00397	0.578
DOC_WW_Pin1_4	248	253	PF00397	0.482
DOC_WW_Pin1_4	294	299	PF00397	0.681
DOC_WW_Pin1_4	31	36	PF00397	0.613
DOC_WW_Pin1_4	346	351	PF00397	0.559
DOC_WW_Pin1_4	420	425	PF00397	0.584
DOC_WW_Pin1_4	546	551	PF00397	0.486
DOC_WW_Pin1_4	619	624	PF00397	0.429
DOC_WW_Pin1_4	684	689	PF00397	0.635
DOC_WW_Pin1_4	99	104	PF00397	0.675
LIG_14-3-3_CanoR_1	109	113	PF00244	0.574
LIG_14-3-3_CanoR_1	141	147	PF00244	0.614
LIG_14-3-3_CanoR_1	202	209	PF00244	0.663
LIG_14-3-3_CanoR_1	318	323	PF00244	0.620
LIG_14-3-3_CanoR_1	511	516	PF00244	0.431
LIG_14-3-3_CanoR_1	583	589	PF00244	0.454
LIG_14-3-3_CanoR_1	650	658	PF00244	0.482
LIG_14-3-3_CanoR_1	80	86	PF00244	0.598
LIG_Actin_WH2_2	228	244	PF00022	0.596
LIG_Actin_WH2_2	520	537	PF00022	0.480
LIG_Actin_WH2_2	577	594	PF00022	0.370
LIG_BIR_III_4	153	157	PF00653	0.626
LIG_BRCT_BRCA1_1	631	635	PF00533	0.373
LIG_Clathr_ClatBox_1	585	589	PF01394	0.334
LIG_FHA_1	134	140	PF00498	0.538
LIG_FHA_1	141	147	PF00498	0.534
LIG_FHA_1	335	341	PF00498	0.557
LIG_FHA_1	349	355	PF00498	0.572
LIG_FHA_1	378	384	PF00498	0.634
LIG_FHA_1	462	468	PF00498	0.425
LIG_FHA_1	585	591	PF00498	0.414
LIG_FHA_2	253	259	PF00498	0.380
LIG_FHA_2	306	312	PF00498	0.637
LIG_FHA_2	455	461	PF00498	0.524
LIG_FHA_2	644	650	PF00498	0.485
LIG_FHA_2	754	760	PF00498	0.616
LIG_Integrin_isoDGR_2	164	166	PF01839	0.675
LIG_Integrin_isoDGR_2	509	511	PF01839	0.423
LIG_Integrin_RGD_1	372	374	PF01839	0.557
LIG_LIR_Apic_2	286	290	PF02991	0.514
LIG_LIR_Apic_2	619	623	PF02991	0.403
LIG_LIR_Gen_1	274	280	PF02991	0.472
LIG_LIR_Gen_1	563	571	PF02991	0.366
LIG_LIR_Gen_1	632	642	PF02991	0.377
LIG_LIR_Nem_3	274	278	PF02991	0.468
LIG_LIR_Nem_3	397	402	PF02991	0.684
LIG_LIR_Nem_3	480	486	PF02991	0.417
LIG_LIR_Nem_3	522	527	PF02991	0.499
LIG_LIR_Nem_3	563	567	PF02991	0.356
LIG_LIR_Nem_3	632	638	PF02991	0.363
LIG_LYPXL_yS_3	399	402	PF13949	0.641
LIG_MYND_1	323	327	PF01753	0.596
LIG_MYND_1	384	388	PF01753	0.640
LIG_NRBOX	580	586	PF00104	0.370
LIG_PCNA_yPIPBox_3	509	521	PF02747	0.365
LIG_Pex14_2	287	291	PF04695	0.513
LIG_PTB_Apo_2	661	668	PF02174	0.378
LIG_SH2_CRK	448	452	PF00017	0.396
LIG_SH2_CRK	524	528	PF00017	0.492
LIG_SH2_CRK	642	646	PF00017	0.463
LIG_SH2_NCK_1	642	646	PF00017	0.463
LIG_SH2_SRC	642	645	PF00017	0.464
LIG_SH2_STAT5	486	489	PF00017	0.394
LIG_SH2_STAT5	498	501	PF00017	0.384
LIG_SH3_3	118	124	PF00018	0.586
LIG_SH3_3	180	186	PF00018	0.623
LIG_SH3_3	311	317	PF00018	0.707
LIG_SH3_3	320	326	PF00018	0.639
LIG_SH3_3	381	387	PF00018	0.677
LIG_SH3_3	403	409	PF00018	0.668
LIG_SH3_3	421	427	PF00018	0.598
LIG_SUMO_SIM_par_1	41	49	PF11976	0.560
LIG_TRAF2_1	704	707	PF00917	0.630
LIG_TYR_ITIM	273	278	PF00017	0.462
LIG_TYR_ITIM	446	451	PF00017	0.375
LIG_UBA3_1	584	592	PF00899	0.338
LIG_ULM_U2AF65_1	647	652	PF00076	0.443
LIG_WRC_WIRS_1	630	635	PF05994	0.371
LIG_WW_2	323	326	PF00397	0.600
MOD_CDC14_SPxK_1	106	109	PF00782	0.569
MOD_CDK_SPK_2	31	36	PF00069	0.573
MOD_CDK_SPxK_1	103	109	PF00069	0.572
MOD_CK1_1	115	121	PF00069	0.580
MOD_CK1_1	142	148	PF00069	0.717
MOD_CK1_1	179	185	PF00069	0.578
MOD_CK1_1	204	210	PF00069	0.671
MOD_CK1_1	223	229	PF00069	0.777
MOD_CK1_1	300	306	PF00069	0.676
MOD_CK1_1	312	318	PF00069	0.796
MOD_CK1_1	335	341	PF00069	0.664
MOD_CK1_1	392	398	PF00069	0.671
MOD_CK1_1	546	552	PF00069	0.545
MOD_CK1_1	710	716	PF00069	0.634
MOD_CK1_1	735	741	PF00069	0.651
MOD_CK1_1	84	90	PF00069	0.690
MOD_CK1_1	92	98	PF00069	0.599
MOD_CK1_1	99	105	PF00069	0.563
MOD_CK2_1	107	113	PF00069	0.683
MOD_CK2_1	248	254	PF00069	0.478
MOD_CK2_1	336	342	PF00069	0.674
MOD_CK2_1	454	460	PF00069	0.521
MOD_CK2_1	613	619	PF00069	0.470
MOD_CK2_1	643	649	PF00069	0.478
MOD_CK2_1	701	707	PF00069	0.770
MOD_CK2_1	710	716	PF00069	0.561
MOD_Cter_Amidation	164	167	PF01082	0.697
MOD_GlcNHglycan	117	120	PF01048	0.622
MOD_GlcNHglycan	172	175	PF01048	0.666
MOD_GlcNHglycan	195	198	PF01048	0.671
MOD_GlcNHglycan	204	207	PF01048	0.481
MOD_GlcNHglycan	210	213	PF01048	0.616
MOD_GlcNHglycan	222	226	PF01048	0.752
MOD_GlcNHglycan	267	270	PF01048	0.462
MOD_GlcNHglycan	299	302	PF01048	0.609
MOD_GlcNHglycan	320	323	PF01048	0.593
MOD_GlcNHglycan	369	372	PF01048	0.716
MOD_GlcNHglycan	380	383	PF01048	0.636
MOD_GlcNHglycan	391	394	PF01048	0.551
MOD_GlcNHglycan	479	482	PF01048	0.422
MOD_GlcNHglycan	518	521	PF01048	0.446
MOD_GlcNHglycan	544	548	PF01048	0.481
MOD_GlcNHglycan	569	572	PF01048	0.412
MOD_GlcNHglycan	684	687	PF01048	0.682
MOD_GlcNHglycan	703	706	PF01048	0.547
MOD_GlcNHglycan	721	724	PF01048	0.613
MOD_GlcNHglycan	734	737	PF01048	0.626
MOD_GlcNHglycan	745	748	PF01048	0.541
MOD_GlcNHglycan	88	91	PF01048	0.776
MOD_GlcNHglycan	98	101	PF01048	0.652
MOD_GSK3_1	103	110	PF00069	0.548
MOD_GSK3_1	135	142	PF00069	0.641
MOD_GSK3_1	189	196	PF00069	0.619
MOD_GSK3_1	197	204	PF00069	0.732
MOD_GSK3_1	217	224	PF00069	0.738
MOD_GSK3_1	248	255	PF00069	0.448
MOD_GSK3_1	290	297	PF00069	0.647
MOD_GSK3_1	300	307	PF00069	0.600
MOD_GSK3_1	332	339	PF00069	0.643
MOD_GSK3_1	363	370	PF00069	0.643
MOD_GSK3_1	373	380	PF00069	0.545
MOD_GSK3_1	387	394	PF00069	0.643
MOD_GSK3_1	42	49	PF00069	0.631
MOD_GSK3_1	511	518	PF00069	0.419
MOD_GSK3_1	529	536	PF00069	0.392
MOD_GSK3_1	565	572	PF00069	0.363
MOD_GSK3_1	619	626	PF00069	0.439
MOD_GSK3_1	706	713	PF00069	0.562
MOD_GSK3_1	715	722	PF00069	0.549
MOD_GSK3_1	84	91	PF00069	0.684
MOD_GSK3_1	92	99	PF00069	0.640
MOD_N-GLC_1	149	154	PF02516	0.626
MOD_N-GLC_1	176	181	PF02516	0.645
MOD_N-GLC_1	682	687	PF02516	0.600
MOD_N-GLC_1	714	719	PF02516	0.570
MOD_N-GLC_2	264	266	PF02516	0.419
MOD_NEK2_1	139	144	PF00069	0.609
MOD_NEK2_1	193	198	PF00069	0.735
MOD_NEK2_1	340	345	PF00069	0.541
MOD_NEK2_1	515	520	PF00069	0.342
MOD_NEK2_1	534	539	PF00069	0.535
MOD_NEK2_1	569	574	PF00069	0.411
MOD_NEK2_1	591	596	PF00069	0.455
MOD_NEK2_1	629	634	PF00069	0.375
MOD_PIKK_1	229	235	PF00454	0.584
MOD_PIKK_1	327	333	PF00454	0.681
MOD_PIKK_1	503	509	PF00454	0.459
MOD_PIKK_1	529	535	PF00454	0.389
MOD_PK_1	332	338	PF00069	0.600
MOD_PKA_1	168	174	PF00069	0.678
MOD_PKA_2	108	114	PF00069	0.571
MOD_PKA_2	140	146	PF00069	0.723
MOD_PKA_2	168	174	PF00069	0.667
MOD_PKA_2	201	207	PF00069	0.665
MOD_PKA_2	649	655	PF00069	0.457
MOD_PKA_2	66	72	PF00069	0.605
MOD_PKA_2	707	713	PF00069	0.632
MOD_PKB_1	166	174	PF00069	0.682
MOD_PKB_1	730	738	PF00069	0.594
MOD_Plk_1	176	182	PF00069	0.634
MOD_Plk_1	189	195	PF00069	0.530
MOD_Plk_1	373	379	PF00069	0.609
MOD_Plk_1	475	481	PF00069	0.432
MOD_Plk_1	706	712	PF00069	0.701
MOD_Plk_4	142	148	PF00069	0.536
MOD_Plk_4	252	258	PF00069	0.396
MOD_Plk_4	42	48	PF00069	0.562
MOD_Plk_4	511	517	PF00069	0.336
MOD_ProDKin_1	112	118	PF00069	0.586
MOD_ProDKin_1	154	160	PF00069	0.614
MOD_ProDKin_1	179	185	PF00069	0.602
MOD_ProDKin_1	226	232	PF00069	0.577
MOD_ProDKin_1	248	254	PF00069	0.478
MOD_ProDKin_1	294	300	PF00069	0.685
MOD_ProDKin_1	31	37	PF00069	0.610
MOD_ProDKin_1	346	352	PF00069	0.560
MOD_ProDKin_1	420	426	PF00069	0.585
MOD_ProDKin_1	546	552	PF00069	0.477
MOD_ProDKin_1	619	625	PF00069	0.434
MOD_ProDKin_1	684	690	PF00069	0.637
MOD_ProDKin_1	99	105	PF00069	0.675
TRG_DiLeu_BaEn_1	431	436	PF01217	0.482
TRG_DiLeu_BaLyEn_6	580	585	PF01217	0.457
TRG_DiLeu_LyEn_5	431	436	PF01217	0.432
TRG_ENDOCYTIC_2	275	278	PF00928	0.466
TRG_ENDOCYTIC_2	399	402	PF00928	0.641
TRG_ENDOCYTIC_2	448	451	PF00928	0.428
TRG_ENDOCYTIC_2	524	527	PF00928	0.409
TRG_ENDOCYTIC_2	630	633	PF00928	0.376
TRG_ENDOCYTIC_2	642	645	PF00928	0.464
TRG_ER_diArg_1	166	169	PF00400	0.676
TRG_ER_diArg_1	2	5	PF00400	0.605
TRG_ER_diArg_1	278	281	PF00400	0.545
TRG_ER_diArg_1	432	434	PF00400	0.446
TRG_ER_diArg_1	50	53	PF00400	0.688
TRG_ER_diArg_1	595	598	PF00400	0.365
TRG_ER_diArg_1	62	65	PF00400	0.564
TRG_Pf-PMV_PEXEL_1	36	41	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	540	544	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	627	631	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYY8	Leptomonas seymouri	51%	91%
A0A3S7WYC3	Leishmania donovani	99%	100%
A4HDI0	Leishmania braziliensis	78%	100%
E9AWW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QAK9	Leishmania major	92%	100%