Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0R8_LEIIN

TriTrypDb:

LINF_240013000

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4I0R8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0R8

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	7
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	7
GO:0000398	mRNA splicing, via spliceosome	8	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006397	mRNA processing	7	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008380	RNA splicing	7	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0016071	mRNA metabolic process	6	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.580
CLV_C14_Caspase3-7	21	25	PF00656	0.632
CLV_NRD_NRD_1	188	190	PF00675	0.685
CLV_NRD_NRD_1	259	261	PF00675	0.533
CLV_NRD_NRD_1	337	339	PF00675	0.525
CLV_NRD_NRD_1	385	387	PF00675	0.607
CLV_NRD_NRD_1	538	540	PF00675	0.568
CLV_NRD_NRD_1	87	89	PF00675	0.639
CLV_PCSK_KEX2_1	14	16	PF00082	0.699
CLV_PCSK_KEX2_1	188	190	PF00082	0.685
CLV_PCSK_KEX2_1	22	24	PF00082	0.704
CLV_PCSK_KEX2_1	538	540	PF00082	0.481
CLV_PCSK_KEX2_1	87	89	PF00082	0.639
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.699
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.704
CLV_PCSK_SKI1_1	321	325	PF00082	0.682
CLV_PCSK_SKI1_1	338	342	PF00082	0.544
CLV_PCSK_SKI1_1	505	509	PF00082	0.478
DEG_APCC_DBOX_1	169	177	PF00400	0.554
DEG_SPOP_SBC_1	106	110	PF00917	0.605
DEG_SPOP_SBC_1	209	213	PF00917	0.528
DEG_SPOP_SBC_1	268	272	PF00917	0.658
DEG_SPOP_SBC_1	282	286	PF00917	0.707
DEG_SPOP_SBC_1	411	415	PF00917	0.659
DOC_CDC14_PxL_1	35	43	PF14671	0.558
DOC_MAPK_gen_1	526	535	PF00069	0.507
DOC_MAPK_gen_1	565	572	PF00069	0.494
DOC_PP1_RVXF_1	370	376	PF00149	0.454
DOC_PP2B_LxvP_1	431	434	PF13499	0.628
DOC_USP7_MATH_1	100	104	PF00917	0.628
DOC_USP7_MATH_1	106	110	PF00917	0.617
DOC_USP7_MATH_1	166	170	PF00917	0.795
DOC_USP7_MATH_1	196	200	PF00917	0.625
DOC_USP7_MATH_1	209	213	PF00917	0.690
DOC_USP7_MATH_1	215	219	PF00917	0.478
DOC_USP7_MATH_1	269	273	PF00917	0.716
DOC_USP7_MATH_1	282	286	PF00917	0.747
DOC_USP7_MATH_1	287	291	PF00917	0.758
DOC_USP7_MATH_1	303	307	PF00917	0.649
DOC_USP7_MATH_1	371	375	PF00917	0.433
DOC_USP7_MATH_1	411	415	PF00917	0.676
DOC_USP7_MATH_1	92	96	PF00917	0.727
DOC_USP7_UBL2_3	335	339	PF12436	0.528
DOC_USP7_UBL2_3	464	468	PF12436	0.409
DOC_WW_Pin1_4	211	216	PF00397	0.609
DOC_WW_Pin1_4	278	283	PF00397	0.751
DOC_WW_Pin1_4	285	290	PF00397	0.682
DOC_WW_Pin1_4	338	343	PF00397	0.562
DOC_WW_Pin1_4	407	412	PF00397	0.647
DOC_WW_Pin1_4	425	430	PF00397	0.671
DOC_WW_Pin1_4	81	86	PF00397	0.657
DOC_WW_Pin1_4	88	93	PF00397	0.701
LIG_14-3-3_CanoR_1	260	269	PF00244	0.621
LIG_14-3-3_CanoR_1	321	329	PF00244	0.551
LIG_14-3-3_CanoR_1	370	376	PF00244	0.547
LIG_14-3-3_CanoR_1	451	460	PF00244	0.452
LIG_14-3-3_CanoR_1	53	61	PF00244	0.572
LIG_14-3-3_CanoR_1	87	93	PF00244	0.688
LIG_BIR_II_1	1	5	PF00653	0.681
LIG_BIR_III_2	9	13	PF00653	0.676
LIG_BRCT_BRCA1_1	108	112	PF00533	0.661
LIG_BRCT_BRCA1_1	217	221	PF00533	0.681
LIG_BRCT_BRCA1_1	494	498	PF00533	0.604
LIG_Clathr_ClatBox_1	514	518	PF01394	0.478
LIG_EVH1_1	431	435	PF00568	0.579
LIG_FHA_1	306	312	PF00498	0.661
LIG_FHA_1	509	515	PF00498	0.436
LIG_FHA_1	564	570	PF00498	0.495
LIG_FHA_2	182	188	PF00498	0.654
LIG_FHA_2	328	334	PF00498	0.523
LIG_FHA_2	350	356	PF00498	0.467
LIG_LIR_Gen_1	218	229	PF02991	0.663
LIG_LIR_Nem_3	218	224	PF02991	0.632
LIG_LIR_Nem_3	374	378	PF02991	0.436
LIG_MLH1_MIPbox_1	109	113	PF16413	0.666
LIG_MYND_1	429	433	PF01753	0.640
LIG_PAM2_1	433	445	PF00658	0.552
LIG_PCNA_yPIPBox_3	250	261	PF02747	0.499
LIG_REV1ctd_RIR_1	373	383	PF16727	0.467
LIG_SH2_PTP2	227	230	PF00017	0.540
LIG_SH2_STAT5	227	230	PF00017	0.542
LIG_SH2_STAT5	383	386	PF00017	0.621
LIG_SH3_3	203	209	PF00018	0.588
LIG_SH3_3	426	432	PF00018	0.688
LIG_SUMO_SIM_par_1	531	537	PF11976	0.422
LIG_TRAF2_1	330	333	PF00917	0.518
MOD_CDK_SPxK_1	81	87	PF00069	0.550
MOD_CDK_SPxxK_3	81	88	PF00069	0.647
MOD_CK1_1	107	113	PF00069	0.622
MOD_CK1_1	136	142	PF00069	0.667
MOD_CK1_1	159	165	PF00069	0.669
MOD_CK1_1	18	24	PF00069	0.554
MOD_CK1_1	199	205	PF00069	0.669
MOD_CK1_1	2	8	PF00069	0.580
MOD_CK1_1	213	219	PF00069	0.657
MOD_CK1_1	280	286	PF00069	0.703
MOD_CK1_1	325	331	PF00069	0.597
MOD_CK1_1	406	412	PF00069	0.624
MOD_CK1_1	425	431	PF00069	0.671
MOD_CK1_1	490	496	PF00069	0.585
MOD_CK2_1	307	313	PF00069	0.510
MOD_CK2_1	327	333	PF00069	0.526
MOD_CK2_1	371	377	PF00069	0.430
MOD_Cter_Amidation	336	339	PF01082	0.506
MOD_Cter_Amidation	461	464	PF01082	0.406
MOD_DYRK1A_RPxSP_1	88	92	PF00069	0.537
MOD_GlcNHglycan	138	141	PF01048	0.658
MOD_GlcNHglycan	184	187	PF01048	0.750
MOD_GlcNHglycan	190	193	PF01048	0.707
MOD_GlcNHglycan	198	201	PF01048	0.701
MOD_GlcNHglycan	202	205	PF01048	0.720
MOD_GlcNHglycan	217	220	PF01048	0.569
MOD_GlcNHglycan	271	274	PF01048	0.682
MOD_GlcNHglycan	275	278	PF01048	0.663
MOD_GlcNHglycan	305	308	PF01048	0.630
MOD_GlcNHglycan	324	327	PF01048	0.462
MOD_GlcNHglycan	379	382	PF01048	0.294
MOD_GlcNHglycan	41	44	PF01048	0.506
MOD_GlcNHglycan	414	417	PF01048	0.639
MOD_GlcNHglycan	424	427	PF01048	0.577
MOD_GlcNHglycan	487	490	PF01048	0.765
MOD_GlcNHglycan	492	495	PF01048	0.691
MOD_GlcNHglycan	88	91	PF01048	0.604
MOD_GlcNHglycan	94	97	PF01048	0.757
MOD_GSK3_1	100	107	PF00069	0.646
MOD_GSK3_1	139	146	PF00069	0.631
MOD_GSK3_1	152	159	PF00069	0.731
MOD_GSK3_1	18	25	PF00069	0.808
MOD_GSK3_1	196	203	PF00069	0.621
MOD_GSK3_1	209	216	PF00069	0.657
MOD_GSK3_1	269	276	PF00069	0.664
MOD_GSK3_1	277	284	PF00069	0.619
MOD_GSK3_1	288	295	PF00069	0.629
MOD_GSK3_1	303	310	PF00069	0.684
MOD_GSK3_1	403	410	PF00069	0.543
MOD_GSK3_1	421	428	PF00069	0.757
MOD_GSK3_1	466	473	PF00069	0.411
MOD_GSK3_1	490	497	PF00069	0.753
MOD_GSK3_1	88	95	PF00069	0.725
MOD_LATS_1	13	19	PF00433	0.687
MOD_N-GLC_1	156	161	PF02516	0.603
MOD_N-GLC_1	182	187	PF02516	0.716
MOD_N-GLC_1	406	411	PF02516	0.609
MOD_N-GLC_1	563	568	PF02516	0.366
MOD_N-GLC_1	81	86	PF02516	0.549
MOD_NEK2_1	143	148	PF00069	0.701
MOD_NEK2_1	235	240	PF00069	0.576
MOD_NEK2_1	349	354	PF00069	0.392
MOD_NEK2_1	366	371	PF00069	0.488
MOD_NEK2_1	388	393	PF00069	0.415
MOD_NEK2_2	371	376	PF00069	0.471
MOD_NEK2_2	494	499	PF00069	0.737
MOD_PKA_1	188	194	PF00069	0.634
MOD_PKA_1	22	28	PF00069	0.624
MOD_PKA_2	188	194	PF00069	0.702
MOD_PKA_2	22	28	PF00069	0.624
MOD_PKA_2	450	456	PF00069	0.445
MOD_PKA_2	86	92	PF00069	0.607
MOD_Plk_1	349	355	PF00069	0.399
MOD_Plk_4	307	313	PF00069	0.570
MOD_Plk_4	371	377	PF00069	0.430
MOD_Plk_4	519	525	PF00069	0.391
MOD_ProDKin_1	211	217	PF00069	0.608
MOD_ProDKin_1	278	284	PF00069	0.751
MOD_ProDKin_1	285	291	PF00069	0.683
MOD_ProDKin_1	338	344	PF00069	0.550
MOD_ProDKin_1	407	413	PF00069	0.655
MOD_ProDKin_1	425	431	PF00069	0.669
MOD_ProDKin_1	81	87	PF00069	0.657
MOD_ProDKin_1	88	94	PF00069	0.701
MOD_SUMO_rev_2	380	388	PF00179	0.312
TRG_ENDOCYTIC_2	227	230	PF00928	0.542
TRG_ER_diArg_1	29	32	PF00400	0.543
TRG_ER_diArg_1	44	47	PF00400	0.555
TRG_ER_diArg_1	476	479	PF00400	0.522
TRG_ER_diArg_1	545	548	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	338	343	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD00	Leptomonas seymouri	47%	100%
A0A3R7R9R9	Trypanosoma rangeli	34%	100%
A0A3S7WYC4	Leishmania donovani	99%	100%
A4HDD7	Leishmania braziliensis	73%	97%
D0A749	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AWS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QAQ4	Leishmania major	90%	100%