Pyridoxal phosphate homeostasis protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

alanine racemase - putative

Species:

Leishmania infantum

UniProt:

A4I0L9_LEIIN

TriTrypDb:

LINF_230025500

Length:

245

Annotations

Annotations by Jardim et al.

Amino acid metabolism, alanine racemase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4I0L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0L9

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	12
GO:0016853	isomerase activity	2	5
GO:0019842	vitamin binding	3	12
GO:0030170	pyridoxal phosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0070279	vitamin B6 binding	3	12
GO:0097159	organic cyclic compound binding	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.368
CLV_NRD_NRD_1	33	35	PF00675	0.433
CLV_PCSK_KEX2_1	33	35	PF00082	0.433
CLV_PCSK_SKI1_1	33	37	PF00082	0.338
CLV_PCSK_SKI1_1	93	97	PF00082	0.317
DEG_APCC_DBOX_1	33	41	PF00400	0.433
DOC_CDC14_PxL_1	96	104	PF14671	0.392
DOC_CYCLIN_RxL_1	90	97	PF00134	0.317
DOC_MAPK_gen_1	122	132	PF00069	0.310
DOC_MAPK_gen_1	168	175	PF00069	0.378

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P624	Leptomonas seymouri	80%	99%
A0A0S4JPZ2	Bodo saltans	49%	96%
A0A1X0NWM6	Trypanosomatidae	68%	99%
A0A3Q8ICU4	Leishmania donovani	100%	100%
A0A422NJG5	Trypanosoma rangeli	67%	100%
A4HD32	Leishmania braziliensis	91%	100%
C9ZNR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	95%
E9AWI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O24748	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	34%	100%
O25156	Helicobacter pylori (strain ATCC 700392 / 26695)	37%	100%

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