Methyltransferase-like protein 12, mitochondrial

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0K6_LEIIN

TriTrypDb:

LINF_230024000

Length:

239

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I0K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0K6

Function

Biological processes
Term	Name	Level	Count
GO:0006140	regulation of nucleotide metabolic process	5	1
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010155	regulation of proton transport	7	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018023	peptidyl-lysine trimethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0022898	regulation of transmembrane transporter activity	4	1
GO:0030808	regulation of nucleotide biosynthetic process	6	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0032259	methylation	2	1
GO:0032409	regulation of transporter activity	3	1
GO:0032411	positive regulation of transporter activity	4	1
GO:0032412	regulation of monoatomic ion transmembrane transporter activity	5	1
GO:0032414	positive regulation of ion transmembrane transporter activity	5	1
GO:0032879	regulation of localization	3	1
GO:0034762	regulation of transmembrane transport	4	1
GO:0034764	positive regulation of transmembrane transport	5	1
GO:0034765	regulation of monoatomic ion transmembrane transport	5	1
GO:0034767	positive regulation of monoatomic ion transmembrane transport	6	1
GO:0036211	protein modification process	4	1
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043269	regulation of monoatomic ion transport	5	1
GO:0043270	positive regulation of monoatomic ion transport	5	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044093	positive regulation of molecular function	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051049	regulation of transport	4	1
GO:0051050	positive regulation of transport	4	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051340	regulation of ligase activity	4	1
GO:0051351	positive regulation of ligase activity	5	1
GO:0062012	regulation of small molecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1900371	regulation of purine nucleotide biosynthetic process	7	1
GO:1900542	regulation of purine nucleotide metabolic process	6	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1903578	regulation of ATP metabolic process	7	1
GO:1904062	regulation of monoatomic cation transmembrane transport	6	1
GO:1904064	positive regulation of cation transmembrane transport	7	1
GO:1905271	regulation of proton-transporting ATP synthase activity, rotational mechanism	5	1
GO:1905273	positive regulation of proton-transporting ATP synthase activity, rotational mechanism	6	1
GO:1905706	regulation of mitochondrial ATP synthesis coupled proton transport	9	1
GO:2001169	regulation of ATP biosynthetic process	8	1
GO:2001257	regulation of cation channel activity	6	1
GO:2001259	positive regulation of cation channel activity	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0008168	methyltransferase activity	4	9
GO:0008170	N-methyltransferase activity	5	9
GO:0008276	protein methyltransferase activity	3	9
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	9
GO:0016278	lysine N-methyltransferase activity	6	9
GO:0016279	protein-lysine N-methyltransferase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016741	transferase activity, transferring one-carbon groups	3	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	84	86	PF00675	0.417
CLV_PCSK_SKI1_1	108	112	PF00082	0.383
DEG_APCC_DBOX_1	107	115	PF00400	0.354
DEG_APCC_DBOX_1	196	204	PF00400	0.370
DOC_MAPK_gen_1	225	233	PF00069	0.413
DOC_MAPK_MEF2A_6	155	163	PF00069	0.458
DOC_MAPK_MEF2A_6	227	235	PF00069	0.358
DOC_PP4_FxxP_1	174	177	PF00568	0.458
DOC_USP7_MATH_1	126	130	PF00917	0.483
DOC_USP7_MATH_1	138	142	PF00917	0.588
DOC_WW_Pin1_4	12	17	PF00397	0.469
DOC_WW_Pin1_4	134	139	PF00397	0.411
DOC_WW_Pin1_4	35	40	PF00397	0.469
DOC_WW_Pin1_4	97	102	PF00397	0.578
LIG_BIR_II_1	1	5	PF00653	0.676
LIG_CaM_IQ_9	78	94	PF13499	0.382
LIG_Clathr_ClatBox_1	142	146	PF01394	0.377
LIG_deltaCOP1_diTrp_1	205	215	PF00928	0.407
LIG_FHA_1	145	151	PF00498	0.457
LIG_FHA_1	154	160	PF00498	0.462
LIG_FHA_1	73	79	PF00498	0.392
LIG_FHA_2	110	116	PF00498	0.431
LIG_FHA_2	117	123	PF00498	0.389
LIG_LIR_Apic_2	173	177	PF02991	0.461
LIG_LIR_Apic_2	212	218	PF02991	0.343
LIG_LIR_Apic_2	33	39	PF02991	0.378
LIG_SH2_CRK	185	189	PF00017	0.405
LIG_SH2_GRB2like	234	237	PF00017	0.293
LIG_SH2_SRC	234	237	PF00017	0.354
LIG_SH2_STAT5	187	190	PF00017	0.340
LIG_SH2_STAT5	234	237	PF00017	0.378
LIG_SH2_STAT5	36	39	PF00017	0.425
LIG_SH3_3	158	164	PF00018	0.468
LIG_SH3_3	174	180	PF00018	0.561
LIG_SH3_3	55	61	PF00018	0.531
LIG_SUMO_SIM_anti_2	191	198	PF11976	0.458
LIG_SUMO_SIM_par_1	140	147	PF11976	0.545
LIG_SUMO_SIM_par_1	198	205	PF11976	0.414
LIG_TRAF2_2	5	10	PF00917	0.469
LIG_TYR_ITIM	183	188	PF00017	0.408
MOD_CK1_1	100	106	PF00069	0.443
MOD_CK1_1	137	143	PF00069	0.560
MOD_CK1_1	144	150	PF00069	0.388
MOD_GlcNHglycan	102	105	PF01048	0.417
MOD_GlcNHglycan	128	131	PF01048	0.450
MOD_GSK3_1	116	123	PF00069	0.457
MOD_GSK3_1	134	141	PF00069	0.468
MOD_GSK3_1	144	151	PF00069	0.506
MOD_GSK3_1	18	25	PF00069	0.471
MOD_GSK3_1	72	79	PF00069	0.440
MOD_N-GLC_1	126	131	PF02516	0.440
MOD_N-GLC_2	160	162	PF02516	0.405
MOD_NEK2_1	116	121	PF00069	0.436
MOD_PIKK_1	148	154	PF00454	0.434
MOD_PKA_2	64	70	PF00069	0.336
MOD_Plk_1	116	122	PF00069	0.425
MOD_Plk_1	126	132	PF00069	0.445
MOD_Plk_2-3	153	159	PF00069	0.352
MOD_Plk_4	116	122	PF00069	0.349
MOD_Plk_4	138	144	PF00069	0.571
MOD_Plk_4	76	82	PF00069	0.393
MOD_ProDKin_1	12	18	PF00069	0.463
MOD_ProDKin_1	134	140	PF00069	0.413
MOD_ProDKin_1	35	41	PF00069	0.469
MOD_ProDKin_1	97	103	PF00069	0.576
TRG_ENDOCYTIC_2	185	188	PF00928	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5N7	Leptomonas seymouri	49%	100%
A0A1X0NWN1	Trypanosomatidae	34%	100%
A0A3S7WXY7	Leishmania donovani	100%	100%
A4HD20	Leishmania braziliensis	75%	100%
C9ZVI5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AWG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QB04	Leishmania major	91%	100%