2'-phosphotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphotransferase - putative

Species:

Leishmania infantum

UniProt:

A4I0S0_LEIIN

TriTrypDb:

LINF_240013200

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I0S0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0S0

Function

Biological processes
Term	Name	Level	Count
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	1
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031125	rRNA 3'-end processing	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043628	regulatory ncRNA 3'-end processing	8	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000215	tRNA 2'-phosphotransferase activity	5	11
GO:0003676	nucleic acid binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140101	catalytic activity, acting on a tRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0000175	3'-5'-RNA exonuclease activity	7	1
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004532	RNA exonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.661
CLV_C14_Caspase3-7	308	312	PF00656	0.729
CLV_C14_Caspase3-7	7	11	PF00656	0.581
CLV_NRD_NRD_1	252	254	PF00675	0.507
CLV_NRD_NRD_1	267	269	PF00675	0.578
CLV_NRD_NRD_1	33	35	PF00675	0.711
CLV_NRD_NRD_1	405	407	PF00675	0.476
CLV_NRD_NRD_1	509	511	PF00675	0.305
CLV_NRD_NRD_1	71	73	PF00675	0.334
CLV_PCSK_KEX2_1	252	254	PF00082	0.483
CLV_PCSK_KEX2_1	267	269	PF00082	0.578
CLV_PCSK_KEX2_1	33	35	PF00082	0.737
CLV_PCSK_KEX2_1	71	73	PF00082	0.334
CLV_PCSK_SKI1_1	102	106	PF00082	0.259
CLV_PCSK_SKI1_1	166	170	PF00082	0.291
CLV_PCSK_SKI1_1	241	245	PF00082	0.233
CLV_PCSK_SKI1_1	456	460	PF00082	0.447
CLV_PCSK_SKI1_1	89	93	PF00082	0.325
DEG_ODPH_VHL_1	50	63	PF01847	0.481
DOC_CKS1_1	179	184	PF01111	0.586
DOC_CKS1_1	18	23	PF01111	0.728
DOC_CKS1_1	539	544	PF01111	0.360
DOC_CYCLIN_yClb5_NLxxxL_5	241	247	PF00134	0.530
DOC_MAPK_gen_1	192	200	PF00069	0.542
DOC_MAPK_gen_1	252	259	PF00069	0.464
DOC_MAPK_gen_1	406	412	PF00069	0.476
DOC_MAPK_gen_1	510	517	PF00069	0.305
DOC_MAPK_MEF2A_6	252	261	PF00069	0.465
DOC_MAPK_MEF2A_6	510	519	PF00069	0.335
DOC_PP1_RVXF_1	378	385	PF00149	0.480
DOC_PP2B_LxvP_1	225	228	PF13499	0.558
DOC_PP2B_PxIxI_1	81	87	PF00149	0.433
DOC_PP4_FxxP_1	330	333	PF00568	0.509
DOC_USP7_MATH_1	151	155	PF00917	0.513
DOC_USP7_MATH_1	19	23	PF00917	0.767
DOC_USP7_MATH_1	282	286	PF00917	0.493
DOC_USP7_MATH_1	292	296	PF00917	0.696
DOC_USP7_MATH_1	38	42	PF00917	0.742
DOC_USP7_MATH_1	387	391	PF00917	0.408
DOC_USP7_UBL2_3	367	371	PF12436	0.445
DOC_USP7_UBL2_3	553	557	PF12436	0.486
DOC_WW_Pin1_4	17	22	PF00397	0.738
DOC_WW_Pin1_4	178	183	PF00397	0.565
DOC_WW_Pin1_4	297	302	PF00397	0.683
DOC_WW_Pin1_4	538	543	PF00397	0.347
DOC_WW_Pin1_4	89	94	PF00397	0.530
LIG_14-3-3_CanoR_1	111	119	PF00244	0.586
LIG_14-3-3_CanoR_1	241	250	PF00244	0.475
LIG_14-3-3_CanoR_1	323	329	PF00244	0.701
LIG_14-3-3_CanoR_1	33	37	PF00244	0.630
LIG_14-3-3_CanoR_1	385	395	PF00244	0.434
LIG_14-3-3_CanoR_1	456	462	PF00244	0.447
LIG_Actin_WH2_2	239	254	PF00022	0.502
LIG_AP2alpha_2	128	130	PF02296	0.586
LIG_APCC_ABBA_1	515	520	PF00400	0.355
LIG_BIR_III_2	148	152	PF00653	0.562
LIG_BIR_III_2	281	285	PF00653	0.641
LIG_BRCT_BRCA1_1	326	330	PF00533	0.573
LIG_BRCT_BRCA1_1	357	361	PF00533	0.648
LIG_BRCT_BRCA1_1	43	47	PF00533	0.718
LIG_FHA_1	242	248	PF00498	0.433
LIG_FHA_1	332	338	PF00498	0.579
LIG_FHA_1	539	545	PF00498	0.330
LIG_FHA_2	157	163	PF00498	0.481
LIG_FHA_2	284	290	PF00498	0.647
LIG_FHA_2	306	312	PF00498	0.726
LIG_FHA_2	457	463	PF00498	0.403
LIG_Integrin_isoDGR_2	563	565	PF01839	0.414
LIG_LIR_Apic_2	327	333	PF02991	0.544
LIG_LIR_Gen_1	154	162	PF02991	0.513
LIG_LIR_Gen_1	390	400	PF02991	0.399
LIG_LIR_Gen_1	56	65	PF02991	0.335
LIG_LIR_Nem_3	128	133	PF02991	0.482
LIG_LIR_Nem_3	154	158	PF02991	0.513
LIG_LIR_Nem_3	390	396	PF02991	0.399
LIG_LIR_Nem_3	44	50	PF02991	0.573
LIG_LIR_Nem_3	56	61	PF02991	0.296
LIG_LIR_Nem_3	80	84	PF02991	0.479
LIG_LIR_Nem_3	96	100	PF02991	0.441
LIG_LYPXL_SIV_4	430	438	PF13949	0.480
LIG_MYND_1	211	215	PF01753	0.502
LIG_NRBOX	246	252	PF00104	0.407
LIG_PDZ_Class_2	565	570	PF00595	0.604
LIG_RPA_C_Fungi	336	348	PF08784	0.554
LIG_SH2_CRK	155	159	PF00017	0.447
LIG_SH2_PTP2	100	103	PF00017	0.335
LIG_SH2_PTP2	393	396	PF00017	0.408
LIG_SH2_PTP2	58	61	PF00017	0.342
LIG_SH2_SRC	518	521	PF00017	0.355
LIG_SH2_STAT5	100	103	PF00017	0.329
LIG_SH2_STAT5	134	137	PF00017	0.474
LIG_SH2_STAT5	155	158	PF00017	0.374
LIG_SH2_STAT5	393	396	PF00017	0.369
LIG_SH2_STAT5	439	442	PF00017	0.319
LIG_SH2_STAT5	484	487	PF00017	0.368
LIG_SH2_STAT5	518	521	PF00017	0.355
LIG_SH2_STAT5	554	557	PF00017	0.393
LIG_SH2_STAT5	58	61	PF00017	0.342
LIG_SH3_3	101	107	PF00018	0.377
LIG_SH3_3	209	215	PF00018	0.386
LIG_SH3_3	295	301	PF00018	0.728
LIG_SUMO_SIM_par_1	255	260	PF11976	0.456
LIG_SUMO_SIM_par_1	333	338	PF11976	0.521
LIG_SUMO_SIM_par_1	82	87	PF11976	0.337
LIG_TRAF2_1	343	346	PF00917	0.548
LIG_TRAF2_1	460	463	PF00917	0.441
LIG_WW_3	300	304	PF00397	0.761
MOD_CDC14_SPxK_1	300	303	PF00782	0.599
MOD_CDK_SPxK_1	17	23	PF00069	0.729
MOD_CDK_SPxK_1	297	303	PF00069	0.596
MOD_CK1_1	41	47	PF00069	0.715
MOD_CK1_1	486	492	PF00069	0.349
MOD_CK2_1	456	462	PF00069	0.372
MOD_CMANNOS	473	476	PF00535	0.447
MOD_GlcNHglycan	124	127	PF01048	0.266
MOD_GlcNHglycan	175	178	PF01048	0.447
MOD_GlcNHglycan	203	206	PF01048	0.457
MOD_GlcNHglycan	215	218	PF01048	0.438
MOD_GlcNHglycan	234	237	PF01048	0.249
MOD_GlcNHglycan	26	29	PF01048	0.724
MOD_GlcNHglycan	294	297	PF01048	0.777
MOD_GlcNHglycan	319	322	PF01048	0.789
MOD_GlcNHglycan	40	43	PF01048	0.736
MOD_GlcNHglycan	506	509	PF01048	0.341
MOD_GSK3_1	107	114	PF00069	0.335
MOD_GSK3_1	13	20	PF00069	0.694
MOD_GSK3_1	297	304	PF00069	0.788
MOD_GSK3_1	367	374	PF00069	0.353
MOD_GSK3_1	38	45	PF00069	0.749
MOD_GSK3_1	559	566	PF00069	0.490
MOD_N-GLC_1	201	206	PF02516	0.402
MOD_N-GLC_1	241	246	PF02516	0.266
MOD_NEK2_1	13	18	PF00069	0.704
MOD_NEK2_1	173	178	PF00069	0.419
MOD_NEK2_1	348	353	PF00069	0.605
MOD_NEK2_1	372	377	PF00069	0.401
MOD_NEK2_1	531	536	PF00069	0.347
MOD_PIKK_1	117	123	PF00454	0.368
MOD_PIKK_1	193	199	PF00454	0.402
MOD_PIKK_1	4	10	PF00454	0.647
MOD_PKA_2	173	179	PF00069	0.447
MOD_PKA_2	213	219	PF00069	0.266
MOD_PKA_2	32	38	PF00069	0.757
MOD_PKA_2	419	425	PF00069	0.438
MOD_Plk_1	14	20	PF00069	0.553
MOD_Plk_1	241	247	PF00069	0.475
MOD_Plk_1	257	263	PF00069	0.500
MOD_Plk_4	164	170	PF00069	0.347
MOD_Plk_4	331	337	PF00069	0.544
MOD_Plk_4	372	378	PF00069	0.390
MOD_Plk_4	468	474	PF00069	0.335
MOD_ProDKin_1	17	23	PF00069	0.739
MOD_ProDKin_1	178	184	PF00069	0.451
MOD_ProDKin_1	297	303	PF00069	0.685
MOD_ProDKin_1	538	544	PF00069	0.347
MOD_ProDKin_1	89	95	PF00069	0.402
MOD_SUMO_rev_2	162	168	PF00179	0.335
MOD_SUMO_rev_2	362	369	PF00179	0.591
TRG_DiLeu_BaEn_2	135	141	PF01217	0.447
TRG_ENDOCYTIC_2	155	158	PF00928	0.378
TRG_ENDOCYTIC_2	393	396	PF00928	0.408
TRG_ENDOCYTIC_2	518	521	PF00928	0.355
TRG_ENDOCYTIC_2	58	61	PF00928	0.327
TRG_ER_diArg_1	251	253	PF00400	0.495
TRG_ER_diArg_1	266	268	PF00400	0.554
TRG_ER_diArg_1	71	73	PF00400	0.415
TRG_NES_CRM1_1	220	230	PF08389	0.452
TRG_NLS_MonoExtN_4	313	320	PF00514	0.582
TRG_Pf-PMV_PEXEL_1	253	258	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWH5	Leptomonas seymouri	58%	92%
A0A0S4J7G0	Bodo saltans	42%	88%
A0A3Q8IBU9	Leishmania donovani	100%	100%
A0A422MZ86	Trypanosoma rangeli	44%	100%
A4HDD9	Leishmania braziliensis	77%	99%
D0A750	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AWS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAQ2	Leishmania major	90%	100%
V5C0L6	Trypanosoma cruzi	46%	89%