Putative ubiquitin-activating enzyme

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-activating enzyme - putative

Species:

Leishmania infantum

UniProt:

A4I0N6_LEIIN

TriTrypDb:

LINF_240009400

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I0N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0N6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0061504	cyclic threonylcarbamoyladenosine biosynthetic process	7	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008641	ubiquitin-like modifier activating enzyme activity	2	11
GO:0016874	ligase activity	2	11
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0140657	ATP-dependent activity	1	11
GO:0016829	lyase activity	2	1
GO:0016835	carbon-oxygen lyase activity	3	1
GO:0016836	hydro-lyase activity	4	1
GO:0061503	tRNA threonylcarbamoyladenosine dehydratase	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.262
CLV_C14_Caspase3-7	167	171	PF00656	0.349
CLV_NRD_NRD_1	183	185	PF00675	0.393
CLV_NRD_NRD_1	251	253	PF00675	0.504
CLV_NRD_NRD_1	256	258	PF00675	0.508
CLV_NRD_NRD_1	267	269	PF00675	0.415
CLV_NRD_NRD_1	85	87	PF00675	0.322
CLV_PCSK_FUR_1	252	256	PF00082	0.549
CLV_PCSK_KEX2_1	183	185	PF00082	0.273
CLV_PCSK_KEX2_1	251	253	PF00082	0.455
CLV_PCSK_KEX2_1	254	256	PF00082	0.459
CLV_PCSK_KEX2_1	261	263	PF00082	0.477
CLV_PCSK_KEX2_1	266	268	PF00082	0.434
CLV_PCSK_KEX2_1	85	87	PF00082	0.297
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.493
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.515
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.475
CLV_PCSK_PC7_1	257	263	PF00082	0.581
CLV_PCSK_SKI1_1	130	134	PF00082	0.278
CLV_PCSK_SKI1_1	187	191	PF00082	0.501
CLV_PCSK_SKI1_1	261	265	PF00082	0.538
DEG_Nend_Nbox_1	1	3	PF02207	0.483
DEG_SPOP_SBC_1	58	62	PF00917	0.340
DOC_MAPK_gen_1	183	191	PF00069	0.333
DOC_MAPK_gen_1	64	71	PF00069	0.287
DOC_USP7_MATH_1	144	148	PF00917	0.340
DOC_USP7_MATH_1	173	177	PF00917	0.215
DOC_USP7_MATH_1	70	74	PF00917	0.262
DOC_USP7_UBL2_3	254	258	PF12436	0.449
DOC_USP7_UBL2_3	261	265	PF12436	0.482
DOC_WW_Pin1_4	268	273	PF00397	0.584
LIG_Actin_WH2_2	222	239	PF00022	0.403
LIG_Clathr_ClatBox_1	68	72	PF01394	0.278
LIG_FHA_1	126	132	PF00498	0.386
LIG_FHA_1	30	36	PF00498	0.393
LIG_FHA_1	8	14	PF00498	0.373
LIG_FHA_2	102	108	PF00498	0.304
LIG_FHA_2	165	171	PF00498	0.361
LIG_FHA_2	50	56	PF00498	0.268
LIG_LIR_Apic_2	219	225	PF02991	0.298
LIG_LIR_Nem_3	55	59	PF02991	0.402
LIG_MYND_1	200	204	PF01753	0.502
LIG_RPA_C_Fungi	172	184	PF08784	0.235
LIG_RPA_C_Insects	172	187	PF08784	0.242
LIG_SH2_CRK	117	121	PF00017	0.218
LIG_SH2_CRK	222	226	PF00017	0.278
LIG_SH2_CRK	56	60	PF00017	0.396
LIG_SH2_NCK_1	56	60	PF00017	0.396
LIG_SH2_STAP1	117	121	PF00017	0.262
LIG_SH3_2	201	206	PF14604	0.479
LIG_SH3_3	198	204	PF00018	0.464
LIG_Sin3_3	232	239	PF02671	0.376
LIG_SUMO_SIM_anti_2	188	196	PF11976	0.461
LIG_SUMO_SIM_anti_2	50	55	PF11976	0.396
LIG_SUMO_SIM_par_1	157	163	PF11976	0.424
LIG_SUMO_SIM_par_1	67	74	PF11976	0.278
LIG_SUMO_SIM_par_1	95	100	PF11976	0.363
LIG_TYR_ITIM	54	59	PF00017	0.386
MOD_CK1_1	157	163	PF00069	0.393
MOD_CK2_1	75	81	PF00069	0.340
MOD_GlcNHglycan	232	235	PF01048	0.352
MOD_GlcNHglycan	3	6	PF01048	0.496
MOD_GSK3_1	18	25	PF00069	0.386
MOD_GSK3_1	187	194	PF00069	0.401
MOD_GSK3_1	212	219	PF00069	0.578
MOD_GSK3_1	268	275	PF00069	0.644
MOD_GSK3_1	71	78	PF00069	0.278
MOD_N-GLC_1	216	221	PF02516	0.397
MOD_NEK2_1	1	6	PF00069	0.517
MOD_NEK2_1	216	221	PF00069	0.459
MOD_NEK2_1	22	27	PF00069	0.398
MOD_NEK2_1	230	235	PF00069	0.238
MOD_NEK2_1	29	34	PF00069	0.396
MOD_NEK2_1	71	76	PF00069	0.262
MOD_OFUCOSY	123	129	PF10250	0.386
MOD_PIKK_1	7	13	PF00454	0.368
MOD_PKA_2	173	179	PF00069	0.365
MOD_Plk_1	187	193	PF00069	0.480
MOD_Plk_1	212	218	PF00069	0.591
MOD_Plk_1	7	13	PF00069	0.348
MOD_Plk_1	71	77	PF00069	0.262
MOD_Plk_4	154	160	PF00069	0.381
MOD_ProDKin_1	268	274	PF00069	0.588
MOD_SUMO_rev_2	256	263	PF00179	0.589
TRG_ENDOCYTIC_2	117	120	PF00928	0.262
TRG_ENDOCYTIC_2	56	59	PF00928	0.396
TRG_ER_diArg_1	114	117	PF00400	0.262
TRG_ER_diArg_1	183	185	PF00400	0.306
TRG_ER_diArg_1	85	88	PF00400	0.322
TRG_NLS_Bipartite_1	251	269	PF00514	0.548
TRG_NLS_MonoCore_2	264	269	PF00514	0.603
TRG_NLS_MonoExtC_3	264	269	PF00514	0.553
TRG_NLS_MonoExtN_4	262	269	PF00514	0.540
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.231
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Q3	Leptomonas seymouri	82%	100%
A0A0S4KJM6	Bodo saltans	67%	84%
A0A1X0NJ23	Trypanosomatidae	65%	95%
A0A3Q8ICX5	Leishmania donovani	96%	100%
A0A422P452	Trypanosoma rangeli	67%	100%
D0A715	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	99%
E9AWN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O32037	Bacillus subtilis (strain 168)	33%	100%
Q46927	Escherichia coli (strain K12)	39%	100%
Q4QAT5	Leishmania major	91%	100%
Q57097	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	34%	100%
V5BVX4	Trypanosoma cruzi	67%	84%