LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Protoheme IX farnesyltransferase, mitochondrial

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protoheme IX farnesyltransferase, mitochondrial
Gene product:
protoheme IX farnesyltransferase - putative
Species:
Leishmania infantum
UniProt:
A4I0M3_LEIIN
TriTrypDb:
LINF_230025900
Length:
433

Annotations

Annotations by Jardim et al.

Heme biosynthesis, Protoheme IX farnesyltransferase, mitochondrial

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0031090 organelle membrane 3 8
GO:0031966 mitochondrial membrane 4 8
GO:0110165 cellular anatomical entity 1 12
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4I0M3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0M3

Function

Biological processes
Term Name Level Count
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006778 porphyrin-containing compound metabolic process 5 12
GO:0006779 porphyrin-containing compound biosynthetic process 6 12
GO:0006783 heme biosynthetic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009058 biosynthetic process 2 12
GO:0009987 cellular process 1 12
GO:0018130 heterocycle biosynthetic process 4 12
GO:0019438 aromatic compound biosynthetic process 4 12
GO:0033013 tetrapyrrole metabolic process 4 12
GO:0033014 tetrapyrrole biosynthetic process 5 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0042168 heme metabolic process 3 12
GO:0042440 pigment metabolic process 2 12
GO:0044237 cellular metabolic process 2 12
GO:0044249 cellular biosynthetic process 3 12
GO:0044271 cellular nitrogen compound biosynthetic process 4 12
GO:0046148 pigment biosynthetic process 3 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901362 organic cyclic compound biosynthetic process 4 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901566 organonitrogen compound biosynthetic process 4 12
GO:1901576 organic substance biosynthetic process 3 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004311 farnesyltranstransferase activity 5 12
GO:0004659 prenyltransferase activity 4 12
GO:0008495 protoheme IX farnesyltransferase activity 6 12
GO:0016740 transferase activity 2 12
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 3 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 117 119 PF00675 0.458
CLV_NRD_NRD_1 191 193 PF00675 0.251
CLV_NRD_NRD_1 301 303 PF00675 0.250
CLV_NRD_NRD_1 66 68 PF00675 0.481
CLV_PCSK_KEX2_1 117 119 PF00082 0.458
CLV_PCSK_KEX2_1 187 189 PF00082 0.250
CLV_PCSK_KEX2_1 191 193 PF00082 0.250
CLV_PCSK_KEX2_1 245 247 PF00082 0.241
CLV_PCSK_KEX2_1 301 303 PF00082 0.250
CLV_PCSK_KEX2_1 66 68 PF00082 0.481
CLV_PCSK_PC1ET2_1 187 189 PF00082 0.250
CLV_PCSK_PC1ET2_1 245 247 PF00082 0.250
CLV_PCSK_PC7_1 62 68 PF00082 0.445
CLV_PCSK_SKI1_1 184 188 PF00082 0.244
CLV_PCSK_SKI1_1 365 369 PF00082 0.388
CLV_PCSK_SKI1_1 40 44 PF00082 0.413
CLV_PCSK_SKI1_1 47 51 PF00082 0.369
CLV_Separin_Metazoa 372 376 PF03568 0.555
DEG_Nend_Nbox_1 1 3 PF02207 0.663
DOC_CKS1_1 240 245 PF01111 0.475
DOC_CKS1_1 273 278 PF01111 0.300
DOC_CYCLIN_RxL_1 362 372 PF00134 0.388
DOC_MAPK_gen_1 187 198 PF00069 0.511
DOC_PP1_RVXF_1 308 315 PF00149 0.450
DOC_PP1_RVXF_1 363 370 PF00149 0.360
DOC_PP4_FxxP_1 198 201 PF00568 0.528
DOC_PP4_FxxP_1 314 317 PF00568 0.450
DOC_PP4_FxxP_1 33 36 PF00568 0.706
DOC_USP7_MATH_1 124 128 PF00917 0.600
DOC_USP7_MATH_1 21 25 PF00917 0.628
DOC_USP7_MATH_1 422 426 PF00917 0.468
DOC_WW_Pin1_4 100 105 PF00397 0.625
DOC_WW_Pin1_4 197 202 PF00397 0.511
DOC_WW_Pin1_4 220 225 PF00397 0.250
DOC_WW_Pin1_4 239 244 PF00397 0.303
DOC_WW_Pin1_4 272 277 PF00397 0.336
LIG_14-3-3_CanoR_1 20 26 PF00244 0.610
LIG_14-3-3_CanoR_1 246 254 PF00244 0.445
LIG_14-3-3_CanoR_1 319 323 PF00244 0.450
LIG_14-3-3_CanoR_1 34 42 PF00244 0.704
LIG_14-3-3_CanoR_1 62 68 PF00244 0.677
LIG_14-3-3_CanoR_1 8 13 PF00244 0.576
LIG_Actin_WH2_2 229 247 PF00022 0.304
LIG_BRCT_BRCA1_1 22 26 PF00533 0.654
LIG_BRCT_BRCA1_1 365 369 PF00533 0.360
LIG_BRCT_BRCA1_1 69 73 PF00533 0.709
LIG_EH1_1 267 275 PF00400 0.236
LIG_FHA_1 13 19 PF00498 0.631
LIG_FHA_1 150 156 PF00498 0.330
LIG_FHA_1 214 220 PF00498 0.398
LIG_FHA_1 273 279 PF00498 0.262
LIG_FHA_2 8 14 PF00498 0.692
LIG_LIR_Gen_1 179 186 PF02991 0.511
LIG_LIR_Gen_1 283 291 PF02991 0.450
LIG_LIR_Gen_1 384 395 PF02991 0.303
LIG_LIR_Nem_3 179 185 PF02991 0.536
LIG_LIR_Nem_3 252 257 PF02991 0.370
LIG_LIR_Nem_3 283 287 PF02991 0.450
LIG_LIR_Nem_3 321 325 PF02991 0.460
LIG_LIR_Nem_3 384 390 PF02991 0.301
LIG_Pex14_1 318 322 PF04695 0.450
LIG_Pex14_2 284 288 PF04695 0.388
LIG_Pex14_2 314 318 PF04695 0.450
LIG_REV1ctd_RIR_1 3 12 PF16727 0.581
LIG_SH2_CRK 182 186 PF00017 0.536
LIG_SH2_CRK 241 245 PF00017 0.445
LIG_SH2_CRK 309 313 PF00017 0.443
LIG_SH2_CRK 364 368 PF00017 0.350
LIG_SH2_NCK_1 304 308 PF00017 0.462
LIG_SH2_PTP2 237 240 PF00017 0.388
LIG_SH2_PTP2 385 388 PF00017 0.337
LIG_SH2_SRC 146 149 PF00017 0.423
LIG_SH2_STAP1 182 186 PF00017 0.511
LIG_SH2_STAP1 323 327 PF00017 0.303
LIG_SH2_STAP1 352 356 PF00017 0.449
LIG_SH2_STAT5 137 140 PF00017 0.354
LIG_SH2_STAT5 146 149 PF00017 0.243
LIG_SH2_STAT5 220 223 PF00017 0.275
LIG_SH2_STAT5 237 240 PF00017 0.289
LIG_SH2_STAT5 241 244 PF00017 0.441
LIG_SH2_STAT5 385 388 PF00017 0.306
LIG_SH2_STAT5 412 415 PF00017 0.342
LIG_SH3_3 219 225 PF00018 0.300
LIG_TYR_ITIM 349 354 PF00017 0.364
LIG_WRC_WIRS_1 281 286 PF05994 0.450
MOD_CDK_SPxK_1 239 245 PF00069 0.303
MOD_CDK_SPxxK_3 239 246 PF00069 0.303
MOD_CK1_1 11 17 PF00069 0.557
MOD_CK1_1 132 138 PF00069 0.405
MOD_CK1_1 170 176 PF00069 0.314
MOD_CK1_1 38 44 PF00069 0.514
MOD_CK1_1 421 427 PF00069 0.598
MOD_CK2_1 205 211 PF00069 0.360
MOD_CK2_1 426 432 PF00069 0.577
MOD_CK2_1 7 13 PF00069 0.643
MOD_GlcNHglycan 134 137 PF01048 0.324
MOD_GlcNHglycan 169 172 PF01048 0.314
MOD_GlcNHglycan 207 210 PF01048 0.266
MOD_GlcNHglycan 247 250 PF01048 0.303
MOD_GlcNHglycan 419 423 PF01048 0.562
MOD_GlcNHglycan 424 427 PF01048 0.590
MOD_GlcNHglycan 69 72 PF01048 0.628
MOD_GlcNHglycan 83 87 PF01048 0.608
MOD_GSK3_1 161 168 PF00069 0.337
MOD_GSK3_1 245 252 PF00069 0.303
MOD_GSK3_1 418 425 PF00069 0.484
MOD_GSK3_1 426 433 PF00069 0.502
MOD_GSK3_1 67 74 PF00069 0.523
MOD_GSK3_1 7 14 PF00069 0.571
MOD_NEK2_1 129 134 PF00069 0.406
MOD_NEK2_1 165 170 PF00069 0.329
MOD_NEK2_1 186 191 PF00069 0.303
MOD_NEK2_1 210 215 PF00069 0.358
MOD_NEK2_1 280 285 PF00069 0.423
MOD_NEK2_1 381 386 PF00069 0.301
MOD_NEK2_1 50 55 PF00069 0.573
MOD_NEK2_1 6 11 PF00069 0.669
MOD_NEK2_1 61 66 PF00069 0.494
MOD_NEK2_2 21 26 PF00069 0.590
MOD_NEK2_2 318 323 PF00069 0.292
MOD_PIKK_1 124 130 PF00454 0.444
MOD_PIKK_1 61 67 PF00454 0.623
MOD_PKA_1 245 251 PF00069 0.289
MOD_PKA_2 245 251 PF00069 0.300
MOD_PKA_2 318 324 PF00069 0.303
MOD_PKA_2 61 67 PF00069 0.601
MOD_PKA_2 7 13 PF00069 0.479
MOD_Plk_1 110 116 PF00069 0.436
MOD_Plk_1 12 18 PF00069 0.558
MOD_Plk_1 210 216 PF00069 0.333
MOD_Plk_1 45 51 PF00069 0.560
MOD_Plk_4 118 124 PF00069 0.467
MOD_Plk_4 13 19 PF00069 0.607
MOD_Plk_4 161 167 PF00069 0.313
MOD_Plk_4 21 27 PF00069 0.474
MOD_Plk_4 249 255 PF00069 0.298
MOD_Plk_4 280 286 PF00069 0.370
MOD_Plk_4 318 324 PF00069 0.303
MOD_Plk_4 325 331 PF00069 0.303
MOD_Plk_4 332 338 PF00069 0.303
MOD_Plk_4 363 369 PF00069 0.410
MOD_Plk_4 386 392 PF00069 0.309
MOD_Plk_4 84 90 PF00069 0.689
MOD_ProDKin_1 100 106 PF00069 0.535
MOD_ProDKin_1 197 203 PF00069 0.388
MOD_ProDKin_1 220 226 PF00069 0.303
MOD_ProDKin_1 239 245 PF00069 0.303
MOD_ProDKin_1 272 278 PF00069 0.423
TRG_ENDOCYTIC_2 182 185 PF00928 0.388
TRG_ENDOCYTIC_2 237 240 PF00928 0.303
TRG_ENDOCYTIC_2 241 244 PF00928 0.267
TRG_ENDOCYTIC_2 309 312 PF00928 0.293
TRG_ENDOCYTIC_2 351 354 PF00928 0.317
TRG_ENDOCYTIC_2 364 367 PF00928 0.226
TRG_ENDOCYTIC_2 385 388 PF00928 0.299
TRG_ER_diArg_1 117 119 PF00400 0.534
TRG_ER_diArg_1 191 193 PF00400 0.318
TRG_ER_diArg_1 66 68 PF00400 0.545

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDJ6 Leptomonas seymouri 80% 100%
A0A0S4JPE1 Bodo saltans 53% 100%
A0A1X0NWM0 Trypanosomatidae 60% 100%
A0A3Q8IFZ4 Leishmania donovani 100% 100%
A0A3R7KFR3 Trypanosoma rangeli 61% 100%
A1KIP0 Mycobacterium bovis (strain BCG / Pasteur 1173P2) 30% 100%
A1QRH1 Mycobacterium tuberculosis (strain F11) 30% 100%
A1SY55 Psychromonas ingrahamii (strain 37) 30% 100%
A1WBL5 Acidovorax sp. (strain JS42) 28% 100%
A1WHP5 Verminephrobacter eiseniae (strain EF01-2) 28% 100%
A4FBP2 Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) 30% 100%
A4HD36 Leishmania braziliensis 88% 100%
A4JI25 Burkholderia vietnamiensis (strain G4 / LMG 22486) 28% 100%
A5U2F4 Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) 30% 100%
A5UPV7 Roseiflexus sp. (strain RS-1) 27% 81%
A6UXP9 Pseudomonas aeruginosa (strain PA7) 26% 100%
A8LW09 Salinispora arenicola (strain CNS-205) 31% 100%
B0R3W4 Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) 27% 94%
B0T0X6 Caulobacter sp. (strain K31) 26% 100%
B1KM58 Shewanella woodyi (strain ATCC 51908 / MS32) 29% 100%
B2IGJ6 Beijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIMB 8712) 29% 100%
B4SHI1 Stenotrophomonas maltophilia (strain R551-3) 29% 100%
B5ZSV2 Rhizobium leguminosarum bv. trifolii (strain WSM2304) 29% 100%
B7KHX2 Gloeothece citriformis (strain PCC 7424) 26% 100%
B9JAP1 Agrobacterium radiobacter (strain K84 / ATCC BAA-868) 28% 100%
B9MF14 Acidovorax ebreus (strain TPSY) 28% 100%
C1AN96 Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019) 30% 100%
C9ZNR4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 63% 96%
E9AWI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O64886 Arabidopsis thaliana 33% 100%
P9WFR6 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 30% 100%
P9WFR7 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 30% 100%
Q02UW5 Pseudomonas aeruginosa (strain UCBPP-PA14) 26% 100%
Q0C3D1 Hyphomonas neptunium (strain ATCC 15444) 27% 100%
Q12E37 Polaromonas sp. (strain JS666 / ATCC BAA-500) 28% 100%
Q1D1K4 Myxococcus xanthus (strain DK1622) 30% 100%
Q1GTA5 Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) 28% 100%
Q1IGZ4 Pseudomonas entomophila (strain L48) 27% 100%
Q1IPI1 Koribacter versatilis (strain Ellin345) 27% 100%
Q1MKI5 Rhizobium leguminosarum bv. viciae (strain 3841) 30% 100%
Q28MJ1 Jannaschia sp. (strain CCS1) 28% 100%
Q2IPE5 Anaeromyxobacter dehalogenans (strain 2CP-C) 30% 100%
Q2JNL3 Synechococcus sp. (strain JA-2-3B'a(2-13)) 29% 100%
Q2KBM1 Rhizobium etli (strain CFN 42 / ATCC 51251) 28% 100%
Q3MFT6 Trichormus variabilis (strain ATCC 29413 / PCC 7937) 29% 100%
Q3SUL3 Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255) 29% 100%
Q3SW48 Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255) 29% 100%
Q4I5G1 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 34% 85%
Q4QAY6 Leishmania major 94% 100%
Q72VU2 Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130) 27% 100%
Q75F43 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 32% 100%
Q7U021 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 30% 100%
Q8F9F8 Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) 27% 100%
Q8YYA3 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) 29% 100%
Q98LF1 Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) 29% 100%
Q9A301 Caulobacter vibrioides (strain ATCC 19089 / CB15) 26% 100%
Q9CCN4 Mycobacterium leprae (strain TN) 28% 100%
Q9HRJ8 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 27% 98%
Q9I719 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 26% 100%
Q9PDL9 Xylella fastidiosa (strain 9a5c) 30% 100%
Q9RM98 Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) 29% 100%
V5BB79 Trypanosoma cruzi 55% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS