Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0P0_LEIIN

TriTrypDb:

LINF_240009800

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I0P0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0P0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.707
CLV_NRD_NRD_1	17	19	PF00675	0.501
CLV_NRD_NRD_1	174	176	PF00675	0.735
CLV_NRD_NRD_1	185	187	PF00675	0.710
CLV_NRD_NRD_1	212	214	PF00675	0.621
CLV_NRD_NRD_1	228	230	PF00675	0.524
CLV_NRD_NRD_1	24	26	PF00675	0.482
CLV_NRD_NRD_1	90	92	PF00675	0.612
CLV_PCSK_KEX2_1	174	176	PF00082	0.735
CLV_PCSK_KEX2_1	185	187	PF00082	0.709
CLV_PCSK_KEX2_1	212	214	PF00082	0.630
CLV_PCSK_KEX2_1	226	228	PF00082	0.529
CLV_PCSK_KEX2_1	23	25	PF00082	0.484
CLV_PCSK_KEX2_1	90	92	PF00082	0.612
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.583
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.484
CLV_PCSK_SKI1_1	11	15	PF00082	0.567
CLV_PCSK_SKI1_1	25	29	PF00082	0.570
CLV_PCSK_SKI1_1	38	42	PF00082	0.614
CLV_PCSK_SKI1_1	91	95	PF00082	0.621
CLV_Separin_Metazoa	8	12	PF03568	0.565
DEG_APCC_DBOX_1	123	131	PF00400	0.701
DEG_Nend_UBRbox_2	1	3	PF02207	0.548
DOC_CYCLIN_RxL_1	33	45	PF00134	0.680
DOC_SPAK_OSR1_1	198	202	PF12202	0.636
DOC_USP7_MATH_1	120	124	PF00917	0.724
DOC_USP7_UBL2_3	19	23	PF12436	0.503
DOC_USP7_UBL2_3	222	226	PF12436	0.654
LIG_14-3-3_CanoR_1	124	128	PF00244	0.665
LIG_14-3-3_CanoR_1	72	76	PF00244	0.573
LIG_14-3-3_CanoR_1	90	94	PF00244	0.614
LIG_BIR_III_2	101	105	PF00653	0.589
LIG_FHA_1	92	98	PF00498	0.676
LIG_FHA_2	133	139	PF00498	0.711
LIG_Integrin_RGD_1	186	188	PF01839	0.803
LIG_SH2_SRC	77	80	PF00017	0.628
LIG_SH2_STAP1	77	81	PF00017	0.624
LIG_SH3_2	208	213	PF14604	0.646
LIG_SH3_3	162	168	PF00018	0.678
LIG_SH3_3	205	211	PF00018	0.551
LIG_TRAF2_1	148	151	PF00917	0.739
LIG_TRAF2_1	217	220	PF00917	0.602
LIG_TRAF2_1	230	233	PF00917	0.676
LIG_UBA3_1	9	14	PF00899	0.506
MOD_CK1_1	123	129	PF00069	0.679
MOD_CK1_1	48	54	PF00069	0.634
MOD_CK1_1	80	86	PF00069	0.611
MOD_CK1_1	89	95	PF00069	0.694
MOD_CK2_1	145	151	PF00069	0.633
MOD_CK2_1	214	220	PF00069	0.694
MOD_GlcNHglycan	135	138	PF01048	0.723
MOD_GlcNHglycan	147	150	PF01048	0.578
MOD_GlcNHglycan	42	45	PF01048	0.601
MOD_GlcNHglycan	47	50	PF01048	0.660
MOD_GlcNHglycan	59	62	PF01048	0.672
MOD_GSK3_1	128	135	PF00069	0.705
MOD_GSK3_1	40	47	PF00069	0.588
MOD_GSK3_1	48	55	PF00069	0.606
MOD_GSK3_1	80	87	PF00069	0.613
MOD_GSK3_1	89	96	PF00069	0.707
MOD_N-GLC_2	192	194	PF02516	0.547
MOD_NEK2_1	40	45	PF00069	0.471
MOD_NEK2_1	71	76	PF00069	0.538
MOD_NEK2_1	93	98	PF00069	0.679
MOD_PIKK_1	201	207	PF00454	0.493
MOD_PKA_2	123	129	PF00069	0.780
MOD_PKA_2	71	77	PF00069	0.607
MOD_PKA_2	89	95	PF00069	0.668
MOD_Plk_1	77	83	PF00069	0.693
MOD_Plk_4	71	77	PF00069	0.555
TRG_DiLeu_BaEn_4	150	156	PF01217	0.677
TRG_ER_diArg_1	211	213	PF00400	0.630
TRG_ER_diArg_1	227	229	PF00400	0.506
TRG_NLS_Bipartite_1	212	230	PF00514	0.634
TRG_NLS_MonoCore_2	225	230	PF00514	0.550
TRG_NLS_MonoExtC_3	225	231	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZZ3	Leptomonas seymouri	47%	100%
A0A3S7WYA2	Leishmania donovani	100%	100%
A4HDA7	Leishmania braziliensis	72%	100%
E9AWP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QAT1	Leishmania major	86%	98%
V5C0P2	Trypanosoma cruzi	31%	100%