Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0U1_LEIIN

TriTrypDb:

LINF_240015600

Length:

918

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0U1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0U1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.662
CLV_NRD_NRD_1	114	116	PF00675	0.806
CLV_NRD_NRD_1	160	162	PF00675	0.593
CLV_NRD_NRD_1	163	165	PF00675	0.597
CLV_NRD_NRD_1	283	285	PF00675	0.684
CLV_NRD_NRD_1	501	503	PF00675	0.686
CLV_NRD_NRD_1	550	552	PF00675	0.779
CLV_NRD_NRD_1	568	570	PF00675	0.522
CLV_NRD_NRD_1	615	617	PF00675	0.741
CLV_NRD_NRD_1	618	620	PF00675	0.693
CLV_PCSK_FUR_1	158	162	PF00082	0.675
CLV_PCSK_FUR_1	281	285	PF00082	0.683
CLV_PCSK_FUR_1	616	620	PF00082	0.731
CLV_PCSK_KEX2_1	114	116	PF00082	0.806
CLV_PCSK_KEX2_1	160	162	PF00082	0.588
CLV_PCSK_KEX2_1	163	165	PF00082	0.601
CLV_PCSK_KEX2_1	283	285	PF00082	0.684
CLV_PCSK_KEX2_1	617	619	PF00082	0.743
CLV_PCSK_KEX2_1	751	753	PF00082	0.513
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.743
CLV_PCSK_PC1ET2_1	751	753	PF00082	0.513
CLV_PCSK_PC7_1	156	162	PF00082	0.741
CLV_PCSK_PC7_1	613	619	PF00082	0.672
CLV_PCSK_SKI1_1	134	138	PF00082	0.717
CLV_PCSK_SKI1_1	552	556	PF00082	0.744
CLV_PCSK_SKI1_1	582	586	PF00082	0.781
CLV_PCSK_SKI1_1	676	680	PF00082	0.657
CLV_Separin_Metazoa	754	758	PF03568	0.634
DEG_APCC_DBOX_1	294	302	PF00400	0.745
DEG_APCC_DBOX_1	877	885	PF00400	0.663
DEG_SCF_FBW7_1	801	808	PF00400	0.582
DEG_SPOP_SBC_1	223	227	PF00917	0.566
DEG_SPOP_SBC_1	36	40	PF00917	0.778
DEG_SPOP_SBC_1	513	517	PF00917	0.737
DEG_SPOP_SBC_1	872	876	PF00917	0.617
DOC_CDC14_PxL_1	302	310	PF14671	0.581
DOC_CDC14_PxL_1	711	719	PF14671	0.645
DOC_CKS1_1	520	525	PF01111	0.777
DOC_CKS1_1	802	807	PF01111	0.596
DOC_CKS1_1	847	852	PF01111	0.692
DOC_CKS1_1	877	882	PF01111	0.684
DOC_CYCLIN_RxL_1	549	556	PF00134	0.716
DOC_CYCLIN_yCln2_LP_2	471	477	PF00134	0.683
DOC_CYCLIN_yCln2_LP_2	540	546	PF00134	0.774
DOC_CYCLIN_yCln2_LP_2	56	62	PF00134	0.734
DOC_CYCLIN_yCln2_LP_2	697	703	PF00134	0.810
DOC_MAPK_MEF2A_6	455	462	PF00069	0.704
DOC_MAPK_MEF2A_6	696	703	PF00069	0.797
DOC_MAPK_MEF2A_6	853	861	PF00069	0.704
DOC_MAPK_MEF2A_6	882	890	PF00069	0.613
DOC_MAPK_MEF2A_6	908	915	PF00069	0.720
DOC_MAPK_RevD_3	737	752	PF00069	0.497
DOC_PP2B_LxvP_1	143	146	PF13499	0.603
DOC_PP2B_LxvP_1	471	474	PF13499	0.757
DOC_PP2B_LxvP_1	540	543	PF13499	0.784
DOC_PP2B_LxvP_1	697	700	PF13499	0.815
DOC_PP2B_LxvP_1	837	840	PF13499	0.735
DOC_PP2B_PxIxI_1	75	81	PF00149	0.618
DOC_PP4_FxxP_1	182	185	PF00568	0.691
DOC_USP7_MATH_1	116	120	PF00917	0.815
DOC_USP7_MATH_1	211	215	PF00917	0.745
DOC_USP7_MATH_1	322	326	PF00917	0.604
DOC_USP7_MATH_1	348	352	PF00917	0.755
DOC_USP7_MATH_1	36	40	PF00917	0.724
DOC_USP7_MATH_1	42	46	PF00917	0.656
DOC_USP7_MATH_1	440	444	PF00917	0.776
DOC_USP7_MATH_1	512	516	PF00917	0.826
DOC_USP7_MATH_1	574	578	PF00917	0.727
DOC_USP7_MATH_1	74	78	PF00917	0.782
DOC_USP7_MATH_1	872	876	PF00917	0.617
DOC_WW_Pin1_4	144	149	PF00397	0.740
DOC_WW_Pin1_4	429	434	PF00397	0.843
DOC_WW_Pin1_4	519	524	PF00397	0.789
DOC_WW_Pin1_4	55	60	PF00397	0.693
DOC_WW_Pin1_4	61	66	PF00397	0.650
DOC_WW_Pin1_4	70	75	PF00397	0.565
DOC_WW_Pin1_4	771	776	PF00397	0.782
DOC_WW_Pin1_4	801	806	PF00397	0.664
DOC_WW_Pin1_4	831	836	PF00397	0.817
DOC_WW_Pin1_4	846	851	PF00397	0.520
DOC_WW_Pin1_4	85	90	PF00397	0.655
DOC_WW_Pin1_4	876	881	PF00397	0.725
LIG_14-3-3_CanoR_1	177	185	PF00244	0.609
LIG_14-3-3_CanoR_1	236	244	PF00244	0.594
LIG_14-3-3_CanoR_1	288	298	PF00244	0.740
LIG_14-3-3_CanoR_1	333	341	PF00244	0.667
LIG_14-3-3_CanoR_1	391	396	PF00244	0.753
LIG_14-3-3_CanoR_1	431	439	PF00244	0.782
LIG_14-3-3_CanoR_1	442	449	PF00244	0.635
LIG_14-3-3_CanoR_1	588	596	PF00244	0.673
LIG_14-3-3_CanoR_1	676	685	PF00244	0.693
LIG_14-3-3_CanoR_1	688	694	PF00244	0.660
LIG_14-3-3_CanoR_1	738	743	PF00244	0.487
LIG_Actin_WH2_2	707	723	PF00022	0.521
LIG_APCC_ABBA_1	302	307	PF00400	0.639
LIG_APCC_ABBA_1	699	704	PF00400	0.809
LIG_BIR_II_1	1	5	PF00653	0.594
LIG_BIR_III_2	47	51	PF00653	0.595
LIG_BIR_III_2	69	73	PF00653	0.716
LIG_BIR_III_2	830	834	PF00653	0.756
LIG_BRCT_BRCA1_1	191	195	PF00533	0.694
LIG_BRCT_BRCA1_1	213	217	PF00533	0.673
LIG_Clathr_ClatBox_1	583	587	PF01394	0.682
LIG_deltaCOP1_diTrp_1	734	737	PF00928	0.509
LIG_DLG_GKlike_1	391	399	PF00625	0.762
LIG_eIF4E_1	527	533	PF01652	0.752
LIG_FHA_1	103	109	PF00498	0.539
LIG_FHA_1	128	134	PF00498	0.511
LIG_FHA_1	218	224	PF00498	0.706
LIG_FHA_1	22	28	PF00498	0.748
LIG_FHA_1	225	231	PF00498	0.654
LIG_FHA_1	236	242	PF00498	0.431
LIG_FHA_1	51	57	PF00498	0.719
LIG_FHA_1	514	520	PF00498	0.778
LIG_FHA_1	554	560	PF00498	0.725
LIG_FHA_1	579	585	PF00498	0.758
LIG_FHA_1	688	694	PF00498	0.633
LIG_FHA_1	784	790	PF00498	0.653
LIG_FHA_1	847	853	PF00498	0.734
LIG_FHA_1	91	97	PF00498	0.727
LIG_FHA_2	277	283	PF00498	0.713
LIG_FHA_2	858	864	PF00498	0.715
LIG_LIR_Apic_2	180	185	PF02991	0.613
LIG_LIR_Apic_2	31	36	PF02991	0.717
LIG_LIR_Gen_1	58	67	PF02991	0.768
LIG_LIR_Gen_1	706	716	PF02991	0.748
LIG_LIR_Nem_3	166	172	PF02991	0.760
LIG_LIR_Nem_3	240	246	PF02991	0.549
LIG_LIR_Nem_3	254	258	PF02991	0.538
LIG_LIR_Nem_3	330	335	PF02991	0.598
LIG_LIR_Nem_3	58	63	PF02991	0.744
LIG_LIR_Nem_3	706	711	PF02991	0.773
LIG_LYPXL_S_1	304	308	PF13949	0.542
LIG_LYPXL_yS_3	305	308	PF13949	0.580
LIG_MYND_3	714	718	PF01753	0.712
LIG_NRBOX	297	303	PF00104	0.710
LIG_PALB2_WD40_1	465	473	PF16756	0.517
LIG_PCNA_PIPBox_1	261	270	PF02747	0.734
LIG_PCNA_yPIPBox_3	481	489	PF02747	0.579
LIG_Pex14_1	488	492	PF04695	0.764
LIG_Rb_LxCxE_1	876	898	PF01857	0.603
LIG_RPA_C_Fungi	409	421	PF08784	0.676
LIG_SH2_CRK	904	908	PF00017	0.736
LIG_SH2_CRK	909	913	PF00017	0.635
LIG_SH2_NCK_1	29	33	PF00017	0.656
LIG_SH2_PTP2	33	36	PF00017	0.727
LIG_SH2_SRC	267	270	PF00017	0.742
LIG_SH2_SRC	29	32	PF00017	0.580
LIG_SH2_SRC	492	495	PF00017	0.773
LIG_SH2_SRC	527	530	PF00017	0.756
LIG_SH2_STAP1	244	248	PF00017	0.582
LIG_SH2_STAP1	29	33	PF00017	0.714
LIG_SH2_STAP1	341	345	PF00017	0.660
LIG_SH2_STAT5	267	270	PF00017	0.742
LIG_SH2_STAT5	33	36	PF00017	0.711
LIG_SH2_STAT5	527	530	PF00017	0.756
LIG_SH2_STAT5	546	549	PF00017	0.440
LIG_SH2_STAT5	719	722	PF00017	0.725
LIG_SH2_STAT5	749	752	PF00017	0.716
LIG_SH3_3	756	762	PF00018	0.726
LIG_SH3_3	763	769	PF00018	0.676
LIG_SH3_3	794	800	PF00018	0.702
LIG_SH3_3	830	836	PF00018	0.828
LIG_SUMO_SIM_anti_2	459	464	PF11976	0.568
LIG_SUMO_SIM_anti_2	581	587	PF11976	0.684
LIG_SUMO_SIM_par_1	104	109	PF11976	0.717
LIG_SUMO_SIM_par_1	581	587	PF11976	0.684
LIG_SUMO_SIM_par_1	798	804	PF11976	0.568
LIG_SUMO_SIM_par_1	834	841	PF11976	0.698
LIG_SUMO_SIM_par_1	885	892	PF11976	0.690
LIG_SUMO_SIM_par_1	911	917	PF11976	0.599
LIG_TRAF2_1	592	595	PF00917	0.569
LIG_TRAF2_1	808	811	PF00917	0.684
LIG_TYR_ITIM	241	246	PF00017	0.562
LIG_TYR_ITIM	907	912	PF00017	0.609
MOD_CDK_SPK_2	801	806	PF00069	0.585
MOD_CDK_SPxK_1	876	882	PF00069	0.669
MOD_CDK_SPxxK_3	805	812	PF00069	0.733
MOD_CDK_SPxxK_3	846	853	PF00069	0.769
MOD_CK1_1	102	108	PF00069	0.715
MOD_CK1_1	222	228	PF00069	0.705
MOD_CK1_1	229	235	PF00069	0.593
MOD_CK1_1	349	355	PF00069	0.846
MOD_CK1_1	443	449	PF00069	0.771
MOD_CK1_1	484	490	PF00069	0.635
MOD_CK1_1	630	636	PF00069	0.812
MOD_CK1_1	671	677	PF00069	0.871
MOD_CK1_1	692	698	PF00069	0.751
MOD_CK1_1	709	715	PF00069	0.442
MOD_CK1_1	790	796	PF00069	0.645
MOD_CK1_1	838	844	PF00069	0.759
MOD_CK1_1	873	879	PF00069	0.600
MOD_CK2_1	16	22	PF00069	0.725
MOD_CK2_1	276	282	PF00069	0.673
MOD_CK2_1	569	575	PF00069	0.695
MOD_CK2_1	589	595	PF00069	0.462
MOD_CK2_1	617	623	PF00069	0.744
MOD_CK2_1	805	811	PF00069	0.771
MOD_CK2_1	892	898	PF00069	0.676
MOD_GlcNHglycan	336	339	PF01048	0.684
MOD_GlcNHglycan	342	346	PF01048	0.648
MOD_GlcNHglycan	358	361	PF01048	0.595
MOD_GlcNHglycan	44	47	PF01048	0.732
MOD_GlcNHglycan	445	448	PF01048	0.845
MOD_GlcNHglycan	452	455	PF01048	0.656
MOD_GlcNHglycan	516	519	PF01048	0.816
MOD_GlcNHglycan	524	527	PF01048	0.625
MOD_GlcNHglycan	571	574	PF01048	0.774
MOD_GlcNHglycan	6	9	PF01048	0.656
MOD_GlcNHglycan	707	711	PF01048	0.689
MOD_GlcNHglycan	721	724	PF01048	0.520
MOD_GlcNHglycan	725	728	PF01048	0.659
MOD_GlcNHglycan	778	781	PF01048	0.705
MOD_GlcNHglycan	863	867	PF01048	0.785
MOD_GSK3_1	121	128	PF00069	0.787
MOD_GSK3_1	18	25	PF00069	0.598
MOD_GSK3_1	189	196	PF00069	0.746
MOD_GSK3_1	203	210	PF00069	0.568
MOD_GSK3_1	211	218	PF00069	0.636
MOD_GSK3_1	219	226	PF00069	0.497
MOD_GSK3_1	346	353	PF00069	0.771
MOD_GSK3_1	38	45	PF00069	0.503
MOD_GSK3_1	4	11	PF00069	0.712
MOD_GSK3_1	441	448	PF00069	0.849
MOD_GSK3_1	477	484	PF00069	0.709
MOD_GSK3_1	574	581	PF00069	0.715
MOD_GSK3_1	627	634	PF00069	0.754
MOD_GSK3_1	687	694	PF00069	0.687
MOD_GSK3_1	70	77	PF00069	0.765
MOD_GSK3_1	719	726	PF00069	0.659
MOD_GSK3_1	78	85	PF00069	0.715
MOD_GSK3_1	783	790	PF00069	0.632
MOD_GSK3_1	801	808	PF00069	0.460
MOD_GSK3_1	831	838	PF00069	0.783
MOD_GSK3_1	857	864	PF00069	0.540
MOD_GSK3_1	872	879	PF00069	0.569
MOD_N-GLC_2	916	918	PF02516	0.707
MOD_NEK2_1	137	142	PF00069	0.637
MOD_NEK2_1	215	220	PF00069	0.586
MOD_NEK2_1	224	229	PF00069	0.701
MOD_NEK2_1	776	781	PF00069	0.708
MOD_NEK2_1	789	794	PF00069	0.442
MOD_NEK2_1	845	850	PF00069	0.784
MOD_NEK2_1	857	862	PF00069	0.501
MOD_NEK2_1	911	916	PF00069	0.714
MOD_PIKK_1	224	230	PF00454	0.702
MOD_PIKK_1	322	328	PF00454	0.699
MOD_PIKK_1	350	356	PF00454	0.742
MOD_PIKK_1	397	403	PF00454	0.818
MOD_PIKK_1	420	426	PF00454	0.588
MOD_PIKK_1	463	469	PF00454	0.701
MOD_PIKK_1	668	674	PF00454	0.868
MOD_PIKK_1	864	870	PF00454	0.738
MOD_PK_1	481	487	PF00069	0.638
MOD_PKA_1	569	575	PF00069	0.695
MOD_PKA_1	617	623	PF00069	0.666
MOD_PKA_2	121	127	PF00069	0.671
MOD_PKA_2	235	241	PF00069	0.601
MOD_PKA_2	441	447	PF00069	0.815
MOD_PKA_2	587	593	PF00069	0.517
MOD_PKA_2	617	623	PF00069	0.666
MOD_PKA_2	687	693	PF00069	0.642
MOD_PKA_2	861	867	PF00069	0.690
MOD_Plk_1	458	464	PF00069	0.496
MOD_Plk_1	574	580	PF00069	0.716
MOD_Plk_1	706	712	PF00069	0.649
MOD_Plk_2-3	121	127	PF00069	0.603
MOD_Plk_2-3	587	593	PF00069	0.546
MOD_Plk_4	211	217	PF00069	0.659
MOD_Plk_4	219	225	PF00069	0.734
MOD_Plk_4	391	397	PF00069	0.757
MOD_Plk_4	458	464	PF00069	0.496
MOD_Plk_4	484	490	PF00069	0.674
MOD_Plk_4	52	58	PF00069	0.674
MOD_Plk_4	527	533	PF00069	0.752
MOD_Plk_4	838	844	PF00069	0.771
MOD_ProDKin_1	144	150	PF00069	0.737
MOD_ProDKin_1	429	435	PF00069	0.844
MOD_ProDKin_1	519	525	PF00069	0.784
MOD_ProDKin_1	55	61	PF00069	0.700
MOD_ProDKin_1	70	76	PF00069	0.565
MOD_ProDKin_1	771	777	PF00069	0.782
MOD_ProDKin_1	801	807	PF00069	0.665
MOD_ProDKin_1	831	837	PF00069	0.815
MOD_ProDKin_1	846	852	PF00069	0.516
MOD_ProDKin_1	85	91	PF00069	0.649
MOD_ProDKin_1	876	882	PF00069	0.714
MOD_SUMO_for_1	152	155	PF00179	0.720
MOD_SUMO_rev_2	269	277	PF00179	0.673
TRG_ENDOCYTIC_2	243	246	PF00928	0.581
TRG_ENDOCYTIC_2	255	258	PF00928	0.492
TRG_ENDOCYTIC_2	305	308	PF00928	0.678
TRG_ENDOCYTIC_2	904	907	PF00928	0.732
TRG_ENDOCYTIC_2	909	912	PF00928	0.641
TRG_ER_diArg_1	113	115	PF00400	0.797
TRG_ER_diArg_1	156	159	PF00400	0.746
TRG_ER_diArg_1	283	285	PF00400	0.509
TRG_ER_diArg_1	548	551	PF00400	0.673
TRG_ER_diArg_1	616	619	PF00400	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYA9	Leishmania donovani	99%	100%
A4HDG0	Leishmania braziliensis	70%	100%
E9AWU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QAM9	Leishmania major	89%	100%