Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0J3_LEIIN

TriTrypDb:

LINF_230022700

Length:

843

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I0J3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0J3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.632
CLV_C14_Caspase3-7	224	228	PF00656	0.502
CLV_C14_Caspase3-7	633	637	PF00656	0.473
CLV_MEL_PAP_1	628	634	PF00089	0.429
CLV_NRD_NRD_1	140	142	PF00675	0.670
CLV_NRD_NRD_1	60	62	PF00675	0.685
CLV_NRD_NRD_1	648	650	PF00675	0.386
CLV_NRD_NRD_1	774	776	PF00675	0.509
CLV_NRD_NRD_1	79	81	PF00675	0.712
CLV_NRD_NRD_1	795	797	PF00675	0.462
CLV_PCSK_KEX2_1	140	142	PF00082	0.670
CLV_PCSK_KEX2_1	291	293	PF00082	0.694
CLV_PCSK_KEX2_1	487	489	PF00082	0.501
CLV_PCSK_KEX2_1	648	650	PF00082	0.386
CLV_PCSK_KEX2_1	774	776	PF00082	0.519
CLV_PCSK_KEX2_1	79	81	PF00082	0.722
CLV_PCSK_KEX2_1	795	797	PF00082	0.455
CLV_PCSK_KEX2_1	822	824	PF00082	0.558
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.736
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.540
CLV_PCSK_PC1ET2_1	795	797	PF00082	0.455
CLV_PCSK_PC1ET2_1	822	824	PF00082	0.558
CLV_PCSK_PC7_1	136	142	PF00082	0.675
CLV_PCSK_PC7_1	770	776	PF00082	0.510
CLV_PCSK_SKI1_1	458	462	PF00082	0.408
CLV_PCSK_SKI1_1	558	562	PF00082	0.505
CLV_PCSK_SKI1_1	583	587	PF00082	0.348
CLV_PCSK_SKI1_1	762	766	PF00082	0.388
CLV_PCSK_SKI1_1	770	774	PF00082	0.406
DEG_SCF_FBW7_1	26	33	PF00400	0.490
DEG_SCF_FBW7_2	568	573	PF00400	0.505
DEG_SPOP_SBC_1	147	151	PF00917	0.714
DOC_CKS1_1	57	62	PF01111	0.540
DOC_CYCLIN_yCln2_LP_2	702	708	PF00134	0.614
DOC_MAPK_gen_1	393	400	PF00069	0.374
DOC_MAPK_HePTP_8	585	597	PF00069	0.349
DOC_MAPK_MEF2A_6	588	597	PF00069	0.348
DOC_PP1_RVXF_1	276	283	PF00149	0.528
DOC_PP1_RVXF_1	629	635	PF00149	0.384
DOC_PP2B_LxvP_1	517	520	PF13499	0.547
DOC_PP4_FxxP_1	815	818	PF00568	0.451
DOC_USP7_MATH_1	119	123	PF00917	0.655
DOC_USP7_MATH_1	159	163	PF00917	0.710
DOC_USP7_MATH_1	30	34	PF00917	0.500
DOC_USP7_MATH_1	301	305	PF00917	0.493
DOC_USP7_MATH_1	315	319	PF00917	0.654
DOC_USP7_MATH_1	332	336	PF00917	0.658
DOC_USP7_MATH_1	345	349	PF00917	0.613
DOC_USP7_MATH_1	630	634	PF00917	0.430
DOC_USP7_UBL2_3	791	795	PF12436	0.448
DOC_WW_Pin1_4	204	209	PF00397	0.697
DOC_WW_Pin1_4	26	31	PF00397	0.487
DOC_WW_Pin1_4	33	38	PF00397	0.461
DOC_WW_Pin1_4	333	338	PF00397	0.753
DOC_WW_Pin1_4	428	433	PF00397	0.484
DOC_WW_Pin1_4	436	441	PF00397	0.402
DOC_WW_Pin1_4	511	516	PF00397	0.503
DOC_WW_Pin1_4	56	61	PF00397	0.555
DOC_WW_Pin1_4	566	571	PF00397	0.500
DOC_WW_Pin1_4	659	664	PF00397	0.520
DOC_WW_Pin1_4	68	73	PF00397	0.551
LIG_14-3-3_CanoR_1	109	117	PF00244	0.692
LIG_14-3-3_CanoR_1	126	135	PF00244	0.526
LIG_14-3-3_CanoR_1	183	189	PF00244	0.417
LIG_14-3-3_CanoR_1	260	269	PF00244	0.575
LIG_14-3-3_CanoR_1	47	55	PF00244	0.475
LIG_14-3-3_CanoR_1	631	635	PF00244	0.459
LIG_14-3-3_CanoR_1	774	782	PF00244	0.443
LIG_14-3-3_CanoR_1	829	833	PF00244	0.644
LIG_BIR_II_1	1	5	PF00653	0.494
LIG_BRCT_BRCA1_1	161	165	PF00533	0.677
LIG_BRCT_BRCA1_1	438	442	PF00533	0.417
LIG_BRCT_BRCA1_1	654	658	PF00533	0.462
LIG_CSL_BTD_1	355	358	PF09270	0.426
LIG_CSL_BTD_1	446	449	PF09270	0.371
LIG_EH1_1	786	794	PF00400	0.546
LIG_EVH1_2	269	273	PF00568	0.420
LIG_FHA_1	130	136	PF00498	0.689
LIG_FHA_1	152	158	PF00498	0.735
LIG_FHA_1	173	179	PF00498	0.497
LIG_FHA_1	185	191	PF00498	0.440
LIG_FHA_1	377	383	PF00498	0.482
LIG_FHA_1	429	435	PF00498	0.474
LIG_FHA_1	512	518	PF00498	0.483
LIG_FHA_1	567	573	PF00498	0.464
LIG_FHA_1	710	716	PF00498	0.473
LIG_FHA_1	788	794	PF00498	0.433
LIG_FHA_1	796	802	PF00498	0.439
LIG_FHA_2	132	138	PF00498	0.684
LIG_FHA_2	166	172	PF00498	0.619
LIG_FHA_2	209	215	PF00498	0.797
LIG_FHA_2	495	501	PF00498	0.500
LIG_FHA_2	557	563	PF00498	0.358
LIG_FHA_2	660	666	PF00498	0.509
LIG_FHA_2	719	725	PF00498	0.418
LIG_FHA_2	823	829	PF00498	0.597
LIG_LIR_Apic_2	33	37	PF02991	0.491
LIG_LIR_Apic_2	403	407	PF02991	0.367
LIG_LIR_Apic_2	408	413	PF02991	0.408
LIG_LIR_Apic_2	534	538	PF02991	0.460
LIG_LIR_Apic_2	814	818	PF02991	0.450
LIG_LIR_Gen_1	184	191	PF02991	0.444
LIG_LIR_Gen_1	295	303	PF02991	0.634
LIG_LIR_Gen_1	352	362	PF02991	0.406
LIG_LIR_Gen_1	396	404	PF02991	0.359
LIG_LIR_Gen_1	609	617	PF02991	0.480
LIG_LIR_LC3C_4	790	794	PF02991	0.553
LIG_LIR_Nem_3	295	300	PF02991	0.636
LIG_LIR_Nem_3	352	357	PF02991	0.416
LIG_LIR_Nem_3	396	400	PF02991	0.356
LIG_LIR_Nem_3	580	585	PF02991	0.346
LIG_LIR_Nem_3	771	776	PF02991	0.431
LIG_MYND_1	8	12	PF01753	0.444
LIG_NRBOX	165	171	PF00104	0.475
LIG_NRP_CendR_1	840	843	PF00754	0.642
LIG_PALB2_WD40_1	268	276	PF16756	0.422
LIG_PCNA_PIPBox_1	243	252	PF02747	0.605
LIG_Pex14_2	406	410	PF04695	0.505
LIG_Pex14_2	582	586	PF04695	0.488
LIG_Pex14_2	611	615	PF04695	0.431
LIG_Pex14_2	650	654	PF04695	0.396
LIG_PTAP_UEV_1	749	754	PF05743	0.403
LIG_PTB_Apo_2	714	721	PF02174	0.429
LIG_PTB_Phospho_1	714	720	PF10480	0.429
LIG_SH2_NCK_1	34	38	PF00017	0.486
LIG_SH2_NCK_1	535	539	PF00017	0.460
LIG_SH2_PTP2	354	357	PF00017	0.504
LIG_SH2_SRC	197	200	PF00017	0.594
LIG_SH2_SRC	516	519	PF00017	0.546
LIG_SH2_SRC	535	538	PF00017	0.278
LIG_SH2_STAP1	813	817	PF00017	0.452
LIG_SH2_STAT3	524	527	PF00017	0.528
LIG_SH2_STAT3	672	675	PF00017	0.372
LIG_SH2_STAT3	720	723	PF00017	0.489
LIG_SH2_STAT5	235	238	PF00017	0.502
LIG_SH2_STAT5	281	284	PF00017	0.568
LIG_SH2_STAT5	354	357	PF00017	0.405
LIG_SH2_STAT5	380	383	PF00017	0.469
LIG_SH2_STAT5	397	400	PF00017	0.259
LIG_SH2_STAT5	404	407	PF00017	0.367
LIG_SH2_STAT5	43	46	PF00017	0.490
LIG_SH2_STAT5	516	519	PF00017	0.511
LIG_SH2_STAT5	672	675	PF00017	0.395
LIG_SH2_STAT5	720	723	PF00017	0.428
LIG_SH2_STAT5	732	735	PF00017	0.383
LIG_SH3_1	34	40	PF00018	0.484
LIG_SH3_1	602	608	PF00018	0.418
LIG_SH3_2	8	13	PF14604	0.467
LIG_SH3_3	113	119	PF00018	0.615
LIG_SH3_3	193	199	PF00018	0.536
LIG_SH3_3	2	8	PF00018	0.482
LIG_SH3_3	263	269	PF00018	0.466
LIG_SH3_3	326	332	PF00018	0.746
LIG_SH3_3	34	40	PF00018	0.484
LIG_SH3_3	352	358	PF00018	0.510
LIG_SH3_3	424	430	PF00018	0.504
LIG_SH3_3	437	443	PF00018	0.393
LIG_SH3_3	446	452	PF00018	0.463
LIG_SH3_3	54	60	PF00018	0.434
LIG_SH3_3	598	604	PF00018	0.394
LIG_SH3_3	629	635	PF00018	0.384
LIG_SH3_3	747	753	PF00018	0.407
LIG_SH3_3	9	15	PF00018	0.441
LIG_SUMO_SIM_par_1	173	181	PF11976	0.585
LIG_SUMO_SIM_par_1	360	366	PF11976	0.492
LIG_TRAF2_1	497	500	PF00917	0.602
LIG_TRAF2_1	721	724	PF00917	0.479
LIG_TRFH_1	545	549	PF08558	0.478
LIG_UBA3_1	581	588	PF00899	0.489
LIG_WRC_WIRS_1	461	466	PF05994	0.497
LIG_WW_3	10	14	PF00397	0.452
MOD_CDK_SPK_2	204	209	PF00069	0.670
MOD_CDK_SPK_2	56	61	PF00069	0.517
MOD_CDK_SPxK_1	56	62	PF00069	0.557
MOD_CDK_SPxK_1	68	74	PF00069	0.551
MOD_CK1_1	122	128	PF00069	0.642
MOD_CK1_1	164	170	PF00069	0.550
MOD_CK1_1	318	324	PF00069	0.778
MOD_CK1_1	33	39	PF00069	0.486
MOD_CK1_1	415	421	PF00069	0.437
MOD_CK1_1	428	434	PF00069	0.422
MOD_CK1_1	6	12	PF00069	0.467
MOD_CK1_1	97	103	PF00069	0.670
MOD_CK2_1	131	137	PF00069	0.693
MOD_CK2_1	165	171	PF00069	0.584
MOD_CK2_1	494	500	PF00069	0.537
MOD_CK2_1	718	724	PF00069	0.424
MOD_CK2_1	89	95	PF00069	0.573
MOD_GlcNHglycan	101	104	PF01048	0.676
MOD_GlcNHglycan	110	113	PF01048	0.576
MOD_GlcNHglycan	127	130	PF01048	0.735
MOD_GlcNHglycan	161	164	PF01048	0.619
MOD_GlcNHglycan	222	227	PF01048	0.739
MOD_GlcNHglycan	285	288	PF01048	0.582
MOD_GlcNHglycan	317	320	PF01048	0.702
MOD_GlcNHglycan	597	600	PF01048	0.427
MOD_GSK3_1	108	115	PF00069	0.473
MOD_GSK3_1	121	128	PF00069	0.725
MOD_GSK3_1	131	138	PF00069	0.631
MOD_GSK3_1	146	153	PF00069	0.503
MOD_GSK3_1	161	168	PF00069	0.630
MOD_GSK3_1	174	181	PF00069	0.565
MOD_GSK3_1	204	211	PF00069	0.704
MOD_GSK3_1	26	33	PF00069	0.490
MOD_GSK3_1	333	340	PF00069	0.757
MOD_GSK3_1	411	418	PF00069	0.417
MOD_GSK3_1	43	50	PF00069	0.423
MOD_GSK3_1	552	559	PF00069	0.403
MOD_GSK3_1	591	598	PF00069	0.471
MOD_GSK3_1	653	660	PF00069	0.440
MOD_GSK3_1	818	825	PF00069	0.549
MOD_GSK3_1	89	96	PF00069	0.629
MOD_GSK3_1	97	104	PF00069	0.594
MOD_LATS_1	556	562	PF00433	0.493
MOD_N-GLC_2	639	641	PF02516	0.526
MOD_NEK2_1	135	140	PF00069	0.580
MOD_NEK2_1	165	170	PF00069	0.461
MOD_NEK2_1	178	183	PF00069	0.591
MOD_NEK2_1	400	405	PF00069	0.409
MOD_NEK2_1	552	557	PF00069	0.468
MOD_NEK2_1	66	71	PF00069	0.549
MOD_NEK2_1	93	98	PF00069	0.638
MOD_NEK2_1	99	104	PF00069	0.622
MOD_NEK2_2	666	671	PF00069	0.460
MOD_PIKK_1	337	343	PF00454	0.652
MOD_PIKK_1	415	421	PF00454	0.527
MOD_PIKK_1	47	53	PF00454	0.473
MOD_PIKK_1	495	501	PF00454	0.599
MOD_PIKK_1	615	621	PF00454	0.471
MOD_PKA_1	795	801	PF00069	0.441
MOD_PKA_1	822	828	PF00069	0.594
MOD_PKA_2	108	114	PF00069	0.690
MOD_PKA_2	119	125	PF00069	0.729
MOD_PKA_2	135	141	PF00069	0.554
MOD_PKA_2	208	214	PF00069	0.631
MOD_PKA_2	630	636	PF00069	0.436
MOD_PKA_2	795	801	PF00069	0.441
MOD_PKA_2	822	828	PF00069	0.594
MOD_Plk_1	172	178	PF00069	0.565
MOD_Plk_1	345	351	PF00069	0.705
MOD_Plk_1	94	100	PF00069	0.588
MOD_Plk_2-3	828	834	PF00069	0.538
MOD_Plk_4	112	118	PF00069	0.646
MOD_Plk_4	161	167	PF00069	0.540
MOD_Plk_4	577	583	PF00069	0.366
MOD_Plk_4	666	672	PF00069	0.462
MOD_Plk_4	89	95	PF00069	0.573
MOD_ProDKin_1	204	210	PF00069	0.706
MOD_ProDKin_1	26	32	PF00069	0.489
MOD_ProDKin_1	33	39	PF00069	0.459
MOD_ProDKin_1	333	339	PF00069	0.753
MOD_ProDKin_1	428	434	PF00069	0.476
MOD_ProDKin_1	436	442	PF00069	0.399
MOD_ProDKin_1	511	517	PF00069	0.509
MOD_ProDKin_1	56	62	PF00069	0.557
MOD_ProDKin_1	566	572	PF00069	0.490
MOD_ProDKin_1	659	665	PF00069	0.516
MOD_ProDKin_1	68	74	PF00069	0.551
MOD_SUMO_rev_2	594	604	PF00179	0.397
TRG_DiLeu_BaEn_2	608	614	PF01217	0.458
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.493
TRG_DiLeu_BaLyEn_6	537	542	PF01217	0.464
TRG_DiLeu_BaLyEn_6	804	809	PF01217	0.472
TRG_DiLeu_BaLyEn_6	837	842	PF01217	0.609
TRG_ENDOCYTIC_2	185	188	PF00928	0.429
TRG_ENDOCYTIC_2	354	357	PF00928	0.425
TRG_ENDOCYTIC_2	397	400	PF00928	0.355
TRG_ENDOCYTIC_2	671	674	PF00928	0.496
TRG_ER_diArg_1	139	141	PF00400	0.666
TRG_ER_diArg_1	22	25	PF00400	0.479
TRG_ER_diArg_1	648	650	PF00400	0.390
TRG_ER_diArg_1	689	692	PF00400	0.429
TRG_ER_diArg_1	773	775	PF00400	0.516
TRG_NES_CRM1_1	592	607	PF08389	0.529
TRG_NLS_MonoExtC_3	794	799	PF00514	0.462
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	422	426	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	799	803	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	807	811	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBN6	Leptomonas seymouri	76%	100%
A0A0S4ISW7	Bodo saltans	48%	100%
A0A1X0NY35	Trypanosomatidae	59%	100%
A0A3Q8IBV8	Leishmania donovani	99%	100%
A0A3R7MZ34	Trypanosoma rangeli	59%	100%
A4HD07	Leishmania braziliensis	86%	100%
C9ZVC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AWF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
Q4QB18	Leishmania major	96%	100%