Elongator complex protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Elongator-like Protein 3b - putative

Species:

Leishmania infantum

UniProt:

A4I0J4_LEIIN

TriTrypDb:

LINF_230022800

Length:

709

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005634	nucleus	5	2
GO:0005635	nuclear envelope	4	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	2
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	2
GO:0033588	elongator holoenzyme complex	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:0005819	spindle	5	1

Expansion

Sequence features

A4I0J4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0J4

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	2
GO:0002098	tRNA wobble uridine modification	8	2
GO:0002926	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	1
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006400	tRNA modification	6	2
GO:0006473	protein acetylation	6	1
GO:0006475	internal protein amino acid acetylation	7	1
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006996	organelle organization	4	1
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	2
GO:0016570	histone modification	5	1
GO:0016573	histone acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0018393	internal peptidyl-lysine acetylation	8	1
GO:0018394	peptidyl-lysine acetylation	7	1
GO:0019538	protein metabolic process	3	1
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0036211	protein modification process	4	1
GO:0043007	maintenance of rDNA	6	1
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	1
GO:0043570	maintenance of DNA repeat elements	5	1
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	2
GO:0051276	chromosome organization	5	1
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	23
GO:0003676	nucleic acid binding	3	23
GO:0003723	RNA binding	4	23
GO:0003824	catalytic activity	1	23
GO:0005488	binding	1	23
GO:0016407	acetyltransferase activity	5	23
GO:0016740	transferase activity	2	23
GO:0016746	acyltransferase activity	3	23
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	23
GO:0043167	ion binding	2	23
GO:0043169	cation binding	3	23
GO:0046872	metal ion binding	4	23
GO:0051536	iron-sulfur cluster binding	3	23
GO:0051539	4 iron, 4 sulfur cluster binding	4	23
GO:0051540	metal cluster binding	2	23
GO:0097159	organic cyclic compound binding	2	23
GO:0106261	tRNA uridine(34) acetyltransferase activity	6	12
GO:1901363	heterocyclic compound binding	2	23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.455
CLV_NRD_NRD_1	119	121	PF00675	0.415
CLV_NRD_NRD_1	160	162	PF00675	0.411
CLV_NRD_NRD_1	189	191	PF00675	0.412
CLV_NRD_NRD_1	343	345	PF00675	0.235
CLV_NRD_NRD_1	643	645	PF00675	0.288
CLV_NRD_NRD_1	704	706	PF00675	0.667
CLV_PCSK_KEX2_1	119	121	PF00082	0.412
CLV_PCSK_KEX2_1	13	15	PF00082	0.654
CLV_PCSK_KEX2_1	343	345	PF00082	0.235
CLV_PCSK_KEX2_1	495	497	PF00082	0.238
CLV_PCSK_KEX2_1	643	645	PF00082	0.295
CLV_PCSK_KEX2_1	704	706	PF00082	0.627
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.654
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.295
CLV_PCSK_SKI1_1	120	124	PF00082	0.421
CLV_PCSK_SKI1_1	624	628	PF00082	0.418
CLV_PCSK_SKI1_1	693	697	PF00082	0.616
DEG_APCC_DBOX_1	474	482	PF00400	0.430
DEG_APCC_DBOX_1	495	503	PF00400	0.430
DOC_MAPK_gen_1	190	201	PF00069	0.384
DOC_MAPK_gen_1	322	330	PF00069	0.391
DOC_MAPK_gen_1	340	350	PF00069	0.512
DOC_MAPK_HePTP_8	188	204	PF00069	0.370
DOC_MAPK_MEF2A_6	322	330	PF00069	0.385
DOC_PIKK_1	97	105	PF02985	0.465
DOC_PP2B_LxvP_1	25	28	PF13499	0.526
DOC_PP4_FxxP_1	205	208	PF00568	0.297
DOC_PP4_FxxP_1	211	214	PF00568	0.192
DOC_USP7_MATH_1	135	139	PF00917	0.485
DOC_USP7_MATH_1	160	164	PF00917	0.374
DOC_USP7_MATH_1	307	311	PF00917	0.452
DOC_USP7_MATH_1	400	404	PF00917	0.443
DOC_USP7_MATH_1	684	688	PF00917	0.642
DOC_WW_Pin1_4	20	25	PF00397	0.558
DOC_WW_Pin1_4	699	704	PF00397	0.449
LIG_14-3-3_CanoR_1	161	169	PF00244	0.406
LIG_14-3-3_CanoR_1	306	312	PF00244	0.455
LIG_14-3-3_CanoR_1	343	349	PF00244	0.458
LIG_14-3-3_CanoR_1	540	548	PF00244	0.259
LIG_AP2alpha_1	535	539	PF02296	0.293
LIG_BIR_II_1	1	5	PF00653	0.515
LIG_EH1_1	459	467	PF00400	0.495
LIG_eIF4E_1	460	466	PF01652	0.464
LIG_EVH1_1	25	29	PF00568	0.528
LIG_FHA_1	430	436	PF00498	0.430
LIG_FHA_1	485	491	PF00498	0.445
LIG_FHA_1	607	613	PF00498	0.349
LIG_FHA_1	632	638	PF00498	0.282
LIG_FHA_1	654	660	PF00498	0.333
LIG_FHA_2	296	302	PF00498	0.440
LIG_FHA_2	314	320	PF00498	0.427
LIG_FHA_2	330	336	PF00498	0.422
LIG_FHA_2	603	609	PF00498	0.316
LIG_LIR_Apic_2	203	208	PF02991	0.276
LIG_LIR_Apic_2	210	214	PF02991	0.429
LIG_LIR_Apic_2	92	96	PF02991	0.518
LIG_LIR_Gen_1	110	118	PF02991	0.528
LIG_LIR_Gen_1	434	445	PF02991	0.430
LIG_LIR_Gen_1	545	555	PF02991	0.298
LIG_LIR_Gen_1	683	692	PF02991	0.457
LIG_LIR_Gen_1	85	93	PF02991	0.498
LIG_LIR_LC3C_4	197	202	PF02991	0.369
LIG_LIR_Nem_3	110	115	PF02991	0.458
LIG_LIR_Nem_3	166	172	PF02991	0.382
LIG_LIR_Nem_3	276	280	PF02991	0.430
LIG_LIR_Nem_3	425	430	PF02991	0.443
LIG_LIR_Nem_3	434	440	PF02991	0.430
LIG_LIR_Nem_3	545	551	PF02991	0.282
LIG_LIR_Nem_3	557	563	PF02991	0.264
LIG_LIR_Nem_3	593	597	PF02991	0.328
LIG_LIR_Nem_3	683	688	PF02991	0.649
LIG_LIR_Nem_3	694	698	PF02991	0.640
LIG_LIR_Nem_3	85	89	PF02991	0.484
LIG_PCNA_yPIPBox_3	174	188	PF02747	0.426
LIG_PDZ_Class_3	704	709	PF00595	0.470
LIG_Pex14_2	241	245	PF04695	0.529
LIG_Pex14_2	411	415	PF04695	0.328
LIG_Pex14_2	535	539	PF04695	0.277
LIG_PTB_Apo_2	454	461	PF02174	0.544
LIG_PTB_Phospho_1	454	460	PF10480	0.544
LIG_SH2_CRK	169	173	PF00017	0.382
LIG_SH2_CRK	594	598	PF00017	0.293
LIG_SH2_CRK	646	650	PF00017	0.303
LIG_SH2_NCK_1	252	256	PF00017	0.442
LIG_SH2_NCK_1	300	304	PF00017	0.443
LIG_SH2_NCK_1	93	97	PF00017	0.444
LIG_SH2_STAP1	284	288	PF00017	0.445
LIG_SH2_STAP1	685	689	PF00017	0.458
LIG_SH2_STAT5	219	222	PF00017	0.430
LIG_SH2_STAT5	230	233	PF00017	0.430
LIG_SH2_STAT5	336	339	PF00017	0.452
LIG_SH2_STAT5	467	470	PF00017	0.424
LIG_SH2_STAT5	489	492	PF00017	0.430
LIG_SH2_STAT5	548	551	PF00017	0.262
LIG_SH3_2	304	309	PF14604	0.495
LIG_SH3_3	21	27	PF00018	0.571
LIG_SH3_3	218	224	PF00018	0.430
LIG_SH3_3	29	35	PF00018	0.532
LIG_SH3_3	301	307	PF00018	0.454
LIG_SH3_3	394	400	PF00018	0.431
LIG_SUMO_SIM_anti_2	197	203	PF11976	0.343
LIG_SUMO_SIM_anti_2	266	272	PF11976	0.430
LIG_SUMO_SIM_par_1	197	203	PF11976	0.343
LIG_SUMO_SIM_par_1	596	601	PF11976	0.277
LIG_TRAF2_1	572	575	PF00917	0.363
LIG_UBA3_1	587	596	PF00899	0.341
LIG_WRC_WIRS_1	685	690	PF05994	0.685
LIG_WRC_WIRS_1	692	697	PF05994	0.585
LIG_WRPW_2	449	452	PF00400	0.277
MOD_CDK_SPK_2	699	704	PF00069	0.442
MOD_CDK_SPxK_1	699	705	PF00069	0.444
MOD_CK1_1	126	132	PF00069	0.470
MOD_CK1_1	163	169	PF00069	0.403
MOD_CK1_1	542	548	PF00069	0.279
MOD_CK1_1	63	69	PF00069	0.758
MOD_CK1_1	667	673	PF00069	0.544
MOD_CK1_1	683	689	PF00069	0.503
MOD_CK1_1	85	91	PF00069	0.496
MOD_CK2_1	135	141	PF00069	0.540
MOD_CK2_1	253	259	PF00069	0.293
MOD_CK2_1	307	313	PF00069	0.271
MOD_CK2_1	335	341	PF00069	0.330
MOD_CK2_1	399	405	PF00069	0.307
MOD_CK2_1	569	575	PF00069	0.321
MOD_CK2_1	602	608	PF00069	0.300
MOD_CK2_1	68	74	PF00069	0.496
MOD_GlcNHglycan	138	141	PF01048	0.523
MOD_GlcNHglycan	196	199	PF01048	0.367
MOD_GlcNHglycan	20	23	PF01048	0.693
MOD_GlcNHglycan	255	258	PF01048	0.300
MOD_GlcNHglycan	301	304	PF01048	0.319
MOD_GlcNHglycan	337	340	PF01048	0.266
MOD_GlcNHglycan	415	418	PF01048	0.500
MOD_GlcNHglycan	43	46	PF01048	0.543
MOD_GlcNHglycan	54	57	PF01048	0.503
MOD_GlcNHglycan	681	685	PF01048	0.589
MOD_GSK3_1	156	163	PF00069	0.418
MOD_GSK3_1	295	302	PF00069	0.300
MOD_GSK3_1	344	351	PF00069	0.305
MOD_GSK3_1	431	438	PF00069	0.283
MOD_GSK3_1	529	536	PF00069	0.230
MOD_GSK3_1	569	576	PF00069	0.356
MOD_GSK3_1	598	605	PF00069	0.277
MOD_GSK3_1	60	67	PF00069	0.678
MOD_GSK3_1	680	687	PF00069	0.584
MOD_N-GLC_1	418	423	PF02516	0.407
MOD_NEK2_1	123	128	PF00069	0.417
MOD_NEK2_1	156	161	PF00069	0.473
MOD_NEK2_1	200	205	PF00069	0.323
MOD_NEK2_1	273	278	PF00069	0.286
MOD_NEK2_1	289	294	PF00069	0.311
MOD_NEK2_1	348	353	PF00069	0.285
MOD_NEK2_1	410	415	PF00069	0.456
MOD_NEK2_1	52	57	PF00069	0.499
MOD_NEK2_1	653	658	PF00069	0.348
MOD_NEK2_1	68	73	PF00069	0.549
MOD_NEK2_1	688	693	PF00069	0.586
MOD_NEK2_1	698	703	PF00069	0.678
MOD_NEK2_2	275	280	PF00069	0.277
MOD_PIKK_1	246	252	PF00454	0.293
MOD_PIKK_1	554	560	PF00454	0.411
MOD_PIKK_1	598	604	PF00454	0.392
MOD_PIKK_1	606	612	PF00454	0.225
MOD_PIKK_1	613	619	PF00454	0.114
MOD_PK_1	60	66	PF00069	0.539
MOD_PKA_2	160	166	PF00069	0.402
MOD_PKA_2	253	259	PF00069	0.300
MOD_PKA_2	539	545	PF00069	0.278
MOD_PKA_2	606	612	PF00069	0.451
MOD_Plk_1	313	319	PF00069	0.283
MOD_Plk_1	418	424	PF00069	0.404
MOD_Plk_1	554	560	PF00069	0.341
MOD_Plk_1	653	659	PF00069	0.356
MOD_Plk_1	680	686	PF00069	0.676
MOD_Plk_2-3	313	319	PF00069	0.312
MOD_Plk_4	200	206	PF00069	0.347
MOD_Plk_4	289	295	PF00069	0.292
MOD_Plk_4	374	380	PF00069	0.337
MOD_Plk_4	410	416	PF00069	0.437
MOD_Plk_4	485	491	PF00069	0.277
MOD_Plk_4	653	659	PF00069	0.340
MOD_Plk_4	664	670	PF00069	0.449
MOD_Plk_4	684	690	PF00069	0.601
MOD_Plk_4	691	697	PF00069	0.638
MOD_Plk_4	85	91	PF00069	0.530
MOD_ProDKin_1	20	26	PF00069	0.558
MOD_ProDKin_1	699	705	PF00069	0.451
MOD_SUMO_rev_2	92	102	PF00179	0.500
TRG_DiLeu_BaEn_4	574	580	PF01217	0.266
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.535
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.264
TRG_ENDOCYTIC_2	169	172	PF00928	0.369
TRG_ENDOCYTIC_2	452	455	PF00928	0.382
TRG_ENDOCYTIC_2	548	551	PF00928	0.255
TRG_ENDOCYTIC_2	560	563	PF00928	0.246
TRG_ENDOCYTIC_2	594	597	PF00928	0.279
TRG_ENDOCYTIC_2	646	649	PF00928	0.247
TRG_ENDOCYTIC_2	685	688	PF00928	0.642
TRG_ER_diArg_1	12	15	PF00400	0.653
TRG_ER_diArg_1	322	325	PF00400	0.279
TRG_ER_diArg_1	342	344	PF00400	0.283
TRG_ER_diArg_1	474	477	PF00400	0.251
TRG_ER_diArg_1	507	510	PF00400	0.449
TRG_ER_diArg_1	563	566	PF00400	0.277
TRG_ER_diArg_1	642	644	PF00400	0.270
TRG_ER_diArg_1	703	705	PF00400	0.614
TRG_ER_FFAT_2	331	341	PF00635	0.266
TRG_NES_CRM1_1	341	354	PF08389	0.293
TRG_NLS_MonoExtC_3	11	16	PF00514	0.485
TRG_NLS_MonoExtC_3	189	194	PF00514	0.411
TRG_NLS_MonoExtN_4	12	17	PF00514	0.491
TRG_NLS_MonoExtN_4	190	195	PF00514	0.409
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	660	664	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P567	Leptomonas seymouri	86%	100%
A0A0N1PFU7	Leptomonas seymouri	45%	95%
A0A0S4IQT9	Bodo saltans	69%	100%
A0A0S4KPU1	Bodo saltans	46%	100%
A0A1X0NG94	Trypanosomatidae	42%	96%
A0A1X0NX69	Trypanosomatidae	76%	100%
A0A3Q8ICG0	Leishmania donovani	46%	93%
A0A3R7KUY9	Trypanosoma rangeli	77%	100%
A0A3S7WXV4	Leishmania donovani	100%	100%
A0A422NDG5	Trypanosoma rangeli	42%	95%
A4H8F0	Leishmania braziliensis	45%	93%
A4HD08	Leishmania braziliensis	93%	100%
A4HWS3	Leishmania infantum	46%	93%
C9ZVC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
C9ZW50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D5VRB9	Methanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)	36%	100%
E9AQI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	92%
E9AWF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O14023	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q02908	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
Q1ZXC6	Dictyostelium discoideum	33%	100%
Q23651	Caenorhabditis elegans	34%	100%
Q2KJ61	Bos taurus	32%	100%
Q4QB17	Leishmania major	96%	100%
Q4QEZ6	Leishmania major	45%	93%
Q58536	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	36%	100%
Q5HZM6	Xenopus laevis	33%	100%
Q5RIC0	Danio rerio	33%	100%
Q5ZHS1	Gallus gallus	33%	100%
Q60LW7	Caenorhabditis briggsae	35%	100%
Q6NVL5	Xenopus tropicalis	32%	100%
Q7X7L3	Oryza sativa subsp. japonica	35%	100%
Q93ZR1	Arabidopsis thaliana	33%	100%
Q9CZX0	Mus musculus	31%	100%
Q9H9T3	Homo sapiens	32%	100%
Q9VQZ6	Drosophila melanogaster	33%	100%
V5B5L2	Trypanosoma cruzi	43%	100%
V5BNQ5	Trypanosoma cruzi	77%	100%