LeishMANIAdb
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Kinesin-like protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Kinesin-like protein
Gene product:
Kinesin-13 3 - putative
Species:
Leishmania infantum
UniProt:
A4I0Q2_LEIIN
TriTrypDb:
LINF_240011400
Length:
577

Annotations

Annotations by Jardim et al.

Structural Proteins, Kinesin-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 17
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0005874 microtubule 6 18
GO:0099080 supramolecular complex 2 18
GO:0099081 supramolecular polymer 3 18
GO:0099512 supramolecular fiber 4 18
GO:0099513 polymeric cytoskeletal fiber 5 18
GO:0110165 cellular anatomical entity 1 18
GO:0005737 cytoplasm 2 1
GO:0005815 microtubule organizing center 2 1
GO:0036064 ciliary basal body 3 1
GO:0051286 cell tip 3 1
GO:0060187 cell pole 2 1
GO:0097542 ciliary tip 2 1

Phosphorylation

Amastigote: 341, 418

Expansion

Sequence features

A4I0Q2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0Q2

Function

Biological processes
Term Name Level Count
GO:0007017 microtubule-based process 2 18
GO:0007018 microtubule-based movement 3 18
GO:0009987 cellular process 1 18
GO:0000226 microtubule cytoskeleton organization 3 1
GO:0006996 organelle organization 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0007019 microtubule depolymerization 5 1
GO:0016043 cellular component organization 3 1
GO:0022411 cellular component disassembly 4 1
GO:0031109 microtubule polymerization or depolymerization 4 1
GO:0032984 protein-containing complex disassembly 5 1
GO:0043933 protein-containing complex organization 4 1
GO:0051261 protein depolymerization 6 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0097435 supramolecular fiber organization 4 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 18
GO:0003774 cytoskeletal motor activity 1 18
GO:0003777 microtubule motor activity 2 18
GO:0005488 binding 1 18
GO:0005515 protein binding 2 18
GO:0005524 ATP binding 5 18
GO:0008017 microtubule binding 5 18
GO:0008092 cytoskeletal protein binding 3 18
GO:0015631 tubulin binding 4 18
GO:0017076 purine nucleotide binding 4 18
GO:0030554 adenyl nucleotide binding 5 18
GO:0032553 ribonucleotide binding 3 18
GO:0032555 purine ribonucleotide binding 4 18
GO:0032559 adenyl ribonucleotide binding 5 18
GO:0035639 purine ribonucleoside triphosphate binding 4 18
GO:0036094 small molecule binding 2 18
GO:0043167 ion binding 2 18
GO:0043168 anion binding 3 18
GO:0097159 organic cyclic compound binding 2 18
GO:0097367 carbohydrate derivative binding 2 18
GO:0140657 ATP-dependent activity 1 18
GO:1901265 nucleoside phosphate binding 3 18
GO:1901363 heterocyclic compound binding 2 18

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 522 526 PF00656 0.449
CLV_NRD_NRD_1 135 137 PF00675 0.332
CLV_NRD_NRD_1 144 146 PF00675 0.361
CLV_NRD_NRD_1 216 218 PF00675 0.329
CLV_NRD_NRD_1 243 245 PF00675 0.306
CLV_NRD_NRD_1 345 347 PF00675 0.629
CLV_NRD_NRD_1 351 353 PF00675 0.619
CLV_NRD_NRD_1 478 480 PF00675 0.426
CLV_NRD_NRD_1 501 503 PF00675 0.407
CLV_NRD_NRD_1 9 11 PF00675 0.365
CLV_PCSK_KEX2_1 11 13 PF00082 0.403
CLV_PCSK_KEX2_1 146 148 PF00082 0.450
CLV_PCSK_KEX2_1 216 218 PF00082 0.357
CLV_PCSK_KEX2_1 345 347 PF00082 0.640
CLV_PCSK_KEX2_1 351 353 PF00082 0.627
CLV_PCSK_KEX2_1 501 503 PF00082 0.407
CLV_PCSK_PC1ET2_1 11 13 PF00082 0.403
CLV_PCSK_PC1ET2_1 146 148 PF00082 0.274
CLV_PCSK_SKI1_1 113 117 PF00082 0.328
CLV_PCSK_SKI1_1 136 140 PF00082 0.306
CLV_PCSK_SKI1_1 146 150 PF00082 0.333
CLV_PCSK_SKI1_1 255 259 PF00082 0.308
CLV_PCSK_SKI1_1 432 436 PF00082 0.434
CLV_PCSK_SKI1_1 535 539 PF00082 0.412
CLV_PCSK_SKI1_1 567 571 PF00082 0.512
CLV_Separin_Metazoa 283 287 PF03568 0.326
DEG_APCC_DBOX_1 66 74 PF00400 0.434
DOC_CKS1_1 22 27 PF01111 0.536
DOC_CYCLIN_RxL_1 252 262 PF00134 0.308
DOC_MAPK_gen_1 216 227 PF00069 0.342
DOC_MAPK_HePTP_8 9 21 PF00069 0.370
DOC_MAPK_MEF2A_6 12 21 PF00069 0.493
DOC_MAPK_MEF2A_6 198 207 PF00069 0.348
DOC_MAPK_RevD_3 124 137 PF00069 0.346
DOC_PP1_RVXF_1 222 228 PF00149 0.309
DOC_USP7_MATH_1 194 198 PF00917 0.370
DOC_USP7_MATH_1 443 447 PF00917 0.673
DOC_USP7_MATH_1 517 521 PF00917 0.519
DOC_USP7_UBL2_3 491 495 PF12436 0.549
DOC_WW_Pin1_4 21 26 PF00397 0.424
DOC_WW_Pin1_4 299 304 PF00397 0.308
DOC_WW_Pin1_4 338 343 PF00397 0.701
DOC_WW_Pin1_4 372 377 PF00397 0.656
DOC_WW_Pin1_4 38 43 PF00397 0.131
DOC_WW_Pin1_4 415 420 PF00397 0.735
LIG_14-3-3_CanoR_1 224 228 PF00244 0.286
LIG_14-3-3_CanoR_1 294 298 PF00244 0.327
LIG_14-3-3_CanoR_1 316 324 PF00244 0.337
LIG_14-3-3_CanoR_1 46 52 PF00244 0.305
LIG_Actin_WH2_2 273 288 PF00022 0.312
LIG_APCC_ABBA_1 40 45 PF00400 0.304
LIG_BIR_II_1 1 5 PF00653 0.558
LIG_deltaCOP1_diTrp_1 365 370 PF00928 0.495
LIG_FHA_1 280 286 PF00498 0.308
LIG_FHA_1 293 299 PF00498 0.308
LIG_FHA_1 316 322 PF00498 0.329
LIG_FHA_1 568 574 PF00498 0.534
LIG_FHA_2 244 250 PF00498 0.308
LIG_FHA_2 48 54 PF00498 0.398
LIG_LIR_Gen_1 173 183 PF02991 0.399
LIG_LIR_Gen_1 226 231 PF02991 0.302
LIG_LIR_Gen_1 48 55 PF02991 0.310
LIG_LIR_Nem_3 129 134 PF02991 0.313
LIG_LIR_Nem_3 173 178 PF02991 0.399
LIG_LIR_Nem_3 226 230 PF02991 0.301
LIG_LIR_Nem_3 48 54 PF02991 0.310
LIG_LIR_Nem_3 95 99 PF02991 0.358
LIG_NRP_CendR_1 576 577 PF00754 0.643
LIG_Pex14_1 366 370 PF04695 0.491
LIG_Pex14_2 51 55 PF04695 0.388
LIG_SH2_CRK 96 100 PF00017 0.398
LIG_SH2_NCK_1 108 112 PF00017 0.326
LIG_SH2_SRC 108 111 PF00017 0.327
LIG_SH2_STAP1 108 112 PF00017 0.326
LIG_SH2_STAP1 317 321 PF00017 0.308
LIG_SH2_STAT5 127 130 PF00017 0.327
LIG_SH2_STAT5 317 320 PF00017 0.312
LIG_SH2_STAT5 43 46 PF00017 0.311
LIG_SH2_STAT5 484 487 PF00017 0.534
LIG_SH2_STAT5 530 533 PF00017 0.366
LIG_SH2_STAT5 96 99 PF00017 0.386
LIG_SH3_2 347 352 PF14604 0.641
LIG_SH3_3 19 25 PF00018 0.500
LIG_SH3_3 28 34 PF00018 0.252
LIG_SH3_3 344 350 PF00018 0.735
LIG_SH3_3 425 431 PF00018 0.516
LIG_SUMO_SIM_anti_2 18 24 PF11976 0.565
LIG_SUMO_SIM_par_1 256 262 PF11976 0.308
LIG_TRAF2_1 520 523 PF00917 0.568
LIG_TRFH_1 38 42 PF08558 0.304
LIG_UBA3_1 138 146 PF00899 0.275
LIG_UBA3_1 257 261 PF00899 0.308
LIG_WRC_WIRS_1 127 132 PF05994 0.317
LIG_WRC_WIRS_1 518 523 PF05994 0.451
MOD_CDK_SPK_2 23 28 PF00069 0.428
MOD_CDK_SPxxK_3 21 28 PF00069 0.416
MOD_CDK_SPxxK_3 338 345 PF00069 0.717
MOD_CK1_1 196 202 PF00069 0.338
MOD_CK1_1 279 285 PF00069 0.305
MOD_CK1_1 293 299 PF00069 0.288
MOD_CK1_1 302 308 PF00069 0.241
MOD_CK1_1 372 378 PF00069 0.709
MOD_CK1_1 41 47 PF00069 0.317
MOD_CK1_1 415 421 PF00069 0.702
MOD_CK1_1 506 512 PF00069 0.557
MOD_CK1_1 571 577 PF00069 0.610
MOD_CK1_1 92 98 PF00069 0.308
MOD_CK2_1 126 132 PF00069 0.317
MOD_CK2_1 243 249 PF00069 0.308
MOD_CK2_1 376 382 PF00069 0.729
MOD_CK2_1 47 53 PF00069 0.415
MOD_CK2_1 517 523 PF00069 0.499
MOD_CK2_1 98 104 PF00069 0.368
MOD_Cter_Amidation 134 137 PF01082 0.334
MOD_Cter_Amidation 343 346 PF01082 0.646
MOD_GlcNHglycan 181 184 PF01048 0.338
MOD_GlcNHglycan 190 193 PF01048 0.286
MOD_GlcNHglycan 211 214 PF01048 0.375
MOD_GlcNHglycan 414 417 PF01048 0.693
MOD_GlcNHglycan 573 576 PF01048 0.564
MOD_GlcNHglycan 91 94 PF01048 0.308
MOD_GSK3_1 292 299 PF00069 0.293
MOD_GSK3_1 311 318 PF00069 0.247
MOD_GSK3_1 365 372 PF00069 0.559
MOD_GSK3_1 408 415 PF00069 0.789
MOD_GSK3_1 41 48 PF00069 0.434
MOD_GSK3_1 513 520 PF00069 0.533
MOD_GSK3_1 563 570 PF00069 0.462
MOD_GSK3_1 94 101 PF00069 0.369
MOD_N-GLC_1 253 258 PF02516 0.308
MOD_N-GLC_1 80 85 PF02516 0.312
MOD_N-GLC_2 159 161 PF02516 0.260
MOD_NEK2_1 269 274 PF00069 0.308
MOD_NEK2_1 276 281 PF00069 0.297
MOD_NEK2_1 285 290 PF00069 0.285
MOD_NEK2_1 297 302 PF00069 0.322
MOD_NEK2_1 315 320 PF00069 0.265
MOD_NEK2_1 55 60 PF00069 0.341
MOD_NEK2_1 565 570 PF00069 0.436
MOD_NEK2_1 72 77 PF00069 0.267
MOD_NEK2_1 98 103 PF00069 0.369
MOD_NEK2_2 80 85 PF00069 0.308
MOD_PIKK_1 302 308 PF00454 0.353
MOD_PIKK_1 315 321 PF00454 0.231
MOD_PIKK_1 98 104 PF00454 0.317
MOD_PK_1 408 414 PF00069 0.665
MOD_PKA_2 207 213 PF00069 0.371
MOD_PKA_2 223 229 PF00069 0.206
MOD_PKA_2 243 249 PF00069 0.305
MOD_PKA_2 276 282 PF00069 0.308
MOD_PKA_2 285 291 PF00069 0.308
MOD_PKA_2 293 299 PF00069 0.308
MOD_PKA_2 315 321 PF00069 0.323
MOD_PKA_2 45 51 PF00069 0.368
MOD_PKB_1 406 414 PF00069 0.717
MOD_Plk_1 253 259 PF00069 0.303
MOD_Plk_1 513 519 PF00069 0.500
MOD_Plk_1 80 86 PF00069 0.312
MOD_Plk_2-3 523 529 PF00069 0.449
MOD_Plk_4 126 132 PF00069 0.360
MOD_Plk_4 253 259 PF00069 0.308
MOD_Plk_4 276 282 PF00069 0.321
MOD_Plk_4 293 299 PF00069 0.338
MOD_Plk_4 432 438 PF00069 0.430
MOD_Plk_4 554 560 PF00069 0.466
MOD_Plk_4 72 78 PF00069 0.309
MOD_Plk_4 94 100 PF00069 0.317
MOD_ProDKin_1 21 27 PF00069 0.427
MOD_ProDKin_1 299 305 PF00069 0.308
MOD_ProDKin_1 338 344 PF00069 0.708
MOD_ProDKin_1 372 378 PF00069 0.659
MOD_ProDKin_1 38 44 PF00069 0.131
MOD_ProDKin_1 415 421 PF00069 0.731
MOD_SUMO_for_1 333 336 PF00179 0.636
MOD_SUMO_for_1 490 493 PF00179 0.500
MOD_SUMO_for_1 511 514 PF00179 0.440
MOD_SUMO_rev_2 238 246 PF00179 0.312
MOD_SUMO_rev_2 487 497 PF00179 0.461
TRG_DiLeu_BaLyEn_6 68 73 PF01217 0.369
TRG_ENDOCYTIC_2 127 130 PF00928 0.310
TRG_ENDOCYTIC_2 96 99 PF00928 0.398
TRG_ER_diArg_1 145 148 PF00400 0.453
TRG_ER_diArg_1 345 347 PF00400 0.641
TRG_ER_diArg_1 350 352 PF00400 0.614
TRG_ER_diArg_1 405 408 PF00400 0.720
TRG_ER_diArg_1 533 536 PF00400 0.584
TRG_ER_diArg_1 9 12 PF00400 0.375
TRG_Pf-PMV_PEXEL_1 12 16 PF00026 0.481
TRG_Pf-PMV_PEXEL_1 136 140 PF00026 0.331

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2G5 Leptomonas seymouri 81% 100%
A0A0N0P6P6 Leptomonas seymouri 42% 87%
A0A0N1PDD6 Leptomonas seymouri 30% 76%
A0A0S4IP49 Bodo saltans 27% 72%
A0A0S4IR67 Bodo saltans 29% 74%
A0A0S4IYW0 Bodo saltans 59% 99%
A0A1X0NIJ1 Trypanosomatidae 64% 98%
A0A1X0NQ03 Trypanosomatidae 26% 70%
A0A1X0NWZ8 Trypanosomatidae 30% 77%
A0A3R7MDH9 Trypanosoma rangeli 27% 81%
A0A3R7NVF2 Trypanosoma rangeli 65% 100%
A0A3S7WY84 Leishmania donovani 100% 100%
A0A3S7X9Y1 Leishmania donovani 31% 100%
A0A422MZ05 Trypanosoma rangeli 27% 85%
A0A422NEQ8 Trypanosoma rangeli 30% 76%
A0A422P4C5 Trypanosoma rangeli 39% 80%
A4HCT2 Leishmania braziliensis 32% 80%
A4HDC2 Leishmania braziliensis 92% 100%
A4HND6 Leishmania braziliensis 30% 100%
A4IC09 Leishmania infantum 31% 100%
C9ZV26 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 77%
C9ZXH0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 84%
D0A729 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 65% 100%
E9AFU7 Leishmania major 30% 100%
E9AJ89 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 86%
E9AWQ4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
E9B6Z9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
Q4QAR9 Leishmania major 98% 100%
Q6P3R1 Xenopus tropicalis 28% 90%
Q7ZYL5 Xenopus laevis 30% 89%
Q940Y8 Arabidopsis thaliana 38% 84%
V5B8X9 Trypanosoma cruzi 27% 82%
V5BHI2 Trypanosoma cruzi 41% 80%
V5BK25 Trypanosoma cruzi 27% 80%
V5BLH7 Trypanosoma cruzi 30% 67%
V5D311 Trypanosoma cruzi 43% 85%
V5D733 Trypanosoma cruzi 30% 77%
V5DSJ9 Trypanosoma cruzi 67% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS