Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC zinc finger domain-like protein

Species:

Leishmania infantum

UniProt:

A4I0K2_LEIIN

TriTrypDb:

LINF_230023600

Length:

450

Annotations

LeishMANIAdb annotations

Related to other eukaryotic ZDHHC palmitoyltransferases, especially animal ZDHHC2.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4I0K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0K2

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016409	palmitoyltransferase activity	5	7
GO:0016417	S-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	7
GO:0019707	protein-cysteine S-acyltransferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.632
CLV_C14_Caspase3-7	200	204	PF00656	0.590
CLV_NRD_NRD_1	408	410	PF00675	0.683
CLV_NRD_NRD_1	429	431	PF00675	0.604
CLV_PCSK_KEX2_1	393	395	PF00082	0.660
CLV_PCSK_KEX2_1	429	431	PF00082	0.604
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.678
CLV_PCSK_SKI1_1	333	337	PF00082	0.266
CLV_PCSK_SKI1_1	364	368	PF00082	0.500
DOC_CYCLIN_RxL_1	361	368	PF00134	0.266
DOC_MAPK_gen_1	429	436	PF00069	0.403
DOC_MAPK_MEF2A_6	202	209	PF00069	0.457
DOC_MAPK_MEF2A_6	300	309	PF00069	0.326
DOC_MAPK_MEF2A_6	40	49	PF00069	0.410
DOC_PP1_RVXF_1	257	263	PF00149	0.363
DOC_PP1_RVXF_1	337	343	PF00149	0.546
DOC_PP2B_LxvP_1	112	115	PF13499	0.567
DOC_PP4_FxxP_1	226	229	PF00568	0.549
DOC_PP4_FxxP_1	67	70	PF00568	0.387
DOC_USP7_MATH_1	129	133	PF00917	0.605
DOC_USP7_MATH_1	150	154	PF00917	0.512
DOC_USP7_MATH_1	20	24	PF00917	0.513
DOC_USP7_MATH_1	85	89	PF00917	0.541
DOC_WW_Pin1_4	121	126	PF00397	0.587
DOC_WW_Pin1_4	166	171	PF00397	0.587
DOC_WW_Pin1_4	182	187	PF00397	0.435
DOC_WW_Pin1_4	210	215	PF00397	0.608
DOC_WW_Pin1_4	230	235	PF00397	0.551
DOC_WW_Pin1_4	395	400	PF00397	0.475
DOC_WW_Pin1_4	422	427	PF00397	0.488
DOC_WW_Pin1_4	66	71	PF00397	0.338
LIG_14-3-3_CanoR_1	131	136	PF00244	0.599
LIG_14-3-3_CanoR_1	140	149	PF00244	0.549
LIG_14-3-3_CanoR_1	415	421	PF00244	0.496
LIG_AP2alpha_2	76	78	PF02296	0.480
LIG_APCC_ABBA_1	205	210	PF00400	0.533
LIG_BRCT_BRCA1_1	68	72	PF00533	0.378
LIG_eIF4E_1	360	366	PF01652	0.397
LIG_EVH1_2	222	226	PF00568	0.532
LIG_FHA_1	142	148	PF00498	0.513
LIG_FHA_1	225	231	PF00498	0.481
LIG_FHA_2	250	256	PF00498	0.418
LIG_FHA_2	439	445	PF00498	0.527
LIG_GBD_Chelix_1	46	54	PF00786	0.396
LIG_IBAR_NPY_1	247	249	PF08397	0.498
LIG_LIR_Apic_2	224	229	PF02991	0.474
LIG_LIR_Apic_2	76	81	PF02991	0.413
LIG_LIR_Apic_2	83	87	PF02991	0.450
LIG_LIR_Gen_1	61	70	PF02991	0.447
LIG_LIR_Nem_3	37	42	PF02991	0.567
LIG_LIR_Nem_3	425	431	PF02991	0.402
LIG_LIR_Nem_3	61	66	PF02991	0.411
LIG_MYND_1	395	399	PF01753	0.456
LIG_MYND_1	87	91	PF01753	0.524
LIG_PCNA_yPIPBox_3	364	378	PF02747	0.322
LIG_RPA_C_Fungi	30	42	PF08784	0.364
LIG_SH2_CRK	104	108	PF00017	0.574
LIG_SH2_CRK	312	316	PF00017	0.411
LIG_SH2_CRK	431	435	PF00017	0.575
LIG_SH2_CRK	6	10	PF00017	0.383
LIG_SH2_CRK	63	67	PF00017	0.411
LIG_SH2_CRK	84	88	PF00017	0.575
LIG_SH2_NCK_1	312	316	PF00017	0.444
LIG_SH2_NCK_1	63	67	PF00017	0.513
LIG_SH2_SRC	104	107	PF00017	0.619
LIG_SH2_STAP1	26	30	PF00017	0.468
LIG_SH2_STAP1	63	67	PF00017	0.513
LIG_SH2_STAT3	106	109	PF00017	0.578
LIG_SH2_STAT5	225	228	PF00017	0.808
LIG_SH3_3	111	117	PF00018	0.676
LIG_SH3_3	135	141	PF00018	0.688
LIG_SH3_3	144	150	PF00018	0.780
LIG_SH3_3	164	170	PF00018	0.626
LIG_SH3_3	237	243	PF00018	0.614
LIG_SH3_3	71	77	PF00018	0.485
LIG_SUMO_SIM_par_1	45	52	PF11976	0.441
LIG_SUMO_SIM_par_1	55	61	PF11976	0.412
LIG_TYR_ITIM	310	315	PF00017	0.353
LIG_UBA3_1	324	333	PF00899	0.299
LIG_WW_1	222	225	PF00397	0.667
LIG_WW_1	81	84	PF00397	0.525
MOD_CDC14_SPxK_1	213	216	PF00782	0.688
MOD_CDK_SPxK_1	182	188	PF00069	0.606
MOD_CDK_SPxK_1	210	216	PF00069	0.688
MOD_CDK_SPxxK_3	395	402	PF00069	0.601
MOD_CDK_SPxxK_3	422	429	PF00069	0.556
MOD_CK1_1	124	130	PF00069	0.743
MOD_CK1_1	133	139	PF00069	0.614
MOD_CK1_1	153	159	PF00069	0.683
MOD_CK1_1	388	394	PF00069	0.507
MOD_CK2_1	172	178	PF00069	0.706
MOD_CK2_1	369	375	PF00069	0.436
MOD_GlcNHglycan	135	138	PF01048	0.627
MOD_GlcNHglycan	255	259	PF01048	0.496
MOD_GlcNHglycan	385	388	PF01048	0.673
MOD_GSK3_1	127	134	PF00069	0.685
MOD_GSK3_1	136	143	PF00069	0.621
MOD_GSK3_1	153	160	PF00069	0.636
MOD_GSK3_1	182	189	PF00069	0.748
MOD_GSK3_1	20	27	PF00069	0.436
MOD_GSK3_1	250	257	PF00069	0.542
MOD_GSK3_1	311	318	PF00069	0.354
MOD_GSK3_1	365	372	PF00069	0.418
MOD_GSK3_1	373	380	PF00069	0.512
MOD_GSK3_1	438	445	PF00069	0.598
MOD_N-GLC_2	264	266	PF02516	0.222
MOD_N-GLC_2	295	297	PF02516	0.353
MOD_NEK2_1	254	259	PF00069	0.494
MOD_NEK2_1	310	315	PF00069	0.410
MOD_NEK2_1	324	329	PF00069	0.373
MOD_NEK2_1	352	357	PF00069	0.367
MOD_NEK2_1	358	363	PF00069	0.361
MOD_NEK2_1	365	370	PF00069	0.323
MOD_NEK2_1	377	382	PF00069	0.324
MOD_NEK2_1	48	53	PF00069	0.404
MOD_NEK2_2	158	163	PF00069	0.616
MOD_OFUCOSY	385	392	PF10250	0.501
MOD_PIKK_1	358	364	PF00454	0.436
MOD_PIKK_1	377	383	PF00454	0.390
MOD_PKA_2	130	136	PF00069	0.723
MOD_Plk_1	442	448	PF00069	0.645
MOD_Plk_4	324	330	PF00069	0.436
MOD_Plk_4	352	358	PF00069	0.377
MOD_Plk_4	373	379	PF00069	0.436
MOD_Plk_4	49	55	PF00069	0.523
MOD_ProDKin_1	121	127	PF00069	0.746
MOD_ProDKin_1	166	172	PF00069	0.751
MOD_ProDKin_1	182	188	PF00069	0.539
MOD_ProDKin_1	210	216	PF00069	0.781
MOD_ProDKin_1	230	236	PF00069	0.700
MOD_ProDKin_1	395	401	PF00069	0.589
MOD_ProDKin_1	422	428	PF00069	0.611
MOD_ProDKin_1	66	72	PF00069	0.401
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.430
TRG_DiLeu_BaLyEn_6	361	366	PF01217	0.299
TRG_ENDOCYTIC_2	303	306	PF00928	0.404
TRG_ENDOCYTIC_2	312	315	PF00928	0.302
TRG_ENDOCYTIC_2	431	434	PF00928	0.569
TRG_ENDOCYTIC_2	62	65	PF00928	0.397
TRG_ER_diArg_1	259	262	PF00400	0.436
TRG_ER_diArg_1	394	397	PF00400	0.661
TRG_ER_diArg_1	428	430	PF00400	0.526
TRG_NLS_MonoCore_2	392	397	PF00514	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G9	Leptomonas seymouri	45%	90%
A0A3Q8ICN3	Leishmania donovani	100%	100%
A4HD16	Leishmania braziliensis	55%	97%
E9AWG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QB08	Leishmania major	82%	100%