LeishMANIAdb
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Hypothetical predicted transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical predicted transmembrane protein
Gene product:
Protein of unknown function (DUF3184) - putative
Species:
Leishmania infantum
UniProt:
A4I0N5_LEIIN
TriTrypDb:
LINF_240009300 *
Length:
781

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Annotations by Jardim et al.

Membrane associated proteins, Hypothetical predicted transmembrane

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 3
GO:0005794 Golgi apparatus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4I0N5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0N5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0016740 transferase activity 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 739 743 PF00656 0.546
CLV_NRD_NRD_1 204 206 PF00675 0.633
CLV_NRD_NRD_1 304 306 PF00675 0.791
CLV_NRD_NRD_1 342 344 PF00675 0.707
CLV_NRD_NRD_1 44 46 PF00675 0.483
CLV_NRD_NRD_1 504 506 PF00675 0.622
CLV_NRD_NRD_1 559 561 PF00675 0.527
CLV_NRD_NRD_1 581 583 PF00675 0.596
CLV_NRD_NRD_1 602 604 PF00675 0.551
CLV_NRD_NRD_1 643 645 PF00675 0.637
CLV_NRD_NRD_1 721 723 PF00675 0.578
CLV_NRD_NRD_1 89 91 PF00675 0.636
CLV_PCSK_FUR_1 557 561 PF00082 0.539
CLV_PCSK_FUR_1 600 604 PF00082 0.528
CLV_PCSK_FUR_1 641 645 PF00082 0.631
CLV_PCSK_KEX2_1 204 206 PF00082 0.663
CLV_PCSK_KEX2_1 329 331 PF00082 0.629
CLV_PCSK_KEX2_1 344 346 PF00082 0.494
CLV_PCSK_KEX2_1 44 46 PF00082 0.539
CLV_PCSK_KEX2_1 504 506 PF00082 0.616
CLV_PCSK_KEX2_1 525 527 PF00082 0.522
CLV_PCSK_KEX2_1 559 561 PF00082 0.527
CLV_PCSK_KEX2_1 581 583 PF00082 0.596
CLV_PCSK_KEX2_1 602 604 PF00082 0.551
CLV_PCSK_KEX2_1 643 645 PF00082 0.637
CLV_PCSK_KEX2_1 721 723 PF00082 0.578
CLV_PCSK_KEX2_1 89 91 PF00082 0.636
CLV_PCSK_PC1ET2_1 329 331 PF00082 0.629
CLV_PCSK_PC1ET2_1 344 346 PF00082 0.494
CLV_PCSK_PC1ET2_1 525 527 PF00082 0.522
CLV_PCSK_SKI1_1 204 208 PF00082 0.623
CLV_PCSK_SKI1_1 247 251 PF00082 0.404
CLV_PCSK_SKI1_1 296 300 PF00082 0.680
CLV_PCSK_SKI1_1 451 455 PF00082 0.450
CLV_PCSK_SKI1_1 470 474 PF00082 0.550
CLV_PCSK_SKI1_1 550 554 PF00082 0.555
CLV_PCSK_SKI1_1 586 590 PF00082 0.667
CLV_PCSK_SKI1_1 602 606 PF00082 0.348
CLV_PCSK_SKI1_1 644 648 PF00082 0.517
CLV_PCSK_SKI1_1 665 669 PF00082 0.646
DEG_APCC_DBOX_1 203 211 PF00400 0.620
DEG_APCC_DBOX_1 270 278 PF00400 0.358
DEG_APCC_DBOX_1 469 477 PF00400 0.549
DEG_APCC_DBOX_1 643 651 PF00400 0.501
DEG_Nend_UBRbox_3 1 3 PF02207 0.389
DEG_ODPH_VHL_1 215 228 PF01847 0.594
DEG_SCF_FBW7_1 179 186 PF00400 0.555
DEG_SPOP_SBC_1 178 182 PF00917 0.625
DOC_CKS1_1 110 115 PF01111 0.645
DOC_CKS1_1 477 482 PF01111 0.733
DOC_CYCLIN_RxL_1 254 264 PF00134 0.377
DOC_CYCLIN_RxL_1 42 51 PF00134 0.542
DOC_CYCLIN_yCln2_LP_2 350 353 PF00134 0.757
DOC_CYCLIN_yCln2_LP_2 361 367 PF00134 0.538
DOC_CYCLIN_yCln2_LP_2 565 568 PF00134 0.497
DOC_CYCLIN_yCln2_LP_2 674 680 PF00134 0.532
DOC_CYCLIN_yCln2_LP_2 68 74 PF00134 0.681
DOC_MAPK_DCC_7 525 535 PF00069 0.487
DOC_MAPK_gen_1 303 311 PF00069 0.701
DOC_MAPK_gen_1 329 337 PF00069 0.646
DOC_MAPK_gen_1 343 350 PF00069 0.605
DOC_MAPK_gen_1 525 532 PF00069 0.497
DOC_MAPK_gen_1 557 566 PF00069 0.509
DOC_MAPK_gen_1 621 629 PF00069 0.515
DOC_MAPK_HePTP_8 327 339 PF00069 0.612
DOC_MAPK_HePTP_8 522 534 PF00069 0.479
DOC_MAPK_MEF2A_6 329 337 PF00069 0.645
DOC_MAPK_MEF2A_6 525 534 PF00069 0.490
DOC_MAPK_MEF2A_6 557 566 PF00069 0.588
DOC_MAPK_MEF2A_6 665 674 PF00069 0.525
DOC_MAPK_NFAT4_5 525 533 PF00069 0.394
DOC_PP1_RVXF_1 43 50 PF00149 0.546
DOC_PP1_RVXF_1 511 518 PF00149 0.654
DOC_PP2B_LxvP_1 214 217 PF13499 0.663
DOC_PP2B_LxvP_1 350 353 PF13499 0.757
DOC_PP2B_LxvP_1 389 392 PF13499 0.492
DOC_PP2B_LxvP_1 565 568 PF13499 0.497
DOC_PP2B_LxvP_1 674 677 PF13499 0.589
DOC_PP2B_PxIxI_1 530 536 PF00149 0.464
DOC_PP4_FxxP_1 20 23 PF00568 0.513
DOC_PP4_FxxP_1 477 480 PF00568 0.711
DOC_USP7_MATH_1 106 110 PF00917 0.629
DOC_USP7_MATH_1 123 127 PF00917 0.431
DOC_USP7_MATH_1 155 159 PF00917 0.628
DOC_USP7_MATH_1 183 187 PF00917 0.692
DOC_USP7_MATH_1 366 370 PF00917 0.610
DOC_USP7_MATH_1 421 425 PF00917 0.599
DOC_USP7_MATH_1 592 596 PF00917 0.566
DOC_USP7_MATH_1 607 611 PF00917 0.357
DOC_USP7_MATH_1 694 698 PF00917 0.532
DOC_USP7_MATH_1 77 81 PF00917 0.679
DOC_USP7_UBL2_3 439 443 PF12436 0.392
DOC_WW_Pin1_4 109 114 PF00397 0.636
DOC_WW_Pin1_4 174 179 PF00397 0.572
DOC_WW_Pin1_4 387 392 PF00397 0.724
DOC_WW_Pin1_4 393 398 PF00397 0.672
DOC_WW_Pin1_4 476 481 PF00397 0.704
DOC_WW_Pin1_4 58 63 PF00397 0.607
LIG_14-3-3_CanoR_1 107 111 PF00244 0.490
LIG_14-3-3_CanoR_1 156 165 PF00244 0.632
LIG_14-3-3_CanoR_1 209 217 PF00244 0.705
LIG_14-3-3_CanoR_1 296 302 PF00244 0.736
LIG_14-3-3_CanoR_1 343 349 PF00244 0.667
LIG_14-3-3_CanoR_1 593 597 PF00244 0.589
LIG_14-3-3_CanoR_1 602 607 PF00244 0.432
LIG_14-3-3_CanoR_1 665 674 PF00244 0.558
LIG_14-3-3_CanoR_1 94 98 PF00244 0.610
LIG_Actin_WH2_2 608 623 PF00022 0.495
LIG_Actin_WH2_2 633 650 PF00022 0.497
LIG_APCC_ABBA_1 337 342 PF00400 0.647
LIG_APCC_ABBA_1 52 57 PF00400 0.572
LIG_BIR_III_4 168 172 PF00653 0.618
LIG_BRCT_BRCA1_1 265 269 PF00533 0.395
LIG_deltaCOP1_diTrp_1 187 190 PF00928 0.693
LIG_eIF4E_1 42 48 PF01652 0.545
LIG_FHA_1 12 18 PF00498 0.650
LIG_FHA_1 170 176 PF00498 0.621
LIG_FHA_1 209 215 PF00498 0.640
LIG_FHA_1 221 227 PF00498 0.549
LIG_FHA_1 256 262 PF00498 0.404
LIG_FHA_1 292 298 PF00498 0.629
LIG_FHA_1 345 351 PF00498 0.669
LIG_FHA_1 477 483 PF00498 0.652
LIG_FHA_1 495 501 PF00498 0.516
LIG_FHA_2 157 163 PF00498 0.591
LIG_FHA_2 344 350 PF00498 0.682
LIG_FHA_2 417 423 PF00498 0.590
LIG_FHA_2 59 65 PF00498 0.625
LIG_FHA_2 701 707 PF00498 0.546
LIG_FHA_2 77 83 PF00498 0.546
LIG_LIR_Apic_2 19 23 PF02991 0.524
LIG_LIR_Apic_2 474 480 PF02991 0.596
LIG_LIR_Apic_2 630 635 PF02991 0.491
LIG_LIR_Gen_1 172 179 PF02991 0.609
LIG_LIR_Gen_1 240 249 PF02991 0.385
LIG_LIR_Gen_1 3 13 PF02991 0.492
LIG_LIR_Gen_1 424 434 PF02991 0.638
LIG_LIR_Gen_1 514 524 PF02991 0.594
LIG_LIR_Gen_1 96 104 PF02991 0.597
LIG_LIR_Nem_3 172 176 PF02991 0.600
LIG_LIR_Nem_3 240 245 PF02991 0.398
LIG_LIR_Nem_3 368 374 PF02991 0.614
LIG_LIR_Nem_3 396 402 PF02991 0.623
LIG_LIR_Nem_3 424 430 PF02991 0.659
LIG_LIR_Nem_3 446 450 PF02991 0.544
LIG_LIR_Nem_3 514 520 PF02991 0.675
LIG_LIR_Nem_3 521 527 PF02991 0.545
LIG_LIR_Nem_3 539 545 PF02991 0.314
LIG_LIR_Nem_3 587 591 PF02991 0.591
LIG_LIR_Nem_3 96 100 PF02991 0.593
LIG_MAD2 225 233 PF02301 0.526
LIG_MAD2 560 568 PF02301 0.491
LIG_Pex14_2 16 20 PF04695 0.516
LIG_SH2_CRK 447 451 PF00017 0.475
LIG_SH2_STAT5 220 223 PF00017 0.688
LIG_SH2_STAT5 326 329 PF00017 0.668
LIG_SH2_STAT5 371 374 PF00017 0.682
LIG_SH2_STAT5 417 420 PF00017 0.580
LIG_SH2_STAT5 42 45 PF00017 0.521
LIG_SH2_STAT5 5 8 PF00017 0.636
LIG_SH3_3 107 113 PF00018 0.616
LIG_SH3_3 173 179 PF00018 0.503
LIG_SH3_3 232 238 PF00018 0.520
LIG_SH3_3 394 400 PF00018 0.689
LIG_SH3_3 561 567 PF00018 0.487
LIG_SH3_3 601 607 PF00018 0.526
LIG_SH3_3 696 702 PF00018 0.531
LIG_SUMO_SIM_anti_2 258 264 PF11976 0.395
LIG_SUMO_SIM_anti_2 734 740 PF11976 0.554
LIG_SUMO_SIM_par_1 225 232 PF11976 0.573
LIG_SUMO_SIM_par_1 530 536 PF11976 0.464
LIG_SUMO_SIM_par_1 734 740 PF11976 0.554
LIG_TRAF2_1 715 718 PF00917 0.632
MOD_CK1_1 109 115 PF00069 0.673
MOD_CK1_1 126 132 PF00069 0.414
MOD_CK1_1 177 183 PF00069 0.634
MOD_CK1_1 186 192 PF00069 0.616
MOD_CK1_1 354 360 PF00069 0.646
MOD_CK1_1 458 464 PF00069 0.492
MOD_CK2_1 156 162 PF00069 0.591
MOD_CK2_1 35 41 PF00069 0.475
MOD_CK2_1 416 422 PF00069 0.583
MOD_CK2_1 533 539 PF00069 0.566
MOD_CK2_1 700 706 PF00069 0.546
MOD_CK2_1 76 82 PF00069 0.648
MOD_Cter_Amidation 202 205 PF01082 0.625
MOD_Cter_Amidation 557 560 PF01082 0.552
MOD_Cter_Amidation 641 644 PF01082 0.642
MOD_Cter_Amidation 719 722 PF01082 0.586
MOD_GlcNHglycan 128 131 PF01048 0.575
MOD_GlcNHglycan 264 268 PF01048 0.506
MOD_GlcNHglycan 422 426 PF01048 0.576
MOD_GlcNHglycan 488 491 PF01048 0.696
MOD_GlcNHglycan 509 512 PF01048 0.738
MOD_GlcNHglycan 726 729 PF01048 0.529
MOD_GlcNHglycan 760 763 PF01048 0.644
MOD_GSK3_1 105 112 PF00069 0.629
MOD_GSK3_1 119 126 PF00069 0.453
MOD_GSK3_1 174 181 PF00069 0.644
MOD_GSK3_1 182 189 PF00069 0.683
MOD_GSK3_1 263 270 PF00069 0.499
MOD_GSK3_1 451 458 PF00069 0.570
MOD_GSK3_1 690 697 PF00069 0.484
MOD_N-GLC_1 126 131 PF02516 0.616
MOD_N-GLC_1 35 40 PF02516 0.488
MOD_N-GLC_1 393 398 PF02516 0.697
MOD_NEK2_1 269 274 PF00069 0.372
MOD_NEK2_1 500 505 PF00069 0.699
MOD_NEK2_1 545 550 PF00069 0.615
MOD_NEK2_1 690 695 PF00069 0.397
MOD_NEK2_1 731 736 PF00069 0.484
MOD_PIKK_1 156 162 PF00454 0.591
MOD_PIKK_1 297 303 PF00454 0.652
MOD_PIKK_1 366 372 PF00454 0.612
MOD_PKA_1 343 349 PF00069 0.623
MOD_PKA_1 602 608 PF00069 0.530
MOD_PKA_2 106 112 PF00069 0.488
MOD_PKA_2 117 123 PF00069 0.501
MOD_PKA_2 148 154 PF00069 0.612
MOD_PKA_2 155 161 PF00069 0.568
MOD_PKA_2 208 214 PF00069 0.638
MOD_PKA_2 344 350 PF00069 0.673
MOD_PKA_2 500 506 PF00069 0.670
MOD_PKA_2 592 598 PF00069 0.568
MOD_PKA_2 602 608 PF00069 0.415
MOD_PKA_2 745 751 PF00069 0.602
MOD_PKA_2 93 99 PF00069 0.614
MOD_PKB_1 308 316 PF00069 0.669
MOD_PKB_1 600 608 PF00069 0.528
MOD_Plk_1 186 192 PF00069 0.679
MOD_Plk_1 247 253 PF00069 0.355
MOD_Plk_2-3 494 500 PF00069 0.714
MOD_Plk_4 413 419 PF00069 0.643
MOD_Plk_4 48 54 PF00069 0.556
MOD_Plk_4 694 700 PF00069 0.525
MOD_Plk_4 731 737 PF00069 0.482
MOD_ProDKin_1 109 115 PF00069 0.640
MOD_ProDKin_1 174 180 PF00069 0.576
MOD_ProDKin_1 387 393 PF00069 0.722
MOD_ProDKin_1 476 482 PF00069 0.715
MOD_ProDKin_1 58 64 PF00069 0.608
MOD_SUMO_for_1 491 494 PF00179 0.617
TRG_DiLeu_BaEn_1 633 638 PF01217 0.504
TRG_DiLeu_BaLyEn_6 20 25 PF01217 0.509
TRG_DiLeu_BaLyEn_6 528 533 PF01217 0.478
TRG_DiLeu_BaLyEn_6 541 546 PF01217 0.357
TRG_ENDOCYTIC_2 427 430 PF00928 0.561
TRG_ENDOCYTIC_2 447 450 PF00928 0.399
TRG_ENDOCYTIC_2 5 8 PF00928 0.549
TRG_ENDOCYTIC_2 585 588 PF00928 0.624
TRG_ENDOCYTIC_2 767 770 PF00928 0.677
TRG_ER_diArg_1 204 206 PF00400 0.630
TRG_ER_diArg_1 25 28 PF00400 0.532
TRG_ER_diArg_1 302 305 PF00400 0.784
TRG_ER_diArg_1 307 310 PF00400 0.697
TRG_ER_diArg_1 43 45 PF00400 0.408
TRG_ER_diArg_1 504 506 PF00400 0.622
TRG_ER_diArg_1 556 559 PF00400 0.554
TRG_ER_diArg_1 600 603 PF00400 0.553
TRG_ER_diArg_1 640 643 PF00400 0.661
TRG_ER_diArg_1 88 90 PF00400 0.667
TRG_NLS_MonoExtN_4 302 309 PF00514 0.710

Homologs

Protein Taxonomy Sequence identity Coverage
A4H8M6 Leishmania braziliensis 32% 100%
A4HZW0 Leishmania infantum 86% 100%
E9AGP0 Leishmania infantum 32% 100%
Q4QER4 Leishmania major 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS