Protein BIG1

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein BIG1

Gene product:

emp24/gp25L/p24 family/GOLD - putative

Species:

Leishmania infantum

UniProt:

A4I0S6_LEIIN

TriTrypDb:

LINF_240013900

Length:

149

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 1
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4I0S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0S6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.379
CLV_PCSK_SKI1_1	31	35	PF00082	0.564
DEG_Nend_UBRbox_2	1	3	PF02207	0.444
DOC_MAPK_MEF2A_6	114	122	PF00069	0.240
DOC_MAPK_MEF2A_6	18	26	PF00069	0.386
DOC_PP1_RVXF_1	112	118	PF00149	0.316
DOC_USP7_MATH_1	35	39	PF00917	0.361
DOC_USP7_UBL2_3	7	11	PF12436	0.385
DOC_WW_Pin1_4	62	67	PF00397	0.495
LIG_14-3-3_CanoR_1	106	110	PF00244	0.351
LIG_14-3-3_CanoR_1	114	118	PF00244	0.321
LIG_BRCT_BRCA1_1	22	26	PF00533	0.354
LIG_FHA_1	40	46	PF00498	0.397
LIG_FHA_2	97	103	PF00498	0.411
LIG_LIR_Gen_1	104	115	PF02991	0.249
LIG_LIR_Gen_1	134	142	PF02991	0.373
LIG_LIR_Gen_1	86	96	PF02991	0.402
LIG_LIR_Nem_3	116	120	PF02991	0.242
LIG_LIR_Nem_3	134	138	PF02991	0.248
LIG_Pex14_1	117	121	PF04695	0.248
LIG_SH2_PTP2	121	124	PF00017	0.303
LIG_SH2_STAP1	85	89	PF00017	0.320
LIG_SH2_STAT5	121	124	PF00017	0.297
LIG_SH2_STAT5	83	86	PF00017	0.323
LIG_SH3_4	7	14	PF00018	0.377
LIG_SUMO_SIM_anti_2	42	47	PF11976	0.390
LIG_SUMO_SIM_par_1	41	47	PF11976	0.391
LIG_SxIP_EBH_1	114	124	PF03271	0.240
LIG_WRC_WIRS_1	132	137	PF05994	0.325
LIG_WRC_WIRS_1	85	90	PF05994	0.321
MOD_CK1_1	20	26	PF00069	0.441
MOD_CK1_1	60	66	PF00069	0.404
MOD_CK2_1	105	111	PF00069	0.362
MOD_GlcNHglycan	74	77	PF01048	0.578
MOD_GSK3_1	35	42	PF00069	0.397
MOD_GSK3_1	57	64	PF00069	0.398
MOD_N-GLC_1	39	44	PF02516	0.602
MOD_PKA_1	57	63	PF00069	0.397
MOD_PKA_2	105	111	PF00069	0.307
MOD_PKA_2	113	119	PF00069	0.281
MOD_Plk_1	39	45	PF00069	0.398
MOD_Plk_1	51	57	PF00069	0.372
MOD_Plk_4	105	111	PF00069	0.395
MOD_Plk_4	113	119	PF00069	0.364
MOD_Plk_4	131	137	PF00069	0.151
MOD_Plk_4	17	23	PF00069	0.362
MOD_ProDKin_1	62	68	PF00069	0.497
MOD_SUMO_rev_2	4	13	PF00179	0.387
TRG_ENDOCYTIC_2	107	110	PF00928	0.404
TRG_ENDOCYTIC_2	121	124	PF00928	0.211
TRG_ENDOCYTIC_2	85	88	PF00928	0.453
TRG_ER_diLys_1	144	149	PF00400	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J7E6	Bodo saltans	25%	68%
D0A756	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	66%