LeishMANIAdb
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Hypothetical predicted multipass transmembrane protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical predicted multipass transmembrane protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I0U6_LEIIN
TriTrypDb:
LINF_240016100
Length:
517

Annotations

LeishMANIAdb annotations

This highly expanded family of Kinetoplastid transporters is likely responsible for the uptake of critical nutrients. Might be a thiamine transporter if relate to human SLC35F proteins.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0016020 membrane 2 19
GO:0110165 cellular anatomical entity 1 19

Phosphorylation

Promastigote: 312

Expansion

Sequence features

A4I0U6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0U6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 174 176 PF00675 0.401
CLV_NRD_NRD_1 483 485 PF00675 0.480
CLV_PCSK_KEX2_1 176 178 PF00082 0.407
CLV_PCSK_KEX2_1 320 322 PF00082 0.499
CLV_PCSK_KEX2_1 482 484 PF00082 0.474
CLV_PCSK_PC1ET2_1 176 178 PF00082 0.418
CLV_PCSK_PC1ET2_1 320 322 PF00082 0.527
CLV_PCSK_PC1ET2_1 482 484 PF00082 0.482
CLV_PCSK_SKI1_1 122 126 PF00082 0.332
CLV_PCSK_SKI1_1 334 338 PF00082 0.366
CLV_PCSK_SKI1_1 472 476 PF00082 0.406
DEG_APCC_DBOX_1 235 243 PF00400 0.595
DEG_Nend_UBRbox_1 1 4 PF02207 0.631
DOC_CYCLIN_yCln2_LP_2 244 250 PF00134 0.730
DOC_MAPK_gen_1 175 184 PF00069 0.583
DOC_MAPK_gen_1 28 36 PF00069 0.600
DOC_MAPK_HePTP_8 386 398 PF00069 0.353
DOC_MAPK_HePTP_8 446 458 PF00069 0.433
DOC_MAPK_MEF2A_6 28 36 PF00069 0.654
DOC_MAPK_MEF2A_6 334 342 PF00069 0.565
DOC_MAPK_MEF2A_6 389 398 PF00069 0.453
DOC_MAPK_MEF2A_6 449 458 PF00069 0.433
DOC_MAPK_NFAT4_5 389 397 PF00069 0.453
DOC_PP2B_LxvP_1 244 247 PF13499 0.623
DOC_PP4_FxxP_1 203 206 PF00568 0.392
DOC_USP7_MATH_1 4 8 PF00917 0.654
DOC_USP7_MATH_1 425 429 PF00917 0.477
DOC_USP7_MATH_1 488 492 PF00917 0.713
DOC_USP7_MATH_1 70 74 PF00917 0.463
DOC_WW_Pin1_4 144 149 PF00397 0.359
DOC_WW_Pin1_4 273 278 PF00397 0.752
DOC_WW_Pin1_4 283 288 PF00397 0.713
DOC_WW_Pin1_4 309 314 PF00397 0.754
DOC_WW_Pin1_4 409 414 PF00397 0.571
LIG_14-3-3_CanoR_1 375 379 PF00244 0.417
LIG_14-3-3_CanoR_1 494 501 PF00244 0.674
LIG_14-3-3_CanoR_1 506 512 PF00244 0.667
LIG_BIR_III_2 280 284 PF00653 0.704
LIG_BIR_III_2 356 360 PF00653 0.416
LIG_BRCT_BRCA1_1 180 184 PF00533 0.441
LIG_BRCT_BRCA1_1 224 228 PF00533 0.447
LIG_BRCT_BRCA1_1 376 380 PF00533 0.387
LIG_Clathr_ClatBox_1 300 304 PF01394 0.720
LIG_eIF4E_1 121 127 PF01652 0.591
LIG_FHA_1 277 283 PF00498 0.755
LIG_FHA_1 428 434 PF00498 0.402
LIG_FHA_1 64 70 PF00498 0.500
LIG_FHA_1 80 86 PF00498 0.401
LIG_FHA_2 14 20 PF00498 0.629
LIG_GBD_Chelix_1 192 200 PF00786 0.423
LIG_GBD_Chelix_1 339 347 PF00786 0.450
LIG_GBD_Chelix_1 457 465 PF00786 0.389
LIG_LIR_Apic_2 201 206 PF02991 0.379
LIG_LIR_Gen_1 178 186 PF02991 0.544
LIG_LIR_Gen_1 187 196 PF02991 0.323
LIG_LIR_Gen_1 214 223 PF02991 0.363
LIG_LIR_Gen_1 255 261 PF02991 0.599
LIG_LIR_Gen_1 349 358 PF02991 0.471
LIG_LIR_Gen_1 384 393 PF02991 0.355
LIG_LIR_Nem_3 167 173 PF02991 0.452
LIG_LIR_Nem_3 187 191 PF02991 0.370
LIG_LIR_Nem_3 214 220 PF02991 0.353
LIG_LIR_Nem_3 255 259 PF02991 0.744
LIG_LIR_Nem_3 349 353 PF02991 0.398
LIG_LIR_Nem_3 384 388 PF02991 0.398
LIG_LIR_Nem_3 98 104 PF02991 0.534
LIG_MLH1_MIPbox_1 180 184 PF16413 0.389
LIG_NRBOX 342 348 PF00104 0.505
LIG_NRBOX 470 476 PF00104 0.660
LIG_Pex14_1 120 124 PF04695 0.629
LIG_Pex14_1 166 170 PF04695 0.481
LIG_Pex14_1 217 221 PF04695 0.362
LIG_Pex14_1 60 64 PF04695 0.362
LIG_Pex14_2 184 188 PF04695 0.478
LIG_Pex14_2 398 402 PF04695 0.452
LIG_Pex14_2 9 13 PF04695 0.657
LIG_REV1ctd_RIR_1 6 15 PF16727 0.654
LIG_SH2_CRK 101 105 PF00017 0.673
LIG_SH2_CRK 256 260 PF00017 0.602
LIG_SH2_GRB2like 407 410 PF00017 0.539
LIG_SH2_NCK_1 487 491 PF00017 0.705
LIG_SH2_SRC 238 241 PF00017 0.575
LIG_SH2_SRC 440 443 PF00017 0.469
LIG_SH2_STAT5 179 182 PF00017 0.566
LIG_SH2_STAT5 221 224 PF00017 0.414
LIG_SH2_STAT5 238 241 PF00017 0.544
LIG_SH2_STAT5 407 410 PF00017 0.568
LIG_SH3_3 113 119 PF00018 0.612
LIG_SH3_3 307 313 PF00018 0.770
LIG_SH3_3 348 354 PF00018 0.485
LIG_SH3_3 59 65 PF00018 0.456
LIG_Sin3_3 216 223 PF02671 0.509
LIG_SUMO_SIM_anti_2 427 433 PF11976 0.396
LIG_TRAF2_1 16 19 PF00917 0.681
LIG_UBA3_1 169 176 PF00899 0.546
LIG_WRC_WIRS_1 185 190 PF05994 0.393
LIG_WRC_WIRS_1 347 352 PF05994 0.452
LIG_WRC_WIRS_1 5 10 PF05994 0.609
MOD_CDK_SPK_2 283 288 PF00069 0.651
MOD_CK1_1 129 135 PF00069 0.452
MOD_CK1_1 198 204 PF00069 0.478
MOD_CK2_1 13 19 PF00069 0.620
MOD_GlcNHglycan 128 131 PF01048 0.412
MOD_GlcNHglycan 161 164 PF01048 0.495
MOD_GlcNHglycan 200 203 PF01048 0.626
MOD_GlcNHglycan 269 274 PF01048 0.551
MOD_GlcNHglycan 313 316 PF01048 0.540
MOD_GlcNHglycan 490 493 PF01048 0.501
MOD_GSK3_1 129 136 PF00069 0.439
MOD_GSK3_1 269 276 PF00069 0.781
MOD_N-GLC_1 71 76 PF02516 0.628
MOD_NEK2_1 126 131 PF00069 0.428
MOD_NEK2_1 184 189 PF00069 0.393
MOD_NEK2_1 196 201 PF00069 0.435
MOD_NEK2_1 222 227 PF00069 0.413
MOD_NEK2_1 259 264 PF00069 0.761
MOD_NEK2_1 271 276 PF00069 0.742
MOD_NEK2_1 346 351 PF00069 0.442
MOD_NEK2_1 392 397 PF00069 0.400
MOD_NEK2_1 398 403 PF00069 0.368
MOD_NEK2_1 88 93 PF00069 0.391
MOD_NEK2_2 4 9 PF00069 0.654
MOD_PIKK_1 322 328 PF00454 0.711
MOD_PIKK_1 71 77 PF00454 0.404
MOD_PKA_2 259 265 PF00069 0.761
MOD_PKA_2 27 33 PF00069 0.675
MOD_PKA_2 374 380 PF00069 0.437
MOD_PKA_2 493 499 PF00069 0.716
MOD_PKA_2 505 511 PF00069 0.720
MOD_Plk_1 441 447 PF00069 0.460
MOD_Plk_1 71 77 PF00069 0.403
MOD_Plk_4 134 140 PF00069 0.433
MOD_Plk_4 178 184 PF00069 0.522
MOD_Plk_4 222 228 PF00069 0.417
MOD_Plk_4 346 352 PF00069 0.454
MOD_Plk_4 363 369 PF00069 0.244
MOD_Plk_4 381 387 PF00069 0.375
MOD_Plk_4 398 404 PF00069 0.372
MOD_Plk_4 4 10 PF00069 0.689
MOD_Plk_4 414 420 PF00069 0.499
MOD_Plk_4 427 433 PF00069 0.355
MOD_Plk_4 79 85 PF00069 0.430
MOD_ProDKin_1 144 150 PF00069 0.358
MOD_ProDKin_1 273 279 PF00069 0.752
MOD_ProDKin_1 283 289 PF00069 0.714
MOD_ProDKin_1 309 315 PF00069 0.747
MOD_ProDKin_1 409 415 PF00069 0.573
MOD_SUMO_for_1 476 479 PF00179 0.685
TRG_ENDOCYTIC_2 101 104 PF00928 0.608
TRG_ENDOCYTIC_2 121 124 PF00928 0.612
TRG_ENDOCYTIC_2 179 182 PF00928 0.561
TRG_ENDOCYTIC_2 256 259 PF00928 0.738
TRG_ER_diArg_1 113 116 PF00400 0.635
TRG_NES_CRM1_1 345 356 PF08389 0.447

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4ILP9 Bodo saltans 21% 100%
A0A0S4J6C9 Bodo saltans 25% 100%
A0A0S4J9G3 Bodo saltans 26% 100%
A0A0S4JFU7 Bodo saltans 25% 100%
A0A1X0NW47 Trypanosomatidae 49% 99%
A0A1X0P8U7 Trypanosomatidae 26% 99%
A0A3R7KUT2 Trypanosoma rangeli 49% 100%
A0A3S5H7D1 Leishmania donovani 100% 100%
A0A422NMM7 Trypanosoma rangeli 29% 97%
A4H3M6 Leishmania braziliensis 25% 100%
A4HDG5 Leishmania braziliensis 75% 100%
D0A268 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 96%
D0A775 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9AWV0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4QAM4 Leishmania major 92% 100%
V5BAL2 Trypanosoma cruzi 53% 100%
V5C284 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS