Lathosterol oxidase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

lathosterol oxidase-like protein

Species:

Leishmania infantum

UniProt:

A4I0I8_LEIIN

TriTrypDb:

LINF_230022300

Length:

302

Annotations

Annotations by Jardim et al.

Sterol metabolism/biosynthesis, Lathosterol oxidase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	9
GO:0031090	organelle membrane	3	1
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4I0I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0I8

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0009058	biosynthetic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0006694	steroid biosynthetic process	5	1
GO:0008202	steroid metabolic process	4	1
GO:0016125	sterol metabolic process	4	1
GO:0016126	sterol biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901617	organic hydroxy compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005506	iron ion binding	6	11
GO:0016491	oxidoreductase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0000248	C-5 sterol desaturase activity	5	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	3
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	3
GO:0070704	sterol desaturase activity	4	3
GO:0050046	delta7-sterol 5(6)-desaturase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	295	297	PF00675	0.610
CLV_NRD_NRD_1	50	52	PF00675	0.361
CLV_PCSK_KEX2_1	295	297	PF00082	0.642
CLV_PCSK_KEX2_1	54	56	PF00082	0.340
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.336
CLV_PCSK_SKI1_1	281	285	PF00082	0.667
CLV_PCSK_SKI1_1	51	55	PF00082	0.358
CLV_PCSK_SKI1_1	6	10	PF00082	0.516
DEG_Nend_UBRbox_2	1	3	PF02207	0.313
DOC_CKS1_1	158	163	PF01111	0.445
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.403
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.520
DOC_MAPK_gen_1	16	25	PF00069	0.310
DOC_MAPK_MEF2A_6	75	82	PF00069	0.520
DOC_PP2B_LxvP_1	91	94	PF13499	0.331
DOC_USP7_MATH_1	161	165	PF00917	0.444
DOC_USP7_MATH_1	294	298	PF00917	0.384
DOC_USP7_MATH_1	81	85	PF00917	0.294
DOC_USP7_UBL2_3	147	151	PF12436	0.520
DOC_WW_Pin1_4	118	123	PF00397	0.400
DOC_WW_Pin1_4	157	162	PF00397	0.444
LIG_14-3-3_CanoR_1	6	12	PF00244	0.362
LIG_BRCT_BRCA1_1	163	167	PF00533	0.437
LIG_BRCT_BRCA1_1	83	87	PF00533	0.294
LIG_deltaCOP1_diTrp_1	112	118	PF00928	0.266
LIG_eIF4E_1	180	186	PF01652	0.308
LIG_FHA_1	202	208	PF00498	0.274
LIG_FHA_1	253	259	PF00498	0.307
LIG_FHA_1	7	13	PF00498	0.338
LIG_FHA_2	238	244	PF00498	0.231
LIG_LIR_Apic_2	155	161	PF02991	0.431
LIG_LIR_Apic_2	266	272	PF02991	0.391
LIG_LIR_Gen_1	112	123	PF02991	0.316
LIG_LIR_Gen_1	239	249	PF02991	0.233
LIG_LIR_Gen_1	36	46	PF02991	0.324
LIG_LIR_Gen_1	77	87	PF02991	0.281
LIG_LIR_Nem_3	104	110	PF02991	0.154
LIG_LIR_Nem_3	112	118	PF02991	0.231
LIG_LIR_Nem_3	129	134	PF02991	0.274
LIG_LIR_Nem_3	164	170	PF02991	0.495
LIG_LIR_Nem_3	2	8	PF02991	0.313
LIG_LIR_Nem_3	234	238	PF02991	0.236
LIG_LIR_Nem_3	239	245	PF02991	0.229
LIG_LIR_Nem_3	271	277	PF02991	0.384
LIG_LIR_Nem_3	36	41	PF02991	0.328
LIG_LIR_Nem_3	43	49	PF02991	0.299
LIG_LIR_Nem_3	77	82	PF02991	0.289
LIG_LIR_Nem_3	84	90	PF02991	0.276
LIG_NRBOX	257	263	PF00104	0.401
LIG_PDZ_Class_2	297	302	PF00595	0.427
LIG_Pex14_2	182	186	PF04695	0.282
LIG_Pex14_2	193	197	PF04695	0.315
LIG_Pex14_2	213	217	PF04695	0.122
LIG_PTB_Apo_2	187	194	PF02174	0.331
LIG_PTB_Apo_2	229	236	PF02174	0.286
LIG_PTB_Phospho_1	229	235	PF10480	0.286
LIG_SH2_CRK	103	107	PF00017	0.291
LIG_SH2_CRK	158	162	PF00017	0.491
LIG_SH2_GRB2like	107	110	PF00017	0.262
LIG_SH2_NCK_1	158	162	PF00017	0.462
LIG_SH2_PTP2	180	183	PF00017	0.339
LIG_SH2_PTP2	269	272	PF00017	0.368
LIG_SH2_SRC	269	272	PF00017	0.368
LIG_SH2_STAP1	103	107	PF00017	0.262
LIG_SH2_STAP1	238	242	PF00017	0.320
LIG_SH2_STAT5	117	120	PF00017	0.270
LIG_SH2_STAT5	134	137	PF00017	0.299
LIG_SH2_STAT5	158	161	PF00017	0.486
LIG_SH2_STAT5	180	183	PF00017	0.285
LIG_SH2_STAT5	184	187	PF00017	0.279
LIG_SH2_STAT5	238	241	PF00017	0.231
LIG_SH2_STAT5	269	272	PF00017	0.368
LIG_SH2_STAT5	38	41	PF00017	0.290
LIG_SH2_STAT5	46	49	PF00017	0.280
LIG_SUMO_SIM_par_1	203	209	PF11976	0.277
LIG_TYR_ITIM	144	149	PF00017	0.471
MOD_CK1_1	45	51	PF00069	0.341
MOD_CK2_1	273	279	PF00069	0.341
MOD_GlcNHglycan	31	34	PF01048	0.372
MOD_GSK3_1	152	159	PF00069	0.444
MOD_GSK3_1	218	225	PF00069	0.231
MOD_GSK3_1	252	259	PF00069	0.324
MOD_GSK3_1	29	36	PF00069	0.402
MOD_N-GLC_1	108	113	PF02516	0.535
MOD_N-GLC_1	218	223	PF02516	0.431
MOD_NEK2_1	152	157	PF00069	0.431
MOD_NEK2_1	217	222	PF00069	0.245
MOD_NEK2_1	245	250	PF00069	0.384
MOD_NEK2_1	28	33	PF00069	0.294
MOD_NEK2_1	40	45	PF00069	0.268
MOD_NEK2_1	7	12	PF00069	0.393
MOD_NEK2_2	203	208	PF00069	0.274
MOD_NEK2_2	222	227	PF00069	0.231
MOD_NEK2_2	33	38	PF00069	0.328
MOD_PKA_2	294	300	PF00069	0.404
MOD_Plk_4	237	243	PF00069	0.285
MOD_Plk_4	257	263	PF00069	0.203
MOD_Plk_4	7	13	PF00069	0.379
MOD_ProDKin_1	118	124	PF00069	0.400
MOD_ProDKin_1	157	163	PF00069	0.444
MOD_SUMO_for_1	288	291	PF00179	0.422
MOD_SUMO_rev_2	260	270	PF00179	0.373
MOD_SUMO_rev_2	275	283	PF00179	0.418
TRG_DiLeu_BaEn_2	278	284	PF01217	0.426
TRG_DiLeu_BaEn_4	279	285	PF01217	0.373
TRG_ENDOCYTIC_2	103	106	PF00928	0.267
TRG_ENDOCYTIC_2	107	110	PF00928	0.265
TRG_ENDOCYTIC_2	117	120	PF00928	0.274
TRG_ENDOCYTIC_2	146	149	PF00928	0.434
TRG_ENDOCYTIC_2	179	182	PF00928	0.433
TRG_ENDOCYTIC_2	238	241	PF00928	0.231
TRG_ENDOCYTIC_2	38	41	PF00928	0.298
TRG_ER_diLys_1	298	302	PF00400	0.429
TRG_NLS_MonoExtC_3	50	55	PF00514	0.518
TRG_Pf-PMV_PEXEL_1	51	56	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0E0SNE8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	37%	93%
A0A0N1HQY0	Leptomonas seymouri	84%	100%
A0A0S4IWX4	Bodo saltans	54%	100%
A0A1X0NWS0	Trypanosomatidae	64%	100%
A0A3R7MRY7	Trypanosoma rangeli	65%	100%
A0A3S7WXZ2	Leishmania donovani	99%	100%
A4HD03	Leishmania braziliensis	88%	100%
C9ZVB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AWF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
I1RFM2	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	39%	87%
O13666	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	92%
O75845	Homo sapiens	38%	100%
O88822	Mus musculus	38%	100%
O93875	Candida albicans	36%	78%
O94457	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
P32353	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	83%
P50860	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	39%	83%
Q39208	Arabidopsis thaliana	28%	100%
Q4QB22	Leishmania major	97%	100%
Q4WB51	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	37%	94%
Q4WDL3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	41%	86%
Q4WIX5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	43%	90%
Q59VG6	Candida albicans (strain SC5314 / ATCC MYA-2876)	36%	78%
Q754B9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	41%	86%
Q7SBB6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	43%	88%
Q8J207	Leptosphaeria maculans	43%	85%
Q8NJ57	Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)	40%	78%
Q9EQS5	Rattus norvegicus	40%	100%
Q9M883	Arabidopsis thaliana	28%	100%
Q9ZT29	Nicotiana tabacum	31%	100%