LeishMANIAdb
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Protein-serine/threonine kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein-serine/threonine kinase
Gene product:
pyruvate dehydrogenase (lipoamide) kinase - putative
Species:
Leishmania infantum
UniProt:
A4I0M4_LEIIN
TriTrypDb:
LINF_240004000 *
Length:
483

Annotations

Annotations by Jardim et al.

Pyruvate metabolism, pyruvate dehydrogenase (Lipoamide) kinase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005759 mitochondrial matrix 5 12
GO:0031974 membrane-enclosed lumen 2 12
GO:0043233 organelle lumen 3 12
GO:0070013 intracellular organelle lumen 4 12
GO:0110165 cellular anatomical entity 1 12
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4I0M4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0M4

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016310 phosphorylation 5 12
GO:0044237 cellular metabolic process 2 12
GO:0006109 regulation of carbohydrate metabolic process 5 1
GO:0006468 protein phosphorylation 5 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0010675 obsolete regulation of cellular carbohydrate metabolic process 5 1
GO:0010906 regulation of glucose metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0019538 protein metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044238 primary metabolic process 2 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0062012 regulation of small molecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0071704 organic substance metabolic process 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004672 protein kinase activity 3 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140096 catalytic activity, acting on a protein 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 54 58 PF00656 0.598
CLV_NRD_NRD_1 157 159 PF00675 0.360
CLV_NRD_NRD_1 209 211 PF00675 0.279
CLV_NRD_NRD_1 35 37 PF00675 0.572
CLV_NRD_NRD_1 69 71 PF00675 0.569
CLV_PCSK_KEX2_1 157 159 PF00082 0.340
CLV_PCSK_KEX2_1 209 211 PF00082 0.279
CLV_PCSK_KEX2_1 35 37 PF00082 0.583
CLV_PCSK_KEX2_1 394 396 PF00082 0.513
CLV_PCSK_PC1ET2_1 394 396 PF00082 0.513
CLV_PCSK_SKI1_1 124 128 PF00082 0.451
CLV_PCSK_SKI1_1 209 213 PF00082 0.265
CLV_PCSK_SKI1_1 395 399 PF00082 0.474
CLV_PCSK_SKI1_1 93 97 PF00082 0.653
CLV_Separin_Metazoa 241 245 PF03568 0.428
DEG_APCC_DBOX_1 148 156 PF00400 0.465
DEG_APCC_DBOX_1 2 10 PF00400 0.504
DEG_APCC_DBOX_1 259 267 PF00400 0.465
DEG_APCC_DBOX_1 27 35 PF00400 0.648
DEG_SCF_FBW7_1 189 196 PF00400 0.560
DEG_SPOP_SBC_1 73 77 PF00917 0.561
DOC_CKS1_1 105 110 PF01111 0.531
DOC_CKS1_1 134 139 PF01111 0.526
DOC_CYCLIN_yClb5_NLxxxL_5 99 106 PF00134 0.679
DOC_CYCLIN_yCln2_LP_2 102 108 PF00134 0.586
DOC_CYCLIN_yCln2_LP_2 293 299 PF00134 0.495
DOC_MAPK_gen_1 120 128 PF00069 0.465
DOC_MAPK_gen_1 203 213 PF00069 0.560
DOC_MAPK_gen_1 312 319 PF00069 0.457
DOC_MAPK_gen_1 375 385 PF00069 0.517
DOC_MAPK_gen_1 394 400 PF00069 0.364
DOC_MAPK_gen_1 93 102 PF00069 0.603
DOC_MAPK_HePTP_8 335 347 PF00069 0.417
DOC_MAPK_JIP1_4 3 9 PF00069 0.429
DOC_MAPK_MEF2A_6 3 11 PF00069 0.505
DOC_MAPK_MEF2A_6 338 347 PF00069 0.418
DOC_MAPK_MEF2A_6 378 387 PF00069 0.496
DOC_PP1_RVXF_1 122 129 PF00149 0.524
DOC_PP1_RVXF_1 260 266 PF00149 0.455
DOC_PP2B_LxvP_1 293 296 PF13499 0.488
DOC_PP2B_LxvP_1 471 474 PF13499 0.386
DOC_SPAK_OSR1_1 264 268 PF12202 0.465
DOC_USP7_MATH_1 327 331 PF00917 0.378
DOC_USP7_MATH_1 479 483 PF00917 0.500
DOC_USP7_MATH_1 72 76 PF00917 0.582
DOC_USP7_UBL2_3 120 124 PF12436 0.481
DOC_USP7_UBL2_3 321 325 PF12436 0.469
DOC_USP7_UBL2_3 378 382 PF12436 0.519
DOC_USP7_UBL2_3 67 71 PF12436 0.596
DOC_WW_Pin1_4 104 109 PF00397 0.560
DOC_WW_Pin1_4 133 138 PF00397 0.507
DOC_WW_Pin1_4 189 194 PF00397 0.541
DOC_WW_Pin1_4 436 441 PF00397 0.415
DOC_WW_Pin1_4 74 79 PF00397 0.458
LIG_14-3-3_CanoR_1 399 407 PF00244 0.383
LIG_Actin_WH2_2 19 37 PF00022 0.518
LIG_APCC_ABBA_1 295 300 PF00400 0.515
LIG_BIR_II_1 1 5 PF00653 0.503
LIG_Clathr_ClatBox_1 8 12 PF01394 0.437
LIG_deltaCOP1_diTrp_1 65 69 PF00928 0.596
LIG_EH1_1 215 223 PF00400 0.465
LIG_eIF4E_1 216 222 PF01652 0.479
LIG_FHA_1 273 279 PF00498 0.459
LIG_FHA_1 292 298 PF00498 0.323
LIG_FHA_1 352 358 PF00498 0.383
LIG_FHA_1 48 54 PF00498 0.610
LIG_FHA_1 95 101 PF00498 0.644
LIG_FHA_2 105 111 PF00498 0.452
LIG_FHA_2 134 140 PF00498 0.392
LIG_FHA_2 194 200 PF00498 0.560
LIG_FHA_2 234 240 PF00498 0.505
LIG_FHA_2 243 249 PF00498 0.435
LIG_FHA_2 379 385 PF00498 0.494
LIG_FHA_2 46 52 PF00498 0.609
LIG_IRF3_LxIS_1 396 401 PF10401 0.425
LIG_LIR_Gen_1 109 119 PF02991 0.434
LIG_LIR_Gen_1 12 23 PF02991 0.442
LIG_LIR_Gen_1 125 134 PF02991 0.469
LIG_LIR_Gen_1 185 194 PF02991 0.482
LIG_LIR_Gen_1 233 243 PF02991 0.514
LIG_LIR_Gen_1 245 253 PF02991 0.369
LIG_LIR_Gen_1 354 362 PF02991 0.439
LIG_LIR_Gen_1 48 56 PF02991 0.608
LIG_LIR_Nem_3 109 114 PF02991 0.442
LIG_LIR_Nem_3 12 18 PF02991 0.442
LIG_LIR_Nem_3 125 131 PF02991 0.468
LIG_LIR_Nem_3 145 151 PF02991 0.323
LIG_LIR_Nem_3 185 189 PF02991 0.451
LIG_LIR_Nem_3 233 238 PF02991 0.495
LIG_LIR_Nem_3 245 249 PF02991 0.374
LIG_LIR_Nem_3 354 358 PF02991 0.334
LIG_LIR_Nem_3 417 422 PF02991 0.471
LIG_LIR_Nem_3 48 52 PF02991 0.608
LIG_LIR_Nem_3 65 69 PF02991 0.597
LIG_MYND_1 43 47 PF01753 0.672
LIG_PDZ_Class_2 478 483 PF00595 0.381
LIG_Pex14_2 252 256 PF04695 0.454
LIG_Pex14_2 59 63 PF04695 0.587
LIG_PTB_Apo_2 127 134 PF02174 0.485
LIG_PTB_Apo_2 266 273 PF02174 0.495
LIG_PTB_Phospho_1 127 133 PF10480 0.490
LIG_PTB_Phospho_1 266 272 PF10480 0.495
LIG_SH2_CRK 270 274 PF00017 0.479
LIG_SH2_CRK 355 359 PF00017 0.355
LIG_SH2_CRK 422 426 PF00017 0.589
LIG_SH2_GRB2like 133 136 PF00017 0.506
LIG_SH2_SRC 355 358 PF00017 0.442
LIG_SH2_SRC 472 475 PF00017 0.447
LIG_SH2_STAP1 331 335 PF00017 0.469
LIG_SH2_STAP1 445 449 PF00017 0.369
LIG_SH2_STAT3 118 121 PF00017 0.389
LIG_SH2_STAT5 133 136 PF00017 0.477
LIG_SH2_STAT5 151 154 PF00017 0.374
LIG_SH2_STAT5 272 275 PF00017 0.456
LIG_SH2_STAT5 352 355 PF00017 0.327
LIG_SH2_STAT5 472 475 PF00017 0.378
LIG_SH3_3 102 108 PF00018 0.558
LIG_SH3_3 284 290 PF00018 0.536
LIG_SH3_3 345 351 PF00018 0.377
LIG_SUMO_SIM_anti_2 315 320 PF11976 0.442
LIG_SUMO_SIM_par_1 315 320 PF11976 0.470
LIG_TRAF2_1 107 110 PF00917 0.510
LIG_TRAF2_1 281 284 PF00917 0.543
LIG_TYR_ITIM 353 358 PF00017 0.355
LIG_UBA3_1 316 321 PF00899 0.452
LIG_WRC_WIRS_1 56 61 PF05994 0.519
MOD_CDC14_SPxK_1 439 442 PF00782 0.382
MOD_CDK_SPK_2 74 79 PF00069 0.576
MOD_CDK_SPxK_1 436 442 PF00069 0.407
MOD_CK1_1 220 226 PF00069 0.540
MOD_CK1_1 417 423 PF00069 0.484
MOD_CK1_1 434 440 PF00069 0.547
MOD_CK2_1 104 110 PF00069 0.475
MOD_CK2_1 194 200 PF00069 0.503
MOD_CK2_1 242 248 PF00069 0.478
MOD_CK2_1 278 284 PF00069 0.543
MOD_CK2_1 378 384 PF00069 0.508
MOD_CK2_1 45 51 PF00069 0.616
MOD_CK2_1 88 94 PF00069 0.636
MOD_CMANNOS 181 184 PF00535 0.295
MOD_GlcNHglycan 18 21 PF01048 0.691
MOD_GlcNHglycan 366 369 PF01048 0.423
MOD_GSK3_1 189 196 PF00069 0.550
MOD_GSK3_1 216 223 PF00069 0.465
MOD_GSK3_1 410 417 PF00069 0.436
MOD_GSK3_1 431 438 PF00069 0.524
MOD_GSK3_1 74 81 PF00069 0.572
MOD_N-GLC_1 216 221 PF02516 0.265
MOD_N-GLC_1 455 460 PF02516 0.511
MOD_NEK2_1 271 276 PF00069 0.468
MOD_NEK2_1 317 322 PF00069 0.479
MOD_NEK2_1 38 43 PF00069 0.564
MOD_NEK2_2 182 187 PF00069 0.465
MOD_NEK2_2 405 410 PF00069 0.523
MOD_PIKK_1 167 173 PF00454 0.465
MOD_PKA_1 312 318 PF00069 0.425
MOD_PKA_2 398 404 PF00069 0.368
MOD_Plk_1 216 222 PF00069 0.479
MOD_Plk_1 383 389 PF00069 0.467
MOD_Plk_1 455 461 PF00069 0.397
MOD_Plk_4 143 149 PF00069 0.535
MOD_Plk_4 217 223 PF00069 0.537
MOD_Plk_4 312 318 PF00069 0.395
MOD_ProDKin_1 104 110 PF00069 0.536
MOD_ProDKin_1 133 139 PF00069 0.504
MOD_ProDKin_1 189 195 PF00069 0.541
MOD_ProDKin_1 436 442 PF00069 0.407
MOD_ProDKin_1 74 80 PF00069 0.458
MOD_SUMO_rev_2 330 340 PF00179 0.468
MOD_SUMO_rev_2 60 69 PF00179 0.512
MOD_SUMO_rev_2 90 98 PF00179 0.668
TRG_DiLeu_BaEn_4 109 115 PF01217 0.488
TRG_DiLeu_BaLyEn_6 40 45 PF01217 0.692
TRG_ENDOCYTIC_2 246 249 PF00928 0.501
TRG_ENDOCYTIC_2 270 273 PF00928 0.444
TRG_ENDOCYTIC_2 355 358 PF00928 0.356
TRG_ENDOCYTIC_2 422 425 PF00928 0.516
TRG_ER_diArg_1 157 160 PF00400 0.560
TRG_ER_diArg_1 208 210 PF00400 0.479
TRG_ER_diArg_1 260 263 PF00400 0.465
TRG_ER_diArg_1 34 36 PF00400 0.583

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAJ6 Leptomonas seymouri 68% 100%
A0A0S4JGW0 Bodo saltans 38% 100%
A0A1X0NJE4 Trypanosomatidae 55% 100%
A0A3S7WY35 Leishmania donovani 100% 100%
A0A422MQ68 Trypanosoma rangeli 48% 100%
A4HD59 Leishmania braziliensis 91% 100%
D0A6X1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9AWJ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
O02623 Ascaris suum 23% 100%
O54937 Rattus norvegicus 23% 100%
O70571 Mus musculus 23% 100%
O88345 Ictidomys tridecemlineatus 22% 100%
Q02332 Caenorhabditis elegans 22% 100%
Q15119 Homo sapiens 23% 100%
Q15120 Homo sapiens 23% 100%
Q16654 Homo sapiens 22% 100%
Q1KMR4 Rhinolophus ferrumequinum 22% 100%
Q4QAX9 Leishmania major 94% 100%
Q64536 Rattus norvegicus 23% 100%
Q922H2 Mus musculus 23% 100%
Q9JK42 Mus musculus 24% 100%
Q9SBJ1 Arabidopsis thaliana 24% 100%
V5C0T8 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS