Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0I7_LEIIN

TriTrypDb:

LINF_230022200

Length:

689

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4I0I7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0I7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.769
CLV_C14_Caspase3-7	296	300	PF00656	0.841
CLV_C14_Caspase3-7	361	365	PF00656	0.691
CLV_C14_Caspase3-7	551	555	PF00656	0.775
CLV_NRD_NRD_1	130	132	PF00675	0.642
CLV_NRD_NRD_1	20	22	PF00675	0.616
CLV_NRD_NRD_1	31	33	PF00675	0.557
CLV_NRD_NRD_1	322	324	PF00675	0.581
CLV_NRD_NRD_1	346	348	PF00675	0.640
CLV_NRD_NRD_1	48	50	PF00675	0.618
CLV_NRD_NRD_1	599	601	PF00675	0.559
CLV_NRD_NRD_1	655	657	PF00675	0.503
CLV_PCSK_FUR_1	320	324	PF00082	0.511
CLV_PCSK_FUR_1	653	657	PF00082	0.511
CLV_PCSK_KEX2_1	132	134	PF00082	0.666
CLV_PCSK_KEX2_1	20	22	PF00082	0.616
CLV_PCSK_KEX2_1	31	33	PF00082	0.557
CLV_PCSK_KEX2_1	322	324	PF00082	0.581
CLV_PCSK_KEX2_1	346	348	PF00082	0.640
CLV_PCSK_KEX2_1	48	50	PF00082	0.673
CLV_PCSK_KEX2_1	599	601	PF00082	0.559
CLV_PCSK_KEX2_1	655	657	PF00082	0.503
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.612
CLV_PCSK_SKI1_1	211	215	PF00082	0.501
CLV_PCSK_SKI1_1	341	345	PF00082	0.576
CLV_PCSK_SKI1_1	411	415	PF00082	0.575
CLV_PCSK_SKI1_1	447	451	PF00082	0.534
CLV_PCSK_SKI1_1	48	52	PF00082	0.639
CLV_PCSK_SKI1_1	537	541	PF00082	0.630
CLV_PCSK_SKI1_1	599	603	PF00082	0.610
CLV_PCSK_SKI1_1	629	633	PF00082	0.485
CLV_PCSK_SKI1_1	74	78	PF00082	0.431
DEG_SCF_FBW7_2	238	243	PF00400	0.786
DEG_SPOP_SBC_1	384	388	PF00917	0.776
DEG_SPOP_SBC_1	404	408	PF00917	0.854
DEG_SPOP_SBC_1	438	442	PF00917	0.697
DOC_CKS1_1	101	106	PF01111	0.832
DOC_CKS1_1	270	275	PF01111	0.764
DOC_MAPK_gen_1	653	663	PF00069	0.690
DOC_MAPK_JIP1_4	229	235	PF00069	0.796
DOC_MAPK_MEF2A_6	655	663	PF00069	0.733
DOC_PP1_RVXF_1	344	351	PF00149	0.838
DOC_PP1_RVXF_1	566	573	PF00149	0.657
DOC_PP2B_LxvP_1	38	41	PF13499	0.794
DOC_PP4_FxxP_1	339	342	PF00568	0.776
DOC_USP7_MATH_1	106	110	PF00917	0.813
DOC_USP7_MATH_1	166	170	PF00917	0.726
DOC_USP7_MATH_1	203	207	PF00917	0.833
DOC_USP7_MATH_1	253	257	PF00917	0.760
DOC_USP7_MATH_1	318	322	PF00917	0.820
DOC_USP7_MATH_1	327	331	PF00917	0.701
DOC_USP7_MATH_1	384	388	PF00917	0.791
DOC_USP7_MATH_1	404	408	PF00917	0.854
DOC_USP7_MATH_1	438	442	PF00917	0.727
DOC_USP7_MATH_1	453	457	PF00917	0.718
DOC_USP7_MATH_1	484	488	PF00917	0.768
DOC_USP7_MATH_1	552	556	PF00917	0.836
DOC_USP7_MATH_1	63	67	PF00917	0.820
DOC_USP7_MATH_1	675	679	PF00917	0.384
DOC_USP7_UBL2_3	537	541	PF12436	0.830
DOC_WW_Pin1_4	100	105	PF00397	0.760
DOC_WW_Pin1_4	186	191	PF00397	0.818
DOC_WW_Pin1_4	195	200	PF00397	0.762
DOC_WW_Pin1_4	236	241	PF00397	0.834
DOC_WW_Pin1_4	269	274	PF00397	0.810
DOC_WW_Pin1_4	281	286	PF00397	0.717
DOC_WW_Pin1_4	31	36	PF00397	0.840
DOC_WW_Pin1_4	417	422	PF00397	0.725
DOC_WW_Pin1_4	447	452	PF00397	0.713
DOC_WW_Pin1_4	472	477	PF00397	0.786
DOC_WW_Pin1_4	480	485	PF00397	0.733
DOC_WW_Pin1_4	50	55	PF00397	0.849
DOC_WW_Pin1_4	584	589	PF00397	0.710
DOC_WW_Pin1_4	637	642	PF00397	0.820
DOC_WW_Pin1_4	8	13	PF00397	0.774
LIG_14-3-3_CanoR_1	20	30	PF00244	0.810
LIG_14-3-3_CanoR_1	232	236	PF00244	0.796
LIG_14-3-3_CanoR_1	31	35	PF00244	0.758
LIG_14-3-3_CanoR_1	437	445	PF00244	0.732
LIG_14-3-3_CanoR_1	48	54	PF00244	0.809
LIG_14-3-3_CanoR_1	490	497	PF00244	0.765
LIG_14-3-3_CanoR_1	599	605	PF00244	0.810
LIG_BRCT_BRCA1_1	677	681	PF00533	0.339
LIG_deltaCOP1_diTrp_1	567	572	PF00928	0.756
LIG_DLG_GKlike_1	297	304	PF00625	0.685
LIG_eIF4E_1	604	610	PF01652	0.729
LIG_FHA_1	187	193	PF00498	0.814
LIG_FHA_1	199	205	PF00498	0.729
LIG_FHA_1	269	275	PF00498	0.736
LIG_FHA_1	307	313	PF00498	0.843
LIG_FHA_1	365	371	PF00498	0.832
LIG_FHA_1	384	390	PF00498	0.832
LIG_FHA_1	489	495	PF00498	0.808
LIG_FHA_1	59	65	PF00498	0.775
LIG_FHA_1	592	598	PF00498	0.787
LIG_FHA_1	600	606	PF00498	0.736
LIG_FHA_1	96	102	PF00498	0.708
LIG_FHA_2	218	224	PF00498	0.769
LIG_GBD_Chelix_1	362	370	PF00786	0.491
LIG_LIR_Apic_2	337	342	PF02991	0.776
LIG_LIR_Gen_1	299	307	PF02991	0.686
LIG_LIR_Gen_1	678	688	PF02991	0.394
LIG_LIR_Gen_1	79	90	PF02991	0.696
LIG_LIR_Nem_3	142	148	PF02991	0.811
LIG_LIR_Nem_3	299	304	PF02991	0.683
LIG_LIR_Nem_3	678	684	PF02991	0.431
LIG_LIR_Nem_3	79	85	PF02991	0.766
LIG_MLH1_MIPbox_1	677	681	PF16413	0.316
LIG_PCNA_PIPBox_1	673	682	PF02747	0.413
LIG_SH2_CRK	301	305	PF00017	0.683
LIG_SH2_SRC	529	532	PF00017	0.843
LIG_SH2_STAT5	604	607	PF00017	0.811
LIG_SH3_2	315	320	PF14604	0.734
LIG_SH3_2	40	45	PF14604	0.835
LIG_SH3_3	117	123	PF00018	0.780
LIG_SH3_3	177	183	PF00018	0.746
LIG_SH3_3	267	273	PF00018	0.790
LIG_SH3_3	309	315	PF00018	0.846
LIG_SH3_3	37	43	PF00018	0.732
LIG_SH3_3	378	384	PF00018	0.707
LIG_SH3_3	387	393	PF00018	0.727
LIG_SH3_3	528	534	PF00018	0.841
LIG_SH3_3	638	644	PF00018	0.768
LIG_SH3_4	537	544	PF00018	0.830
LIG_SUMO_SIM_anti_2	271	278	PF11976	0.713
LIG_SUMO_SIM_par_1	189	194	PF11976	0.812
LIG_SUMO_SIM_par_1	200	206	PF11976	0.739
LIG_SUMO_SIM_par_1	3	11	PF11976	0.697
LIG_SUMO_SIM_par_1	308	314	PF11976	0.794
LIG_SUMO_SIM_par_1	59	66	PF11976	0.705
LIG_SUMO_SIM_par_1	672	678	PF11976	0.433
LIG_TRAF2_1	619	622	PF00917	0.758
LIG_UBA3_1	460	468	PF00899	0.702
LIG_UBA3_1	659	667	PF00899	0.580
LIG_WRC_WIRS_1	676	681	PF05994	0.457
MOD_CDC14_SPxK_1	640	643	PF00782	0.674
MOD_CDK_SPK_2	31	36	PF00069	0.707
MOD_CDK_SPxK_1	637	643	PF00069	0.677
MOD_CDK_SPxxK_3	100	107	PF00069	0.833
MOD_CK1_1	14	20	PF00069	0.831
MOD_CK1_1	141	147	PF00069	0.784
MOD_CK1_1	175	181	PF00069	0.798
MOD_CK1_1	198	204	PF00069	0.762
MOD_CK1_1	217	223	PF00069	0.628
MOD_CK1_1	256	262	PF00069	0.757
MOD_CK1_1	286	292	PF00069	0.798
MOD_CK1_1	293	299	PF00069	0.786
MOD_CK1_1	300	306	PF00069	0.697
MOD_CK1_1	308	314	PF00069	0.673
MOD_CK1_1	326	332	PF00069	0.686
MOD_CK1_1	385	391	PF00069	0.802
MOD_CK1_1	403	409	PF00069	0.844
MOD_CK1_1	412	418	PF00069	0.763
MOD_CK1_1	441	447	PF00069	0.724
MOD_CK1_1	456	462	PF00069	0.734
MOD_CK1_1	483	489	PF00069	0.847
MOD_CK1_1	501	507	PF00069	0.620
MOD_CK1_1	515	521	PF00069	0.834
MOD_CK1_1	53	59	PF00069	0.713
MOD_CK1_1	544	550	PF00069	0.812
MOD_CK1_1	574	580	PF00069	0.696
MOD_CK1_1	592	598	PF00069	0.708
MOD_CK1_1	624	630	PF00069	0.738
MOD_CK1_1	646	652	PF00069	0.788
MOD_CK1_1	7	13	PF00069	0.802
MOD_CK2_1	318	324	PF00069	0.808
MOD_CK2_1	7	13	PF00069	0.747
MOD_CMANNOS	569	572	PF00535	0.611
MOD_Cter_Amidation	597	600	PF01082	0.491
MOD_Cter_Amidation	653	656	PF01082	0.517
MOD_DYRK1A_RPxSP_1	447	451	PF00069	0.769
MOD_GlcNHglycan	133	136	PF01048	0.535
MOD_GlcNHglycan	16	19	PF01048	0.531
MOD_GlcNHglycan	164	167	PF01048	0.613
MOD_GlcNHglycan	177	180	PF01048	0.520
MOD_GlcNHglycan	205	208	PF01048	0.633
MOD_GlcNHglycan	217	220	PF01048	0.511
MOD_GlcNHglycan	247	250	PF01048	0.594
MOD_GlcNHglycan	285	288	PF01048	0.560
MOD_GlcNHglycan	292	295	PF01048	0.523
MOD_GlcNHglycan	324	328	PF01048	0.534
MOD_GlcNHglycan	336	339	PF01048	0.496
MOD_GlcNHglycan	402	405	PF01048	0.607
MOD_GlcNHglycan	411	414	PF01048	0.488
MOD_GlcNHglycan	446	450	PF01048	0.594
MOD_GlcNHglycan	455	458	PF01048	0.592
MOD_GlcNHglycan	500	503	PF01048	0.539
MOD_GlcNHglycan	508	511	PF01048	0.512
MOD_GlcNHglycan	520	523	PF01048	0.628
MOD_GlcNHglycan	550	553	PF01048	0.563
MOD_GlcNHglycan	621	626	PF01048	0.630
MOD_GlcNHglycan	65	68	PF01048	0.544
MOD_GSK3_1	108	115	PF00069	0.802
MOD_GSK3_1	137	144	PF00069	0.717
MOD_GSK3_1	162	169	PF00069	0.716
MOD_GSK3_1	182	189	PF00069	0.836
MOD_GSK3_1	194	201	PF00069	0.712
MOD_GSK3_1	209	216	PF00069	0.693
MOD_GSK3_1	217	224	PF00069	0.764
MOD_GSK3_1	22	29	PF00069	0.832
MOD_GSK3_1	251	258	PF00069	0.757
MOD_GSK3_1	268	275	PF00069	0.702
MOD_GSK3_1	286	293	PF00069	0.734
MOD_GSK3_1	302	309	PF00069	0.671
MOD_GSK3_1	318	325	PF00069	0.674
MOD_GSK3_1	327	334	PF00069	0.740
MOD_GSK3_1	366	373	PF00069	0.826
MOD_GSK3_1	4	11	PF00069	0.826
MOD_GSK3_1	400	407	PF00069	0.758
MOD_GSK3_1	433	440	PF00069	0.738
MOD_GSK3_1	441	448	PF00069	0.722
MOD_GSK3_1	452	459	PF00069	0.723
MOD_GSK3_1	480	487	PF00069	0.789
MOD_GSK3_1	49	56	PF00069	0.757
MOD_GSK3_1	504	511	PF00069	0.757
MOD_GSK3_1	512	519	PF00069	0.817
MOD_GSK3_1	544	551	PF00069	0.732
MOD_GSK3_1	552	559	PF00069	0.701
MOD_GSK3_1	580	587	PF00069	0.677
MOD_GSK3_1	639	646	PF00069	0.801
MOD_GSK3_1	96	103	PF00069	0.844
MOD_N-GLC_1	175	180	PF02516	0.577
MOD_N-GLC_1	186	191	PF02516	0.545
MOD_N-GLC_1	209	214	PF02516	0.592
MOD_N-GLC_1	251	256	PF02516	0.581
MOD_N-GLC_1	404	409	PF02516	0.654
MOD_N-GLC_1	574	579	PF02516	0.457
MOD_NEK2_1	112	117	PF00069	0.808
MOD_NEK2_1	233	238	PF00069	0.752
MOD_NEK2_1	251	256	PF00069	0.629
MOD_NEK2_1	366	371	PF00069	0.760
MOD_NEK2_1	445	450	PF00069	0.774
MOD_NEK2_1	503	508	PF00069	0.708
MOD_NEK2_1	96	101	PF00069	0.841
MOD_NEK2_2	209	214	PF00069	0.698
MOD_NEK2_2	4	9	PF00069	0.780
MOD_NEK2_2	675	680	PF00069	0.339
MOD_PIKK_1	112	118	PF00454	0.810
MOD_PIKK_1	251	257	PF00454	0.782
MOD_PIKK_1	89	95	PF00454	0.755
MOD_PK_1	643	649	PF00069	0.751
MOD_PKA_1	131	137	PF00069	0.752
MOD_PKA_1	322	328	PF00069	0.776
MOD_PKA_1	48	54	PF00069	0.809
MOD_PKA_1	599	605	PF00069	0.754
MOD_PKA_2	106	112	PF00069	0.831
MOD_PKA_2	126	132	PF00069	0.769
MOD_PKA_2	231	237	PF00069	0.796
MOD_PKA_2	30	36	PF00069	0.849
MOD_PKA_2	322	328	PF00069	0.821
MOD_PKA_2	370	376	PF00069	0.839
MOD_PKA_2	48	54	PF00069	0.809
MOD_PKA_2	489	495	PF00069	0.796
MOD_PKA_2	544	550	PF00069	0.832
MOD_PKA_2	599	605	PF00069	0.754
MOD_PKB_1	295	303	PF00069	0.757
MOD_PKB_1	320	328	PF00069	0.736
MOD_Plk_1	107	113	PF00069	0.855
MOD_Plk_1	141	147	PF00069	0.757
MOD_Plk_1	209	215	PF00069	0.732
MOD_Plk_1	26	32	PF00069	0.794
MOD_Plk_1	574	580	PF00069	0.660
MOD_Plk_2-3	108	114	PF00069	0.859
MOD_Plk_2-3	358	364	PF00069	0.690
MOD_Plk_4	11	17	PF00069	0.775
MOD_Plk_4	272	278	PF00069	0.762
MOD_Plk_4	385	391	PF00069	0.735
MOD_Plk_4	456	462	PF00069	0.710
MOD_Plk_4	592	598	PF00069	0.810
MOD_Plk_4	600	606	PF00069	0.725
MOD_Plk_4	643	649	PF00069	0.678
MOD_Plk_4	675	681	PF00069	0.461
MOD_ProDKin_1	100	106	PF00069	0.760
MOD_ProDKin_1	186	192	PF00069	0.817
MOD_ProDKin_1	195	201	PF00069	0.763
MOD_ProDKin_1	236	242	PF00069	0.832
MOD_ProDKin_1	269	275	PF00069	0.809
MOD_ProDKin_1	281	287	PF00069	0.719
MOD_ProDKin_1	31	37	PF00069	0.840
MOD_ProDKin_1	417	423	PF00069	0.726
MOD_ProDKin_1	447	453	PF00069	0.711
MOD_ProDKin_1	472	478	PF00069	0.789
MOD_ProDKin_1	480	486	PF00069	0.731
MOD_ProDKin_1	50	56	PF00069	0.849
MOD_ProDKin_1	584	590	PF00069	0.710
MOD_ProDKin_1	637	643	PF00069	0.821
MOD_ProDKin_1	8	14	PF00069	0.775
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.769
TRG_ENDOCYTIC_2	301	304	PF00928	0.683
TRG_ER_diArg_1	130	133	PF00400	0.852
TRG_ER_diArg_1	20	22	PF00400	0.791
TRG_ER_diArg_1	30	32	PF00400	0.709
TRG_ER_diArg_1	320	323	PF00400	0.738
TRG_ER_diArg_1	346	348	PF00400	0.840
TRG_ER_diArg_1	377	380	PF00400	0.771
TRG_ER_diArg_1	47	49	PF00400	0.816
TRG_ER_diArg_1	599	601	PF00400	0.759
TRG_ER_diArg_1	614	617	PF00400	0.697
TRG_ER_diArg_1	653	656	PF00400	0.717

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFX5	Leishmania donovani	99%	100%
A4HD02	Leishmania braziliensis	52%	99%
E9AWE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	98%
Q4QB23	Leishmania major	86%	100%