Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0L3_LEIIN

TriTrypDb:

LINF_230024700

Length:

852

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0L3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0L3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.735
CLV_C14_Caspase3-7	198	202	PF00656	0.711
CLV_C14_Caspase3-7	585	589	PF00656	0.619
CLV_C14_Caspase3-7	838	842	PF00656	0.634
CLV_NRD_NRD_1	13	15	PF00675	0.685
CLV_NRD_NRD_1	174	176	PF00675	0.612
CLV_NRD_NRD_1	274	276	PF00675	0.318
CLV_NRD_NRD_1	294	296	PF00675	0.631
CLV_NRD_NRD_1	450	452	PF00675	0.731
CLV_NRD_NRD_1	553	555	PF00675	0.691
CLV_NRD_NRD_1	668	670	PF00675	0.510
CLV_NRD_NRD_1	97	99	PF00675	0.575
CLV_PCSK_KEX2_1	12	14	PF00082	0.690
CLV_PCSK_KEX2_1	174	176	PF00082	0.614
CLV_PCSK_KEX2_1	294	296	PF00082	0.632
CLV_PCSK_KEX2_1	452	454	PF00082	0.764
CLV_PCSK_KEX2_1	553	555	PF00082	0.691
CLV_PCSK_KEX2_1	668	670	PF00082	0.514
CLV_PCSK_KEX2_1	97	99	PF00082	0.575
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.764
CLV_PCSK_SKI1_1	14	18	PF00082	0.626
CLV_PCSK_SKI1_1	175	179	PF00082	0.581
CLV_PCSK_SKI1_1	186	190	PF00082	0.617
CLV_PCSK_SKI1_1	205	209	PF00082	0.477
CLV_PCSK_SKI1_1	437	441	PF00082	0.672
CLV_PCSK_SKI1_1	554	558	PF00082	0.614
CLV_PCSK_SKI1_1	604	608	PF00082	0.538
CLV_PCSK_SKI1_1	661	665	PF00082	0.448
CLV_PCSK_SKI1_1	702	706	PF00082	0.432
CLV_PCSK_SKI1_1	714	718	PF00082	0.448
CLV_PCSK_SKI1_1	812	816	PF00082	0.439
DEG_APCC_DBOX_1	263	271	PF00400	0.644
DEG_APCC_DBOX_1	713	721	PF00400	0.546
DEG_SCF_FBW7_1	139	145	PF00400	0.619
DEG_SCF_FBW7_2	303	310	PF00400	0.497
DEG_SPOP_SBC_1	211	215	PF00917	0.659
DEG_SPOP_SBC_1	464	468	PF00917	0.613
DEG_SPOP_SBC_1	80	84	PF00917	0.593
DOC_CKS1_1	139	144	PF01111	0.621
DOC_CYCLIN_yCln2_LP_2	184	190	PF00134	0.640
DOC_MAPK_MEF2A_6	18	27	PF00069	0.697
DOC_MAPK_MEF2A_6	259	267	PF00069	0.738
DOC_MAPK_MEF2A_6	318	326	PF00069	0.502
DOC_PP2B_LxvP_1	324	327	PF13499	0.428
DOC_PP2B_LxvP_1	56	59	PF13499	0.626
DOC_PP4_FxxP_1	216	219	PF00568	0.745
DOC_PP4_FxxP_1	794	797	PF00568	0.461
DOC_SPAK_OSR1_1	295	299	PF12202	0.526
DOC_USP7_MATH_1	161	165	PF00917	0.624
DOC_USP7_MATH_1	190	194	PF00917	0.700
DOC_USP7_MATH_1	269	273	PF00917	0.510
DOC_USP7_MATH_1	41	45	PF00917	0.647
DOC_USP7_MATH_1	459	463	PF00917	0.690
DOC_USP7_MATH_1	48	52	PF00917	0.520
DOC_USP7_MATH_1	537	541	PF00917	0.788
DOC_USP7_MATH_1	556	560	PF00917	0.473
DOC_USP7_MATH_1	57	61	PF00917	0.581
DOC_USP7_MATH_1	580	584	PF00917	0.647
DOC_USP7_MATH_1	587	591	PF00917	0.622
DOC_USP7_MATH_1	766	770	PF00917	0.501
DOC_USP7_MATH_1	80	84	PF00917	0.678
DOC_WW_Pin1_4	138	143	PF00397	0.679
DOC_WW_Pin1_4	215	220	PF00397	0.804
DOC_WW_Pin1_4	227	232	PF00397	0.647
DOC_WW_Pin1_4	303	308	PF00397	0.542
DOC_WW_Pin1_4	363	368	PF00397	0.706
DOC_WW_Pin1_4	491	496	PF00397	0.741
DOC_WW_Pin1_4	554	559	PF00397	0.718
DOC_WW_Pin1_4	562	567	PF00397	0.642
DOC_WW_Pin1_4	680	685	PF00397	0.539
DOC_WW_Pin1_4	76	81	PF00397	0.687
DOC_WW_Pin1_4	841	846	PF00397	0.499
LIG_14-3-3_CanoR_1	174	184	PF00244	0.607
LIG_14-3-3_CanoR_1	461	465	PF00244	0.584
LIG_14-3-3_CanoR_1	746	751	PF00244	0.423
LIG_14-3-3_CanoR_1	812	817	PF00244	0.433
LIG_APCC_ABBA_1	325	330	PF00400	0.558
LIG_APCC_ABBAyCdc20_2	437	443	PF00400	0.791
LIG_BIR_III_4	426	430	PF00653	0.790
LIG_BIR_III_4	832	836	PF00653	0.535
LIG_BRCT_BRCA1_1	192	196	PF00533	0.581
LIG_BRCT_BRCA1_1	270	274	PF00533	0.460
LIG_BRCT_BRCA1_2	270	276	PF00533	0.505
LIG_eIF4E_1	605	611	PF01652	0.472
LIG_FHA_1	20	26	PF00498	0.695
LIG_FHA_1	363	369	PF00498	0.585
LIG_FHA_1	388	394	PF00498	0.556
LIG_FHA_1	507	513	PF00498	0.697
LIG_FHA_1	563	569	PF00498	0.649
LIG_FHA_1	727	733	PF00498	0.447
LIG_FHA_1	76	82	PF00498	0.736
LIG_FHA_1	777	783	PF00498	0.495
LIG_FHA_1	813	819	PF00498	0.432
LIG_FHA_1	91	97	PF00498	0.489
LIG_FHA_2	143	149	PF00498	0.700
LIG_FHA_2	196	202	PF00498	0.718
LIG_FHA_2	3	9	PF00498	0.685
LIG_FHA_2	406	412	PF00498	0.769
LIG_FHA_2	41	47	PF00498	0.566
LIG_FHA_2	486	492	PF00498	0.741
LIG_FHA_2	555	561	PF00498	0.720
LIG_FHA_2	747	753	PF00498	0.408
LIG_LIR_Apic_2	213	219	PF02991	0.819
LIG_LIR_Gen_1	394	405	PF02991	0.565
LIG_LIR_LC3C_4	430	435	PF02991	0.670
LIG_LIR_Nem_3	394	400	PF02991	0.537
LIG_LIR_Nem_3	60	65	PF02991	0.510
LIG_LIR_Nem_3	699	704	PF02991	0.471
LIG_LIR_Nem_3	817	823	PF02991	0.545
LIG_MYND_1	566	570	PF01753	0.721
LIG_PCNA_yPIPBox_3	275	289	PF02747	0.539
LIG_PDZ_Class_3	847	852	PF00595	0.615
LIG_SH2_CRK	62	66	PF00017	0.574
LIG_SH2_NCK_1	522	526	PF00017	0.696
LIG_SH2_PTP2	656	659	PF00017	0.446
LIG_SH2_STAP1	522	526	PF00017	0.696
LIG_SH2_STAT3	111	114	PF00017	0.550
LIG_SH2_STAT3	290	293	PF00017	0.600
LIG_SH2_STAT5	111	114	PF00017	0.550
LIG_SH2_STAT5	605	608	PF00017	0.485
LIG_SH2_STAT5	633	636	PF00017	0.471
LIG_SH2_STAT5	647	650	PF00017	0.313
LIG_SH2_STAT5	656	659	PF00017	0.446
LIG_SH2_STAT5	820	823	PF00017	0.433
LIG_SH3_1	237	243	PF00018	0.703
LIG_SH3_3	225	231	PF00018	0.661
LIG_SH3_3	237	243	PF00018	0.734
LIG_SH3_3	409	415	PF00018	0.635
LIG_SH3_3	512	518	PF00018	0.680
LIG_SH3_3	527	533	PF00018	0.629
LIG_SH3_3	564	570	PF00018	0.722
LIG_SH3_3	737	743	PF00018	0.632
LIG_SH3_3	801	807	PF00018	0.513
LIG_SUMO_SIM_anti_2	376	384	PF11976	0.667
LIG_SUMO_SIM_anti_2	815	820	PF11976	0.434
LIG_SUMO_SIM_par_1	702	707	PF11976	0.430
LIG_SUMO_SIM_par_1	731	736	PF11976	0.467
LIG_TRAF2_1	392	395	PF00917	0.569
LIG_TYR_ITIM	818	823	PF00017	0.431
LIG_WW_3	218	222	PF00397	0.612
LIG_WW_3	658	662	PF00397	0.442
MOD_CDC14_SPxK_1	218	221	PF00782	0.611
MOD_CDC14_SPxK_1	683	686	PF00782	0.529
MOD_CDK_SPxK_1	215	221	PF00069	0.610
MOD_CDK_SPxK_1	680	686	PF00069	0.536
MOD_CDK_SPxxK_3	227	234	PF00069	0.611
MOD_CDK_SPxxK_3	491	498	PF00069	0.742
MOD_CDK_SPxxK_3	562	569	PF00069	0.606
MOD_CDK_SPxxK_3	841	848	PF00069	0.494
MOD_CK1_1	152	158	PF00069	0.639
MOD_CK1_1	197	203	PF00069	0.716
MOD_CK1_1	215	221	PF00069	0.751
MOD_CK1_1	226	232	PF00069	0.669
MOD_CK1_1	416	422	PF00069	0.695
MOD_CK1_1	463	469	PF00069	0.688
MOD_CK1_1	493	499	PF00069	0.749
MOD_CK1_1	552	558	PF00069	0.703
MOD_CK1_1	582	588	PF00069	0.576
MOD_CK1_1	625	631	PF00069	0.579
MOD_CK1_1	75	81	PF00069	0.703
MOD_CK1_1	786	792	PF00069	0.609
MOD_CK1_1	84	90	PF00069	0.660
MOD_CK2_1	405	411	PF00069	0.753
MOD_CK2_1	467	473	PF00069	0.732
MOD_CK2_1	475	481	PF00069	0.581
MOD_CK2_1	746	752	PF00069	0.419
MOD_Cter_Amidation	10	13	PF01082	0.678
MOD_DYRK1A_RPxSP_1	554	558	PF00069	0.712
MOD_GlcNHglycan	192	195	PF01048	0.709
MOD_GlcNHglycan	225	228	PF01048	0.761
MOD_GlcNHglycan	271	274	PF01048	0.523
MOD_GlcNHglycan	436	440	PF01048	0.780
MOD_GlcNHglycan	455	458	PF01048	0.511
MOD_GlcNHglycan	467	470	PF01048	0.644
MOD_GlcNHglycan	554	557	PF01048	0.671
MOD_GlcNHglycan	582	585	PF01048	0.750
MOD_GlcNHglycan	588	592	PF01048	0.609
MOD_GlcNHglycan	59	62	PF01048	0.625
MOD_GlcNHglycan	624	627	PF01048	0.580
MOD_GlcNHglycan	776	779	PF01048	0.480
MOD_GlcNHglycan	784	788	PF01048	0.518
MOD_GlcNHglycan	86	89	PF01048	0.698
MOD_GSK3_1	134	141	PF00069	0.689
MOD_GSK3_1	149	156	PF00069	0.621
MOD_GSK3_1	19	26	PF00069	0.697
MOD_GSK3_1	190	197	PF00069	0.718
MOD_GSK3_1	210	217	PF00069	0.813
MOD_GSK3_1	223	230	PF00069	0.554
MOD_GSK3_1	358	365	PF00069	0.734
MOD_GSK3_1	413	420	PF00069	0.787
MOD_GSK3_1	459	466	PF00069	0.684
MOD_GSK3_1	475	482	PF00069	0.751
MOD_GSK3_1	48	55	PF00069	0.553
MOD_GSK3_1	490	497	PF00069	0.603
MOD_GSK3_1	502	509	PF00069	0.671
MOD_GSK3_1	543	550	PF00069	0.803
MOD_GSK3_1	552	559	PF00069	0.647
MOD_GSK3_1	621	628	PF00069	0.574
MOD_GSK3_1	67	74	PF00069	0.472
MOD_GSK3_1	746	753	PF00069	0.616
MOD_GSK3_1	75	82	PF00069	0.671
MOD_N-GLC_1	547	552	PF02516	0.807
MOD_NEK2_1	105	110	PF00069	0.512
MOD_NEK2_1	23	28	PF00069	0.623
MOD_NEK2_1	268	273	PF00069	0.522
MOD_NEK2_1	417	422	PF00069	0.658
MOD_NEK2_1	485	490	PF00069	0.724
MOD_NEK2_1	52	57	PF00069	0.493
MOD_NEK2_1	549	554	PF00069	0.731
MOD_NEK2_1	597	602	PF00069	0.457
MOD_NEK2_2	460	465	PF00069	0.568
MOD_OFUCOSY	748	754	PF10250	0.537
MOD_PIKK_1	175	181	PF00454	0.604
MOD_PIKK_1	427	433	PF00454	0.782
MOD_PIKK_1	531	537	PF00454	0.703
MOD_PIKK_1	543	549	PF00454	0.656
MOD_PIKK_1	589	595	PF00454	0.620
MOD_PIKK_1	723	729	PF00454	0.455
MOD_PIKK_1	90	96	PF00454	0.682
MOD_PKA_2	114	120	PF00069	0.650
MOD_PKA_2	444	450	PF00069	0.817
MOD_PKA_2	460	466	PF00069	0.678
MOD_PKA_2	499	505	PF00069	0.713
MOD_PKA_2	552	558	PF00069	0.719
MOD_PKB_1	451	459	PF00069	0.690
MOD_Plk_1	435	441	PF00069	0.779
MOD_Plk_1	783	789	PF00069	0.447
MOD_Plk_4	114	120	PF00069	0.650
MOD_Plk_4	19	25	PF00069	0.700
MOD_Plk_4	413	419	PF00069	0.573
MOD_Plk_4	502	508	PF00069	0.674
MOD_ProDKin_1	138	144	PF00069	0.681
MOD_ProDKin_1	215	221	PF00069	0.807
MOD_ProDKin_1	227	233	PF00069	0.646
MOD_ProDKin_1	303	309	PF00069	0.536
MOD_ProDKin_1	363	369	PF00069	0.704
MOD_ProDKin_1	491	497	PF00069	0.742
MOD_ProDKin_1	554	560	PF00069	0.721
MOD_ProDKin_1	562	568	PF00069	0.643
MOD_ProDKin_1	680	686	PF00069	0.536
MOD_ProDKin_1	76	82	PF00069	0.687
MOD_ProDKin_1	841	847	PF00069	0.493
TRG_DiLeu_BaEn_1	377	382	PF01217	0.664
TRG_DiLeu_BaEn_1	481	486	PF01217	0.556
TRG_DiLeu_BaEn_4	168	174	PF01217	0.625
TRG_ENDOCYTIC_2	62	65	PF00928	0.518
TRG_ENDOCYTIC_2	633	636	PF00928	0.546
TRG_ENDOCYTIC_2	820	823	PF00928	0.433
TRG_ER_diArg_1	12	14	PF00400	0.690
TRG_ER_diArg_1	173	175	PF00400	0.609
TRG_ER_diArg_1	263	266	PF00400	0.728
TRG_ER_diArg_1	294	296	PF00400	0.632
TRG_ER_diArg_1	498	501	PF00400	0.709
TRG_ER_diArg_1	96	98	PF00400	0.580
TRG_NES_CRM1_1	100	116	PF08389	0.552
TRG_NLS_MonoExtN_4	449	455	PF00514	0.692
TRG_Pf-PMV_PEXEL_1	171	176	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	205	210	PF00026	0.692

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P625	Leptomonas seymouri	44%	99%
A0A3S7WXX2	Leishmania donovani	99%	100%
A4HD26	Leishmania braziliensis	71%	98%
E9AWH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QAZ7	Leishmania major	92%	100%