LeishMANIAdb
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Cilia- and flagella-associated protein 53

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cilia- and flagella-associated protein 53
Gene product:
Tumour suppressor - Mitostatin - putative
Species:
Leishmania infantum
UniProt:
A4I0L6_LEIIN
TriTrypDb:
LINF_230025100
Length:
490

Annotations

Annotations by Jardim et al.

Flagella, Tumour suppressor, Mitostatin, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I0L6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0L6

Function

Biological processes
Term Name Level Count
GO:0003341 cilium movement 4 12
GO:0006996 organelle organization 4 12
GO:0007017 microtubule-based process 2 12
GO:0007018 microtubule-based movement 3 12
GO:0009987 cellular process 1 12
GO:0016043 cellular component organization 3 12
GO:0022607 cellular component assembly 4 12
GO:0030030 cell projection organization 4 12
GO:0030031 cell projection assembly 5 12
GO:0044782 cilium organization 5 12
GO:0060271 cilium assembly 6 12
GO:0070925 organelle assembly 5 12
GO:0071840 cellular component organization or biogenesis 2 12
GO:0120031 plasma membrane bounded cell projection assembly 6 12
GO:0120036 plasma membrane bounded cell projection organization 5 12
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 156 160 PF00656 0.542
CLV_C14_Caspase3-7 286 290 PF00656 0.492
CLV_NRD_NRD_1 100 102 PF00675 0.451
CLV_NRD_NRD_1 105 107 PF00675 0.428
CLV_NRD_NRD_1 16 18 PF00675 0.461
CLV_NRD_NRD_1 165 167 PF00675 0.252
CLV_NRD_NRD_1 199 201 PF00675 0.303
CLV_NRD_NRD_1 217 219 PF00675 0.188
CLV_NRD_NRD_1 227 229 PF00675 0.240
CLV_NRD_NRD_1 245 247 PF00675 0.221
CLV_NRD_NRD_1 251 253 PF00675 0.250
CLV_NRD_NRD_1 308 310 PF00675 0.282
CLV_NRD_NRD_1 345 347 PF00675 0.341
CLV_NRD_NRD_1 370 372 PF00675 0.265
CLV_NRD_NRD_1 387 389 PF00675 0.245
CLV_NRD_NRD_1 412 414 PF00675 0.275
CLV_NRD_NRD_1 73 75 PF00675 0.434
CLV_PCSK_FUR_1 112 116 PF00082 0.560
CLV_PCSK_FUR_1 14 18 PF00082 0.480
CLV_PCSK_FUR_1 200 204 PF00082 0.361
CLV_PCSK_FUR_1 33 37 PF00082 0.449
CLV_PCSK_FUR_1 410 414 PF00082 0.266
CLV_PCSK_FUR_1 71 75 PF00082 0.476
CLV_PCSK_KEX2_1 100 102 PF00082 0.451
CLV_PCSK_KEX2_1 114 116 PF00082 0.424
CLV_PCSK_KEX2_1 119 121 PF00082 0.431
CLV_PCSK_KEX2_1 16 18 PF00082 0.461
CLV_PCSK_KEX2_1 164 166 PF00082 0.262
CLV_PCSK_KEX2_1 202 204 PF00082 0.349
CLV_PCSK_KEX2_1 227 229 PF00082 0.279
CLV_PCSK_KEX2_1 247 249 PF00082 0.205
CLV_PCSK_KEX2_1 251 253 PF00082 0.258
CLV_PCSK_KEX2_1 270 272 PF00082 0.239
CLV_PCSK_KEX2_1 308 310 PF00082 0.272
CLV_PCSK_KEX2_1 347 349 PF00082 0.244
CLV_PCSK_KEX2_1 35 37 PF00082 0.552
CLV_PCSK_KEX2_1 358 360 PF00082 0.247
CLV_PCSK_KEX2_1 370 372 PF00082 0.236
CLV_PCSK_KEX2_1 377 379 PF00082 0.209
CLV_PCSK_KEX2_1 412 414 PF00082 0.262
CLV_PCSK_KEX2_1 442 444 PF00082 0.273
CLV_PCSK_KEX2_1 71 73 PF00082 0.433
CLV_PCSK_PC1ET2_1 114 116 PF00082 0.498
CLV_PCSK_PC1ET2_1 119 121 PF00082 0.479
CLV_PCSK_PC1ET2_1 202 204 PF00082 0.314
CLV_PCSK_PC1ET2_1 247 249 PF00082 0.302
CLV_PCSK_PC1ET2_1 270 272 PF00082 0.342
CLV_PCSK_PC1ET2_1 347 349 PF00082 0.252
CLV_PCSK_PC1ET2_1 35 37 PF00082 0.601
CLV_PCSK_PC1ET2_1 358 360 PF00082 0.252
CLV_PCSK_PC1ET2_1 377 379 PF00082 0.180
CLV_PCSK_PC1ET2_1 442 444 PF00082 0.328
CLV_PCSK_PC7_1 115 121 PF00082 0.568
CLV_PCSK_SKI1_1 184 188 PF00082 0.342
CLV_PCSK_SKI1_1 285 289 PF00082 0.252
CLV_PCSK_SKI1_1 330 334 PF00082 0.265
CLV_PCSK_SKI1_1 364 368 PF00082 0.266
CLV_PCSK_SKI1_1 413 417 PF00082 0.312
CLV_PCSK_SKI1_1 439 443 PF00082 0.306
CLV_PCSK_SKI1_1 51 55 PF00082 0.582
DEG_APCC_DBOX_1 71 79 PF00400 0.410
DEG_APCC_KENBOX_2 222 226 PF00400 0.521
DOC_CDC14_PxL_1 475 483 PF14671 0.434
DOC_MAPK_gen_1 471 480 PF00069 0.423
DOC_PP1_RVXF_1 34 41 PF00149 0.475
DOC_PP1_RVXF_1 346 353 PF00149 0.447
DOC_USP7_MATH_1 470 474 PF00917 0.363
DOC_USP7_UBL2_3 219 223 PF12436 0.502
DOC_USP7_UBL2_3 281 285 PF12436 0.465
DOC_USP7_UBL2_3 343 347 PF12436 0.452
LIG_14-3-3_CanoR_1 33 39 PF00244 0.578
LIG_Actin_WH2_2 255 272 PF00022 0.542
LIG_deltaCOP1_diTrp_1 342 352 PF00928 0.456
LIG_eIF4E_1 475 481 PF01652 0.427
LIG_FHA_2 185 191 PF00498 0.447
LIG_FHA_2 27 33 PF00498 0.465
LIG_LIR_Gen_1 152 162 PF02991 0.542
LIG_LIR_Gen_1 276 284 PF02991 0.443
LIG_LIR_Nem_3 230 236 PF02991 0.485
LIG_LIR_Nem_3 276 280 PF02991 0.443
LIG_LIR_Nem_3 473 478 PF02991 0.420
LIG_NRBOX 74 80 PF00104 0.465
LIG_PCNA_yPIPBox_3 43 57 PF02747 0.561
LIG_Pex14_2 20 24 PF04695 0.531
LIG_RPA_C_Plants 303 314 PF08784 0.456
LIG_SH2_CRK 234 238 PF00017 0.542
LIG_SH2_STAP1 175 179 PF00017 0.502
LIG_SH2_STAP1 456 460 PF00017 0.484
LIG_SH2_STAT3 175 178 PF00017 0.542
LIG_SH2_STAT5 423 426 PF00017 0.452
LIG_SH3_1 476 482 PF00018 0.405
LIG_SH3_2 479 484 PF14604 0.453
LIG_SH3_3 476 482 PF00018 0.405
LIG_TRAF2_1 29 32 PF00917 0.458
LIG_TYR_ITIM 54 59 PF00017 0.502
LIG_UBA3_1 262 270 PF00899 0.421
LIG_UBA3_1 317 322 PF00899 0.313
LIG_UBA3_1 386 394 PF00899 0.313
MOD_CK1_1 88 94 PF00069 0.574
MOD_CK2_1 16 22 PF00069 0.455
MOD_CK2_1 184 190 PF00069 0.223
MOD_CK2_1 26 32 PF00069 0.489
MOD_CK2_1 6 12 PF00069 0.579
MOD_CK2_1 89 95 PF00069 0.526
MOD_GSK3_1 84 91 PF00069 0.545
MOD_NEK2_1 395 400 PF00069 0.374
MOD_NEK2_1 417 422 PF00069 0.386
MOD_NEK2_1 85 90 PF00069 0.599
MOD_PIKK_1 417 423 PF00454 0.347
MOD_PKA_1 16 22 PF00069 0.526
MOD_PKA_1 227 233 PF00069 0.313
MOD_PKA_1 358 364 PF00069 0.405
MOD_PKA_2 16 22 PF00069 0.601
MOD_PKA_2 227 233 PF00069 0.365
MOD_PKA_2 358 364 PF00069 0.378
MOD_PKB_1 14 22 PF00069 0.527
MOD_Plk_4 16 22 PF00069 0.497
MOD_Plk_4 358 364 PF00069 0.405
MOD_Plk_4 85 91 PF00069 0.557
MOD_SUMO_for_1 113 116 PF00179 0.438
MOD_SUMO_for_1 280 283 PF00179 0.447
MOD_SUMO_rev_2 116 121 PF00179 0.577
MOD_SUMO_rev_2 264 272 PF00179 0.404
MOD_SUMO_rev_2 278 287 PF00179 0.313
MOD_SUMO_rev_2 391 396 PF00179 0.457
MOD_SUMO_rev_2 46 53 PF00179 0.496
TRG_DiLeu_BaEn_1 232 237 PF01217 0.421
TRG_DiLeu_BaEn_1 49 54 PF01217 0.425
TRG_DiLeu_BaEn_2 390 396 PF01217 0.316
TRG_DiLeu_BaEn_4 116 122 PF01217 0.455
TRG_DiLeu_BaLyEn_6 100 105 PF01217 0.456
TRG_DiLeu_BaLyEn_6 476 481 PF01217 0.432
TRG_DiLeu_LyEn_5 232 237 PF01217 0.421
TRG_ENDOCYTIC_2 155 158 PF00928 0.365
TRG_ENDOCYTIC_2 234 237 PF00928 0.421
TRG_ENDOCYTIC_2 277 280 PF00928 0.280
TRG_ENDOCYTIC_2 475 478 PF00928 0.442
TRG_ENDOCYTIC_2 56 59 PF00928 0.560
TRG_ER_diArg_1 14 17 PF00400 0.498
TRG_ER_diArg_1 164 166 PF00400 0.344
TRG_ER_diArg_1 246 249 PF00400 0.378
TRG_ER_diArg_1 308 310 PF00400 0.400
TRG_ER_diArg_1 345 348 PF00400 0.393
TRG_ER_diArg_1 412 414 PF00400 0.315
TRG_ER_diArg_1 71 74 PF00400 0.433
TRG_NLS_MonoCore_2 199 204 PF00514 0.223
TRG_NLS_MonoExtN_4 200 205 PF00514 0.267
TRG_NLS_MonoExtN_4 482 487 PF00514 0.594
TRG_Pf-PMV_PEXEL_1 192 197 PF00026 0.385
TRG_Pf-PMV_PEXEL_1 235 239 PF00026 0.374
TRG_Pf-PMV_PEXEL_1 256 260 PF00026 0.405
TRG_Pf-PMV_PEXEL_1 388 392 PF00026 0.393
TRG_Pf-PMV_PEXEL_1 73 77 PF00026 0.550

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCD5 Leptomonas seymouri 72% 100%
A0A0S4IRE4 Bodo saltans 38% 99%
A0A1X0NWN4 Trypanosomatidae 49% 100%
A0A3Q8IMD7 Leishmania donovani 100% 100%
A0A422NJE4 Trypanosoma rangeli 49% 100%
A4HD29 Leishmania braziliensis 85% 100%
C9ZNQ4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9AWH7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4QAZ3 Leishmania major 95% 100%
V5D760 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS