Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0V5_LEIIN

TriTrypDb:

LINF_240017000

Length:

1279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0V5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0V5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1047	1051	PF00656	0.721
CLV_C14_Caspase3-7	357	361	PF00656	0.691
CLV_NRD_NRD_1	1263	1265	PF00675	0.455
CLV_NRD_NRD_1	273	275	PF00675	0.678
CLV_NRD_NRD_1	355	357	PF00675	0.536
CLV_NRD_NRD_1	448	450	PF00675	0.578
CLV_NRD_NRD_1	476	478	PF00675	0.653
CLV_NRD_NRD_1	540	542	PF00675	0.570
CLV_NRD_NRD_1	575	577	PF00675	0.585
CLV_NRD_NRD_1	682	684	PF00675	0.638
CLV_NRD_NRD_1	695	697	PF00675	0.603
CLV_NRD_NRD_1	8	10	PF00675	0.493
CLV_NRD_NRD_1	968	970	PF00675	0.431
CLV_PCSK_KEX2_1	1253	1255	PF00082	0.594
CLV_PCSK_KEX2_1	355	357	PF00082	0.533
CLV_PCSK_KEX2_1	448	450	PF00082	0.578
CLV_PCSK_KEX2_1	476	478	PF00082	0.653
CLV_PCSK_KEX2_1	540	542	PF00082	0.569
CLV_PCSK_KEX2_1	575	577	PF00082	0.585
CLV_PCSK_KEX2_1	682	684	PF00082	0.638
CLV_PCSK_KEX2_1	694	696	PF00082	0.612
CLV_PCSK_KEX2_1	7	9	PF00082	0.498
CLV_PCSK_KEX2_1	778	780	PF00082	0.532
CLV_PCSK_KEX2_1	968	970	PF00082	0.431
CLV_PCSK_PC1ET2_1	1253	1255	PF00082	0.594
CLV_PCSK_PC1ET2_1	694	696	PF00082	0.625
CLV_PCSK_PC1ET2_1	778	780	PF00082	0.525
CLV_PCSK_SKI1_1	1088	1092	PF00082	0.465
CLV_PCSK_SKI1_1	266	270	PF00082	0.503
CLV_PCSK_SKI1_1	28	32	PF00082	0.505
CLV_PCSK_SKI1_1	366	370	PF00082	0.757
CLV_PCSK_SKI1_1	414	418	PF00082	0.678
CLV_PCSK_SKI1_1	449	453	PF00082	0.569
CLV_PCSK_SKI1_1	503	507	PF00082	0.618
CLV_PCSK_SKI1_1	543	547	PF00082	0.516
CLV_PCSK_SKI1_1	578	582	PF00082	0.636
CLV_PCSK_SKI1_1	812	816	PF00082	0.630
CLV_PCSK_SKI1_1	828	832	PF00082	0.547
DEG_APCC_DBOX_1	811	819	PF00400	0.622
DEG_Nend_UBRbox_4	1	3	PF02207	0.520
DEG_SPOP_SBC_1	636	640	PF00917	0.579
DEG_SPOP_SBC_1	821	825	PF00917	0.688
DOC_ANK_TNKS_1	904	911	PF00023	0.500
DOC_CDC14_PxL_1	20	28	PF14671	0.495
DOC_CKS1_1	873	878	PF01111	0.460
DOC_MAPK_gen_1	182	191	PF00069	0.720
DOC_MAPK_gen_1	575	581	PF00069	0.593
DOC_MAPK_gen_1	682	690	PF00069	0.479
DOC_MAPK_HePTP_8	680	692	PF00069	0.606
DOC_MAPK_MEF2A_6	22	31	PF00069	0.497
DOC_MAPK_MEF2A_6	667	675	PF00069	0.639
DOC_MAPK_MEF2A_6	683	692	PF00069	0.362
DOC_MAPK_MEF2A_6	866	873	PF00069	0.538
DOC_PP2B_LxvP_1	452	455	PF13499	0.571
DOC_PP2B_LxvP_1	634	637	PF13499	0.484
DOC_PP2B_LxvP_1	742	745	PF13499	0.718
DOC_PP2B_LxvP_1	840	843	PF13499	0.628
DOC_PP4_FxxP_1	364	367	PF00568	0.613
DOC_USP7_MATH_1	1034	1038	PF00917	0.787
DOC_USP7_MATH_1	1125	1129	PF00917	0.719
DOC_USP7_MATH_1	173	177	PF00917	0.658
DOC_USP7_MATH_1	203	207	PF00917	0.691
DOC_USP7_MATH_1	260	264	PF00917	0.624
DOC_USP7_MATH_1	32	36	PF00917	0.508
DOC_USP7_MATH_1	354	358	PF00917	0.697
DOC_USP7_MATH_1	457	461	PF00917	0.418
DOC_USP7_MATH_1	480	484	PF00917	0.671
DOC_USP7_MATH_1	637	641	PF00917	0.634
DOC_USP7_MATH_1	644	648	PF00917	0.603
DOC_USP7_MATH_1	699	703	PF00917	0.682
DOC_USP7_MATH_1	820	824	PF00917	0.741
DOC_USP7_MATH_1	830	834	PF00917	0.668
DOC_USP7_UBL2_3	390	394	PF12436	0.526
DOC_WW_Pin1_4	1121	1126	PF00397	0.780
DOC_WW_Pin1_4	1145	1150	PF00397	0.757
DOC_WW_Pin1_4	169	174	PF00397	0.723
DOC_WW_Pin1_4	258	263	PF00397	0.691
DOC_WW_Pin1_4	30	35	PF00397	0.505
DOC_WW_Pin1_4	800	805	PF00397	0.624
DOC_WW_Pin1_4	872	877	PF00397	0.464
DOC_WW_Pin1_4	88	93	PF00397	0.506
DOC_WW_Pin1_4	995	1000	PF00397	0.475
LIG_14-3-3_CanoR_1	1099	1109	PF00244	0.769
LIG_14-3-3_CanoR_1	1162	1168	PF00244	0.631
LIG_14-3-3_CanoR_1	123	128	PF00244	0.668
LIG_14-3-3_CanoR_1	414	423	PF00244	0.685
LIG_14-3-3_CanoR_1	543	549	PF00244	0.657
LIG_14-3-3_CanoR_1	667	671	PF00244	0.642
LIG_14-3-3_CanoR_1	779	784	PF00244	0.581
LIG_14-3-3_CanoR_1	790	798	PF00244	0.584
LIG_BIR_III_4	1048	1052	PF00653	0.662
LIG_BIR_III_4	660	664	PF00653	0.706
LIG_CSL_BTD_1	634	637	PF09270	0.484
LIG_CtBP_PxDLS_1	1054	1058	PF00389	0.522
LIG_CtBP_PxDLS_1	346	350	PF00389	0.761
LIG_deltaCOP1_diTrp_1	391	396	PF00928	0.445
LIG_deltaCOP1_diTrp_1	519	527	PF00928	0.630
LIG_eIF4E_1	1052	1058	PF01652	0.547
LIG_FHA_1	1082	1088	PF00498	0.604
LIG_FHA_1	1169	1175	PF00498	0.619
LIG_FHA_1	1211	1217	PF00498	0.748
LIG_FHA_1	238	244	PF00498	0.519
LIG_FHA_1	267	273	PF00498	0.654
LIG_FHA_1	382	388	PF00498	0.600
LIG_FHA_1	544	550	PF00498	0.615
LIG_FHA_1	772	778	PF00498	0.671
LIG_FHA_1	79	85	PF00498	0.535
LIG_FHA_1	95	101	PF00498	0.519
LIG_FHA_2	1133	1139	PF00498	0.625
LIG_FHA_2	332	338	PF00498	0.653
LIG_FHA_2	376	382	PF00498	0.686
LIG_FHA_2	703	709	PF00498	0.544
LIG_FHA_2	801	807	PF00498	0.612
LIG_GBD_Chelix_1	1018	1026	PF00786	0.580
LIG_GBD_Chelix_1	1271	1279	PF00786	0.451
LIG_HP1_1	999	1003	PF01393	0.481
LIG_LIR_Apic_2	110	116	PF02991	0.593
LIG_LIR_Apic_2	1175	1181	PF02991	0.729
LIG_LIR_Apic_2	362	367	PF02991	0.609
LIG_LIR_Apic_2	892	897	PF02991	0.632
LIG_LIR_Gen_1	186	195	PF02991	0.651
LIG_LIR_Gen_1	399	408	PF02991	0.497
LIG_LIR_Gen_1	460	470	PF02991	0.404
LIG_LIR_Gen_1	705	711	PF02991	0.514
LIG_LIR_Gen_1	835	845	PF02991	0.717
LIG_LIR_Gen_1	916	926	PF02991	0.406
LIG_LIR_Nem_3	1050	1055	PF02991	0.671
LIG_LIR_Nem_3	1073	1079	PF02991	0.620
LIG_LIR_Nem_3	186	191	PF02991	0.653
LIG_LIR_Nem_3	295	299	PF02991	0.539
LIG_LIR_Nem_3	391	396	PF02991	0.451
LIG_LIR_Nem_3	399	405	PF02991	0.453
LIG_LIR_Nem_3	460	466	PF02991	0.396
LIG_LIR_Nem_3	521	527	PF02991	0.600
LIG_LIR_Nem_3	669	673	PF02991	0.503
LIG_LIR_Nem_3	705	710	PF02991	0.524
LIG_LIR_Nem_3	835	840	PF02991	0.742
LIG_LIR_Nem_3	916	921	PF02991	0.423
LIG_LYPXL_yS_3	670	673	PF13949	0.483
LIG_NRBOX	55	61	PF00104	0.462
LIG_NRBOX	761	767	PF00104	0.595
LIG_PCNA_PIPBox_1	605	614	PF02747	0.506
LIG_PCNA_yPIPBox_3	603	612	PF02747	0.510
LIG_PTB_Apo_2	231	238	PF02174	0.475
LIG_PTB_Apo_2	580	587	PF02174	0.509
LIG_PTB_Phospho_1	580	586	PF10480	0.511
LIG_Rb_LxCxE_1	705	723	PF01857	0.523
LIG_REV1ctd_RIR_1	597	607	PF16727	0.656
LIG_SH2_CRK	188	192	PF00017	0.799
LIG_SH2_CRK	296	300	PF00017	0.439
LIG_SH2_CRK	463	467	PF00017	0.454
LIG_SH2_CRK	586	590	PF00017	0.487
LIG_SH2_CRK	894	898	PF00017	0.563
LIG_SH2_GRB2like	877	880	PF00017	0.547
LIG_SH2_NCK_1	402	406	PF00017	0.430
LIG_SH2_NCK_1	894	898	PF00017	0.635
LIG_SH2_PTP2	1052	1055	PF00017	0.641
LIG_SH2_PTP2	918	921	PF00017	0.400
LIG_SH2_SRC	1052	1055	PF00017	0.641
LIG_SH2_SRC	221	224	PF00017	0.628
LIG_SH2_STAP1	402	406	PF00017	0.430
LIG_SH2_STAP1	586	590	PF00017	0.497
LIG_SH2_STAP1	707	711	PF00017	0.460
LIG_SH2_STAT3	611	614	PF00017	0.522
LIG_SH2_STAT5	1004	1007	PF00017	0.500
LIG_SH2_STAT5	1052	1055	PF00017	0.641
LIG_SH2_STAT5	107	110	PF00017	0.411
LIG_SH2_STAT5	113	116	PF00017	0.483
LIG_SH2_STAT5	1191	1194	PF00017	0.516
LIG_SH2_STAT5	221	224	PF00017	0.599
LIG_SH2_STAT5	236	239	PF00017	0.399
LIG_SH2_STAT5	837	840	PF00017	0.741
LIG_SH2_STAT5	877	880	PF00017	0.475
LIG_SH2_STAT5	918	921	PF00017	0.400
LIG_SH3_3	210	216	PF00018	0.688
LIG_SH3_3	245	251	PF00018	0.603
LIG_SH3_3	501	507	PF00018	0.786
LIG_SH3_3	546	552	PF00018	0.625
LIG_SH3_3	586	592	PF00018	0.498
LIG_SH3_3	624	630	PF00018	0.567
LIG_SH3_3	716	722	PF00018	0.525
LIG_SH3_3	870	876	PF00018	0.435
LIG_SH3_3	940	946	PF00018	0.667
LIG_SUMO_SIM_anti_2	238	245	PF11976	0.472
LIG_SUMO_SIM_anti_2	577	583	PF11976	0.476
LIG_SUMO_SIM_anti_2	687	693	PF11976	0.464
LIG_SUMO_SIM_anti_2	997	1004	PF11976	0.427
LIG_SUMO_SIM_par_1	107	112	PF11976	0.370
LIG_SUMO_SIM_par_1	1170	1175	PF11976	0.615
LIG_SUMO_SIM_par_1	238	245	PF11976	0.467
LIG_SUMO_SIM_par_1	58	64	PF11976	0.460
LIG_SUMO_SIM_par_1	687	693	PF11976	0.429
LIG_SUMO_SIM_par_1	96	101	PF11976	0.581
LIG_TRAF2_1	1118	1121	PF00917	0.752
LIG_TRAF2_1	804	807	PF00917	0.471
LIG_TRAF2_1	926	929	PF00917	0.417
LIG_UBA3_1	1245	1253	PF00899	0.456
LIG_UBA3_1	386	394	PF00899	0.537
MOD_CDK_SPK_2	1121	1126	PF00069	0.703
MOD_CK1_1	278	284	PF00069	0.797
MOD_CK1_1	422	428	PF00069	0.793
MOD_CK1_1	443	449	PF00069	0.566
MOD_CK1_1	547	553	PF00069	0.645
MOD_CK1_1	639	645	PF00069	0.586
MOD_CK1_1	702	708	PF00069	0.586
MOD_CK1_1	782	788	PF00069	0.580
MOD_CK1_1	824	830	PF00069	0.722
MOD_CK1_1	91	97	PF00069	0.470
MOD_CK1_1	955	961	PF00069	0.599
MOD_CK2_1	1034	1040	PF00069	0.656
MOD_CK2_1	165	171	PF00069	0.703
MOD_CK2_1	644	650	PF00069	0.594
MOD_CK2_1	702	708	PF00069	0.548
MOD_CK2_1	800	806	PF00069	0.610
MOD_CK2_1	944	950	PF00069	0.730
MOD_Cter_Amidation	446	449	PF01082	0.557
MOD_GlcNHglycan	1044	1047	PF01048	0.775
MOD_GlcNHglycan	1163	1166	PF01048	0.732
MOD_GlcNHglycan	1227	1231	PF01048	0.790
MOD_GlcNHglycan	167	170	PF01048	0.728
MOD_GlcNHglycan	175	178	PF01048	0.630
MOD_GlcNHglycan	227	230	PF01048	0.582
MOD_GlcNHglycan	277	280	PF01048	0.657
MOD_GlcNHglycan	282	285	PF01048	0.742
MOD_GlcNHglycan	318	321	PF01048	0.490
MOD_GlcNHglycan	34	37	PF01048	0.498
MOD_GlcNHglycan	424	427	PF01048	0.805
MOD_GlcNHglycan	432	435	PF01048	0.675
MOD_GlcNHglycan	442	445	PF01048	0.469
MOD_GlcNHglycan	482	485	PF01048	0.631
MOD_GlcNHglycan	508	511	PF01048	0.681
MOD_GlcNHglycan	639	642	PF01048	0.692
MOD_GlcNHglycan	701	704	PF01048	0.647
MOD_GlcNHglycan	828	831	PF01048	0.761
MOD_GlcNHglycan	832	835	PF01048	0.698
MOD_GlcNHglycan	855	859	PF01048	0.791
MOD_GlcNHglycan	901	904	PF01048	0.744
MOD_GlcNHglycan	952	955	PF01048	0.736
MOD_GSK3_1	1121	1128	PF00069	0.774
MOD_GSK3_1	1157	1164	PF00069	0.773
MOD_GSK3_1	1170	1177	PF00069	0.607
MOD_GSK3_1	156	163	PF00069	0.620
MOD_GSK3_1	165	172	PF00069	0.662
MOD_GSK3_1	173	180	PF00069	0.534
MOD_GSK3_1	235	242	PF00069	0.567
MOD_GSK3_1	480	487	PF00069	0.706
MOD_GSK3_1	543	550	PF00069	0.622
MOD_GSK3_1	635	642	PF00069	0.510
MOD_GSK3_1	644	651	PF00069	0.606
MOD_GSK3_1	74	81	PF00069	0.535
MOD_GSK3_1	820	827	PF00069	0.641
MOD_GSK3_1	84	91	PF00069	0.474
MOD_GSK3_1	94	101	PF00069	0.559
MOD_GSK3_1	950	957	PF00069	0.579
MOD_GSK3_1	958	965	PF00069	0.501
MOD_GSK3_1	985	992	PF00069	0.618
MOD_N-GLC_1	1040	1045	PF02516	0.720
MOD_N-GLC_1	648	653	PF02516	0.634
MOD_N-GLC_2	793	795	PF02516	0.395
MOD_N-GLC_2	980	982	PF02516	0.468
MOD_NEK2_1	1081	1086	PF00069	0.531
MOD_NEK2_1	109	114	PF00069	0.432
MOD_NEK2_1	237	242	PF00069	0.467
MOD_NEK2_1	406	411	PF00069	0.682
MOD_NEK2_1	430	435	PF00069	0.553
MOD_NEK2_1	456	461	PF00069	0.483
MOD_NEK2_1	466	471	PF00069	0.479
MOD_NEK2_1	544	549	PF00069	0.552
MOD_NEK2_1	594	599	PF00069	0.517
MOD_NEK2_1	61	66	PF00069	0.499
MOD_NEK2_1	735	740	PF00069	0.691
MOD_NEK2_2	177	182	PF00069	0.576
MOD_PIKK_1	302	308	PF00454	0.521
MOD_PIKK_1	39	45	PF00454	0.518
MOD_PIKK_1	496	502	PF00454	0.669
MOD_PIKK_1	750	756	PF00454	0.694
MOD_PIKK_1	896	902	PF00454	0.795
MOD_PIKK_1	985	991	PF00454	0.648
MOD_PK_1	728	734	PF00069	0.636
MOD_PK_1	79	85	PF00069	0.502
MOD_PKA_1	7	13	PF00069	0.492
MOD_PKA_2	1027	1033	PF00069	0.701
MOD_PKA_2	1098	1104	PF00069	0.727
MOD_PKA_2	1107	1113	PF00069	0.679
MOD_PKA_2	1125	1131	PF00069	0.522
MOD_PKA_2	1161	1167	PF00069	0.760
MOD_PKA_2	1168	1174	PF00069	0.637
MOD_PKA_2	189	195	PF00069	0.604
MOD_PKA_2	354	360	PF00069	0.691
MOD_PKA_2	574	580	PF00069	0.638
MOD_PKA_2	666	672	PF00069	0.635
MOD_PKA_2	7	13	PF00069	0.492
MOD_PKA_2	789	795	PF00069	0.512
MOD_PKB_1	541	549	PF00069	0.634
MOD_Plk_1	109	115	PF00069	0.436
MOD_Plk_1	1174	1180	PF00069	0.734
MOD_Plk_1	369	375	PF00069	0.770
MOD_Plk_1	735	741	PF00069	0.569
MOD_Plk_2-3	1170	1176	PF00069	0.612
MOD_Plk_4	109	115	PF00069	0.499
MOD_Plk_4	1174	1180	PF00069	0.600
MOD_Plk_4	204	210	PF00069	0.682
MOD_Plk_4	239	245	PF00069	0.536
MOD_Plk_4	382	388	PF00069	0.633
MOD_Plk_4	466	472	PF00069	0.486
MOD_Plk_4	544	550	PF00069	0.622
MOD_Plk_4	79	85	PF00069	0.533
MOD_Plk_4	889	895	PF00069	0.563
MOD_Plk_4	94	100	PF00069	0.556
MOD_Plk_4	958	964	PF00069	0.555
MOD_ProDKin_1	1121	1127	PF00069	0.781
MOD_ProDKin_1	1145	1151	PF00069	0.755
MOD_ProDKin_1	169	175	PF00069	0.724
MOD_ProDKin_1	258	264	PF00069	0.683
MOD_ProDKin_1	30	36	PF00069	0.506
MOD_ProDKin_1	800	806	PF00069	0.623
MOD_ProDKin_1	872	878	PF00069	0.459
MOD_ProDKin_1	88	94	PF00069	0.504
MOD_ProDKin_1	995	1001	PF00069	0.465
MOD_SUMO_rev_2	560	569	PF00179	0.627
TRG_DiLeu_BaEn_1	706	711	PF01217	0.445
TRG_ENDOCYTIC_2	1052	1055	PF00928	0.641
TRG_ENDOCYTIC_2	1076	1079	PF00928	0.652
TRG_ENDOCYTIC_2	188	191	PF00928	0.664
TRG_ENDOCYTIC_2	296	299	PF00928	0.442
TRG_ENDOCYTIC_2	402	405	PF00928	0.472
TRG_ENDOCYTIC_2	463	466	PF00928	0.450
TRG_ENDOCYTIC_2	586	589	PF00928	0.498
TRG_ENDOCYTIC_2	670	673	PF00928	0.483
TRG_ENDOCYTIC_2	707	710	PF00928	0.510
TRG_ENDOCYTIC_2	837	840	PF00928	0.741
TRG_ENDOCYTIC_2	918	921	PF00928	0.400
TRG_ER_diArg_1	355	358	PF00400	0.532
TRG_ER_diArg_1	475	477	PF00400	0.612
TRG_ER_diArg_1	540	542	PF00400	0.573
TRG_ER_diArg_1	575	578	PF00400	0.691
TRG_ER_diArg_1	7	9	PF00400	0.498
TRG_ER_diArg_1	968	971	PF00400	0.436
TRG_NLS_Bipartite_1	682	698	PF00514	0.536
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.672
TRG_Pf-PMV_PEXEL_1	449	453	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I480	Leptomonas seymouri	36%	100%
A0A3S7WYG5	Leishmania donovani	99%	100%
A4HDH4	Leishmania braziliensis	68%	99%
E9AWV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QAL5	Leishmania major	88%	100%