Adenylate kinase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Adenylate kinase

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0K5_LEIIN

TriTrypDb:

LINF_230023900

Length:

285

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I0K5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0K5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	236	238	PF00675	0.460
CLV_PCSK_KEX2_1	236	238	PF00082	0.608
CLV_PCSK_SKI1_1	108	112	PF00082	0.457
CLV_PCSK_SKI1_1	133	137	PF00082	0.551
CLV_PCSK_SKI1_1	276	280	PF00082	0.524
CLV_PCSK_SKI1_1	42	46	PF00082	0.593
DEG_APCC_DBOX_1	275	283	PF00400	0.522
DEG_APCC_DBOX_1	37	45	PF00400	0.597
DEG_ODPH_VHL_1	65	77	PF01847	0.479
DEG_SPOP_SBC_1	146	150	PF00917	0.380
DOC_CKS1_1	183	188	PF01111	0.476
DOC_CKS1_1	69	74	PF01111	0.536
DOC_MAPK_gen_1	8	16	PF00069	0.496
DOC_MAPK_RevD_3	222	237	PF00069	0.541
DOC_USP7_MATH_1	102	106	PF00917	0.502
DOC_USP7_MATH_1	147	151	PF00917	0.461
DOC_WW_Pin1_4	182	187	PF00397	0.499
DOC_WW_Pin1_4	236	241	PF00397	0.569
DOC_WW_Pin1_4	36	41	PF00397	0.606
DOC_WW_Pin1_4	68	73	PF00397	0.559
LIG_14-3-3_CanoR_1	141	145	PF00244	0.476
LIG_14-3-3_CanoR_1	190	196	PF00244	0.466
LIG_14-3-3_CanoR_1	245	250	PF00244	0.418
LIG_BIR_II_1	1	5	PF00653	0.579
LIG_BIR_III_3	1	5	PF00653	0.579
LIG_BRCT_BRCA1_1	192	196	PF00533	0.554
LIG_CtBP_PxDLS_1	157	161	PF00389	0.508
LIG_FHA_1	273	279	PF00498	0.510
LIG_FHA_1	69	75	PF00498	0.406
LIG_FHA_2	203	209	PF00498	0.508
LIG_FHA_2	214	220	PF00498	0.352
LIG_LIR_Nem_3	193	199	PF02991	0.511
LIG_LIR_Nem_3	251	255	PF02991	0.374
LIG_LYPXL_SIV_4	254	262	PF13949	0.447
LIG_MYND_1	68	72	PF01753	0.351
LIG_PCNA_yPIPBox_3	18	29	PF02747	0.490
LIG_Pex14_2	252	256	PF04695	0.504
LIG_SH2_STAT3	7	10	PF00017	0.407
LIG_SH2_STAT5	123	126	PF00017	0.376
LIG_SH3_1	237	243	PF00018	0.574
LIG_SH3_2	240	245	PF14604	0.494
LIG_SH3_2	37	42	PF14604	0.601
LIG_SH3_3	119	125	PF00018	0.550
LIG_SH3_3	180	186	PF00018	0.500
LIG_SH3_3	237	243	PF00018	0.461
LIG_SH3_3	34	40	PF00018	0.603
LIG_SUMO_SIM_par_1	73	78	PF11976	0.420
LIG_SxIP_EBH_1	234	245	PF03271	0.396
LIG_TRAF2_1	216	219	PF00917	0.538
LIG_WRC_WIRS_1	249	254	PF05994	0.452
MOD_CDC14_SPxK_1	39	42	PF00782	0.602
MOD_CDK_SPK_2	68	73	PF00069	0.482
MOD_CDK_SPxK_1	36	42	PF00069	0.604
MOD_CK1_1	151	157	PF00069	0.453
MOD_CK1_1	248	254	PF00069	0.350
MOD_CK2_1	202	208	PF00069	0.506
MOD_CK2_1	213	219	PF00069	0.355
MOD_DYRK1A_RPxSP_1	36	40	PF00069	0.602
MOD_GlcNHglycan	153	156	PF01048	0.444
MOD_GlcNHglycan	2	5	PF01048	0.565
MOD_GlcNHglycan	256	259	PF01048	0.525
MOD_GlcNHglycan	57	60	PF01048	0.518
MOD_GSK3_1	147	154	PF00069	0.483
MOD_GSK3_1	218	225	PF00069	0.504
MOD_GSK3_1	32	39	PF00069	0.533
MOD_GSK3_1	83	90	PF00069	0.524
MOD_NEK2_2	191	196	PF00069	0.493
MOD_PKA_2	140	146	PF00069	0.478
MOD_Plk_1	218	224	PF00069	0.507
MOD_Plk_4	102	108	PF00069	0.509
MOD_Plk_4	148	154	PF00069	0.478
MOD_Plk_4	191	197	PF00069	0.412
MOD_ProDKin_1	182	188	PF00069	0.500
MOD_ProDKin_1	236	242	PF00069	0.569
MOD_ProDKin_1	36	42	PF00069	0.604
MOD_ProDKin_1	68	74	PF00069	0.549
MOD_SUMO_for_1	17	20	PF00179	0.547
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICN4	Leishmania donovani	100%	100%
A4HD19	Leishmania braziliensis	74%	96%
E9AWG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QB05	Leishmania major	94%	100%