Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I0I4_LEIIN

TriTrypDb:

LINF_230021800

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4I0I4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I0I4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.720
CLV_NRD_NRD_1	12	14	PF00675	0.453
CLV_NRD_NRD_1	220	222	PF00675	0.571
CLV_NRD_NRD_1	224	226	PF00675	0.545
CLV_NRD_NRD_1	71	73	PF00675	0.348
CLV_PCSK_KEX2_1	12	14	PF00082	0.453
CLV_PCSK_KEX2_1	220	222	PF00082	0.571
CLV_PCSK_KEX2_1	224	226	PF00082	0.545
CLV_PCSK_KEX2_1	71	73	PF00082	0.348
CLV_PCSK_PC7_1	220	226	PF00082	0.520
CLV_PCSK_PC7_1	67	73	PF00082	0.342
CLV_PCSK_SKI1_1	125	129	PF00082	0.492
DEG_SCF_FBW7_1	209	214	PF00400	0.733
DEG_SCF_FBW7_1	285	292	PF00400	0.732
DEG_SPOP_SBC_1	264	268	PF00917	0.744
DEG_SPOP_SBC_1	325	329	PF00917	0.670
DOC_CKS1_1	286	291	PF01111	0.726
DOC_MAPK_gen_1	121	130	PF00069	0.633
DOC_MAPK_MEF2A_6	349	358	PF00069	0.708
DOC_PP2B_LxvP_1	335	338	PF13499	0.729
DOC_PP2B_PxIxI_1	353	359	PF00149	0.725
DOC_USP7_MATH_1	113	117	PF00917	0.714
DOC_USP7_MATH_1	129	133	PF00917	0.753
DOC_USP7_MATH_1	152	156	PF00917	0.810
DOC_USP7_MATH_1	162	166	PF00917	0.646
DOC_USP7_MATH_1	178	182	PF00917	0.694
DOC_USP7_MATH_1	211	215	PF00917	0.780
DOC_USP7_MATH_1	223	227	PF00917	0.703
DOC_USP7_MATH_1	236	240	PF00917	0.608
DOC_USP7_MATH_1	257	261	PF00917	0.760
DOC_USP7_MATH_1	264	268	PF00917	0.747
DOC_USP7_MATH_1	289	293	PF00917	0.751
DOC_WW_Pin1_4	131	136	PF00397	0.730
DOC_WW_Pin1_4	207	212	PF00397	0.766
DOC_WW_Pin1_4	219	224	PF00397	0.677
DOC_WW_Pin1_4	255	260	PF00397	0.728
DOC_WW_Pin1_4	278	283	PF00397	0.751
DOC_WW_Pin1_4	285	290	PF00397	0.743
DOC_WW_Pin1_4	294	299	PF00397	0.672
DOC_WW_Pin1_4	311	316	PF00397	0.625
DOC_WW_Pin1_4	333	338	PF00397	0.728
DOC_WW_Pin1_4	350	355	PF00397	0.629
DOC_WW_Pin1_4	366	371	PF00397	0.638
LIG_14-3-3_CanoR_1	224	232	PF00244	0.820
LIG_14-3-3_CanoR_1	235	244	PF00244	0.656
LIG_14-3-3_CanoR_1	307	316	PF00244	0.706
LIG_14-3-3_CanoR_1	349	354	PF00244	0.707
LIG_14-3-3_CanoR_1	99	104	PF00244	0.632
LIG_APCC_ABBA_1	91	96	PF00400	0.668
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_BRCT_BRCA1_1	181	185	PF00533	0.764
LIG_CSL_BTD_1	299	302	PF09270	0.744
LIG_FHA_1	174	180	PF00498	0.693
LIG_FHA_1	286	292	PF00498	0.709
LIG_FHA_1	360	366	PF00498	0.678
LIG_FHA_2	241	247	PF00498	0.731
LIG_FHA_2	306	312	PF00498	0.721
LIG_FHA_2	337	343	PF00498	0.733
LIG_LIR_Gen_1	182	192	PF02991	0.710
LIG_LIR_Gen_1	228	238	PF02991	0.714
LIG_LIR_Gen_1	239	246	PF02991	0.651
LIG_LIR_Nem_3	182	188	PF02991	0.706
LIG_LIR_Nem_3	228	233	PF02991	0.675
LIG_LIR_Nem_3	239	244	PF02991	0.683
LIG_PCNA_yPIPBox_3	81	91	PF02747	0.688
LIG_Pex14_1	51	55	PF04695	0.405
LIG_SH2_SRC	340	343	PF00017	0.736
LIG_SH2_STAP1	340	344	PF00017	0.736
LIG_SH2_STAT5	232	235	PF00017	0.654
LIG_SH2_STAT5	94	97	PF00017	0.711
LIG_SH3_2	302	307	PF14604	0.664
LIG_SH3_3	253	259	PF00018	0.758
LIG_SH3_3	27	33	PF00018	0.405
LIG_SH3_3	283	289	PF00018	0.732
LIG_SH3_3	292	298	PF00018	0.693
LIG_SH3_3	299	305	PF00018	0.668
LIG_SH3_3	87	93	PF00018	0.706
LIG_SUMO_SIM_par_1	314	320	PF11976	0.706
LIG_TRAF2_1	193	196	PF00917	0.736
LIG_TRAF2_1	339	342	PF00917	0.736
LIG_WW_1	337	340	PF00397	0.733
MOD_CDK_SPK_2	219	224	PF00069	0.700
MOD_CDK_SPK_2	350	355	PF00069	0.724
MOD_CDK_SPxK_1	219	225	PF00069	0.673
MOD_CK1_1	114	120	PF00069	0.766
MOD_CK1_1	151	157	PF00069	0.700
MOD_CK1_1	239	245	PF00069	0.656
MOD_CK1_1	258	264	PF00069	0.842
MOD_CK1_1	267	273	PF00069	0.776
MOD_CK1_1	317	323	PF00069	0.799
MOD_CK1_1	327	333	PF00069	0.710
MOD_CK1_1	336	342	PF00069	0.626
MOD_CK1_1	347	353	PF00069	0.640
MOD_CK2_1	113	119	PF00069	0.756
MOD_CK2_1	174	180	PF00069	0.689
MOD_CK2_1	190	196	PF00069	0.806
MOD_CK2_1	240	246	PF00069	0.728
MOD_CK2_1	336	342	PF00069	0.732
MOD_Cter_Amidation	218	221	PF01082	0.559
MOD_DYRK1A_RPxSP_1	133	137	PF00069	0.750
MOD_GlcNHglycan	150	153	PF01048	0.554
MOD_GlcNHglycan	154	157	PF01048	0.558
MOD_GlcNHglycan	159	162	PF01048	0.449
MOD_GlcNHglycan	164	167	PF01048	0.406
MOD_GlcNHglycan	176	179	PF01048	0.494
MOD_GlcNHglycan	180	184	PF01048	0.455
MOD_GlcNHglycan	211	214	PF01048	0.616
MOD_GlcNHglycan	215	218	PF01048	0.634
MOD_GlcNHglycan	291	294	PF01048	0.545
MOD_GlcNHglycan	359	362	PF01048	0.460
MOD_GSK3_1	111	118	PF00069	0.712
MOD_GSK3_1	129	136	PF00069	0.659
MOD_GSK3_1	148	155	PF00069	0.657
MOD_GSK3_1	162	169	PF00069	0.766
MOD_GSK3_1	174	181	PF00069	0.711
MOD_GSK3_1	186	193	PF00069	0.628
MOD_GSK3_1	205	212	PF00069	0.758
MOD_GSK3_1	215	222	PF00069	0.739
MOD_GSK3_1	236	243	PF00069	0.742
MOD_GSK3_1	246	253	PF00069	0.777
MOD_GSK3_1	258	265	PF00069	0.780
MOD_GSK3_1	269	276	PF00069	0.728
MOD_GSK3_1	281	288	PF00069	0.665
MOD_GSK3_1	305	312	PF00069	0.740
MOD_GSK3_1	320	327	PF00069	0.664
MOD_GSK3_1	344	351	PF00069	0.678
MOD_GSK3_1	366	373	PF00069	0.654
MOD_GSK3_1	95	102	PF00069	0.642
MOD_N-GLC_1	152	157	PF02516	0.561
MOD_NEK2_1	172	177	PF00069	0.720
MOD_NEK2_1	179	184	PF00069	0.642
MOD_NEK2_1	186	191	PF00069	0.613
MOD_NEK2_1	309	314	PF00069	0.708
MOD_NEK2_1	359	364	PF00069	0.675
MOD_PIKK_1	317	323	PF00454	0.716
MOD_PIKK_1	327	333	PF00454	0.670
MOD_PK_1	99	105	PF00069	0.635
MOD_PKA_2	223	229	PF00069	0.743
MOD_PKA_2	348	354	PF00069	0.706
MOD_Plk_1	239	245	PF00069	0.699
MOD_Plk_1	95	101	PF00069	0.667
MOD_Plk_2-3	240	246	PF00069	0.728
MOD_Plk_2-3	250	256	PF00069	0.726
MOD_Plk_4	44	50	PF00069	0.405
MOD_ProDKin_1	131	137	PF00069	0.731
MOD_ProDKin_1	207	213	PF00069	0.764
MOD_ProDKin_1	219	225	PF00069	0.677
MOD_ProDKin_1	255	261	PF00069	0.726
MOD_ProDKin_1	278	284	PF00069	0.752
MOD_ProDKin_1	285	291	PF00069	0.742
MOD_ProDKin_1	294	300	PF00069	0.672
MOD_ProDKin_1	311	317	PF00069	0.624
MOD_ProDKin_1	333	339	PF00069	0.729
MOD_ProDKin_1	350	356	PF00069	0.629
MOD_ProDKin_1	366	372	PF00069	0.638
MOD_SUMO_rev_2	310	315	PF00179	0.702
TRG_DiLeu_BaEn_1	96	101	PF01217	0.670
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.405
TRG_ER_diArg_1	11	13	PF00400	0.656
TRG_ER_diArg_1	223	225	PF00400	0.720
TRG_ER_diArg_1	70	72	PF00400	0.587
TRG_ER_diArg_1	82	85	PF00400	0.633
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WXU4	Leishmania donovani	98%	100%
A4HCZ9	Leishmania braziliensis	64%	100%
E9AWE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QB26	Leishmania major	86%	100%