Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0V0_LEIIN

TriTrypDb:

LINF_240016500

Length:

802

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0V0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0V0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.509
CLV_C14_Caspase3-7	3	7	PF00656	0.509
CLV_C14_Caspase3-7	324	328	PF00656	0.557
CLV_C14_Caspase3-7	691	695	PF00656	0.476
CLV_NRD_NRD_1	191	193	PF00675	0.751
CLV_NRD_NRD_1	219	221	PF00675	0.724
CLV_NRD_NRD_1	293	295	PF00675	0.785
CLV_NRD_NRD_1	311	313	PF00675	0.668
CLV_NRD_NRD_1	57	59	PF00675	0.749
CLV_NRD_NRD_1	67	69	PF00675	0.708
CLV_PCSK_KEX2_1	191	193	PF00082	0.749
CLV_PCSK_KEX2_1	292	294	PF00082	0.746
CLV_PCSK_KEX2_1	311	313	PF00082	0.650
CLV_PCSK_KEX2_1	57	59	PF00082	0.749
CLV_PCSK_KEX2_1	67	69	PF00082	0.708
CLV_PCSK_KEX2_1	727	729	PF00082	0.794
CLV_PCSK_PC1ET2_1	727	729	PF00082	0.687
CLV_PCSK_PC7_1	63	69	PF00082	0.732
DEG_SPOP_SBC_1	328	332	PF00917	0.527
DOC_ANK_TNKS_1	376	383	PF00023	0.499
DOC_CKS1_1	369	374	PF01111	0.519
DOC_CKS1_1	99	104	PF01111	0.552
DOC_CYCLIN_yCln2_LP_2	516	522	PF00134	0.422
DOC_CYCLIN_yCln2_LP_2	787	793	PF00134	0.649
DOC_MAPK_gen_1	292	303	PF00069	0.496
DOC_MAPK_gen_1	389	396	PF00069	0.528
DOC_MAPK_gen_1	473	480	PF00069	0.458
DOC_MAPK_MEF2A_6	786	795	PF00069	0.650
DOC_PP2B_LxvP_1	90	93	PF13499	0.537
DOC_PP4_FxxP_1	350	353	PF00568	0.528
DOC_USP7_MATH_1	158	162	PF00917	0.545
DOC_USP7_MATH_1	180	184	PF00917	0.539
DOC_USP7_MATH_1	187	191	PF00917	0.616
DOC_USP7_MATH_1	328	332	PF00917	0.504
DOC_USP7_MATH_1	357	361	PF00917	0.512
DOC_USP7_MATH_1	418	422	PF00917	0.510
DOC_USP7_MATH_1	617	621	PF00917	0.510
DOC_USP7_MATH_1	636	640	PF00917	0.459
DOC_USP7_MATH_1	735	739	PF00917	0.476
DOC_WW_Pin1_4	19	24	PF00397	0.520
DOC_WW_Pin1_4	278	283	PF00397	0.544
DOC_WW_Pin1_4	28	33	PF00397	0.495
DOC_WW_Pin1_4	286	291	PF00397	0.479
DOC_WW_Pin1_4	368	373	PF00397	0.528
DOC_WW_Pin1_4	384	389	PF00397	0.491
DOC_WW_Pin1_4	396	401	PF00397	0.444
DOC_WW_Pin1_4	432	437	PF00397	0.529
DOC_WW_Pin1_4	515	520	PF00397	0.449
DOC_WW_Pin1_4	581	586	PF00397	0.465
DOC_WW_Pin1_4	587	592	PF00397	0.450
DOC_WW_Pin1_4	731	736	PF00397	0.531
DOC_WW_Pin1_4	742	747	PF00397	0.441
DOC_WW_Pin1_4	77	82	PF00397	0.485
DOC_WW_Pin1_4	95	100	PF00397	0.494
LIG_14-3-3_CanoR_1	218	224	PF00244	0.480
LIG_14-3-3_CanoR_1	559	565	PF00244	0.519
LIG_14-3-3_CanoR_1	82	90	PF00244	0.528
LIG_14-3-3_CanoR_1	94	99	PF00244	0.539
LIG_BIR_II_1	1	5	PF00653	0.535
LIG_BRCT_BRCA1_1	749	753	PF00533	0.484
LIG_FHA_1	174	180	PF00498	0.520
LIG_FHA_1	368	374	PF00498	0.471
LIG_FHA_1	654	660	PF00498	0.409
LIG_FHA_1	700	706	PF00498	0.518
LIG_FHA_2	129	135	PF00498	0.529
LIG_FHA_2	268	274	PF00498	0.505
LIG_FHA_2	319	325	PF00498	0.463
LIG_FHA_2	385	391	PF00498	0.578
LIG_FHA_2	689	695	PF00498	0.476
LIG_FHA_2	83	89	PF00498	0.583
LIG_Integrin_isoDGR_2	422	424	PF01839	0.654
LIG_Integrin_RGD_1	271	273	PF01839	0.727
LIG_LIR_Apic_2	276	282	PF02991	0.560
LIG_LIR_Gen_1	399	408	PF02991	0.520
LIG_LIR_Gen_1	598	607	PF02991	0.519
LIG_LIR_Gen_1	87	96	PF02991	0.504
LIG_LIR_Nem_3	245	251	PF02991	0.429
LIG_LIR_Nem_3	31	37	PF02991	0.486
LIG_LIR_Nem_3	399	404	PF02991	0.523
LIG_LIR_Nem_3	506	511	PF02991	0.482
LIG_LIR_Nem_3	575	579	PF02991	0.440
LIG_LIR_Nem_3	598	604	PF02991	0.519
LIG_LIR_Nem_3	750	755	PF02991	0.435
LIG_LIR_Nem_3	87	92	PF02991	0.523
LIG_LYPXL_yS_3	789	792	PF13949	0.713
LIG_MYND_1	23	27	PF01753	0.566
LIG_MYND_1	282	286	PF01753	0.540
LIG_MYND_1	362	366	PF01753	0.465
LIG_Pex14_1	545	549	PF04695	0.463
LIG_PTB_Apo_2	600	607	PF02174	0.481
LIG_SH2_CRK	248	252	PF00017	0.501
LIG_SH2_CRK	279	283	PF00017	0.543
LIG_SH2_CRK	601	605	PF00017	0.519
LIG_SH2_CRK	685	689	PF00017	0.497
LIG_SH2_GRB2like	601	604	PF00017	0.483
LIG_SH2_NCK_1	522	526	PF00017	0.421
LIG_SH2_NCK_1	601	605	PF00017	0.481
LIG_SH2_SRC	515	518	PF00017	0.522
LIG_SH2_STAP1	701	705	PF00017	0.385
LIG_SH2_STAT5	241	244	PF00017	0.522
LIG_SH2_STAT5	255	258	PF00017	0.400
LIG_SH2_STAT5	401	404	PF00017	0.466
LIG_SH2_STAT5	413	416	PF00017	0.468
LIG_SH2_STAT5	487	490	PF00017	0.451
LIG_SH2_STAT5	509	512	PF00017	0.466
LIG_SH2_STAT5	515	518	PF00017	0.470
LIG_SH2_STAT5	549	552	PF00017	0.468
LIG_SH2_STAT5	646	649	PF00017	0.554
LIG_SH2_STAT5	653	656	PF00017	0.447
LIG_SH2_STAT5	701	704	PF00017	0.460
LIG_SH3_1	279	285	PF00018	0.640
LIG_SH3_1	359	365	PF00018	0.512
LIG_SH3_1	67	73	PF00018	0.583
LIG_SH3_2	282	287	PF14604	0.538
LIG_SH3_2	372	377	PF14604	0.585
LIG_SH3_3	248	254	PF00018	0.426
LIG_SH3_3	26	32	PF00018	0.530
LIG_SH3_3	279	285	PF00018	0.644
LIG_SH3_3	298	304	PF00018	0.521
LIG_SH3_3	359	365	PF00018	0.510
LIG_SH3_3	366	372	PF00018	0.526
LIG_SH3_3	579	585	PF00018	0.533
LIG_SH3_3	67	73	PF00018	0.583
LIG_SH3_3	790	796	PF00018	0.647
LIG_SH3_3	96	102	PF00018	0.571
LIG_SH3_CIN85_PxpxPR_1	372	377	PF14604	0.501
LIG_SUMO_SIM_anti_2	313	327	PF11976	0.479
LIG_SUMO_SIM_par_1	789	794	PF11976	0.679
LIG_TRFH_1	685	689	PF08558	0.522
LIG_TYR_ITIM	787	792	PF00017	0.646
LIG_WRC_WIRS_1	573	578	PF05994	0.527
LIG_WW_2	362	365	PF00397	0.576
LIG_WW_3	284	288	PF00397	0.728
LIG_WW_3	374	378	PF00397	0.656
MOD_CDC14_SPxK_1	289	292	PF00782	0.689
MOD_CDK_SPK_2	278	283	PF00069	0.685
MOD_CDK_SPK_2	384	389	PF00069	0.686
MOD_CDK_SPK_2	587	592	PF00069	0.499
MOD_CDK_SPK_2	77	82	PF00069	0.601
MOD_CDK_SPK_2	95	100	PF00069	0.593
MOD_CDK_SPxK_1	286	292	PF00069	0.686
MOD_CDK_SPxxK_3	286	293	PF00069	0.687
MOD_CDK_SPxxK_3	384	391	PF00069	0.683
MOD_CDK_SPxxK_3	77	84	PF00069	0.592
MOD_CK1_1	108	114	PF00069	0.592
MOD_CK1_1	153	159	PF00069	0.827
MOD_CK1_1	183	189	PF00069	0.737
MOD_CK1_1	208	214	PF00069	0.563
MOD_CK1_1	219	225	PF00069	0.660
MOD_CK1_1	313	319	PF00069	0.642
MOD_CK1_1	330	336	PF00069	0.675
MOD_CK1_1	340	346	PF00069	0.651
MOD_CK1_1	432	438	PF00069	0.689
MOD_CK1_1	584	590	PF00069	0.557
MOD_CK1_1	624	630	PF00069	0.580
MOD_CK1_1	745	751	PF00069	0.557
MOD_CK1_1	98	104	PF00069	0.670
MOD_CK2_1	128	134	PF00069	0.650
MOD_CK2_1	311	317	PF00069	0.637
MOD_CK2_1	33	39	PF00069	0.727
MOD_CK2_1	384	390	PF00069	0.739
MOD_CK2_1	735	741	PF00069	0.623
MOD_GlcNHglycan	107	110	PF01048	0.645
MOD_GlcNHglycan	153	156	PF01048	0.607
MOD_GlcNHglycan	160	163	PF01048	0.642
MOD_GlcNHglycan	168	171	PF01048	0.782
MOD_GlcNHglycan	185	188	PF01048	0.682
MOD_GlcNHglycan	207	210	PF01048	0.614
MOD_GlcNHglycan	608	611	PF01048	0.612
MOD_GlcNHglycan	619	622	PF01048	0.585
MOD_GlcNHglycan	721	724	PF01048	0.651
MOD_GlcNHglycan	729	732	PF01048	0.520
MOD_GSK3_1	183	190	PF00069	0.765
MOD_GSK3_1	19	26	PF00069	0.639
MOD_GSK3_1	201	208	PF00069	0.545
MOD_GSK3_1	243	250	PF00069	0.545
MOD_GSK3_1	274	281	PF00069	0.743
MOD_GSK3_1	295	302	PF00069	0.639
MOD_GSK3_1	311	318	PF00069	0.676
MOD_GSK3_1	353	360	PF00069	0.720
MOD_GSK3_1	396	403	PF00069	0.649
MOD_GSK3_1	533	540	PF00069	0.595
MOD_GSK3_1	606	613	PF00069	0.706
MOD_GSK3_1	617	624	PF00069	0.553
MOD_GSK3_1	706	713	PF00069	0.641
MOD_GSK3_1	727	734	PF00069	0.611
MOD_GSK3_1	94	101	PF00069	0.684
MOD_LATS_1	309	315	PF00433	0.696
MOD_N-GLC_1	4	9	PF02516	0.671
MOD_N-GLC_1	77	82	PF02516	0.676
MOD_NEK2_1	136	141	PF00069	0.612
MOD_NEK2_1	242	247	PF00069	0.511
MOD_NEK2_1	507	512	PF00069	0.569
MOD_NEK2_1	533	538	PF00069	0.567
MOD_NEK2_1	606	611	PF00069	0.606
MOD_NEK2_1	753	758	PF00069	0.350
MOD_NEK2_2	180	185	PF00069	0.655
MOD_NEK2_2	274	279	PF00069	0.689
MOD_NEK2_2	572	577	PF00069	0.532
MOD_OFUCOSY	629	635	PF10250	0.585
MOD_OFUCOSY	661	668	PF10250	0.491
MOD_OFUCOSY	703	710	PF10250	0.463
MOD_PIKK_1	108	114	PF00454	0.599
MOD_PIKK_1	173	179	PF00454	0.698
MOD_PIKK_1	337	343	PF00454	0.740
MOD_PIKK_1	537	543	PF00454	0.719
MOD_PK_1	299	305	PF00069	0.593
MOD_PKA_1	293	299	PF00069	0.603
MOD_PKA_1	311	317	PF00069	0.620
MOD_PKA_1	727	733	PF00069	0.517
MOD_PKA_2	150	156	PF00069	0.748
MOD_PKA_2	219	225	PF00069	0.654
MOD_PKA_2	267	273	PF00069	0.756
MOD_PKA_2	293	299	PF00069	0.760
MOD_PKA_2	310	316	PF00069	0.567
MOD_PKA_2	558	564	PF00069	0.735
MOD_PKA_2	610	616	PF00069	0.618
MOD_PKA_2	727	733	PF00069	0.544
MOD_PKB_1	149	157	PF00069	0.680
MOD_Plk_1	243	249	PF00069	0.525
MOD_Plk_1	274	280	PF00069	0.688
MOD_Plk_1	357	363	PF00069	0.581
MOD_Plk_2-3	118	124	PF00069	0.696
MOD_Plk_4	243	249	PF00069	0.615
MOD_Plk_4	274	280	PF00069	0.688
MOD_Plk_4	584	590	PF00069	0.561
MOD_ProDKin_1	19	25	PF00069	0.655
MOD_ProDKin_1	278	284	PF00069	0.689
MOD_ProDKin_1	28	34	PF00069	0.623
MOD_ProDKin_1	286	292	PF00069	0.599
MOD_ProDKin_1	368	374	PF00069	0.665
MOD_ProDKin_1	384	390	PF00069	0.613
MOD_ProDKin_1	396	402	PF00069	0.549
MOD_ProDKin_1	432	438	PF00069	0.664
MOD_ProDKin_1	515	521	PF00069	0.556
MOD_ProDKin_1	581	587	PF00069	0.576
MOD_ProDKin_1	731	737	PF00069	0.672
MOD_ProDKin_1	742	748	PF00069	0.544
MOD_ProDKin_1	77	83	PF00069	0.602
MOD_ProDKin_1	95	101	PF00069	0.619
MOD_SUMO_for_1	336	339	PF00179	0.662
TRG_DiLeu_BaEn_1	474	479	PF01217	0.567
TRG_DiLeu_BaLyEn_6	675	680	PF01217	0.494
TRG_ENDOCYTIC_2	248	251	PF00928	0.539
TRG_ENDOCYTIC_2	401	404	PF00928	0.579
TRG_ENDOCYTIC_2	508	511	PF00928	0.575
TRG_ENDOCYTIC_2	601	604	PF00928	0.566
TRG_ENDOCYTIC_2	685	688	PF00928	0.623
TRG_ENDOCYTIC_2	789	792	PF00928	0.645
TRG_ER_diArg_1	140	143	PF00400	0.662
TRG_ER_diArg_1	191	194	PF00400	0.701
TRG_ER_diArg_1	217	220	PF00400	0.561
TRG_ER_diArg_1	291	294	PF00400	0.684
TRG_ER_diArg_1	483	486	PF00400	0.583
TRG_ER_diArg_1	57	59	PF00400	0.696
TRG_ER_diArg_1	67	69	PF00400	0.639
TRG_ER_diArg_1	81	84	PF00400	0.555
TRG_Pf-PMV_PEXEL_1	678	683	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5I7	Leptomonas seymouri	40%	88%
A0A3Q8ICW0	Leishmania donovani	99%	100%
A4HDG9	Leishmania braziliensis	64%	100%
E9AWV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QAM0	Leishmania major	90%	100%