DUF523 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF523) - putative

Species:

Leishmania infantum

UniProt:

A4I0Q9_LEIIN

TriTrypDb:

LINF_240012100

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0Q9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0Q9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.655
CLV_C14_Caspase3-7	336	340	PF00656	0.587
CLV_C14_Caspase3-7	416	420	PF00656	0.630
CLV_NRD_NRD_1	187	189	PF00675	0.543
CLV_NRD_NRD_1	323	325	PF00675	0.788
CLV_NRD_NRD_1	333	335	PF00675	0.501
CLV_NRD_NRD_1	402	404	PF00675	0.661
CLV_PCSK_KEX2_1	187	189	PF00082	0.543
CLV_PCSK_KEX2_1	219	221	PF00082	0.487
CLV_PCSK_KEX2_1	323	325	PF00082	0.788
CLV_PCSK_KEX2_1	333	335	PF00082	0.501
CLV_PCSK_KEX2_1	401	403	PF00082	0.778
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.487
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.778
CLV_PCSK_SKI1_1	347	351	PF00082	0.620
CLV_PCSK_SKI1_1	379	383	PF00082	0.514
DEG_APCC_DBOX_1	170	178	PF00400	0.502
DEG_APCC_DBOX_1	346	354	PF00400	0.629
DEG_Nend_UBRbox_4	1	3	PF02207	0.621
DEG_SCF_FBW7_1	93	98	PF00400	0.591
DEG_SPOP_SBC_1	95	99	PF00917	0.597
DOC_CKS1_1	62	67	PF01111	0.678
DOC_CYCLIN_yCln2_LP_2	117	123	PF00134	0.465
DOC_MAPK_DCC_7	103	112	PF00069	0.545
DOC_MAPK_gen_1	31	40	PF00069	0.586
DOC_MAPK_MEF2A_6	103	112	PF00069	0.615
DOC_MAPK_MEF2A_6	135	142	PF00069	0.475
DOC_PP2B_LxvP_1	165	168	PF13499	0.503
DOC_PP2B_LxvP_1	249	252	PF13499	0.540
DOC_USP7_MATH_1	195	199	PF00917	0.712
DOC_USP7_MATH_1	210	214	PF00917	0.557
DOC_USP7_MATH_1	325	329	PF00917	0.674
DOC_WW_Pin1_4	134	139	PF00397	0.469
DOC_WW_Pin1_4	25	30	PF00397	0.677
DOC_WW_Pin1_4	275	280	PF00397	0.473
DOC_WW_Pin1_4	292	297	PF00397	0.648
DOC_WW_Pin1_4	61	66	PF00397	0.679
DOC_WW_Pin1_4	91	96	PF00397	0.752
LIG_14-3-3_CanoR_1	124	134	PF00244	0.574
LIG_14-3-3_CanoR_1	34	39	PF00244	0.636
LIG_14-3-3_CanoR_1	365	374	PF00244	0.673
LIG_BRCT_BRCA1_1	316	320	PF00533	0.674
LIG_CaM_NSCaTE_8	82	89	PF13499	0.593
LIG_FHA_1	135	141	PF00498	0.492
LIG_FHA_1	258	264	PF00498	0.434
LIG_FHA_1	341	347	PF00498	0.563
LIG_FHA_2	242	248	PF00498	0.690
LIG_FHA_2	414	420	PF00498	0.543
LIG_FHA_2	97	103	PF00498	0.719
LIG_LIR_Nem_3	144	150	PF02991	0.426
LIG_LIR_Nem_3	161	167	PF02991	0.480
LIG_LIR_Nem_3	79	85	PF02991	0.700
LIG_NRBOX	258	264	PF00104	0.613
LIG_PDZ_Class_3	433	438	PF00595	0.412
LIG_SH2_CRK	238	242	PF00017	0.496
LIG_SH2_CRK	4	8	PF00017	0.617
LIG_SH2_NCK_1	238	242	PF00017	0.574
LIG_SH2_SRC	289	292	PF00017	0.658
LIG_SH2_STAP1	289	293	PF00017	0.574
LIG_SH2_STAP1	4	8	PF00017	0.667
LIG_SH2_STAT5	224	227	PF00017	0.591
LIG_SH3_2	170	175	PF14604	0.501
LIG_SH3_3	102	108	PF00018	0.687
LIG_SH3_3	154	160	PF00018	0.448
LIG_SH3_3	167	173	PF00018	0.505
LIG_SH3_3	27	33	PF00018	0.573
LIG_SH3_3	290	296	PF00018	0.714
LIG_SUMO_SIM_anti_2	6	11	PF11976	0.619
LIG_SUMO_SIM_par_1	106	113	PF11976	0.474
LIG_SUMO_SIM_par_1	6	11	PF11976	0.619
LIG_UBA3_1	262	267	PF00899	0.520
LIG_WRC_WIRS_1	418	423	PF05994	0.604
MOD_CDK_SPxK_1	25	31	PF00069	0.649
MOD_CDK_SPxxK_3	61	68	PF00069	0.664
MOD_CK1_1	180	186	PF00069	0.702
MOD_CK1_1	199	205	PF00069	0.532
MOD_CK1_1	295	301	PF00069	0.597
MOD_CK1_1	417	423	PF00069	0.608
MOD_CK1_1	96	102	PF00069	0.659
MOD_CK2_1	225	231	PF00069	0.583
MOD_CK2_1	241	247	PF00069	0.638
MOD_CK2_1	417	423	PF00069	0.559
MOD_Cter_Amidation	321	324	PF01082	0.787
MOD_GlcNHglycan	10	13	PF01048	0.647
MOD_GlcNHglycan	112	115	PF01048	0.550
MOD_GlcNHglycan	189	192	PF01048	0.728
MOD_GlcNHglycan	199	202	PF01048	0.598
MOD_GlcNHglycan	208	211	PF01048	0.592
MOD_GlcNHglycan	227	231	PF01048	0.596
MOD_GlcNHglycan	255	258	PF01048	0.601
MOD_GlcNHglycan	327	330	PF01048	0.661
MOD_GSK3_1	115	122	PF00069	0.534
MOD_GSK3_1	126	133	PF00069	0.520
MOD_GSK3_1	195	202	PF00069	0.731
MOD_GSK3_1	206	213	PF00069	0.619
MOD_GSK3_1	253	260	PF00069	0.482
MOD_GSK3_1	273	280	PF00069	0.466
MOD_GSK3_1	291	298	PF00069	0.471
MOD_GSK3_1	314	321	PF00069	0.655
MOD_GSK3_1	413	420	PF00069	0.654
MOD_GSK3_1	89	96	PF00069	0.701
MOD_N-GLC_1	23	28	PF02516	0.557
MOD_N-GLC_1	241	246	PF02516	0.749
MOD_N-GLC_1	406	411	PF02516	0.704
MOD_N-GLC_2	307	309	PF02516	0.741
MOD_NEK2_1	206	211	PF00069	0.727
MOD_NEK2_1	225	230	PF00069	0.594
MOD_NEK2_1	349	354	PF00069	0.557
MOD_NEK2_1	421	426	PF00069	0.519
MOD_PIKK_1	257	263	PF00454	0.440
MOD_PIKK_1	340	346	PF00454	0.557
MOD_PIKK_1	431	437	PF00454	0.559
MOD_PK_1	314	320	PF00069	0.633
MOD_PKA_1	187	193	PF00069	0.563
MOD_PKA_2	123	129	PF00069	0.647
MOD_PKA_2	177	183	PF00069	0.587
MOD_PKA_2	187	193	PF00069	0.647
MOD_PKA_2	33	39	PF00069	0.691
MOD_PKA_2	431	437	PF00069	0.636
MOD_Plk_1	23	29	PF00069	0.559
MOD_Plk_1	241	247	PF00069	0.677
MOD_Plk_1	89	95	PF00069	0.619
MOD_Plk_4	3	9	PF00069	0.728
MOD_Plk_4	417	423	PF00069	0.459
MOD_ProDKin_1	134	140	PF00069	0.464
MOD_ProDKin_1	25	31	PF00069	0.681
MOD_ProDKin_1	275	281	PF00069	0.469
MOD_ProDKin_1	292	298	PF00069	0.650
MOD_ProDKin_1	61	67	PF00069	0.674
MOD_ProDKin_1	91	97	PF00069	0.756
TRG_DiLeu_BaEn_1	221	226	PF01217	0.627
TRG_DiLeu_BaEn_1	231	236	PF01217	0.483
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.499
TRG_DiLeu_BaLyEn_6	376	381	PF01217	0.454
TRG_ENDOCYTIC_2	4	7	PF00928	0.616
TRG_ER_diArg_1	323	325	PF00400	0.788
TRG_ER_diArg_1	333	335	PF00400	0.501
TRG_ER_diArg_1	402	404	PF00400	0.606
TRG_NES_CRM1_1	149	161	PF08389	0.463
TRG_NLS_MonoCore_2	399	404	PF00514	0.594
TRG_NLS_MonoExtN_4	398	405	PF00514	0.757
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3F4	Leptomonas seymouri	43%	100%
A0A3S7WY61	Leishmania donovani	98%	100%
A4HDC8	Leishmania braziliensis	72%	100%
E9AWR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QAR2	Leishmania major	90%	100%