MARVEL domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4I0L5_LEIIN

TriTrypDb:

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4I0L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0L5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	31	33	PF00675	0.415
CLV_PCSK_KEX2_1	31	33	PF00082	0.415
CLV_PCSK_SKI1_1	155	159	PF00082	0.621
DEG_Nend_UBRbox_1	1	4	PF02207	0.631
DOC_MAPK_gen_1	31	39	PF00069	0.600
DOC_WW_Pin1_4	24	29	PF00397	0.613
LIG_14-3-3_CanoR_1	104	108	PF00244	0.702
LIG_14-3-3_CanoR_1	110	119	PF00244	0.692
LIG_Actin_WH2_2	90	106	PF00022	0.454
LIG_eIF4E_1	92	98	PF01652	0.518
LIG_FHA_1	139	145	PF00498	0.454
LIG_FHA_1	78	84	PF00498	0.520
LIG_FHA_1	94	100	PF00498	0.520
LIG_GBD_Chelix_1	99	107	PF00786	0.619
LIG_LIR_Gen_1	120	130	PF02991	0.467
LIG_LIR_Gen_1	164	174	PF02991	0.486
LIG_LIR_Gen_1	95	103	PF02991	0.516
LIG_LIR_Nem_3	120	125	PF02991	0.613
LIG_LIR_Nem_3	138	143	PF02991	0.272
LIG_LIR_Nem_3	164	169	PF02991	0.510
LIG_LIR_Nem_3	170	174	PF02991	0.414
LIG_LIR_Nem_3	85	90	PF02991	0.518
LIG_LIR_Nem_3	95	101	PF02991	0.358
LIG_Pex14_2	58	62	PF04695	0.518
LIG_Rb_LxCxE_1	114	134	PF01857	0.627
LIG_Rb_LxCxE_1	15	27	PF01857	0.758
LIG_SH2_STAP1	122	126	PF00017	0.513
LIG_SH2_STAT5	92	95	PF00017	0.518
LIG_Sin3_3	62	69	PF02671	0.486
LIG_SUMO_SIM_anti_2	175	181	PF11976	0.358
LIG_SUMO_SIM_anti_2	20	27	PF11976	0.627
LIG_SUMO_SIM_par_1	128	134	PF11976	0.518
LIG_WRC_WIRS_1	163	168	PF05994	0.486
MOD_CDK_SPxxK_3	24	31	PF00069	0.638
MOD_CK1_1	114	120	PF00069	0.739
MOD_CK1_1	138	144	PF00069	0.518
MOD_CK2_1	117	123	PF00069	0.732
MOD_GlcNHglycan	14	17	PF01048	0.564
MOD_GlcNHglycan	47	50	PF01048	0.375
MOD_GSK3_1	110	117	PF00069	0.638
MOD_GSK3_1	131	138	PF00069	0.518
MOD_GSK3_1	161	168	PF00069	0.518
MOD_GSK3_1	20	27	PF00069	0.657
MOD_GSK3_1	41	48	PF00069	0.370
MOD_N-GLC_1	114	119	PF02516	0.445
MOD_NEK2_1	103	108	PF00069	0.574
MOD_NEK2_1	131	136	PF00069	0.518
MOD_NEK2_1	145	150	PF00069	0.423
MOD_NEK2_1	45	50	PF00069	0.518
MOD_NEK2_1	64	69	PF00069	0.277
MOD_NEK2_1	77	82	PF00069	0.314
MOD_NEK2_1	93	98	PF00069	0.322
MOD_NEK2_2	135	140	PF00069	0.358
MOD_PKA_2	103	109	PF00069	0.695
MOD_PKA_2	111	117	PF00069	0.670
MOD_Plk_1	114	120	PF00069	0.739
MOD_Plk_1	20	26	PF00069	0.632
MOD_Plk_4	20	26	PF00069	0.632
MOD_Plk_4	93	99	PF00069	0.518
MOD_ProDKin_1	24	30	PF00069	0.610
TRG_ENDOCYTIC_2	122	125	PF00928	0.467
TRG_ER_diArg_1	109	112	PF00400	0.747
TRG_ER_diArg_1	30	32	PF00400	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WXY1	Leishmania donovani	98%	92%
Q4QAZ5	Leishmania major	85%	100%