Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0T6_LEIIN

TriTrypDb:

LINF_240014900

Length:

764

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0T6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	317	321	PF00656	0.518
CLV_C14_Caspase3-7	454	458	PF00656	0.441
CLV_MEL_PAP_1	552	558	PF00089	0.435
CLV_NRD_NRD_1	174	176	PF00675	0.647
CLV_NRD_NRD_1	288	290	PF00675	0.573
CLV_NRD_NRD_1	306	308	PF00675	0.632
CLV_NRD_NRD_1	534	536	PF00675	0.471
CLV_NRD_NRD_1	558	560	PF00675	0.430
CLV_NRD_NRD_1	606	608	PF00675	0.492
CLV_NRD_NRD_1	65	67	PF00675	0.677
CLV_NRD_NRD_1	676	678	PF00675	0.544
CLV_NRD_NRD_1	692	694	PF00675	0.436
CLV_NRD_NRD_1	75	77	PF00675	0.661
CLV_PCSK_KEX2_1	174	176	PF00082	0.647
CLV_PCSK_KEX2_1	288	290	PF00082	0.573
CLV_PCSK_KEX2_1	306	308	PF00082	0.632
CLV_PCSK_KEX2_1	534	536	PF00082	0.471
CLV_PCSK_KEX2_1	558	560	PF00082	0.430
CLV_PCSK_KEX2_1	606	608	PF00082	0.492
CLV_PCSK_KEX2_1	674	676	PF00082	0.535
CLV_PCSK_KEX2_1	692	694	PF00082	0.424
CLV_PCSK_KEX2_1	75	77	PF00082	0.717
CLV_PCSK_PC1ET2_1	674	676	PF00082	0.495
CLV_PCSK_PC7_1	530	536	PF00082	0.444
CLV_PCSK_SKI1_1	268	272	PF00082	0.571
CLV_PCSK_SKI1_1	313	317	PF00082	0.570
CLV_PCSK_SKI1_1	339	343	PF00082	0.578
CLV_PCSK_SKI1_1	535	539	PF00082	0.541
CLV_PCSK_SKI1_1	573	577	PF00082	0.525
CLV_PCSK_SKI1_1	623	627	PF00082	0.522
CLV_PCSK_SKI1_1	67	71	PF00082	0.734
CLV_PCSK_SKI1_1	75	79	PF00082	0.680
CLV_PCSK_SKI1_1	753	757	PF00082	0.388
CLV_Separin_Metazoa	372	376	PF03568	0.326
DEG_Nend_Nbox_1	1	3	PF02207	0.409
DEG_SPOP_SBC_1	314	318	PF00917	0.375
DEG_SPOP_SBC_1	456	460	PF00917	0.561
DOC_CDC14_PxL_1	23	31	PF14671	0.431
DOC_CKS1_1	489	494	PF01111	0.602
DOC_CYCLIN_yCln2_LP_2	539	545	PF00134	0.599
DOC_MAPK_gen_1	66	72	PF00069	0.477
DOC_PP2B_LxvP_1	494	497	PF13499	0.601
DOC_USP7_MATH_1	106	110	PF00917	0.486
DOC_USP7_MATH_1	152	156	PF00917	0.499
DOC_USP7_MATH_1	314	318	PF00917	0.377
DOC_USP7_MATH_1	343	347	PF00917	0.291
DOC_USP7_MATH_1	425	429	PF00917	0.500
DOC_USP7_MATH_1	451	455	PF00917	0.544
DOC_USP7_MATH_1	473	477	PF00917	0.301
DOC_USP7_MATH_1	497	501	PF00917	0.677
DOC_USP7_MATH_1	634	638	PF00917	0.706
DOC_USP7_MATH_1	754	758	PF00917	0.615
DOC_USP7_MATH_1	81	85	PF00917	0.549
DOC_WW_Pin1_4	248	253	PF00397	0.460
DOC_WW_Pin1_4	293	298	PF00397	0.435
DOC_WW_Pin1_4	356	361	PF00397	0.527
DOC_WW_Pin1_4	41	46	PF00397	0.565
DOC_WW_Pin1_4	488	493	PF00397	0.593
DOC_WW_Pin1_4	538	543	PF00397	0.616
DOC_WW_Pin1_4	592	597	PF00397	0.777
DOC_WW_Pin1_4	681	686	PF00397	0.680
DOC_WW_Pin1_4	741	746	PF00397	0.757
DOC_WW_Pin1_4	79	84	PF00397	0.553
LIG_14-3-3_CanoR_1	414	421	PF00244	0.474
LIG_14-3-3_CanoR_1	447	456	PF00244	0.522
LIG_14-3-3_CanoR_1	530	534	PF00244	0.631
LIG_14-3-3_CanoR_1	535	540	PF00244	0.729
LIG_14-3-3_CanoR_1	692	698	PF00244	0.667
LIG_14-3-3_CanoR_1	75	80	PF00244	0.597
LIG_14-3-3_CanoR_1	753	759	PF00244	0.604
LIG_APCC_ABBA_1	20	25	PF00400	0.466
LIG_BRCT_BRCA1_1	470	474	PF00533	0.325
LIG_BRCT_BRCA1_1	498	502	PF00533	0.546
LIG_BRCT_BRCA1_1	514	518	PF00533	0.553
LIG_CaM_IQ_9	661	677	PF13499	0.631
LIG_eIF4E_1	23	29	PF01652	0.442
LIG_EVH1_2	599	603	PF00568	0.694
LIG_FHA_1	155	161	PF00498	0.521
LIG_FHA_1	163	169	PF00498	0.371
LIG_FHA_1	244	250	PF00498	0.459
LIG_FHA_1	31	37	PF00498	0.326
LIG_FHA_1	328	334	PF00498	0.487
LIG_FHA_1	336	342	PF00498	0.408
LIG_FHA_1	410	416	PF00498	0.402
LIG_FHA_1	462	468	PF00498	0.392
LIG_FHA_1	479	485	PF00498	0.227
LIG_FHA_1	489	495	PF00498	0.613
LIG_FHA_1	5	11	PF00498	0.375
LIG_FHA_1	570	576	PF00498	0.732
LIG_FHA_1	614	620	PF00498	0.766
LIG_FHA_1	731	737	PF00498	0.725
LIG_FHA_1	742	748	PF00498	0.589
LIG_FHA_1	754	760	PF00498	0.596
LIG_LIR_Apic_2	531	536	PF02991	0.711
LIG_LIR_Gen_1	5	15	PF02991	0.398
LIG_LIR_Gen_1	515	525	PF02991	0.555
LIG_LIR_Gen_1	733	741	PF02991	0.726
LIG_LIR_Nem_3	499	505	PF02991	0.542
LIG_LIR_Nem_3	5	11	PF02991	0.313
LIG_LIR_Nem_3	515	521	PF02991	0.561
LIG_LIR_Nem_3	733	737	PF02991	0.726
LIG_LIR_Nem_3	750	755	PF02991	0.693
LIG_PCNA_PIPBox_1	506	515	PF02747	0.621
LIG_PTB_Apo_2	349	356	PF02174	0.429
LIG_PTB_Phospho_1	349	355	PF10480	0.427
LIG_SH2_CRK	657	661	PF00017	0.701
LIG_SH2_NCK_1	405	409	PF00017	0.478
LIG_SH2_PTP2	178	181	PF00017	0.410
LIG_SH2_SRC	178	181	PF00017	0.398
LIG_SH2_STAP1	187	191	PF00017	0.407
LIG_SH2_STAP1	210	214	PF00017	0.338
LIG_SH2_STAP1	657	661	PF00017	0.701
LIG_SH2_STAP1	730	734	PF00017	0.727
LIG_SH2_STAT5	167	170	PF00017	0.457
LIG_SH2_STAT5	178	181	PF00017	0.410
LIG_SH2_STAT5	340	343	PF00017	0.364
LIG_SH2_STAT5	441	444	PF00017	0.487
LIG_SH2_STAT5	579	582	PF00017	0.638
LIG_SH3_3	188	194	PF00018	0.336
LIG_SH3_3	439	445	PF00018	0.487
LIG_SH3_3	593	599	PF00018	0.716
LIG_SUMO_SIM_anti_2	481	486	PF11976	0.335
LIG_SUMO_SIM_par_1	25	33	PF11976	0.439
LIG_SUMO_SIM_par_1	535	541	PF11976	0.725
LIG_SUMO_SIM_par_1	735	740	PF11976	0.639
LIG_SUMO_SIM_par_1	98	104	PF11976	0.449
LIG_TRFH_1	8	12	PF08558	0.459
LIG_TYR_ITIM	403	408	PF00017	0.412
MOD_CDC14_SPxK_1	296	299	PF00782	0.552
MOD_CDK_SPxK_1	293	299	PF00069	0.533
MOD_CK1_1	109	115	PF00069	0.607
MOD_CK1_1	154	160	PF00069	0.598
MOD_CK1_1	222	228	PF00069	0.600
MOD_CK1_1	258	264	PF00069	0.493
MOD_CK1_1	32	38	PF00069	0.450
MOD_CK1_1	335	341	PF00069	0.636
MOD_CK1_1	43	49	PF00069	0.543
MOD_CK1_1	459	465	PF00069	0.702
MOD_CK1_1	478	484	PF00069	0.196
MOD_CK1_1	500	506	PF00069	0.419
MOD_CK1_1	520	526	PF00069	0.529
MOD_CK1_1	595	601	PF00069	0.638
MOD_CK1_1	699	705	PF00069	0.733
MOD_CK1_1	82	88	PF00069	0.778
MOD_Cter_Amidation	172	175	PF01082	0.494
MOD_Cter_Amidation	556	559	PF01082	0.499
MOD_Cter_Amidation	64	67	PF01082	0.574
MOD_GlcNHglycan	111	114	PF01048	0.526
MOD_GlcNHglycan	154	157	PF01048	0.694
MOD_GlcNHglycan	224	227	PF01048	0.484
MOD_GlcNHglycan	230	233	PF01048	0.499
MOD_GlcNHglycan	375	378	PF01048	0.398
MOD_GlcNHglycan	379	382	PF01048	0.390
MOD_GlcNHglycan	438	441	PF01048	0.623
MOD_GlcNHglycan	442	445	PF01048	0.602
MOD_GlcNHglycan	449	452	PF01048	0.599
MOD_GlcNHglycan	475	478	PF01048	0.346
MOD_GlcNHglycan	502	505	PF01048	0.478
MOD_GlcNHglycan	514	517	PF01048	0.354
MOD_GlcNHglycan	616	619	PF01048	0.657
MOD_GlcNHglycan	701	704	PF01048	0.705
MOD_GlcNHglycan	719	722	PF01048	0.465
MOD_GlcNHglycan	84	87	PF01048	0.603
MOD_GSK3_1	142	149	PF00069	0.623
MOD_GSK3_1	228	235	PF00069	0.591
MOD_GSK3_1	28	35	PF00069	0.493
MOD_GSK3_1	293	300	PF00069	0.528
MOD_GSK3_1	316	323	PF00069	0.577
MOD_GSK3_1	373	380	PF00069	0.389
MOD_GSK3_1	39	46	PF00069	0.516
MOD_GSK3_1	409	416	PF00069	0.451
MOD_GSK3_1	436	443	PF00069	0.725
MOD_GSK3_1	447	454	PF00069	0.622
MOD_GSK3_1	455	462	PF00069	0.612
MOD_GSK3_1	468	475	PF00069	0.280
MOD_GSK3_1	496	503	PF00069	0.547
MOD_GSK3_1	75	82	PF00069	0.667
MOD_N-GLC_1	142	147	PF02516	0.592
MOD_N-GLC_1	425	430	PF02516	0.583
MOD_NEK2_1	214	219	PF00069	0.383
MOD_NEK2_1	271	276	PF00069	0.503
MOD_NEK2_1	28	33	PF00069	0.496
MOD_NEK2_1	342	347	PF00069	0.483
MOD_NEK2_1	354	359	PF00069	0.375
MOD_NEK2_1	373	378	PF00069	0.537
MOD_NEK2_1	446	451	PF00069	0.669
MOD_NEK2_1	472	477	PF00069	0.346
MOD_NEK2_1	529	534	PF00069	0.630
MOD_NEK2_1	56	61	PF00069	0.665
MOD_NEK2_2	106	111	PF00069	0.605
MOD_NEK2_2	497	502	PF00069	0.531
MOD_NEK2_2	636	641	PF00069	0.678
MOD_PIKK_1	258	264	PF00454	0.512
MOD_PIKK_1	634	640	PF00454	0.751
MOD_PK_1	142	148	PF00069	0.502
MOD_PKA_1	75	81	PF00069	0.643
MOD_PKA_2	152	158	PF00069	0.705
MOD_PKA_2	219	225	PF00069	0.626
MOD_PKA_2	413	419	PF00069	0.603
MOD_PKA_2	436	442	PF00069	0.721
MOD_PKA_2	446	452	PF00069	0.635
MOD_PKA_2	529	535	PF00069	0.515
MOD_PKA_2	75	81	PF00069	0.706
MOD_Plk_1	142	148	PF00069	0.565
MOD_Plk_1	18	24	PF00069	0.498
MOD_Plk_1	4	10	PF00069	0.368
MOD_Plk_1	409	415	PF00069	0.446
MOD_Plk_1	456	462	PF00069	0.614
MOD_Plk_4	18	24	PF00069	0.596
MOD_Plk_4	219	225	PF00069	0.467
MOD_Plk_4	343	349	PF00069	0.317
MOD_Plk_4	43	49	PF00069	0.627
MOD_Plk_4	451	457	PF00069	0.695
MOD_Plk_4	497	503	PF00069	0.419
MOD_Plk_4	517	523	PF00069	0.300
MOD_Plk_4	535	541	PF00069	0.662
MOD_Plk_4	696	702	PF00069	0.583
MOD_Plk_4	754	760	PF00069	0.492
MOD_ProDKin_1	248	254	PF00069	0.572
MOD_ProDKin_1	293	299	PF00069	0.533
MOD_ProDKin_1	356	362	PF00069	0.666
MOD_ProDKin_1	41	47	PF00069	0.721
MOD_ProDKin_1	488	494	PF00069	0.476
MOD_ProDKin_1	538	544	PF00069	0.498
MOD_ProDKin_1	592	598	PF00069	0.732
MOD_ProDKin_1	681	687	PF00069	0.599
MOD_ProDKin_1	741	747	PF00069	0.706
MOD_ProDKin_1	79	85	PF00069	0.702
MOD_SUMO_rev_2	380	389	PF00179	0.395
TRG_DiLeu_BaEn_1	25	30	PF01217	0.444
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.553
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.584
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.542
TRG_DiLeu_BaLyEn_6	465	470	PF01217	0.421
TRG_ENDOCYTIC_2	405	408	PF00928	0.411
TRG_ENDOCYTIC_2	657	660	PF00928	0.514
TRG_ENDOCYTIC_2	752	755	PF00928	0.609
TRG_ER_diArg_1	287	289	PF00400	0.436
TRG_ER_diArg_1	298	301	PF00400	0.527
TRG_ER_diArg_1	305	307	PF00400	0.473
TRG_ER_diArg_1	533	535	PF00400	0.582
TRG_ER_diArg_1	606	609	PF00400	0.657
TRG_ER_diArg_1	620	623	PF00400	0.478
TRG_ER_diArg_1	675	677	PF00400	0.691
TRG_ER_diArg_1	75	77	PF00400	0.636
TRG_NLS_MonoCore_2	673	678	PF00514	0.620
TRG_NLS_MonoExtC_3	673	678	PF00514	0.620
TRG_Pf-PMV_PEXEL_1	288	293	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKM5	Leptomonas seymouri	38%	99%
A0A3Q8IG41	Leishmania donovani	100%	100%
A4HDF3	Leishmania braziliensis	73%	100%
E9AWT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	98%
Q4QAN6	Leishmania major	91%	100%