Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0M9_LEIIN

TriTrypDb:

LINF_240005400

Length:

400

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 1
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4I0M9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0M9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.358
CLV_PCSK_KEX2_1	306	308	PF00082	0.477
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.449
CLV_PCSK_PC7_1	302	308	PF00082	0.448
CLV_PCSK_SKI1_1	223	227	PF00082	0.535
CLV_PCSK_SKI1_1	307	311	PF00082	0.470
DOC_CYCLIN_RxL_1	154	165	PF00134	0.393
DOC_CYCLIN_yCln2_LP_2	146	149	PF00134	0.460
DOC_MAPK_gen_1	275	283	PF00069	0.332
DOC_MAPK_gen_1	314	322	PF00069	0.670
DOC_MAPK_MEF2A_6	276	285	PF00069	0.270
DOC_PP2B_LxvP_1	146	149	PF13499	0.447
DOC_USP7_MATH_1	166	170	PF00917	0.437
DOC_USP7_MATH_1	173	177	PF00917	0.371
DOC_USP7_UBL2_3	102	106	PF12436	0.349
DOC_USP7_UBL2_3	306	310	PF12436	0.658
DOC_WW_Pin1_4	1	6	PF00397	0.430
DOC_WW_Pin1_4	358	363	PF00397	0.742
DOC_WW_Pin1_4	62	67	PF00397	0.454
LIG_14-3-3_CanoR_1	157	162	PF00244	0.379
LIG_14-3-3_CanoR_1	174	178	PF00244	0.233
LIG_14-3-3_CanoR_1	307	316	PF00244	0.590
LIG_14-3-3_CanoR_1	321	327	PF00244	0.648
LIG_14-3-3_CanoR_1	368	374	PF00244	0.661
LIG_Actin_WH2_2	53	70	PF00022	0.301
LIG_BRCT_BRCA1_1	15	19	PF00533	0.575
LIG_BRCT_BRCA1_1	159	163	PF00533	0.378
LIG_BRCT_BRCA1_1	24	28	PF00533	0.386
LIG_BRCT_BRCA1_1	3	7	PF00533	0.418
LIG_FHA_1	110	116	PF00498	0.433
LIG_FHA_1	208	214	PF00498	0.375
LIG_FHA_1	48	54	PF00498	0.383
LIG_FHA_2	191	197	PF00498	0.405
LIG_FHA_2	201	207	PF00498	0.462
LIG_LIR_Gen_1	141	149	PF02991	0.446
LIG_LIR_Gen_1	294	303	PF02991	0.551
LIG_LIR_Gen_1	4	15	PF02991	0.488
LIG_LIR_Gen_1	46	57	PF02991	0.360
LIG_LIR_Nem_3	132	136	PF02991	0.400
LIG_LIR_Nem_3	141	146	PF02991	0.447
LIG_LIR_Nem_3	154	159	PF02991	0.418
LIG_LIR_Nem_3	162	167	PF02991	0.376
LIG_LIR_Nem_3	193	197	PF02991	0.414
LIG_LIR_Nem_3	232	236	PF02991	0.385
LIG_LIR_Nem_3	294	298	PF02991	0.668
LIG_LIR_Nem_3	4	10	PF02991	0.484
LIG_LIR_Nem_3	46	52	PF02991	0.365
LIG_PCNA_PIPBox_1	178	187	PF02747	0.313
LIG_PCNA_yPIPBox_3	174	185	PF02747	0.311
LIG_Pex14_1	278	282	PF04695	0.318
LIG_SH2_CRK	164	168	PF00017	0.342
LIG_SH2_CRK	236	240	PF00017	0.445
LIG_SH2_CRK	3	7	PF00017	0.509
LIG_SH2_CRK	336	340	PF00017	0.702
LIG_SH2_CRK	346	350	PF00017	0.721
LIG_SH2_CRK	359	363	PF00017	0.590
LIG_SH2_GRB2like	136	139	PF00017	0.435
LIG_SH2_NCK_1	164	168	PF00017	0.342
LIG_SH2_NCK_1	359	363	PF00017	0.664
LIG_SH2_SRC	334	337	PF00017	0.707
LIG_SH2_STAP1	104	108	PF00017	0.341
LIG_SH2_STAP1	233	237	PF00017	0.380
LIG_SH2_STAP1	386	390	PF00017	0.675
LIG_SH2_STAT3	386	389	PF00017	0.754
LIG_SH2_STAT3	396	399	PF00017	0.705
LIG_SH2_STAT5	104	107	PF00017	0.355
LIG_SH2_STAT5	136	139	PF00017	0.413
LIG_SH2_STAT5	164	167	PF00017	0.394
LIG_SH2_STAT5	247	250	PF00017	0.337
LIG_SH2_STAT5	279	282	PF00017	0.316
LIG_SH2_STAT5	295	298	PF00017	0.576
LIG_SH2_STAT5	390	393	PF00017	0.680
LIG_SH2_STAT5	86	89	PF00017	0.405
LIG_SH3_2	63	68	PF14604	0.339
LIG_SH3_3	57	63	PF00018	0.475
LIG_SUMO_SIM_par_1	111	116	PF11976	0.351
LIG_SUMO_SIM_par_1	78	83	PF11976	0.376
LIG_TYR_ITIM	192	197	PF00017	0.374
LIG_TYR_ITSM	160	167	PF00017	0.330
LIG_WRC_WIRS_1	181	186	PF05994	0.370
MOD_CDC14_SPxK_1	65	68	PF00782	0.336
MOD_CDK_SPxK_1	62	68	PF00069	0.342
MOD_CK1_1	109	115	PF00069	0.325
MOD_CK1_1	139	145	PF00069	0.416
MOD_CK1_1	151	157	PF00069	0.496
MOD_CK1_1	176	182	PF00069	0.420
MOD_CK1_1	207	213	PF00069	0.426
MOD_CK1_1	308	314	PF00069	0.502
MOD_CK1_1	361	367	PF00069	0.738
MOD_CK1_1	92	98	PF00069	0.388
MOD_Cter_Amidation	304	307	PF01082	0.395
MOD_GlcNHglycan	108	111	PF01048	0.640
MOD_GlcNHglycan	115	118	PF01048	0.587
MOD_GlcNHglycan	303	306	PF01048	0.363
MOD_GlcNHglycan	322	325	PF01048	0.528
MOD_GSK3_1	102	109	PF00069	0.481
MOD_GSK3_1	113	120	PF00069	0.403
MOD_GSK3_1	134	141	PF00069	0.467
MOD_GSK3_1	147	154	PF00069	0.468
MOD_GSK3_1	162	169	PF00069	0.323
MOD_GSK3_1	173	180	PF00069	0.324
MOD_GSK3_1	200	207	PF00069	0.391
MOD_GSK3_1	262	269	PF00069	0.449
MOD_GSK3_1	301	308	PF00069	0.548
MOD_GSK3_1	43	50	PF00069	0.344
MOD_GSK3_1	62	69	PF00069	0.491
MOD_GSK3_1	80	87	PF00069	0.313
MOD_N-GLC_1	100	105	PF02516	0.569
MOD_N-GLC_1	134	139	PF02516	0.620
MOD_N-GLC_1	151	156	PF02516	0.614
MOD_N-GLC_1	157	162	PF02516	0.505
MOD_N-GLC_1	266	271	PF02516	0.660
MOD_N-GLC_1	35	40	PF02516	0.546
MOD_N-GLC_2	138	140	PF02516	0.665
MOD_NEK2_1	113	118	PF00069	0.374
MOD_NEK2_1	119	124	PF00069	0.347
MOD_NEK2_1	13	18	PF00069	0.560
MOD_NEK2_1	159	164	PF00069	0.314
MOD_NEK2_1	177	182	PF00069	0.386
MOD_NEK2_1	197	202	PF00069	0.429
MOD_NEK2_1	291	296	PF00069	0.481
MOD_NEK2_1	43	48	PF00069	0.394
MOD_NEK2_1	52	57	PF00069	0.344
MOD_NEK2_2	305	310	PF00069	0.542
MOD_PIKK_1	166	172	PF00454	0.436
MOD_PIKK_1	197	203	PF00454	0.412
MOD_PKA_2	173	179	PF00069	0.410
MOD_PKA_2	301	307	PF00069	0.609
MOD_PKA_2	320	326	PF00069	0.607
MOD_PKA_2	367	373	PF00069	0.690
MOD_Plk_1	100	106	PF00069	0.310
MOD_Plk_1	151	157	PF00069	0.397
MOD_Plk_1	22	28	PF00069	0.449
MOD_Plk_1	223	229	PF00069	0.401
MOD_Plk_1	35	41	PF00069	0.299
MOD_Plk_4	129	135	PF00069	0.408
MOD_Plk_4	159	165	PF00069	0.315
MOD_Plk_4	180	186	PF00069	0.376
MOD_Plk_4	204	210	PF00069	0.414
MOD_Plk_4	226	232	PF00069	0.373
MOD_Plk_4	235	241	PF00069	0.338
MOD_Plk_4	80	86	PF00069	0.354
MOD_ProDKin_1	1	7	PF00069	0.427
MOD_ProDKin_1	358	364	PF00069	0.742
MOD_ProDKin_1	62	68	PF00069	0.457
TRG_ENDOCYTIC_2	164	167	PF00928	0.338
TRG_ENDOCYTIC_2	194	197	PF00928	0.381
TRG_ENDOCYTIC_2	236	239	PF00928	0.404
TRG_ENDOCYTIC_2	279	282	PF00928	0.309
TRG_ENDOCYTIC_2	295	298	PF00928	0.609
TRG_ENDOCYTIC_2	3	6	PF00928	0.510
TRG_ENDOCYTIC_2	346	349	PF00928	0.683

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0L6	Leptomonas seymouri	46%	95%
A0A3R7P473	Trypanosoma rangeli	31%	100%
A0A3S7WY17	Leishmania donovani	99%	100%
A4HD64	Leishmania braziliensis	61%	99%
D0A6X7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AWJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QAX4	Leishmania major	91%	100%
V5C0T3	Trypanosoma cruzi	27%	100%