LeishMANIAdb
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Putative CMP-sialic acid transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative CMP-sialic acid transporter
Gene product:
UDP-galactose transporter - putative
Species:
Leishmania infantum
UniProt:
A4I0N2_LEIIN
TriTrypDb:
LINF_240008300 *
Length:
557

Annotations

LeishMANIAdb annotations

Homologous to animal UDP-N-acetylglucosamine, UDP-galactose and CMP-sialic acid transporters. Only expanded in the Leptomonas lineage. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 14
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 17
GO:0016020 membrane 2 17
GO:0031090 organelle membrane 3 17
GO:0098588 bounding membrane of organelle 4 17
GO:0110165 cellular anatomical entity 1 17

Expansion

Sequence features

A4I0N2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0N2

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0006811 monoatomic ion transport 4 1
GO:0006820 monoatomic anion transport 5 1
GO:0009987 cellular process 1 1
GO:0015711 organic anion transport 5 1
GO:0015780 nucleotide-sugar transmembrane transport 3 1
GO:0015931 nucleobase-containing compound transport 5 1
GO:0034220 monoatomic ion transmembrane transport 3 1
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 1
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 1
GO:0072334 UDP-galactose transmembrane transport 5 1
GO:0090481 pyrimidine nucleotide-sugar transmembrane transport 4 1
GO:0098656 monoatomic anion transmembrane transport 4 1
GO:1901264 carbohydrate derivative transport 5 1
GO:0008643 carbohydrate transport 5 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 17
GO:0005338 nucleotide-sugar transmembrane transporter activity 4 17
GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 5 17
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 17
GO:0022857 transmembrane transporter activity 2 17
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 17
GO:0005459 UDP-galactose transmembrane transporter activity 6 1
GO:0015136 sialic acid transmembrane transporter activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 100 102 PF00675 0.479
CLV_NRD_NRD_1 271 273 PF00675 0.369
CLV_NRD_NRD_1 35 37 PF00675 0.557
CLV_PCSK_FUR_1 16 20 PF00082 0.428
CLV_PCSK_KEX2_1 100 102 PF00082 0.484
CLV_PCSK_KEX2_1 18 20 PF00082 0.528
CLV_PCSK_KEX2_1 273 275 PF00082 0.352
CLV_PCSK_KEX2_1 37 39 PF00082 0.420
CLV_PCSK_KEX2_1 431 433 PF00082 0.376
CLV_PCSK_PC1ET2_1 18 20 PF00082 0.427
CLV_PCSK_PC1ET2_1 273 275 PF00082 0.377
CLV_PCSK_PC1ET2_1 37 39 PF00082 0.354
CLV_PCSK_PC1ET2_1 431 433 PF00082 0.376
CLV_PCSK_SKI1_1 101 105 PF00082 0.433
CLV_PCSK_SKI1_1 145 149 PF00082 0.723
CLV_PCSK_SKI1_1 243 247 PF00082 0.491
CLV_PCSK_SKI1_1 267 271 PF00082 0.359
CLV_PCSK_SKI1_1 332 336 PF00082 0.391
CLV_PCSK_SKI1_1 341 345 PF00082 0.352
DOC_CKS1_1 531 536 PF01111 0.326
DOC_MAPK_gen_1 100 106 PF00069 0.627
DOC_MAPK_gen_1 243 253 PF00069 0.578
DOC_MAPK_gen_1 272 280 PF00069 0.573
DOC_MAPK_gen_1 282 289 PF00069 0.482
DOC_MAPK_gen_1 292 301 PF00069 0.530
DOC_MAPK_MEF2A_6 332 340 PF00069 0.381
DOC_MAPK_MEF2A_6 352 361 PF00069 0.363
DOC_PP1_RVXF_1 265 271 PF00149 0.486
DOC_PP1_RVXF_1 330 336 PF00149 0.431
DOC_PP1_RVXF_1 482 489 PF00149 0.286
DOC_PP2B_LxvP_1 186 189 PF13499 0.578
DOC_PP4_FxxP_1 531 534 PF00568 0.354
DOC_PP4_FxxP_1 93 96 PF00568 0.667
DOC_USP7_MATH_1 385 389 PF00917 0.378
DOC_USP7_MATH_1 60 64 PF00917 0.613
DOC_USP7_MATH_2 202 208 PF00917 0.582
DOC_USP7_UBL2_3 243 247 PF12436 0.584
DOC_WW_Pin1_4 28 33 PF00397 0.588
DOC_WW_Pin1_4 346 351 PF00397 0.586
DOC_WW_Pin1_4 38 43 PF00397 0.581
DOC_WW_Pin1_4 49 54 PF00397 0.593
DOC_WW_Pin1_4 530 535 PF00397 0.394
DOC_WW_Pin1_4 92 97 PF00397 0.672
LIG_14-3-3_CanoR_1 441 448 PF00244 0.567
LIG_14-3-3_CanoR_1 5 12 PF00244 0.808
LIG_AP2alpha_1 478 482 PF02296 0.376
LIG_BIR_III_4 26 30 PF00653 0.616
LIG_BRCT_BRCA1_1 420 424 PF00533 0.464
LIG_BRCT_BRCA1_1 475 479 PF00533 0.366
LIG_BRCT_BRCA1_1 514 518 PF00533 0.456
LIG_CaM_IQ_9 236 251 PF13499 0.569
LIG_CaMK_CASK_1 95 101 PF00069 0.555
LIG_EH1_1 305 313 PF00400 0.464
LIG_eIF4E_1 293 299 PF01652 0.576
LIG_eIF4E_1 306 312 PF01652 0.464
LIG_eIF4E_1 329 335 PF01652 0.451
LIG_EVH1_2 44 48 PF00568 0.583
LIG_FHA_1 156 162 PF00498 0.399
LIG_FHA_1 481 487 PF00498 0.354
LIG_FHA_1 523 529 PF00498 0.407
LIG_FHA_1 536 542 PF00498 0.295
LIG_FHA_2 371 377 PF00498 0.400
LIG_FHA_2 475 481 PF00498 0.353
LIG_GBD_Chelix_1 304 312 PF00786 0.394
LIG_HCF-1_HBM_1 290 293 PF13415 0.586
LIG_IRF3_LxIS_1 161 167 PF10401 0.240
LIG_LIR_Gen_1 323 333 PF02991 0.326
LIG_LIR_Gen_1 421 429 PF02991 0.468
LIG_LIR_Gen_1 480 490 PF02991 0.359
LIG_LIR_Gen_1 515 526 PF02991 0.424
LIG_LIR_Gen_1 543 552 PF02991 0.415
LIG_LIR_Nem_3 167 173 PF02991 0.377
LIG_LIR_Nem_3 207 211 PF02991 0.562
LIG_LIR_Nem_3 323 328 PF02991 0.334
LIG_LIR_Nem_3 418 423 PF02991 0.462
LIG_LIR_Nem_3 449 455 PF02991 0.375
LIG_LIR_Nem_3 476 482 PF02991 0.311
LIG_LIR_Nem_3 515 521 PF02991 0.434
LIG_LIR_Nem_3 543 547 PF02991 0.394
LIG_MLH1_MIPbox_1 475 479 PF16413 0.376
LIG_Pex14_1 98 102 PF04695 0.711
LIG_Pex14_2 275 279 PF04695 0.544
LIG_Pex14_2 416 420 PF04695 0.451
LIG_Pex14_2 453 457 PF04695 0.432
LIG_Pex14_2 474 478 PF04695 0.335
LIG_Pex14_2 514 518 PF04695 0.441
LIG_PTB_Apo_2 115 122 PF02174 0.464
LIG_SH2_GRB2like 215 218 PF00017 0.531
LIG_SH2_SRC 215 218 PF00017 0.531
LIG_SH2_STAP1 211 215 PF00017 0.533
LIG_SH2_STAP1 315 319 PF00017 0.394
LIG_SH2_STAT3 127 130 PF00017 0.394
LIG_SH2_STAT3 306 309 PF00017 0.364
LIG_SH2_STAT5 102 105 PF00017 0.659
LIG_SH2_STAT5 127 130 PF00017 0.342
LIG_SH2_STAT5 215 218 PF00017 0.672
LIG_SH2_STAT5 233 236 PF00017 0.691
LIG_SH2_STAT5 452 455 PF00017 0.390
LIG_SH2_STAT5 506 509 PF00017 0.576
LIG_SH2_STAT5 553 556 PF00017 0.543
LIG_SH3_2 32 37 PF14604 0.606
LIG_SH3_3 29 35 PF00018 0.606
LIG_SH3_3 39 45 PF00018 0.579
LIG_SH3_3 50 56 PF00018 0.779
LIG_Sin3_3 108 115 PF02671 0.478
LIG_SUMO_SIM_anti_2 295 302 PF11976 0.554
LIG_SUMO_SIM_par_1 310 316 PF11976 0.394
LIG_TRAF2_1 210 213 PF00917 0.555
LIG_TRFH_1 346 350 PF08558 0.586
LIG_TYR_ITIM 450 455 PF00017 0.478
LIG_UBA3_1 176 181 PF00899 0.650
LIG_UBA3_1 311 318 PF00899 0.394
LIG_WRC_WIRS_1 147 152 PF05994 0.475
LIG_WRC_WIRS_1 511 516 PF05994 0.516
LIG_WRC_WIRS_1 541 546 PF05994 0.379
MOD_CDC14_SPxK_1 349 352 PF00782 0.586
MOD_CDK_SPxK_1 346 352 PF00069 0.586
MOD_CK1_1 193 199 PF00069 0.811
MOD_CK1_1 226 232 PF00069 0.609
MOD_CK1_1 401 407 PF00069 0.356
MOD_CK1_1 418 424 PF00069 0.221
MOD_CK1_1 49 55 PF00069 0.628
MOD_CK1_1 513 519 PF00069 0.435
MOD_CK1_1 63 69 PF00069 0.564
MOD_CK1_1 75 81 PF00069 0.735
MOD_CK1_1 8 14 PF00069 0.634
MOD_CK2_1 215 221 PF00069 0.601
MOD_CK2_1 385 391 PF00069 0.390
MOD_CK2_1 551 557 PF00069 0.240
MOD_GlcNHglycan 417 420 PF01048 0.387
MOD_GlcNHglycan 438 441 PF01048 0.353
MOD_GlcNHglycan 522 525 PF01048 0.316
MOD_GSK3_1 146 153 PF00069 0.491
MOD_GSK3_1 193 200 PF00069 0.761
MOD_GSK3_1 211 218 PF00069 0.644
MOD_GSK3_1 219 226 PF00069 0.665
MOD_GSK3_1 253 260 PF00069 0.667
MOD_GSK3_1 393 400 PF00069 0.335
MOD_GSK3_1 401 408 PF00069 0.283
MOD_GSK3_1 436 443 PF00069 0.531
MOD_GSK3_1 44 51 PF00069 0.620
MOD_GSK3_1 520 527 PF00069 0.338
MOD_GSK3_1 73 80 PF00069 0.718
MOD_GSK3_1 8 15 PF00069 0.634
MOD_N-GLC_1 535 540 PF02516 0.586
MOD_NEK2_1 12 17 PF00069 0.613
MOD_NEK2_1 150 155 PF00069 0.379
MOD_NEK2_1 164 169 PF00069 0.284
MOD_NEK2_1 219 224 PF00069 0.668
MOD_NEK2_1 313 318 PF00069 0.422
MOD_NEK2_1 361 366 PF00069 0.460
MOD_NEK2_1 377 382 PF00069 0.352
MOD_NEK2_1 405 410 PF00069 0.315
MOD_NEK2_1 436 441 PF00069 0.519
MOD_NEK2_1 474 479 PF00069 0.365
MOD_NEK2_1 48 53 PF00069 0.628
MOD_NEK2_1 522 527 PF00069 0.373
MOD_NEK2_1 535 540 PF00069 0.300
MOD_NEK2_1 545 550 PF00069 0.349
MOD_NEK2_2 143 148 PF00069 0.323
MOD_NEK2_2 228 233 PF00069 0.641
MOD_NEK2_2 524 529 PF00069 0.460
MOD_PIKK_1 223 229 PF00454 0.599
MOD_PIKK_1 236 242 PF00454 0.552
MOD_PKA_2 440 446 PF00069 0.476
MOD_PKA_2 73 79 PF00069 0.755
MOD_Plk_1 211 217 PF00069 0.641
MOD_Plk_1 63 69 PF00069 0.606
MOD_Plk_4 204 210 PF00069 0.709
MOD_Plk_4 211 217 PF00069 0.655
MOD_Plk_4 228 234 PF00069 0.687
MOD_Plk_4 293 299 PF00069 0.574
MOD_Plk_4 320 326 PF00069 0.305
MOD_Plk_4 474 480 PF00069 0.321
MOD_Plk_4 524 530 PF00069 0.376
MOD_Plk_4 535 541 PF00069 0.292
MOD_ProDKin_1 28 34 PF00069 0.588
MOD_ProDKin_1 346 352 PF00069 0.586
MOD_ProDKin_1 38 44 PF00069 0.580
MOD_ProDKin_1 49 55 PF00069 0.592
MOD_ProDKin_1 530 536 PF00069 0.394
MOD_ProDKin_1 92 98 PF00069 0.668
TRG_DiLeu_BaEn_2 203 209 PF01217 0.595
TRG_ENDOCYTIC_2 452 455 PF00928 0.378
TRG_ER_diArg_1 272 275 PF00400 0.563
TRG_ER_diArg_1 35 38 PF00400 0.758
TRG_ER_diArg_1 99 101 PF00400 0.689
TRG_NES_CRM1_1 309 321 PF08389 0.394
TRG_NES_CRM1_1 493 508 PF08389 0.357
TRG_NLS_Bipartite_1 18 40 PF00514 0.613
TRG_NLS_MonoExtN_4 35 40 PF00514 0.608

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6R3 Leptomonas seymouri 23% 100%
A0A0N0P7L9 Leptomonas seymouri 54% 100%
A0A0S4JHP4 Bodo saltans 27% 100%
A0A1X0NTD6 Trypanosomatidae 30% 100%
A0A3Q8IES0 Leishmania donovani 79% 100%
A0A3S7WY47 Leishmania donovani 99% 100%
A0A422P321 Trypanosoma rangeli 28% 100%
A4HD92 Leishmania braziliensis 61% 94%
A4HDA0 Leishmania braziliensis 60% 94%
D0AAP4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9AH47 Leishmania infantum 79% 100%
E9AWM5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
E9AWM6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 94%
Q4QAU5 Leishmania major 75% 100%
V5BLB8 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS