Vps39_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0T2_LEIIN

TriTrypDb:

LINF_240014500

Length:

941

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I0T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0T2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	596	600	PF00656	0.678
CLV_C14_Caspase3-7	879	883	PF00656	0.767
CLV_C14_Caspase3-7	885	889	PF00656	0.625
CLV_MEL_PAP_1	910	916	PF00089	0.511
CLV_NRD_NRD_1	247	249	PF00675	0.394
CLV_NRD_NRD_1	301	303	PF00675	0.772
CLV_NRD_NRD_1	433	435	PF00675	0.529
CLV_NRD_NRD_1	487	489	PF00675	0.515
CLV_NRD_NRD_1	65	67	PF00675	0.721
CLV_NRD_NRD_1	761	763	PF00675	0.688
CLV_PCSK_KEX2_1	247	249	PF00082	0.394
CLV_PCSK_KEX2_1	301	303	PF00082	0.772
CLV_PCSK_KEX2_1	433	435	PF00082	0.529
CLV_PCSK_KEX2_1	487	489	PF00082	0.515
CLV_PCSK_KEX2_1	65	67	PF00082	0.719
CLV_PCSK_KEX2_1	761	763	PF00082	0.688
CLV_PCSK_SKI1_1	103	107	PF00082	0.480
CLV_PCSK_SKI1_1	141	145	PF00082	0.495
CLV_PCSK_SKI1_1	248	252	PF00082	0.549
CLV_PCSK_SKI1_1	426	430	PF00082	0.550
CLV_PCSK_SKI1_1	495	499	PF00082	0.596
CLV_PCSK_SKI1_1	631	635	PF00082	0.776
CLV_PCSK_SKI1_1	676	680	PF00082	0.716
CLV_PCSK_SKI1_1	80	84	PF00082	0.437
CLV_PCSK_SKI1_1	898	902	PF00082	0.517
DEG_APCC_DBOX_1	897	905	PF00400	0.513
DEG_Nend_UBRbox_1	1	4	PF02207	0.529
DEG_SCF_FBW7_1	105	110	PF00400	0.649
DOC_CKS1_1	104	109	PF01111	0.585
DOC_CYCLIN_yCln2_LP_2	399	405	PF00134	0.541
DOC_MAPK_gen_1	247	253	PF00069	0.416
DOC_MAPK_gen_1	392	401	PF00069	0.501
DOC_MAPK_gen_1	918	926	PF00069	0.447
DOC_MAPK_HePTP_8	154	166	PF00069	0.524
DOC_MAPK_HePTP_8	4	16	PF00069	0.556
DOC_MAPK_MEF2A_6	157	166	PF00069	0.558
DOC_MAPK_MEF2A_6	7	16	PF00069	0.552
DOC_MAPK_MEF2A_6	787	794	PF00069	0.454
DOC_MAPK_MEF2A_6	920	928	PF00069	0.439
DOC_PP2B_LxvP_1	251	254	PF13499	0.558
DOC_PP2B_LxvP_1	358	361	PF13499	0.473
DOC_PP2B_LxvP_1	399	402	PF13499	0.523
DOC_PP2B_LxvP_1	84	87	PF13499	0.544
DOC_PP4_FxxP_1	104	107	PF00568	0.585
DOC_USP7_MATH_1	118	122	PF00917	0.654
DOC_USP7_MATH_1	126	130	PF00917	0.538
DOC_USP7_MATH_1	150	154	PF00917	0.511
DOC_USP7_MATH_1	207	211	PF00917	0.675
DOC_USP7_MATH_1	336	340	PF00917	0.695
DOC_USP7_MATH_1	342	346	PF00917	0.566
DOC_USP7_MATH_1	51	55	PF00917	0.535
DOC_USP7_MATH_1	643	647	PF00917	0.700
DOC_USP7_MATH_1	775	779	PF00917	0.770
DOC_USP7_MATH_1	839	843	PF00917	0.690
DOC_USP7_MATH_1	85	89	PF00917	0.453
DOC_USP7_MATH_1	886	890	PF00917	0.774
DOC_USP7_MATH_1	892	896	PF00917	0.603
DOC_WW_Pin1_4	103	108	PF00397	0.521
DOC_WW_Pin1_4	121	126	PF00397	0.707
DOC_WW_Pin1_4	186	191	PF00397	0.606
DOC_WW_Pin1_4	547	552	PF00397	0.732
DOC_WW_Pin1_4	73	78	PF00397	0.460
DOC_WW_Pin1_4	771	776	PF00397	0.728
LIG_14-3-3_CanoR_1	132	138	PF00244	0.636
LIG_14-3-3_CanoR_1	157	166	PF00244	0.583
LIG_14-3-3_CanoR_1	174	182	PF00244	0.480
LIG_14-3-3_CanoR_1	222	227	PF00244	0.574
LIG_14-3-3_CanoR_1	248	254	PF00244	0.466
LIG_14-3-3_CanoR_1	268	273	PF00244	0.488
LIG_14-3-3_CanoR_1	283	288	PF00244	0.537
LIG_14-3-3_CanoR_1	37	42	PF00244	0.485
LIG_14-3-3_CanoR_1	433	441	PF00244	0.532
LIG_14-3-3_CanoR_1	450	454	PF00244	0.324
LIG_14-3-3_CanoR_1	544	551	PF00244	0.720
LIG_14-3-3_CanoR_1	66	72	PF00244	0.640
LIG_14-3-3_CanoR_1	80	85	PF00244	0.334
LIG_14-3-3_CanoR_1	850	854	PF00244	0.506
LIG_14-3-3_CanoR_1	913	917	PF00244	0.482
LIG_14-3-3_CanoR_1	918	923	PF00244	0.484
LIG_Actin_WH2_2	42	59	PF00022	0.416
LIG_Actin_WH2_2	479	497	PF00022	0.501
LIG_Actin_WH2_2	897	915	PF00022	0.529
LIG_APCC_ABBA_1	934	939	PF00400	0.507
LIG_CAP-Gly_1	938	941	PF01302	0.612
LIG_Clathr_ClatBox_1	868	872	PF01394	0.695
LIG_Clathr_ClatBox_1	91	95	PF01394	0.434
LIG_deltaCOP1_diTrp_1	307	311	PF00928	0.724
LIG_FHA_1	122	128	PF00498	0.650
LIG_FHA_1	166	172	PF00498	0.521
LIG_FHA_1	176	182	PF00498	0.511
LIG_FHA_1	436	442	PF00498	0.566
LIG_FHA_1	450	456	PF00498	0.349
LIG_FHA_1	478	484	PF00498	0.531
LIG_FHA_1	743	749	PF00498	0.633
LIG_FHA_1	753	759	PF00498	0.537
LIG_FHA_1	794	800	PF00498	0.563
LIG_FHA_1	81	87	PF00498	0.414
LIG_FHA_1	854	860	PF00498	0.529
LIG_FHA_2	415	421	PF00498	0.682
LIG_FHA_2	594	600	PF00498	0.684
LIG_FHA_2	703	709	PF00498	0.600
LIG_FHA_2	903	909	PF00498	0.518
LIG_LIR_Gen_1	271	280	PF02991	0.524
LIG_LIR_Gen_1	307	316	PF02991	0.709
LIG_LIR_Gen_1	378	384	PF02991	0.508
LIG_LIR_Gen_1	386	395	PF02991	0.515
LIG_LIR_Gen_1	921	929	PF02991	0.455
LIG_LIR_LC3C_4	755	760	PF02991	0.611
LIG_LIR_Nem_3	271	275	PF02991	0.547
LIG_LIR_Nem_3	307	311	PF02991	0.788
LIG_LIR_Nem_3	378	383	PF02991	0.512
LIG_LIR_Nem_3	386	390	PF02991	0.510
LIG_LIR_Nem_3	755	759	PF02991	0.583
LIG_LIR_Nem_3	816	822	PF02991	0.500
LIG_LIR_Nem_3	921	925	PF02991	0.444
LIG_PCNA_PIPBox_1	581	590	PF02747	0.616
LIG_PCNA_yPIPBox_3	580	588	PF02747	0.614
LIG_Rb_pABgroove_1	931	939	PF01858	0.483
LIG_SH2_CRK	756	760	PF00017	0.600
LIG_SH2_NCK_1	380	384	PF00017	0.510
LIG_SH2_PTP2	931	934	PF00017	0.436
LIG_SH2_STAP1	380	384	PF00017	0.524
LIG_SH2_STAP1	469	473	PF00017	0.530
LIG_SH2_STAP1	815	819	PF00017	0.391
LIG_SH2_STAP1	937	941	PF00017	0.591
LIG_SH2_STAT3	427	430	PF00017	0.546
LIG_SH2_STAT5	330	333	PF00017	0.530
LIG_SH2_STAT5	368	371	PF00017	0.394
LIG_SH2_STAT5	587	590	PF00017	0.645
LIG_SH2_STAT5	822	825	PF00017	0.620
LIG_SH2_STAT5	931	934	PF00017	0.436
LIG_SH3_2	255	260	PF14604	0.539
LIG_SH3_3	128	134	PF00018	0.675
LIG_SH3_3	136	142	PF00018	0.449
LIG_SH3_3	252	258	PF00018	0.604
LIG_SH3_3	545	551	PF00018	0.806
LIG_SH3_3	828	834	PF00018	0.504
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.679
LIG_SUMO_SIM_anti_2	223	228	PF11976	0.461
LIG_SUMO_SIM_anti_2	438	446	PF11976	0.613
LIG_SUMO_SIM_anti_2	88	95	PF11976	0.444
LIG_SUMO_SIM_par_1	11	17	PF11976	0.455
LIG_SUMO_SIM_par_1	82	88	PF11976	0.437
LIG_SUMO_SIM_par_1	867	875	PF11976	0.726
LIG_SUMO_SIM_par_1	89	95	PF11976	0.448
LIG_SUMO_SIM_par_1	932	940	PF11976	0.506
LIG_TRAF2_1	533	536	PF00917	0.594
LIG_TRAF2_1	592	595	PF00917	0.791
LIG_TRFH_1	47	51	PF08558	0.596
LIG_WRC_WIRS_1	44	49	PF05994	0.462
MOD_CDK_SPxxK_3	73	80	PF00069	0.460
MOD_CK1_1	121	127	PF00069	0.617
MOD_CK1_1	153	159	PF00069	0.625
MOD_CK1_1	189	195	PF00069	0.716
MOD_CK1_1	263	269	PF00069	0.688
MOD_CK1_1	546	552	PF00069	0.798
MOD_CK1_1	586	592	PF00069	0.743
MOD_CK1_1	6	12	PF00069	0.514
MOD_CK1_1	644	650	PF00069	0.726
MOD_CK1_1	842	848	PF00069	0.695
MOD_CK2_1	342	348	PF00069	0.671
MOD_CK2_1	5	11	PF00069	0.513
MOD_CK2_1	702	708	PF00069	0.605
MOD_CK2_1	777	783	PF00069	0.763
MOD_CK2_1	902	908	PF00069	0.515
MOD_GlcNHglycan	113	116	PF01048	0.695
MOD_GlcNHglycan	159	162	PF01048	0.441
MOD_GlcNHglycan	209	212	PF01048	0.765
MOD_GlcNHglycan	218	221	PF01048	0.572
MOD_GlcNHglycan	262	265	PF01048	0.695
MOD_GlcNHglycan	288	291	PF01048	0.678
MOD_GlcNHglycan	30	33	PF01048	0.533
MOD_GlcNHglycan	313	316	PF01048	0.699
MOD_GlcNHglycan	338	341	PF01048	0.727
MOD_GlcNHglycan	355	358	PF01048	0.589
MOD_GlcNHglycan	409	412	PF01048	0.552
MOD_GlcNHglycan	545	548	PF01048	0.797
MOD_GlcNHglycan	576	579	PF01048	0.642
MOD_GlcNHglycan	58	61	PF01048	0.644
MOD_GlcNHglycan	634	637	PF01048	0.703
MOD_GlcNHglycan	643	646	PF01048	0.724
MOD_GlcNHglycan	681	684	PF01048	0.754
MOD_GlcNHglycan	77	80	PF01048	0.521
MOD_GlcNHglycan	777	780	PF01048	0.746
MOD_GlcNHglycan	815	818	PF01048	0.455
MOD_GlcNHglycan	841	844	PF01048	0.684
MOD_GlcNHglycan	87	90	PF01048	0.462
MOD_GlcNHglycan	888	892	PF01048	0.676
MOD_GlcNHglycan	895	898	PF01048	0.609
MOD_GSK3_1	103	110	PF00069	0.507
MOD_GSK3_1	153	160	PF00069	0.400
MOD_GSK3_1	203	210	PF00069	0.748
MOD_GSK3_1	216	223	PF00069	0.612
MOD_GSK3_1	331	338	PF00069	0.608
MOD_GSK3_1	35	42	PF00069	0.497
MOD_GSK3_1	449	456	PF00069	0.327
MOD_GSK3_1	542	549	PF00069	0.826
MOD_GSK3_1	583	590	PF00069	0.650
MOD_GSK3_1	620	627	PF00069	0.762
MOD_GSK3_1	637	644	PF00069	0.592
MOD_GSK3_1	737	744	PF00069	0.587
MOD_GSK3_1	771	778	PF00069	0.797
MOD_GSK3_1	835	842	PF00069	0.644
MOD_GSK3_1	849	856	PF00069	0.555
MOD_GSK3_1	914	921	PF00069	0.486
MOD_N-GLC_1	353	358	PF02516	0.598
MOD_NEK2_1	14	19	PF00069	0.447
MOD_NEK2_1	202	207	PF00069	0.730
MOD_NEK2_1	249	254	PF00069	0.547
MOD_NEK2_1	3	8	PF00069	0.516
MOD_NEK2_1	311	316	PF00069	0.642
MOD_NEK2_1	329	334	PF00069	0.495
MOD_NEK2_1	407	412	PF00069	0.553
MOD_NEK2_1	432	437	PF00069	0.543
MOD_NEK2_1	45	50	PF00069	0.484
MOD_NEK2_1	489	494	PF00069	0.533
MOD_NEK2_1	512	517	PF00069	0.551
MOD_NEK2_1	576	581	PF00069	0.730
MOD_NEK2_1	702	707	PF00069	0.530
MOD_NEK2_1	738	743	PF00069	0.573
MOD_NEK2_1	782	787	PF00069	0.678
MOD_NEK2_1	794	799	PF00069	0.503
MOD_NEK2_1	912	917	PF00069	0.486
MOD_PIKK_1	26	32	PF00454	0.478
MOD_PIKK_1	477	483	PF00454	0.627
MOD_PIKK_1	590	596	PF00454	0.686
MOD_PIKK_1	646	652	PF00454	0.712
MOD_PKA_1	761	767	PF00069	0.662
MOD_PKA_2	294	300	PF00069	0.819
MOD_PKA_2	36	42	PF00069	0.480
MOD_PKA_2	373	379	PF00069	0.587
MOD_PKA_2	432	438	PF00069	0.501
MOD_PKA_2	449	455	PF00069	0.287
MOD_PKA_2	519	525	PF00069	0.734
MOD_PKA_2	543	549	PF00069	0.762
MOD_PKA_2	738	744	PF00069	0.472
MOD_PKA_2	761	767	PF00069	0.662
MOD_PKA_2	849	855	PF00069	0.547
MOD_PKA_2	912	918	PF00069	0.488
MOD_Plk_1	353	359	PF00069	0.592
MOD_Plk_1	370	376	PF00069	0.279
MOD_Plk_1	453	459	PF00069	0.470
MOD_Plk_1	674	680	PF00069	0.780
MOD_Plk_1	782	788	PF00069	0.684
MOD_Plk_4	189	195	PF00069	0.679
MOD_Plk_4	222	228	PF00069	0.447
MOD_Plk_4	342	348	PF00069	0.653
MOD_Plk_4	40	46	PF00069	0.533
MOD_Plk_4	489	495	PF00069	0.565
MOD_Plk_4	51	57	PF00069	0.462
MOD_Plk_4	566	572	PF00069	0.824
MOD_Plk_4	583	589	PF00069	0.465
MOD_Plk_4	620	626	PF00069	0.603
MOD_Plk_4	777	783	PF00069	0.678
MOD_Plk_4	815	821	PF00069	0.493
MOD_Plk_4	853	859	PF00069	0.544
MOD_Plk_4	932	938	PF00069	0.474
MOD_ProDKin_1	103	109	PF00069	0.543
MOD_ProDKin_1	121	127	PF00069	0.692
MOD_ProDKin_1	186	192	PF00069	0.618
MOD_ProDKin_1	547	553	PF00069	0.733
MOD_ProDKin_1	73	79	PF00069	0.459
MOD_ProDKin_1	771	777	PF00069	0.726
MOD_SUMO_for_1	799	802	PF00179	0.595
MOD_SUMO_rev_2	669	678	PF00179	0.741
TRG_DiLeu_BaEn_1	97	102	PF01217	0.602
TRG_DiLeu_BaEn_3	824	830	PF01217	0.413
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.578
TRG_DiLeu_BaLyEn_6	864	869	PF01217	0.571
TRG_ENDOCYTIC_2	380	383	PF00928	0.516
TRG_ENDOCYTIC_2	699	702	PF00928	0.676
TRG_ENDOCYTIC_2	756	759	PF00928	0.591
TRG_ENDOCYTIC_2	820	823	PF00928	0.486
TRG_ENDOCYTIC_2	931	934	PF00928	0.436
TRG_ER_diArg_1	246	248	PF00400	0.388
TRG_ER_diArg_1	391	394	PF00400	0.501
TRG_ER_diArg_1	432	434	PF00400	0.510
TRG_ER_diArg_1	486	488	PF00400	0.502
TRG_ER_diArg_1	760	762	PF00400	0.682
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	532	536	PF00026	0.727
TRG_Pf-PMV_PEXEL_1	666	670	PF00026	0.724
TRG_Pf-PMV_PEXEL_1	867	872	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5F2	Leptomonas seymouri	42%	91%
A0A3Q8ICU6	Leishmania donovani	100%	100%
A4HDE9	Leishmania braziliensis	73%	100%
E9AWT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	98%
Q4QAP0	Leishmania major	93%	100%